Gene 4111 (Tetrahymena)

4111

Species: Tetrahymena
Alias: 3675.m00055, TTHERM_00585040, PreTt04111, 80.m00157, 689, 4111
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
4111.AA Protein None 687 None Fasta, JSON
4111.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
4111.NA RNA None 2064 None Fasta, JSON

Protein domain

Protein domains of 4111.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 4111.AA ULK 13-270 39 3.2e-134 452.19 In-house 1-324 (324) Show / Hide 
Range on Protein: 13-270
Range on HMM: 1-324/324
Sequence Identity: 39% (128 aa)

ILVNHKLGRGSYG-TVYRGYLEQDE--NQMIAAKQIPIKEICSSTSR------IQYIKREIENLQKID---SKY--VVKLFGVSRTQ--TNLYMFLEYCV
. .||.|| ||.| .||.|. ....  || .|.|.|..|..  . ..      .| .|.||....|..   ...  .|||. ...|.  .|.|...||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

DGDLKSYLKKK-------ENKILSEPEAIKIFKHIVEGFKELNKYKIIHRDIKPANLLISNGI-------------VKLADFGFSKVVE---DEEARLRS
.|||..|.||.       |.|.|||.|||..||.|..|||||.| .||||||||.|.||.||.             .|.|||||.|.|.    |.  . .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

FI------GSPLYMAPELQE----QMPFS-SKCDVWSTGIVLYEMLYGKTP---WNGSSQL----NLFEN-------IKNQPLVFP---DEPIRSNKLKS
.       |.||||||....    |.|.. .|||.|| |...|||||||.|   |  ..|     .| .|       |||||. ||   ..|..|...|.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIKKMLQYYEKDRISWSEIFDDDLI
||..|||| ||||||| |||.  ..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 4111.AA ULK 13-270 37 5.3e-132 444.82 In-house 1-329 (329) Show / Hide 
Range on Protein: 13-270
Range on HMM: 1-329/329
Sequence Identity: 37% (125 aa)

ILVNHKLGRGSYGTVYRGYLEQDE---NQMIAAKQIPIKEICSSTSR------IQYIKREIENLQKID----SKY----VVKLFGVSRTQ--TNLYMFLE
. .||.|| ||.|.||.|. ....   |...|.|.|.....  .         .| .|.||....|..    .|.    .|||. ...|.  .|.|...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCVDGDLKSYLKKK--------ENKILSEPEAIKIFKHIVEGFKELNKYKIIHRDIKPANLLISNGI-------------VKLADFGFSKVVEDE---EA
|| .|||..|.||.        |.|.|||.|||..||.|..|||||.| .||||||||.| ||.||.             .|.|||||.|.|...   ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

RLRSFI------GSPLYMAPELQE----QMPFS-SKCDVWSTGIVLYEMLYGKTP---WNGSSQL-----NLFEN-------IKNQPLVFP---DEPIRS
 . ..       |.||||||.. .    |.|.. .|||.|| |...|||||||.|   |  ..|      .|..|       ||.||| ||   ..|..|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

NKLKSLIKKMLQYYEKDRISWSEIFDDDLI
...|.||..|||| ||||||| |.|.  ..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 4111.AA S_TKc 13-270 28 2.9e-82 280.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-270
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

ILVNHKLGRGSYGTVYRGYLEQDENQMIAAKQIPIKEICSSTSRIQYIKREIENLQKIDSKYVVKLFGVSRTQTNLYMFLEYCVD--GDLKSYLKKKEN-
  .  |.|.|..|.||...     ..  | |.|.           . |.|||. |.| . ...|||..| .. ..|||..|||    |||..|.||.   
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

---KILSEPEAIKIFKHIVEGFKELNKYKIIHRDIKPANLLISNGIVKLADFGFSKVVEDEEARLRSFIGSPLYMAPELQEQMPFSS-KCDVWSTGIVLY
   . ..| .| .... |... . . . .|||||.||.|.|...  .|..|||.....       ..|.|.| |||||.    ...  |||.|| |..||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLYGKTPWNGSSQLNLFENIKNQPLVFPDEPIRSNKLKSLIKKMLQYYEKDRISWSEIFD-------DDLI
|||.|..|.    .  .|..|.            |  .|..|.|.||.  ..|..  |..        .  .
EMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 4111.AA Ciliate-E2c 13-270 31 1.2e-79 270.92 In-house 1-310 (310) Show / Hide 
Range on Protein: 13-270
Range on HMM: 1-310/310
Sequence Identity: 31% (98 aa)

ILVNHKLGRGSYGTVYRGYLEQDENQMIAA---------KQIPIKEI---CSSTSRIQ-YIKREIENLQKIDSKYVVKLFGVSRTQTNLYMFLEYCVDGD
|  |  || ||||.||..|.  |..  |.          | .. |..     . . |   |.|||... . ......|      |  ..| ..||| .|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LKSYLKKK-ENKILSEPEAIKIFKHIVEGFKELNKY-KIIHRDIKPANLLISNGIVKLADFGFSKVVEDEEARLRS----FIGSPLYMAPELQEQ-MPFS
|..|...| .   ..| . .  |. |. .||.| |  .|.||||||.| || ||..|.||||||| . |..    .      |.|.||||.  |      
LEQYIYHKPK---PNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYT

SKCDVWSTGIVLYEMLYGKTPWN------------------GSSQLNLFENIK---------------NQPLVFPDE--PIRSNKLKSLIKKMLQYYEKD
.| |.|| |..||.||. | ||                   ....  |...|.               .|.. ||..    .| ..| ||.||||. |..
EKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEK

RISWSEIFDDDLI
||.|.|||.. .|
RIDWDEIFNHECI
Kinase 4111.AA Pkinase 13-270 26 1.2e-73 255.83 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-270
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

ILVNHKLGRGSYGTVYRGYLEQDENQMIAAKQIPIKEICSSTSRIQYIK-REIENLQKIDSKYVVKLFGVSRTQTNLYMFLEYCVDG----DLKSYLKKK
. .  |.|.||.|.||... ....... | |.|. ... .|  ... .. .||. .........|.|... .. ...|| .|||  |    ||..|.. .
YHIGRKIGSGSFGCVYKCH-HKGTGKIVAVKIIKKRHE-KSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

ENKIL--SEPEAIKIFKHIVEGFKELNKYKIIHRDIKPANLLIS-NGIV----KLADFGFSKVV-EDEEARLRSFIGSPLYMAPEL-QEQMPFSSKCDVW
... .  || |...... |..| . . . .|||||.||.|.||. || .    |..|||..|.. .     . .| |.| |||||. ... . ..|.|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

STGIVLYEMLYGKTPWNGS------SQLNLFENIKNQPLVFPDEPIRS-------------------NKLKSLIKKMLQYYEKDRISWSEIFDDDLI
| |..||||| |..|. |.      .|. ....|.  || |. .  .|                     .|..||..|..  |.|... .|. .. .
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 4111.AA Ciliate-E2 13-270 23 2.1e-73 250.19 In-house 1-365 (365) Show / Hide 
Range on Protein: 13-270
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

ILVNHKLGRGSYGTVYRG--YLEQDENQMI---------------AAKQIPIKEICSS----TSRIQYIKREIE----------NLQKIDSKYVVKLFGV
. .. |.|.|..|.||..  ...| . ...               ..|.. .| .  .    ......| |||.          .|.........|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

SR--TQTNLYMFLEYCVDGDLKSYLK---KKENKI------LSEPEAIKIFKHIVE---------------GFKELNKYK-IIHRDIKPANLLISNGIVK
    ...|.|. .|||  |||..|.|   ||.|..      ..| |...|.|.|..               ....| . . |||||||| |.|.    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

LADFGFSKVVEDE-------------------------------EARLRSFIGSPLYMAPELQEQMP---------FSSKCDVWSTGIVLYEMLYGKTPW
..|||.|| . |.                               .   ....|.| |||||  .  .          . |||.|| |..|||||.||.|.
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

NGSSQLNLFENIKNQPLVFP----------------DEPIRSNKLKSLIKK----MLQYYEKDRIS-WSEIFDDDLI
        ...||.... ||                .    |.. | ||||    |||. .. ||. |..|..   .
--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 4111.AA CAMK 18-270 20 1.2e-71 229.94 In-house 1-425 (425) Show / Hide 
Range on Protein: 18-270
Range on HMM: 1-425/425
Sequence Identity: 20% (86 aa)

KLGRGSYGTVYRGYLEQDEN-----------QMIAAKQIPIKEICS------------------------STSRIQYIKREIENLQK-------IDSKYV
.|||||.|.|....  .. .           |  |.| |. | . .                        . .  . ..|||| ..|       .| . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLFGVSR------------TQTN--------LYMFL---EYCVDG----DLKSYLKKKEN-------------KILSEPEAIKIFKHIVEGFKELNKYK
.||. |              | ..        .||..   |||  |    || .|......             . ..| || ..|. |... . . . .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPANLLI-SN-----------------GIVKLADFGFSKVVED-----------------------EEARLRSFIGSPLYMA-PELQEQ-----
|.|||.|| |.|. .|                 . .|..||||......                       |   .. | |.| ||| ||. ..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------MPFSSKCDVWSTGIVLYEMLYGKTPWNGS-------------SQLNLFENIKNQPLVFPDEPIRS----------------------NKLK
          . . |||.|| |..|| || |. |..|.             .. .|||.|..    ||....                           |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SLIKKMLQYYEKDRISWSEIFDDDLI
.||.||||.  ..|.. ... ..  .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 4111.AA CAMKL 12-270 27 2.6e-68 217.08 In-house 1-297 (297) Show / Hide 
Range on Protein: 12-270
Range on HMM: 1-297/297
Sequence Identity: 27% (84 aa)

YILVNHKLGRGSYGTVYRGYLEQDENQMIAAKQIPIKEICSSTSRIQY-----------IKREIENLQKID---SKYVVKLFGVSRTQTN------LYMF
|...   ||.||.|.|  .  ..  ... | | | .| |.  .   .            |.|||. .....    . ..||. |  |...      .|..
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEYCVDGD--LKSYLKKKENKI--LSEPEAIKIFKHIVEGFKELNKYKIIHRDIKPANLLIS-NG--IVKLADFGFSKVVED----EEARLRSFIGSPLY
.|||  |.  |  |..|....   ..|.|| ..|. ||.. . . . .|.|||||| |.|.. ||   .|..|||||   ..    ..  |. | ||| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MAPELQEQ--MPFS-SKCDVWSTGIVLYEMLYGKTPWNGS--------SQLNLFENIKNQPLVFPDEPIRSNKLKSLIKKMLQYYEKDRISWSEIFDDDL
||||. .    |.   | |.|| |..|| |..|. |...          . .|.. |. .   .|  .  |  ...||.||||   ..|..  .|  .  
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

I
 
M
Kinase 4111.AA AGC 13-264 20 3.2e-68 174.55 In-house 1-389 (395) Show / Hide 
Range on Protein: 13-264
Range on HMM: 1-389/395
Sequence Identity: 20% (79 aa)

ILVNHKLGRGSYGTVYRGYLEQ-----DENQMIAAKQIPI--KEICSSTSRIQYIKRE------------IENLQKID----------SKYVVK-LFGVS
  .   .|.||.|.||           | ... | | .    | ..     ......|             . |.|..          . ..|| |.   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

RTQTN--LYMFLEYCV----------DGDLKSYLKKK-ENKILSEPEAIKIFK-------HIVEGFKELNK-YKIIHRD-IKPANLLISN-GIVKLADFG
 ....  ||. .||.           ...| ..|...  .....|..|  ..        .|| ..  | .  .||||| .|| |.|. . | .||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FSKVVEDEE--------------------------------------------------ARLRSFIG--SPLYMAPELQEQMPFSSKCDVWS--TGIVLY
..|.. ...                                                  .|  .| |  .| |||||       .  || ||   |...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLYGKTPWNGSS----------QLNLFENIK------NQPLVFP--------DEPIRSNKLKSLIKKMLQYYEKDRIS----------WSEI
|||.|..| .| .          .  .|..|.      |... ||        ...  |. .|.||||.|.   ..|.            .||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEI
Kinase 4111.AA Ciliate-E2-Unclassified 13-270 24 2.9e-66 226.45 In-house 1-352 (352) Show / Hide 
Range on Protein: 13-270
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

ILVNHKLGRGSYGTVYRGYLEQDENQMIAAKQIPIKEICS------STSRIQYIKREIENLQ----------------KIDSKYVVKLFGVSRTQTNLYM
  .....|.|..|.||. . ...  |  | |..  . |..      .  .|  .. |..|..                 ... ..||.| . ... |.|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

FLEYCVDGDLKSYLKKKEN---------------KILSEPEAI-----KIFKHIVEGFKELNKYK-IIHRDIKPANLLISNG----IVKLADFGFSKVVE
 .||| .|||. |.||...               ||..| .|.     ..|..|..|.. | . . |||||||| |.|..|.     .|..|||.||  .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

DE---------------EARLRSFIGSPLYM----APELQEQMPFS----SKCDVWSTGIVLYEMLYGKTPWNGSSQLN----------------LFENI
.                . .. .|.|.| ||    |||. ..   .     |||.|| |..|||||.|. | .. ..                  |..||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KNQPLVFPDEP------IRSNKLKSLIK----KMLQYYEKDRISWSEIFDDDLI
|.... || .|      . |.. | .|.    |||..  . ||....|.   ..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 4111.AA STE 14-270 23 1.4e-56 194.33 In-house 1-359 (359) Show / Hide 
Range on Protein: 14-270
Range on HMM: 1-359/359
Sequence Identity: 23% (84 aa)

LVN-HKLGRGSYGTVYRGYLEQ-----DENQM---------IAAKQIPIKEIC-------------SSTSRIQYIKREIENLQKID--SKYVVKLFGVSR
. .  |.|.|..||||...        . ..          .| ||.....               . .. .| |..||. ..| .  ....|| .|   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TQ-------TNLYMFLEYCVDGDLKSYLK-K-KENKILS----------EPEAIKIFKHIVEG-FKELNKYKIIHRDIKPANLLISNGIVKLADFGFSKV
         ..|....||.  | | . .| | . .| |.          |.. ..| . |..|  . | . .|||||||||| |.    |||.|||... 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

VED---------------EEA-RLRSFIGSPLYMAPELQEQM------PFSSKCDVWSTGIVLYEMLYGKTPWNGSSQL-NLFENIKN------------
..|                 . .  .|.|.| .||||  .|.      . . |||.|| |... ||. || ||   . . ..|. ..|            
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

---QPLVFPD-----------------EPIRSNKLKSLIKKMLQYYEKDRISWSEIFD--DDLI
   .|  .||                     | ..|  |.| ||.  ..| . |.        |
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 4111.AA CAMKK 12-270 22 6.9e-53 165.96 In-house 1-396 (396) Show / Hide 
Range on Protein: 12-270
Range on HMM: 1-396/396
Sequence Identity: 22% (89 aa)

YILVNHKLGRGSYGTVYRGYLEQDE---------NQ----MIAAKQIPIK-------------EICSSTSRIQYIKREIENLQKIDSKYVVKLFGV--SR
| |.  ..|.|..| | . | | |.         |     .   |.. .              .    ..... ...||. . |.. ...|||. |  ..
YELM-KEIGQGQFGKVKLAYNEYDTQKHYAIKIFNKKYVFKKLKKKQQFYRDPPKRMTNMNQNGEMQMMNPFDCVYQEIAIMKKCNHPNIVKLYEVIDDP

TQTNLYMF-LEYCVDGDLKSYLKKKE-----------------------NKILSEPE---------------------AIKIFKHIVEGFKELN-KYK--
.....||  .|||  |....  ..|.                        .|.||..                     | |.| ... | . |  . |  
QNDKIYMVQMEYCERGQIMWWPYWKQDYQPNWPYQYTELYSNRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKAC

-----------------IIHRDIKPANLLI-SNG---IVKLADFGFSKVVEDEEARLRS-----------FIGSPLYMAPELQEQ-MPFS----------
                 |||||||| |.|| ..|    ||.|||| |. .|.....| .             | | .|||||..    ..          
SYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFR

-----SKCDVWSTGIVLYEMLYGKTPWNGSSQLNLFE---NIKNQPLVFPD-----------EPIRSNKLKSLIKKMLQYYEKDRISWSEIFDDDLI
      ..|.|..|. || ...||.| .. . . |..    |||.|..||.           .|  |. ||.|||.||.  ...||. ..|  .. .
FIYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTKRITIPQIKVHPWV
Kinase 4111.AA Pkinase_Tyr 13-214 28 1.5e-30 104.1 Pfam 1-216 (270) Show / Hide 
Range on Protein: 13-214
Range on HMM: 1-216/270
Sequence Identity: 28% (62 aa)

ILVNHKLGRGSYGTVYRGYLE---QDENQMIAAKQIPIKEICSSTS-RIQYIKREIENLQKI-DSKYVVKLFGVSR-TQTN--LYMFLEYCVDGDLKSYL
|  ..|||.|..|.||.|..    .....  | | .  || ...    ..   ||.. . .. . . .|.| ||    .    .|. .||.  |||..||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KKK--ENKILSEPEAIKIFKHIVEGFKELNKYKIIHRDIKPANLLIS-NGIVKLADFGFSKVV-EDEEA-RLRSFIGSPL-YMAPE-LQEQMPFSSKCDV
.|.  ... |. .. ...   | .|   |   ..||||.   | |.. |..|| .||| .. . .|..  | |.    |   |||| ...   |..| ||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDV

WSTGIVLYEMLY-GKTP-W
|| |....|..  |..| .
WSFGVLMWEIFTYGEQPTY
Kinase 4111.AA TyrKc 13-269 25 5.7e-20 73.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-269
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

ILVNHKLGRGSYGTVYRGYLEQDENQMIAAKQIPIKEICSSTSRIQYIKREIENLQKI--DSKYVVKLFGVSRTQ-------TNLYMFLEYCVDGDLKSY
|  ..|||.| .|.||.| .     .. | | .           .. . ||.. . |.  . . .|.|.|| ..|         |.. .||.  ||||.|
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKKKENKILSEPEAIKIFKHIVEGFKELNKYKIIHRDIKPANLLISNG-IVKLADFGFSKVVEDE--------EARLRSFIGSP--L---YMAPELQEQM
|.|...| |. .. ...   | .|   | . ..||||.   | |.... .|| .||| |. ..|.          | ..  |.   |    ||||     
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PFSSKCDVWSTGIVLYEML-YGKTPWNG-----SSQLNLFENIKNQ-PLVFPDE------PIRSNKLKSLIKKMLQYYEKDRISWSEIFDDDL
 |..| |||| |....|.. ||..|. |      |   ..|..|.   .  |..      .. . .. ...|.  ..  .|| . |||  ...
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF