Gene 28933 (Tetrahymena)

28933

Species: Tetrahymena
Alias: PreTt28933, 28933, TTHERM_00575430, 3812.m02628, 227, 77.m00145
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
28933.AA Protein None 780 None Fasta, JSON
28933.kin_dom Protein Kinase Domain None 247 None Fasta, JSON
28933.NA RNA None 2343 None Fasta, JSON

Protein domain

Protein domains of 28933.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28933.AA ULK 45-291 37 6.1e-118 398.12 In-house 1-324 (324) Show / Hide 
Range on Protein: 45-291
Range on HMM: 1-324/324
Sequence Identity: 37% (123 aa)

YQLNDQIGKGYSS-KVFKGKDERT---DEEVAVKVID---MKMMSN----EVQLFLLQNEISVMKKLALTGNIN--ILKLNDVFQTA--NNTYIITEICN
|.||...|||    ||.||....|   .. ||.|.||   |.. .|    .....||.|||..||||  . . |  | || |.|.|.  ||.|||.| ||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

QGDLRDLLKKYNT---------LEESQAVKILKHIINGYRELAKHRIVHRDIKPANILINDGIPK-------------LADFGFAKDID---APPYKYYY
.|||....||...         |.|..|....|.|.||..|| || |.||||||.||||..|.||             .||||||| .|       ....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

NV------GTPMYMCPQ---------------SDIWSIGVLYFELLYGVTP---WTAETEK----ELHHK-------VCNVPVQFP---KHIKISNESIE
 |      |||.||.||               .||||.|....|.||| .|   | .....    .| ..       ..| |.|||   | .|||.|...
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FIRGCLQVDERRRFSLEQIENHPLM
.||..||.||. |.| |.| |||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 28933.AA ULK 45-291 36 5.4e-115 388.33 In-house 1-329 (329) Show / Hide 
Range on Protein: 45-291
Range on HMM: 1-329/329
Sequence Identity: 36% (120 aa)

YQLNDQIGKGYSSKVFKGKDERT----DEEVAVKVID---MKMMSN----EVQLFLLQNEISVMKKLALT-GNIN----ILKLNDVFQTA--NNTYIITE
|.||...|||   ||.||....|    .| ||.|.||   |.. .|    .....||.||| .||||  . ...|    | || |.|.|.  ||.|||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

ICNQGDLRDLLKKYNT----------LEESQAVKILKHIINGYRELAKHRIVHRDIKPANILINDGIPK-------------LADFGFAKDIDAP---PY
 ||.|||....||...          |.|..|....|.|.||..|| ||.|.||||||.||||..|.||             .||||||| .| .     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

KYYYNV------GTPMYMCPQ---------------SDIWSIGVLYFELLYGVTP---WTAETEK-----ELHHK-------VCNVPVQFP---KHIKIS
 ... |      |||.||.||               .||||.|....|.||| .|   | .....     .|  .       ... | |||   ....||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

NESIEFIRGCLQVDERRRFSLEQIENHPLM
.|....||..||.||. |.| |.. |||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 28933.AA S_TKc 45-291 29 4.8e-69 236.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 45-291
Range on HMM: 1-231/231
Sequence Identity: 29% (79 aa)

YQLNDQIGKGYSSKVFKGKDERTDEEVAVKVIDMKMMSNEVQLFLLQNEISVMKKLALTGNINILKLNDVFQTANNTYIITEICNQ--GDLRDLLKKYNT
|.. ..||||  .||.|... .|...||.|.|.            ...||...||    .  || || ||||. .. |...| |..  |||.|..||...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------LEESQAVKILKHIINGYRELAKHRIVHRDIKPANILINDGIPKLADFGFAKDIDAPPYKYYYNVGTPMYMCP--------QSDIWSIGVLYFEL
      . | .| .... |...   . .|.|.|||.||.|||...   |..|||.|. .       .  .||| || |         .|.||.|.. .|.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEM

LYGVTPWTAETEKELHHKVCNVPVQFPKHIKISNESIEFIRGCLQVDERRRFSLEQIEN-------HPLM
|.| .|.   ..... .|..            | | ..|||.|||.| ..| .  .. .       || .
LCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 28933.AA Ciliate-E2 45-291 22 5.3e-68 232.24 In-house 1-365 (365) Show / Hide 
Range on Protein: 45-291
Range on HMM: 1-365/365
Sequence Identity: 22% (86 aa)

YQLNDQIGKGYSSKVFKGKDERTDEEVAVKVIDMKM------------------MSNEVQLFLLQNEISVMKKLA-------------LTGNINILKLND
| .. .||.|  ..|.|.|. ......| |.|| ..                  . .. |.. . .||..|...              .  . ||.|. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

VFQ--TANNTYIITEICNQGDLRDLLK------------KYNTLEESQAVKILKHIINGY---------------RELAKHR-IVHRDIKPANILINDGI
.||  . || |...| |..|||.|..|            . . . | .. .| |.|..|.               ..| .   |.|||||| |||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

PKLADFGFAKDIDAP-----------PYKYYYN---------------------VGTPMYMCP-------------------QSDIWSIGVLYFELLYGV
.|..|||..|..| .            |..  |                     .|||.||.|                   ..||||.||. .|.|.| 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

TPWTAETEKELHHKVCNVPVQFP----------------KHIKISNESIEFIRG----CLQVDERRRFS-LEQIENHPLM
.|.          . .. ...||                .. |.|.| . .|.     .||.|.  |..  ||| ||| .
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 28933.AA CAMK 50-291 20 1.9e-63 203.02 In-house 1-425 (425) Show / Hide 
Range on Protein: 50-291
Range on HMM: 1-425/425
Sequence Identity: 20% (89 aa)

QIGKGYSSKVFKGKDERTD------------EEVAVKVIDMKMMSN-------------------------EVQLFLLQNEISVMKKLALTG----NINI
..|.|  .||..... .|             ..||.|.|| | ...                         .. .  ...||..||||  .|      ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKLNDVFQ------------TANN--------TYIIT---EICNQG----DLRDLLKKY---------------NTLEESQAVKILKHIINGYRELAKHR
.|| .|..            | ..         |...   | |  |    || | ...                  ..|..| .. . |. . . . .| 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKPANILIND------------------GIPKLADFGFAKDIDA-----------------------PPYKYYYNVGTPMYMC------------
|||||.|| |||..|                  .  |..|||||. .|                        .  |..  .||| ||.            
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-------------PQSDIWSIGVLYFELLYGVTPWTAE-------------TEKELHHKVCNVPVQFP-----------------------KHIKISNES
             |..|.||.||. . .| |  |. ..             ...||..|...   .||                       .| ..| | 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQEC

IEFIRGCLQVDERRRFSLEQIENHPLM
. .||..||||  .|...||. ||| |
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 28933.AA Ciliate-E2-Unclassified 45-291 23 2.6e-61 209.99 In-house 1-352 (352) Show / Hide 
Range on Protein: 45-291
Range on HMM: 1-352/352
Sequence Identity: 23% (82 aa)

YQLNDQIGKGYSSKVFKGKDERTDEEV-----AVKVIDMK---MMSNEVQLFLLQNEISVMK-------------KLALTGNINILKLNDVFQTANNTYI
| .. |||.|  .||.| ... .. ..     . |... |   .|... .. . ..|.  .|              |    ...|.|. ..||. .| ||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ITEICNQGDLRDLLKKYNT-----------------LEESQAV-----KILKHIINGY-RELAKHRIVHRDIKPANILINDG----IPKLADFGFAKDID
..| |..|||.. .||...                 ..| ||.     .....|..|      |. |.|||||| |||....     .|..|||..| ..
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

APPYKYYYN----------------VGTPMYM-----------CPQS-------DIWSIGVLYFELLYGVTPWTAETEKE----------------LHHK
 ..... .|                .|||.||           . ..       |||| ||. .|.|.|  |  ......                |. .
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

VCNVPVQFPKHI------KISNESIEFIR----GCLQVDERRRFSLEQIENHPLM
 .. ..||||.       ..|.| ..||.     .|...   | ..||| |||..
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 28933.AA AGC 45-291 18 3.5e-61 155.92 In-house 1-395 (395) Show / Hide 
Range on Protein: 45-291
Range on HMM: 1-395/395
Sequence Identity: 18% (74 aa)

YQLNDQIGKGYSSKVFKGKDE------RTDEEVAVKVIDMKM---MSNEVQLFLLQNE------------ISVMKKLALTG-------NINILK-LNDVF
...   ||||  .||.  ..        |..  |.||.. |    . .. ..   ..|              ...|.  |.       . .| | |   |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTANN--TYIITEICN--------QGDLRDLLKKYN-----TLEESQAVKILK-------HIINGYRELAK-HRIVHRD-IKPANILIND-GIPKLADFG
|. ..   |.. | ..         |..  .| ...     ...|..|  ..        .|. .   | . . |.||| .|| |||... |  ||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKDIDAPP--------------------------------------------------YKYYYNVG--TPMYMC------PQSDIWS--IGVLYFELLY
..| .   .                                                   . .  .|  || ||       .. |.||   |.| .|.|.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEILYGKACDWWSFGLGCLMYEMLT

GVTPWTAET----------EKELHHKVC------NVPVQFPKH--------IKISNESIEFIRGCLQVDERRRFS----------LEQIENHPLM
| .| ....          ..|...|..      | .|.|| .         ..|.|   .|...|..| ..|             |.| |||  
GYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 28933.AA Ciliate-E2c 45-291 27 5.4e-54 185.7 In-house 1-310 (310) Show / Hide 
Range on Protein: 45-291
Range on HMM: 1-310/310
Sequence Identity: 27% (87 aa)

YQLNDQIGKGYSSKVFKG---KDERTDEEV------------AVKVIDMKMMSNEVQLFLLQNEISVMKKLALTGNINILKLNDVFQTANNTYIITEICN
.  |   |.|   ||.|.   .|...  ..            . |..|..| .   ..  . .||  ||..    . .|.|  | .|| .. |.|.| ||
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMN---HPHIIKFYDAKQTDKHIYLIMEYCN

QGDLRDLLKKYNTLEESQAVKILKHIINGYRELAKH-RIVHRDIKPANILINDGIPKLADFGFAKDIDAPPYKYYY----NVGTPMYMCPQ---------
.|.| .....   ..| | .   . ||..  .| |  .| ||||||.||||..|..|.|||||.| ..   .....     .|||||| ||         
GGTLEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYT

--SDIWSIGVLYFELLYGVTPWT------------------AETEKELHHKVC---------------NVPVQFPKH--IKISNESIEFIRGCLQVDERR
  ||||| ||. .. |.   ||                   ..| |.|   .                . ...||.   ..|| |  ..|.  |||||  
EKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEK

RFSLEQIENHPLM
|.. ..| ||.. 
RIDWDEIFNHECI
Kinase 28933.AA STE 45-291 23 2.2e-45 157.12 In-house 1-359 (359) Show / Hide 
Range on Protein: 45-291
Range on HMM: 1-359/359
Sequence Identity: 23% (84 aa)

YQLNDQIGKGYSSKVFKGKDE------RTDEE---------VAVKVIDMKMMSN--------------EVQLFLLQNEISVMKKLALTGNINILKLNDVF
... ..|||| . .|.|...       .|.|.         .|.|.....  .|              . ..  ...||..|||.  .   || |  . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM-HPNIVKYYGCY

QTA-------NNTYIITEICNQGDLRDLLK-KYNTLE-------------ESQAVKILKHIING-YRELAKHRIVHRDIKPANILINDGIPKLADFGFAK
          .. .|. | .. | |.|..| || ...             |||  .|.. |. |    | .|.|.||||||||||.     ||.|||...
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCG

DIDAPPY----------------KYYYNVGTPMYMCP----Q------------SDIWSIGVLYFELLYGVTPWTAETEKELHHKVC-------------
 ..                    | .  |||| .| |    |            .||||.| .  |.. |  ||  ..  .                   
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---NVPVQFPKH-----------------IKISNESIEFIRGCLQVDERRRFSLEQIEN--HPLM
   . | ..| |                  | | | ..||. ||| | . | . .|  .  ||  
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 28933.AA SAK 45-291 30 4.4e-39 130.59 In-house 1-254 (254) Show / Hide 
Range on Protein: 45-291
Range on HMM: 1-254/254
Sequence Identity: 30% (80 aa)

YQLNDQIGKGYSSKVFKGKDERTDEEVAVKVIDMKMMSNEVQLFLLQNEISVMKKLALTGNINILKLNDVFQTANNTYIITEICNQGDL-RDLLKKYNTL
||  . .|||    |.. |   |  |||.|.|| |.| .       .||. .  .|       ||.|   |. .|  |.. |.|  |.. | . ..    
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHP---SILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPF

EESQAVKILKHIINGYRELAKHRIVHRDIKPANILINDGIP-KLADFGFAKDIDAPPYKYYYNVGTPMYMCP----------QSDIWSIGVLYFELLYGV
 |  | .....|. |   |  | |.|||.  .|||.   .  |.|||| |  .  |  | |   ||| |. |          |||.||.| ... || | 
TEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGR

TPWTAETEKELHHKVCNVPVQFPKHIKISNESIEFIRGCLQVDERRRFSLEQIENHPLM
 |.  .. |.   ||       | |  .| |  . |   |. .   | .|. .  || |
PPFDTDAVKNTLNKVMMAEYIMPAH--LSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase 28933.AA Pkinase 45-212 29 6.2e-37 131.68 Pfam 1-178 (293) Show / Hide 
Range on Protein: 45-212
Range on HMM: 1-178/293
Sequence Identity: 29% (55 aa)

YQLNDQIGKGYSSKVFKGKDERTDEEVAVKVIDMKMMSNEVQ--LFLLQNEISVMKKLALTGNINILKLNDVFQTANNTYIITEICNQG----DLRDLLK
|..  .||.| ...|.|...  | ..||||.|. .  . ...  ...| .||..||.|      ||..| |.|.. .. |...| |. |    || |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--KYNTL--EESQAVKILKHIINGYRELAKHRIVHRDIKPANILIN-DGIP----KLADFGFAKDI-DAPPYKYYYNVGTPMYM
  .....  .| .. .... |. |   . ...|.|||.||.||||. .| .    |..|||.|| .   .   ..  .||| ||
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYM
Kinase 28933.AA CAMKL 45-214 29 9.5e-37 114.7 In-house 1-202 (297) Show / Hide 
Range on Protein: 45-214
Range on HMM: 1-202/297
Sequence Identity: 29% (60 aa)

YQLNDQIGKGYSSKVFKGKD-ERTDEEVAVKVIDMKMMS-NEVQLFL-----------LQNEISVMKKLALTG-NINILKLNDVFQTANN------TYII
|.. ...|||  .||  ...   | |.||.|.|| | .. ... .             .. ||. ||.|  .|   || || .|..| ..       |..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLN-IGKHPNIIKLYEVIETPEHDIETKKIYLV

TEICNQGD--LRDLLKKY----NTLEESQAVKILKHIINGYRELAKHRIVHRDIKPANILIN-DG--IPKLADFGFAKDID---APPYK-YYYNVGTPMY
.| |  |.  | | ..|       ..|..| .. . |. .   . .|.|||||||| |||.  .|    |..||||.  ..    .| .      |.| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MCP
|.|
MAP
Kinase 28933.AA CAMKL 217-291 30 2.1e-20 61.66 In-house 218-297 (297) Show / Hide 
Range on Protein: 217-291
Range on HMM: 218-297/297
Sequence Identity: 30% (25 aa)

DIWSIGVLYFELLYGVTPWTAETEK-------ELHHKVCNVPVQFPKHIKISNESIEFIRGCLQVDERRRFSLEQIENHPLM
||||.||. . ...|  |. ..| .       .|..|.     ..|.....| . . .||. |||.  .|....||.||| |
DIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 28933.AA Pkinase 214-291 23 1e-15 56.65 Pfam 191-293 (293) Show / Hide 
Range on Protein: 214-291
Range on HMM: 191-293/293
Sequence Identity: 23% (24 aa)

PQSDIWSIGVLYFELLYGVTPWTAE------TEKELHHKVCNVPVQFPKHIKIS-------------------NESIEFIRGCLQVDERRRFSLEQIENH
| .|.||.|.. .|.| | .|.  .      ...... ..   |. |.   ..|                    | ..||..||..|  .| . ||| .|
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PLM
| .
PWF
Kinase 28933.AA TyrKc 45-291 21 9.7e-14 -0.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 45-291
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YQLNDQIGKGYSSKVFKGKDERTDEEVAVKVIDMKMMSNEVQLFLLQNEISVMKKL-ALTGNINILKLNDVFQTA-------NNTYIITEICNQGDLRDL
 .|....| |   .|.||.     ..||||..          .  . .|...|.||     . ||..|  |  .           .|..| .  |||.| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGG--HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKKYNT-LEESQAVKILKHIINGYRELAKHRIVHRDIKPANILINDG-IPKLADFGFAKDIDAPPYKY--------YYNV----GTP-------------
|.|.   |  .. ...   | .| . |......|||.   |.|.... . | .||| ..||    | .        || .    |.              
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDI----YDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

MYMC--PQSDIWSIGVLYFELL-YGVTPWTA-----ETEKELHHKVCNVPVQFPKHI-------KISNESIEFIRGCLQVDERRRFSLEQIENHPLM
.| .  ..||.|| ||. .|.. || .|.        . .|....| .     . .          . |  . .. | . |   | . ..|  | ..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 28933.AA Pkinase_Tyr 45-195 27 1.3e-13 46.68 Pfam 1-161 (270) Show / Hide 
Range on Protein: 45-195
Range on HMM: 1-161/270
Sequence Identity: 27% (45 aa)

YQLNDQIGKGYSSKVFKGKDE----RTDEEVAVKVIDMKMMSNE--VQLFLLQNEISVMKKLALTGNINILKLNDVFQ-TANN--TYIITEICNQGDLRD
 ... ..|.|   .|.||.       |. .||||..  . |. .   . |.   |...||.|    . ||..|  |          ||..| .  |||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR--EAKIMKQLG--HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

LLKKY----NTLEESQAVKILKHIINGYRELAKHRIVHRDIKPANILIN-DGIPKLADFGFAKDI
 |.|     . |  .. ...   | .|   |. ....|||.   |.|.. ... | .||| |.||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI