Gene 5380 (Tetrahymena)

5380

Species: Tetrahymena
Alias: 5380, 3708.m00003, 49.m00152, PreTt05380, 438, TTHERM_00436250
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
5380.AA Protein None 676 None Fasta, JSON
5380.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
5380.NA RNA None 2031 None Fasta, JSON

Protein domain

Protein domains of 5380.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5380.AA ULK 36-294 35 1.9e-128 433.01 In-house 1-324 (324) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-324/324
Sequence Identity: 35% (115 aa)

YSLIKEIGQGSFA-RVYRGRTETNG-VQEDFAIKMISKGYLREDNQE--------LIDKEISILLKLR---HKN--IIRLVDFKKTT--NNWYLIFEYCE
|.|....|.|||.  ||.|| . .. .....|.|||.| .......|        |...||.|. ||    |.|  |..| |...|.  ||.|.|.|||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

LGDLEQYMKEK-------FNGKFPLSIALTFIQQLKSAFQEIRRLKFVHRDLKLANILLTKDL------------TVKLGDFGFAKHFDDN----SLLQS
 ||||||.|..       ...... ..|. |..|. ..|.|..  . .|||.|..|||....             ..|..|||||||.|.|     ..|.
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

YC------GTPITMAPEILK----REKYN-EKCDIWSLGIIIYQMIYGRPP----FNPHKGAHIQDLIN-------LIEKNQIDF----SAIQIPPEVKD
..      |||..|||.||.    ...|.  ||||||||.|.|.|.||..|    ||. .   ||.|||       .|....|.|    ....| ||.||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LILKMLVVDPNQRISFEDFFEHPCM
|| .||..|...|||.|..|.||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 5380.AA ULK 36-294 36 6.7e-128 431.21 In-house 1-329 (329) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-329/329
Sequence Identity: 36% (119 aa)

YSLIKEIGQGSFARVYRGRTETNG--VQEDFAIKMISKGYLREDNQE--------LIDKEISILLKLR----HKN----IIRLVDFKKTT--NNWYLIFE
|.|....|.|||..||.|| . ..  |.|..|.|||.| .....|.|        |...|| |. ||     |||    |..| |...|.  ||.|.|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCELGDLEQYMKEK--------FNGKFPLSIALTFIQQLKSAFQEIRRLKFVHRDLKLANILLTKDL------------TVKLGDFGFAKHFDDN----S
||. ||||||.|..        ...... ..|. |..|. ..|.|..  . .|||.|..|||....             ..|..|||||||.|..     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LLQSYC------GTPITMAPEILK----REKYN-EKCDIWSLGIIIYQMIYGRPP----FNPHKGAHIQDLINL-------IEKNQIDFS----AIQIPP
.....       |||..|||.||.    ...|.  ||||||||.|.|.|.||.||    ||. .  .||.|||.       |.|....|     ..|| |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

EVKDLILKMLVVDPNQRISFEDFFEHPCM
|.|||| .||..|...|||.|..|.||..
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 5380.AA Ciliate-E2 36-294 25 8.5e-90 304.63 In-house 1-365 (365) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-365/365
Sequence Identity: 25% (98 aa)

YSLIKEIGQGSFARVYRGRTETNGVQE----------------DFAIKMISKGYLREDNQELIDKEISIL----------------LKLRHKNIIRLVDF
| .|| ||||.|. ||...   .. |.                 ..||.. . ...... | | .||.|.                 .| |.|||.....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

KK--TTNNWYLIFEYCELGDLEQYMKEK---FNGKFP------LSIALTFIQQLKS---------------AFQEIRRLK-FVHRDLKLANILLTKDLTV
 .  ..|| ||..|||. |||..|.|..   .| ...      .  ......|. .               |....   .  .|||.|. |||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGFAKHFDDN--------------------------------SLLQSYCGTPITMAPEILKREK---------YNEKCDIWSLGIIIYQMIYGRPP
|. |||..| .||.                                 . ...||||  ||||||...|         |..||||||||.|.|.|..|.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FNPHKGAHIQDLINLIEKNQIDFS-----------------AIQIPPEVKDLILK----MLVVDPNQRIS-FEDFFEHPCM
|           .. |....|||.                   ....|.|||| |    ||..||..||. .|. ..|| .
F-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 5380.AA S_TKc 36-294 32 3.5e-87 296.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

YSLIKEIGQGSFARVYRGRTETNGVQEDFAIKMISKGYLREDNQELIDKEISILLKLRHKNIIRLVDFKKTTNNWYLIFEYCEL--GDLEQYMKEKFNGK
| ....||.|.|..||..|      .. .|||.|.         | | .||.|| | .|.||..| |.  . .. |...|||.   ||| .|.|..  ..
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FPLSIALTFIQQLKSAFQEIRRLKFVHRDLKLANILLTKDLTVKLGDFGFAKHFDDNSLLQSYCGTPITMAPEILKREKYNE-KCDIWSLGIIIYQ
    ||   |  ...|. .| . . .....||||| .||||..  ..|..|||.|...       ..||||  ||||.|   .|.  |||.||.|.|.| 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MIYGRPPFNPHKGAHIQDLINLIEKNQIDFSAIQIPPEVKDLILKMLVVDPNQRISFEDFFE-------HPCM
|..|.|||      ..| ....|            .||.||.| |.|..||..|..  . ..       || .
MLCGYPPFP-----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5380.AA AGC 36-294 21 2.1e-82 212.08 In-house 1-395 (395) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-395/395
Sequence Identity: 21% (84 aa)

YSLIKEIGQGSFARVYRGRTETNGV----QEDFAIKMISKGY-LREDN---QELIDKE------------ISILLKLR----------HKNIIR-LVDFK
. ..| ||.||| .||  |  ....    .. .|.|...| .   ...   .| .  |              || |..          | .|.. |    
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KTTNN--WYLIFEYCE--------LGDLEQYMKEK---FNGKFPLSIALTFIQQ-------LKSAFQEIRR-LKFVHRD-LKLANILLTKDLTVKLGDFG
.. ..   |.. ||..         |..| ..  .    .|.|. . |  .. .       . .|.. . . ....||| ||. ||||..|  .|| |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKHFD---------------------------------------------------DNSLLQSYCG--TPITMAPEILKREKYNEKCDIWS--LGIIIY
..| .                                                    .. . .. ||  ||  ||||||    |.  ||.||  ||...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

QMIYGRPPFNPHKGA-------HIQDLINLIE------KNQIDFSA---------IQIPPEVKDLILKMLVVDPNQRIS----------FEDFFEHPCM
.|..|.|||. .          .  .. ..|.      .... |            .. || |||| |.|..||..|.           .|.  .||  
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 5380.AA CAMK 41-294 24 1.1e-81 262.83 In-house 1-425 (425) Show / Hide 
Range on Protein: 41-294
Range on HMM: 1-425/425
Sequence Identity: 24% (103 aa)

EIGQGSFARVYRGRTE-TNGVQ---------EDFAIKMISKGYLRED--------------------------NQELIDKEISILLK-------LRHKNI
..|.|||. |....   |.| .         . .|||.|.|  |...                          ... . .||.|. |       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLVD--------------------FKKTTNNWYLIF---EYCELG----DLEQYMKEKFN-------------GKFPLSIALTFIQQLKSAFQEIRRLK
|.| .                    | ..... |...   |||. |    || .| .|. .             |.|. . | ....|. || . .  ..
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

FVHRDLKLANILLTKD-----------------LTVKLGDFGFAKHFDD------------------------NSLLQSYCGTPITMA-PEILKR-----
 ||||||. ||||...                  ..|. |||||..||.                        . ... .||||  || ||.|..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EKYNEKCDIWSLGIIIYQMIYGRPPFNPHK----------GAHIQDLINLIEKNQIDFSAIQIPP-----------------------EVK
         . |..|||.||.|.| | |  |.|||.  .          |.....|   | | . ||   ...|                       |.|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLILKMLVVDPNQRISFEDFFEHPCM
||| |||.|||..|.. |.  .|| |
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 5380.AA Ciliate-E2-Unclassified 36-294 25 1.2e-79 270.88 In-house 1-352 (352) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-352/352
Sequence Identity: 25% (89 aa)

YSLIKEIGQGSFARVYRGRTETNGVQ----EDFAIKMISKGYLRED----NQELIDKEIS-------------ILLKLRHKNIIRLVDFKKTTNNWYLIF
| .|| ||||.|. ||. . . .. .    .   |..... . ..     |.... ....             ||| . | .|..... .....| |.. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYCELGDLEQYMKEKFN---------------GKFPLSIAL-----TFIQQLKSAFQEIRRLK-FVHRDLKLANILLTKDL---TVKLGDFGFAKHFDDN
|||| |||.||.|.. .                .|.   |.     ... |. .... . . . ..|||.|. |||....     .|. |||..|. ..|
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

----------------SLLQSYCGTPITM----APEILKREKYN----EKCDIWSLGIIIYQMIYGRPPFNPHKGAH-------------IQDLINLIEK
                 .... ||||..|    |||.|....|.    .||||||||.|.|.|..|..||.  .                .. |.. | .
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

NQIDFSA-------IQIPPEVKDLIL----KMLVVDPNQRISFEDFFEHPCM
..|.|.         ...||.||.|     |||...||.||.||. ..|| .
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 5380.AA Ciliate-E2a 36-294 33 1e-71 210.37 In-house 1-275 (275) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-275/275
Sequence Identity: 33% (93 aa)

YSLIKEIGQGSFARVYRGRTETNGVQEDFAIKMISKGYLREDN--QELIDKEISILLKLRHKNIIRLVDFKKTTNNWYLIFEYCELGDLEQYMKEKFNGK
|..||.||.|.|..||  .   .|  ..||.| ..|  ....   .| . .||.|. .|.|.|||.| .. .. || ||..|||| |.|....|.. . .
YKFIKKIGKGNFGSVYLAQHKQTG--KQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFF

FPLSIALTFIQQLKS-AFQEIRRLKFVHRDLKLANILLT---KD----LTVKLGDFGFAKHF--DDNSLLQSYCGTPITMA------PEILKREKYNEKC
.    .  ..||| . ... .  .. .|||||. |||..   |.    . .|. |||.|. .  |..  . . ||||  .|      .|.||...| .||
EEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKC

DIWSLGIIIYQMIYGRPPFNPHKGAHIQDLINLIEKNQIDFSAIQ----IPPEVKDLILKMLVVDPNQRISFEDFFEHPCM
|.||.|.|.| ...|.|||   ||   .. . ...| .|||.  .    .. | |||. |||..||..||. ..  .|| .
DMWSCGVIFYILLCGKPPF---KGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 5380.AA CAMKL 36-294 29 7.4e-71 225.32 In-house 1-297 (297) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-297/297
Sequence Identity: 29% (89 aa)

YSLIKEIGQGSFARVYRGRT-ETNGVQEDFAIKMISKGYLREDNQEL-------------IDKEISILLKLR---HKNIIRLVDFKKTTNN------WYL
| ..|..|.|||. |  ..   |.  .|  |||.| |  ...| . .             | .||.|. .|.   |.|||.| .   | ..       ||
YRIGKTLGKGSFGKVKLATHIRTT--GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

IFEYCELGD--LEQYMKEKFN--GKFPLSIALTFIQQLKSAFQEIRRLKFVHRDLKLANILLTKDL--TVKLGDFGFAKHFDD-----NSLLQSYCGTPI
. |||. |.  | .| ... .  |..| . |  . .|. || . . ... ||||.|. ||||...   ..|. ||||. ....     . .|   ||.| 
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

TMAPEILKR--EKYN-EKCDIWSLGIIIYQMIYGRPPFN--PHK--GAHIQDLINLIEKNQIDF--SAIQIPPEVKDLILKMLVVDPNQRISFEDFFEHP
 |||||...  ..|.  | ||||.|.| | |..|. ||.  ...  |.  . .  .... .  .    .... ...||| |||.|.|..|.. ..  .||
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP

CM
 |
WM
Kinase 5380.AA Pkinase 36-294 29 1.3e-70 245.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

YSLIKEIGQGSFARVYRGRTETNGVQEDFAIKMISKGYLREDNQELIDK--EISILLKLRHKNIIRLVDFKKTTNNWYLIFEYCELG----DLEQYMKEK
| ... ||.|||..||...   .|    .|.| |.|   ... ..   .  ||.|...|.|.||.|| |.  . .. |...|||| |    ||  |.. .
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

FNGKF--PLSIALTFIQQLKSAFQEIRRLKFVHRDLKLANILLTKDLTV----KLGDFGFAKH--FDDNSLLQSYCGTPITMAPEILK-REKYNEKCDIW
 .|.|  .   .  .. |. .. . . . ...|||||..|||. .. ..    |..|||.||.     || ....||||  ||||... ...|  |.|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGIIIYQMIYGRPPFNPH----KGAHIQDLINLIEKNQIDFSAIQI--------------------PPEVKDLILKMLVVDPNQRISFEDFFEHPCM
|.|.|.|.|. |||||  |    . .  . .|..| . ...|.  .                     ..| ||.| ..| .||..|...|. ..|| .
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 5380.AA Ciliate-E2c 36-294 29 5.5e-68 232.17 In-house 1-310 (310) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-310/310
Sequence Identity: 29% (94 aa)

YSLIKEIGQGSFARVYRG--RTETNGVQED------FAIKMISKGYL-----REDNQE-LIDKEISILLKLRHKNIIRLVDFKKTTNNWYLIFEYCELGD
..  .  |.||.. ||..   .. .....       |||||.    .      | ...  | .|| .. .. |..||. .|.|.|... ||| |||. |.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LEQYMKEK--FNGKFPLSIALTFIQQLKSAFQEIRRL-KFVHRDLKLANILLTKDLTVKLGDFGFAKHFDDNSLL-QS----YCGTPITMAPEILKREKY
|||| ..|   | |      |.   |. |||...    .  |||.| .|||. ... .|. ||||.| ..|      .    .||||. |||.||.. .|
LEQYIYHKPKPNEK----QCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGM-IKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNY

NE-KCDIWSLGIIIYQMIYGRPPFN---------------PHKGAHIQDLINLIE---------------KNQIDFSAI---QIPPEVKDLILKMLVVDP
.. | ||||||.  |.|.. ..|.                | ..   . |.  |.               . .| |.      | .|||.|| |||.||.
YTEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDE

NQRISFEDFFEHPCM
. ||.... | |.| 
EKRIDWDEIFNHECI
Kinase 5380.AA CAMK-Unique 36-294 24 4.3e-58 190.29 In-house 1-363 (363) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-363/363
Sequence Identity: 24% (88 aa)

YSLIKEIGQGSFARVYRGRTETNGVQEDFAIKMISKGYLREDNQEL------------------IDKEISILLKLRHKNIIRLVDF----KKTTN-----
| ... ||.|.|  ||.. . ..|.   .|.||. | .  .. | .                   ..|..|.... | |||.|.|.    . . .     
YKMHRIIGHGNFGHVYECMDRETGKK--WACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCD

----------NWYLIFEYCELGDLEQYMKE------------------KFNGKFPL--SIALTFIQQLKSAFQEIRRLKFVHRDLKLANILLTKD-----
          . |.. |||. ||| ... .                  . .|.|    . ... .|.| ||      .. ||||||| ||.. .      
LIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN

-----------LTVKLGDFGFAKHFDDNSLLQ---SYCGTPITMAP--------------EILKREKYNEKC----DIWSLGIIIYQMIYGRPPFNPHKG
           . .|| ||| ..|.. |       ..||||. |||              |.... .| ..|    |||||| | | |. |.|||..   
HHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECE

A-----HIQDLINLIEKNQI---DFSAIQIP----PEVKDLILKMLVVDPNQRISFEDFFEHPCM
.     |   ..  | | ..   | .. ..|    .| ||.. . ..|||..|.| .   ||.  
DRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 5380.AA Pkinase_Tyr 36-224 27 1.5e-30 104.14 Pfam 1-202 (270) Show / Hide 
Range on Protein: 36-224
Range on HMM: 1-202/270
Sequence Identity: 27% (56 aa)

YSLIKEIGQGSFARVYRGRTE--TNGVQEDFAIKMISKGYLRED--NQELIDKEISILLKL-RHKNIIRLVDFKK-TTNN--WYLIFEYCELGDLEQYMK
 ...|..|.|.| .||.|.      . . . |.||.  |.  |.   ....  |..|. .| .|.||.||.           .|...||...|||  | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

EK--FNGKFPLSIALTFIQQLKSAFQEIRRLKFVHRDLKLANILLTKDLTVKLGDFGFAKHF--DDNS-LLQSYCGTPIT-MAPEILKREKYNEKCDIWS
..   .......  | . .|  .. .   . ...||||   |.|.|....|| .||| |.    ||.    .. .  ||  |||| ..  |...| |.||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

LGI
 |.
FGV
Kinase 5380.AA TyrKc 36-294 23 1e-23 86.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

YSLIKEIGQGSFARVYRGRTETNGVQEDFAIKMISKGYLREDNQELIDKEISILLKL--RHKNIIRLVDFKKTT-------NNWYLIFEYCELGDLEQYM
 .|.|..| | | .||.|.       .. |.||. ..      .| . .|..|. ||  .|.||.||.    .           ....||...||| .| 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KEKFNGKFPLSIALTFIQQLKSAFQEIRRLKFVHRDLKLANILLTKDLTVKLGDFGFAKHFDDN--------SLLQSY--CGT---PIT-MAPEILKREK
... .  ....  | |  |  .  . . . ...||||   |.|.....||| .||| ..  .|            ..   .|    ||  |||| ..  |
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YNEKCDIWSLGIIIYQMI-YGRPPFNP---HKGAHIQDLINLIEKNQIDFSAIQ--------IPPEVKDLILKMLVVDPNQRISFEDFFEHPCM
...| |.|| |. .. .  || .|      .     |..|.....                  |.|. .....    ||..| .|..   | |.
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF