Gene 30213 (Tetrahymena)

30213

Species: Tetrahymena
Alias: PreTt30213, 3705.m00053, 30213, 472, 33.m00225, TTHERM_00327100
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
30213.AA Protein None 552 None Fasta, JSON
30213.kin_dom Protein Kinase Domain None 254 None Fasta, JSON
30213.NA RNA None 1659 None Fasta, JSON

Protein domain

Protein domains of 30213.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 30213.AA ULK 9-262 34 7.79999999999e-125 421.02 In-house 1-324 (324) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-324/324
Sequence Identity: 34% (112 aa)

IISEQKLGEGGFG-TVYQGIDVIN---QKFVACKAVSIAKLAQIPKLVE------LFAQEIALQQKLK---SPF--TVELYKVYKCQDH--FYLILEFCE
..  ..||.| || .||.|.....   ...|||| ... |. ..... |      |. .|| ...|||   .|.  .|.||.......|  .|.|.|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLSQYVKKNGP---------LPEQKAIGFLMQILAGFRVLHQNSIIHRDLKPANILMSGN-------------VLKIADFGAARTVDLENQAATKI--
||||.|| |||..         |.||.||.|..||..||. ||.. |||||.||.|||.. .             |||||||| |..|| .|......  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

--------GTPLFLAPEIQE----DKEYG-FEVDIYSLGVLLYFMLFNDYPFGGSGIQLYNN---------------MKSEKIDFKK--NGVVISSQLKD
        ||||. ||.|..     |.|. ...||.|||...| ||.. ||| .. .. ...               .| ..|.|.|  ....||...||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIVRLLKYDREQRITWAQIYQHPIV
|| |.|.||...||.| .|..||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 30213.AA ULK 9-262 34 2.9e-121 409.17 In-house 1-329 (329) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-329/329
Sequence Identity: 34% (112 aa)

IISEQKLGEGGFGTVYQGIDVIN----QKFVACKAVSIAKLAQIPKLVE------LFAQEIALQQKLK----SPF----TVELYKVYKCQDH--FYLILE
..  ..||.| ||.||.|.....    .. |||| ... |. |.... |      |. .|| ...|||    ...    .|.||.......|  .|.|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCEGGDLSQYVKKNGP----------LPEQKAIGFLMQILAGFRVLHQNSIIHRDLKPANILMSGN-------------VLKIADFGAARTVDLE----N
.|.||||.|| |||..          |.||.|| |..|||.||. ||.. |||||.||.|||.. .             |||||||| |..|| .    .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

QAATKI------GTPLFLAPEIQE----DKEYG-FEVDIYSLGVLLYFMLFNDYPFGGSGIQLY-----NN----------MKSEKIDFKK--NGVVISS
.. |        ||||. ||.| .     |.|. ...||.|||...| ||.. .|| ..  ..|     ..          .|.....|.|  |...||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

QLKDLIVRLLKYDREQRITWAQIYQHPIV
..|||| |.|.||...||.| ....||..
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 30213.AA Ciliate-E2 9-262 25 5.8e-83 281.93 In-house 1-365 (365) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

IISEQKLGEGGFGTVYQGIDVINQKFVA----------------CKAVSIAKLAQIPKLVELFAQEIALQQ----------------KLKSPFTVELYKV
..  .|.|.|.||.||.. .  .|| .|                .|.  .|.  .... .| . ||| . .                .|..|. ...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YK--CQDHFYLILEFCEGGDLSQYVKKN-----------GPLPEQKAIGFLMQILA---------------GFRVLHQNS-IIHRDLKPANILMSGNVLK
..   ....||..|.|.|||| .| |.|           ... |.... .  |||                ... ||..  |||||.|| |||.    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGAARTVDLE--------------------------------NQAATKIGTPLFLAPEIQEDKE---------YGFEVDIYSLGVLLYFMLFNDYPF
|.||| .. .| .                                |.. | .||| ..|||| . |.         |....||.||||.||.|||. .||
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

GGSGIQLYNNMKSEKIDFKKN---------------GVVISSQLKDLIVR----LLKYDREQRIT-WAQIYQHPIV
       ... |  |||| ..                  .| . |||| .    .|..| |.||| | || .||. 
-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 30213.AA S_TKc 9-262 31 1.8e-79 271.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

IISEQKLGEGGFGTVYQGIDVINQKFVACKAVSIAKLAQIPKLVELFAQEIALQQKLKSPFTVELYKVYKCQDHFYLILEFCEG--GDLSQYVKKNGP--
    .|.|.|.||.||.....  .. ||.| ..           | . .||.. .| . |. | || |.   ||.|...|.|.|  ||| .| ||.|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPEQKAIGFLMQILAGFRVLHQNSIIHRDLKPANILMSGNVLKIADFGAARTVDLENQAATKIGTPLFLAPEIQEDKEYGF-EVDIYSLGVLLYFM
    .||  |  .. ||. .   .|.. ||||||||.|||..  ..||.||| || .       | .||| ..|||.     ||. ..|..|.|..|| |
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LFNDYPFGGSGIQLYNNMKSEKIDFKKNGVVISSQLKDLIVRLLKYDREQRITWAQIYQ-------HPIV
|    ||     .......             |...||.| ..|..| |.|.|  .. |       || .
LCGYPPFP-QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 30213.AA Ciliate-E2-Unclassified 9-262 26 7.3e-73 248.37 In-house 1-352 (352) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-352/352
Sequence Identity: 26% (95 aa)

IISEQKLGEGGFGTVYQGIDVINQKFV-----ACKAVSIAKLAQIPKLVELFAQEIALQQK------------------LKSPFTVELYKVYKCQDHFYL
 .  ...|.||||.||. ..  .. ..     ..|. ..... .  |  |.  .......|                  ...|| | .. . . ....|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ILEFCEGGDLSQYVKKNGP-----------------LPEQKAI-----GFLMQILAGFRVLHQNS-IIHRDLKPANILMSGN----VLKIADFGAARTVD
..|.||||||.|| ||..                  ..||.|.      .. ||| |.  ||..  |||||.|| |||.. |     .||.||| ..  .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

LENQ----------------AATKIGTPLFL----APEIQEDKEYG----FEVDIYSLGVLLYFMLFNDYPFGG-SGIQ----------------LYNNM
  |.                . |..||| ..    |||. . ..|.    ...||.||||.||.|||. |||.. . .|                ||.| 
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KSEKIDFKKNG-----VVISSQLKDLIV----RLLKYDREQRITWAQIYQHPIV
|  .|.|.|         .| . ||.|     ..||.. ..|||. || .||. 
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 30213.AA CAMK 14-262 22 9e-72 230.33 In-house 1-425 (425) Show / Hide 
Range on Protein: 14-262
Range on HMM: 1-425/425
Sequence Identity: 22% (95 aa)

KLGEGGFGTVYQGIDVINQ------------KFVACKAVSIAKLAQ------------------------IPKLVELFAQEIALQQK-------LKSPFT
.||.|.||.|. .|.  ..            . ||.| ..  ||                           ||  . . .||.. .|       |. |  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VELYKVYKC-------------------QDHFYLIL---EFCEGG----DLSQYVKKNGP---------------LPEQKAIGFLMQILAGFRVLHQNSI
. || ||                     ..|.|...   |.|.||    || .|....|.               ..|. |  .  ||. . . .|.. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPANILMSGN------------------VLKIADFGAARTVDLEN------------------------QAATKIGTPLFLA-PEIQEDKE----
.|||||| |||.. |                   .||.||| |. .|  .                           |  ||| . | ||. . |     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YGFEVDIYSLGVLLYFMLFNDYPFGGSG--------------IQLYNNMKSEKIDFKKN-------------GVVISSQ--------LKD
          ||...|. |.||.||.||   .|| |.                .|. . .. | ||                   || .         ||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIVRLLKYDREQRITWAQIYQHPIV
|| ..|..| |.|.| .|. .|| .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 30213.AA Pkinase 9-262 30 1.7e-71 248.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

IISEQKLGEGGFGTVYQGIDVINQKFVACKAVSIAKLAQIPKLVELFA-QEIALQQKLKSPFTVELYKVYKCQDHFYLILEFCEGG----DLSQYVK--K
.  ..|.|.|.||.||..... ..| ||.| ..    .   |.....  .||.. ..|..|. |.|| ..   || |...|.||||    ||. |..  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NGPL--PEQKAIGFLMQILAGFRVLHQNSIIHRDLKPANILMS--GNV---LKIADFGAARTV-DLENQAATKI-GTPLFLAPEI-QEDKEYGFEVDIYS
.|..  .|. .. .. ||| |   .|...||||||||.|||..  |..   .||.||| |. .    |. .| . ||| ..|||. .....|| .||..|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLLYFMLFNDYPFGGS-------GIQLYNNMKSEKIDFK-------------------KNGVVISSQLKDLIVRLLKYDREQRITWAQIYQHPIV
.|..|| ||.   || |.        .|.... .. ...|                    .. . .|. .||.| ..|..| ..|.|..|| ||| .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 30213.AA AGC 9-262 20 7.3e-67 170.96 In-house 1-395 (395) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-395/395
Sequence Identity: 20% (82 aa)

IISEQKLGEGGFGTVYQGIDV------INQKFVACKAVS----IAKLA--QIPK-LVEL-------FAQEIALQQKLK----------SPFTVE-LYKVY
      .|.|.||.||.  ..       ..|. |.| ..    | ..   .. . ..|        . .|    .|..          .|| |  |.  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KCQDH--FYLILEFCE---------GG-DLSQYVK---KNGPLPEQKAIGFLMQ-------ILAGFRVLHQ-NSIIHRD-LKPANILMSG-NVLKIADFG
. .||   |...|...         || .| .. .   |.| ..|. |  .. .       |. ..  ||. . ||||| ||| |||.     .|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

AARTVDLEN---------------------------------------------------QAATKIG--TPLFLAPEIQEDKEYGFEVDIYS--LGVLLY
 .  .  ..                                                   .. |  |  || ..||||     ||...|..|  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

FMLFNDYPFGGSGI-----------QLYNNMK------SEKIDFKKNG-------VVISSQLKDLIVRLLKYDREQRIT----------WAQIYQHPIV
 ||.   || |              ..... .      ..|. |  ..       . .|...|||| .||. |.|.|..            .| .||  
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 30213.AA CAMKL 8-262 28 2.7e-61 194.32 In-house 1-297 (297) Show / Hide 
Range on Protein: 8-262
Range on HMM: 1-297/297
Sequence Identity: 28% (85 aa)

YIISEQKLGEGGFGTVYQGID-VINQKFVACKAVSIAKLAQIPKLVELFAQ-----------EIALQQKLK---SPFTVELYKVYKCQDH------FYLI
|.| .  ||.|.||.|  ...  .... || | . . |.  .|.    .             ||.....|.    |  . || |.  ..|      .||.
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEFCEGGD--LSQYVKKN----GPLPEQKAIGFLMQILAGFRVLHQNSIIHRDLKPANILMS--GN-VLKIADFGAARTVD-L----ENQAATKIGTPLF
.| |.||.  | .|..|.    |..||  |  .  ||...   .|.. |.|||.|| ||| .  || ..||.||| .   .      ..   |  |.| .
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

LAPEIQED--K-EYGFEVDIYSLGVLLYFMLFNDYPFGGSGIQ-------LYNNMKSEKIDFKKNGVVISSQLKDLIVRLLKYDREQRITWAQIYQHPIV
 |||| ..  |  .|..||| |.||.||.|..  .|| .  ..       .. ... .   .    . .| ...||| ..|. . |.|.|  || .|| .
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 30213.AA Ciliate-E2c 10-262 27 1.5e-54 187.54 In-house 1-310 (310) Show / Hide 
Range on Protein: 10-262
Range on HMM: 1-310/310
Sequence Identity: 27% (84 aa)

ISEQK-LGEGGFGTVYQG---IDVINQKFV---------ACKAVSIA--KLAQIPKLVELFAQEIALQQKLKSPFTVELYKVYKCQDHFYLILEFCEGGD
|.. . || |..|.|| .    |. |.. .            . ..   ... . .  |   .|| .. ....|  .. |   .   |.|||.|.|.||.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LSQYVKKNGPLPEQKAIGFLMQILAGFRVLHQN-SIIHRDLKPANILMSGNVLKIADFGAARTVDLENQAATK-----IGTPLFLAPEIQED-KEYGFEV
| ||....  . |.  .    ||...| .||..  |.|||.||.|||    ..|||||| .. .. .|   |       |||.. ||.| |  ..|    
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS

DIYSLGVLLYFMLFNDYPFG-------------------GSGIQLYNNMK---------------SEKIDFKKN-GVVISSQLKDLIVRLLKYDREQRIT
|| ||||.||.||.  .|.                    ..  .|  . .                 .| | .|  . || ..|.|| . | .| | || 
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID

WAQIYQHPIV
| .|  |.. 
WDEIFNHECI
Kinase 30213.AA Ciliate-E2b 9-207 29 2.3e-54 163.68 In-house 1-211 (272) Show / Hide 
Range on Protein: 9-207
Range on HMM: 1-211/272
Sequence Identity: 29% (63 aa)

IISEQKLGEGGFGTVYQGID-VINQKFVACKAVSIAKLAQIPKLVELFAQEIALQQKLKSPFTVELYKVYKCQDHFYLILEFCEGGDLSQYVKKNG--PL
.|   ||| | || ||..      ... | |..|.... |   .     ||. . .|.. || . ... .|  .| |...||| |..|  ..   |   |
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQ-NMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLL

PEQKAIGFLMQILAGFRVLHQNSIIHRDLKPANILMSG-NVLKIADFGAARTVDLENQ----AATKIGTPLFLAPEIQE-----DKEYGFEVDIYSLGVL
 .. .  .  .|. ... ||...||.||.|| ||.      .|..|.|.| . . .|.      | |||| ..|||| .      | |...|||.|.|. 
STYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGIC

LYFMLFNDYPFG
||....   |..
LYEFMCGYVPWA
Kinase 30213.AA STE 10-262 21 3.1e-51 176.55 In-house 1-359 (359) Show / Hide 
Range on Protein: 10-262
Range on HMM: 1-359/359
Sequence Identity: 21% (78 aa)

ISE-QKLGEGGFGTVYQGIDV----IN-----------QKFVACKAVSIAK------------LAQI-PKLVELFAQEIALQQKLK--SPFTVELYKVYK
    .|.|.|.|||||.....    |.           ....| | ... .            | .. .. .. . .|| . .|..  .|. |. |  | 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

CQ-------DHFYLILEFCEGGDLSQYVKKN--------------GPLPEQKAIGFLMQILAG-FRVLHQNSIIHRDLKPANILMSGNVLKIADFGAART
         |. ....|...|| |.. .|..              ...||.  . .. ||| |    ||.. |||||.||||||.     |..||| .  
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

VDLEN-----------------QAATKIGTPLFLAPEIQE------DKEYGFEVDIYSLGVLLYFMLFNDYPFGG-SGI-----------------QLYN
.. ..                 .  | .||| . |||. .      ||.|.. .||.||| ..  |.   .|.   .                   || .
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-C

NMKSEKIDFKKNGV----------------VISSQLKDLIVRLLKYDREQRITWAQIYQ--HPIV
 .. .   .. .                    |. .|| | . |..| ..| |  |  .  || .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 30213.AA TyrKc 9-260 24 1e-16 47.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-260
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

IISEQKLGEGGFGTVYQGIDVINQKFVACKAVSIAKLAQIPKLVELFAQEIALQQKL--KSPFTVELYKVYKCQ-------DHFYLILEFCEGGDLSQYV
|  ..||||| ||.||.|.       || | .   .       .| | .|. .  ||  . |  | || |   |       .  ....|....||| .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKNGP-LPEQKAIGFLMQILAGFRVLHQNSIIHRDLKPANILMSGNV-LKIADFGAARTVDLE--------NQAATK--IGT---PLF-LAPEIQEDKEY
.|..| |. .. . |  || .| . ||.. .|||||   |.| . |   ||.||| .| .. .           ...   |    |.  .|||   ....
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GFEVDIYSLGVLLY--FMLFNDYPFG-----GSGIQLYNNMKSEKIDFKKNG------VVISSQLKDLIVRLLKYDREQRITWAQIYQHP
 .. |..| ||...  | .    . |      | ...... |. .   .         |  .. . ... .  ..| |.| | ..|..  
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 30213.AA Pkinase_Tyr 80-197 30 1.3e-12 43.39 Pfam 77-205 (270) Show / Hide 
Range on Protein: 80-197
Range on HMM: 77-205/270
Sequence Identity: 30% (40 aa)

QDH--FYLILEFCEGGDLSQYVKK----NGPLPEQKAIGFLMQILAGFRVLHQNSIIHRDLKPANILMS-GNVLKIADFGAARTVDLENQAA-TKIG---
...   |...|....|||  | .|    ..||. .  ... .|| .|   |... .|||||   |.| . .|| ||.||| ||..  .     .| |   
GEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGK

TPLF-LAPEIQEDKEYGFEVDIYSLGVLLY
 | . .|||   ....  . |..| |||..
LPIKWMAPECINYGKFTTKSDVWSFGVLMW
Kinase 30213.AA Pkinase_Tyr 9-27 57 0.013102 9.46 Pfam 1-19 (270) Show / Hide 
Range on Protein: 9-27
Range on HMM: 1-19/270
Sequence Identity: 57% (11 aa)

IISEQKLGEGGFGTVYQGI
|.  .||||| ||.||.|.
ITFGKKLGEGAFGEVYKGT