Gene 5688 (Tetrahymena)

5688

Species: Tetrahymena
Alias: PreTt05688, 3681.m00116, 50.m00257, 5688, TTHERM_00442880, 653
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
5688.AA Protein None 549 None Fasta, JSON
5688.NA RNA None 1647 None Fasta, JSON
5688.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of 5688.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5688.AA ULK 10-265 36 8.10000000001e-133 447.54 In-house 1-324 (324) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-324/324
Sequence Identity: 36% (120 aa)

WDNSGFLGEGSYG-KVYKGKDVKT---GELVAVKCMD---MSQFTD----QFMKESLENEIGVMKILH---SNN--VVRMLHCEQDK--KTTYIILELCP
.  .  ||.||.| |||||...||   ...||.|..|   |...      |.|...|.||| .||.|.   ..|  .|..... ...  . .|||.|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

DGDLRKFIHSNGG--------HLNETLSLEILNQLMFGFKELVDHGFIHRDIKPENTLIKNK-------------VYKVADFGFACKADI--SGKKLIKE
.|||...|. |..         |.|   .... |.. |||||..|. |||||||.| ||.|.             |.|.|||||| . |     . ....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

CV------GTPLYMAPQLLE----NTPYT-SKSDLWSIGMMFYEMLFGKTP---WPARDIN----SYLRN-------MKNSPLRFP---YDKPIGKNTKD
||      |||||||||.|.    . ||. .|.|.||.|..|||||.||.|   | ..| .    . ..|       .|| |..||   .|..| ...||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FITRCLTINEKSRISWEEVFQHPIL
.| |.|...|| ||||||.|.||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 5688.AA ULK 10-265 37 8.70000000001e-130 437.48 In-house 1-329 (329) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-329/329
Sequence Identity: 37% (124 aa)

WDNSGFLGEGSYGKVYKGKDVKT----GELVAVKCMD---MSQFTD----QFMKESLENEIGVMKIL-----HSN---NVVRMLHCEQDK--KTTYIILE
.  .  ||.||.||||||...||    .|.||.| .|   |.|. .    |.|...|.||| .|| |     | |   |.|..... ...  . .|||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCPDGDLRKFIHSNGG---------HLNETLSLEILNQLMFGFKELVDHGFIHRDIKPENTLIKNK-------------VYKVADFGFACKADIS--GKK
.|..|||...|. |..         .|.|   .... |.. |||||..|. |||||||.| ||.|.             |.|.|||||| . | .   ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LIKECV------GTPLYMAPQLLE----NTPYT-SKSDLWSIGMMFYEMLFGKTP---WPARDIN-----SYLRN-------MKNSPLRFP---YDKPIG
... ||      |||||||||.|.    . ||. .|.|.||.|..|||||.||.|   | ..| .     . ..|       .|. ||.||   .|..| 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

KNTKDFITRCLTINEKSRISWEEVFQHPIL
...||.| |.|...|| ||||||.|.||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 5688.AA S_TKc 10-265 29 1.4e-77 264.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-231/231
Sequence Identity: 29% (81 aa)

WDNSGFLGEGSYGKVYKGKDVKTGELVAVKCMDMSQFTDQFMKESLENEIGVMKILHSNNVVRMLHCEQDKKTTYIILELCPD--GDLRKFIHSNGGH--
..    .|.|..|||||....|||..||.|...          |....|| ..|  |  |.|... . || .  |...|.|.   |||...|...|.|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LNETLSLEILNQLMFGFKELVDHGFIHRDIKPENTLIKNKVYKVADFGFACKADISGKKLIKECVGTPLYMAPQLLENTPYTS-KSDLWSIGMMFYE
   ..|     .. |.  . . . .||.||||.|||| |. . . |..|||.|..         . ..||| |||| .|   .|.  |.| ||.| ..||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLFGKTPWPARDINSYLRNMKNSPLRFPYDKPIGKNTKDFITRCLTINEKSRISWEEVFQ-------HPIL
|| |..|.|  ...  .....             .  |||| .||. . . |..  |..|       || .
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5688.AA Pkinase 10-265 29 4.7e-72 250.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

WDNSGFLGEGSYGKVYKGKDVKTGELVAVKCMDMSQFTDQFMKESLEN--EIGVMKILHSNNVVRMLHCEQDKKTTYIILELCPDG----DLRKFIH-SN
.   . .|.||.|.|||.....||..||||... .  ..  ..... .  || .|| |.. |.||.... .||.  |...|.|. |    ||  .|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

GGHL--NETLSLEILNQLMFGFKELVDHGFIHRDIKPENTLIK-NKVY----KVADFGFACKADISGKKLIKECVGTPLYMAPQLLE-NTPYTSKSDLWS
.| .   |     .. |.  | . . ..|.||||.|||| ||. | .     |..|||.|...|.  .   .  .||| |||| ..  ...|..|.| ||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGMMFYEMLFGKTPWPAR------DINSYLRNMKNSPLRFPYDKPIG-------------------KNTKDFITRCLTINEKSRISWEEVFQHPIL
.| ..||||.|..|.| .      | .  ... .  ||.|......                    .. ||||..||. . |.|...|...||| .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 5688.AA Ciliate-E2 16-265 22 7.3e-67 228.45 In-house 7-365 (365) Show / Hide 
Range on Protein: 16-265
Range on HMM: 7-365/365
Sequence Identity: 22% (83 aa)

LGEGSYGKVYKGKDVKTGE-----------------------LVAVKCMDMSQFTDQFMKESLENEIG----------VMKILHSNNVVRMLHCEQ--DK
.|.|..|.|||.|. |...                       ..|.|.|  .|   ....... .||           ....| ..|...|  | |  |.
IGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDD

KTTYIILELCPDGDLRKFI----HSNGGHLN------ETLSLEILNQLMF---------------GFKELVDHG-FIHRDIKPENTLIKNKVYKVADFGF
.. |...|.|  |||...|    .. . ...      |   ..|  |.                 ....|   .  ||||||||| |.     |..|||.
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGL

ACKADISGK------------------------------KLIKECVGTPLYMAPQLLENTP---------YTSKSDLWSIGMMFYEMLFGKTPWPARDIN
. |.|.. .                               ... ..||| ||||. |.. .         |. |.|.||.|...|||||||.|.      
SKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------

SYLRNMKNSPLRFPYD----------------KPIGKNTKDFITR----CLTINEKSRIS-WEEVFQHPIL
  ... |. ...||                  | . ...||.| .    .|  ... ||. ||....||..
--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 5688.AA Ciliate-E2-Unclassified 16-265 24 6.6e-63 215.31 In-house 7-352 (352) Show / Hide 
Range on Protein: 16-265
Range on HMM: 7-352/352
Sequence Identity: 24% (84 aa)

LGEGSYGKVYKGKDVKTGELVAVKCMD-MSQFTDQFMKESLENEIGVMKILHSNN----------------------VVRMLHCEQDKKTTYIILELCPD
.|.|..||||| .. |.... | | |  . .. .. ....  ...  ||.. ...                      .|.|..|.|||.. ||..|.|..
IGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEG

GDLRKFIHSNGG----------------HLNETLSL-----EILNQLMFGFKELVDHG-FIHRDIKPENTLIKNK----VYKVADFGFAC----------
|||...| ....                .. |  ..      .. |.  |.. |   . .||||||||| |..|.      |..|||..           
GDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDT

----KADISGKKLIKECVGTPLYM----APQLLENTPYT----SKSDLWSIGMMFYEMLFGKTPWPARDINS----------------YLRNMKNSPLRF
    | .|  ..... ..||| ||    || .|..  |      |.| || |. .||||||. | .... ..                ...| |. .. |
NQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQF

PYDKP------IGKNTKDFIT----RCLTINEKSRISWEEVFQHPIL
|  ..      . .. ||||.    ..|  | ..||..|....||..
PKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 5688.AA CAMK 15-265 19 1.6e-62 200.01 In-house 1-425 (425) Show / Hide 
Range on Protein: 15-265
Range on HMM: 1-425/425
Sequence Identity: 19% (81 aa)

FLGEGSYGKVYKGKDVKTG------------ELVAVKCMDMSQFTD-------------------------QFMKESLENEIGVMKI-------LHSNNV
 ||.||.|||..... .|.            . ||.| .| .. .|                         .........|| .||        |.  |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRMLHCEQD-------------------KKTTYIIL---ELCPDG----DLRKFIHSNGG--------------HLNETLSLEILNQLMFGFKELVDHGF
.....  .|                   .|  |...   |.|. |    ||  .| ..|.              ...|     .  |.  . . . .|. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENTLIKNK------------------VYKVADFGFACKADISG----------------------KKLIKECVGTPLYMA-PQLLEN------
.|||.|||| |. ..                    |..|||||.| | .                        .. |...||| ||| | .|.       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------TPYTSKSDLWSIGMMFYEMLFGKTPWPAR-------------DINSYLRNMKNSPLRFP--YDKPIG--------------------KNTKD
        ..|. |.| ||.| . | || |. |. .              ...  ... ..   .||  | .||                     .  ||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FITRCLTINEKSRISWEEVFQHPIL
.| ..|. . . |.. |.. .|| .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 5688.AA AGC 16-265 19 7.7e-62 157.67 In-house 7-395 (395) Show / Hide 
Range on Protein: 16-265
Range on HMM: 7-395/395
Sequence Identity: 19% (75 aa)

LGEGSYGKVYKGKDV------KTGELVAVKCMDMSQ---FTDQFMKESLENE------------IGVMKILH----------SNNVVR-MLHCEQDKKT-
.|.||.||||  ...       ||.. |.|... .     ... | |   .|              ... ..          . ..|. . .. |||.  
IGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHT

-TYIILELCP--------DGDLRKFIHSNG----GHLNETLSLEILNQ-------LMFGFKELVD-HGFIHRD-IKPENTLIKNKVY-KVADFGFACKAD
  |...|..|         |..  |.|  |    |...|  .  .. .       .  ..  | . .|.|||| .|||| |. .. . | .|||....  
YLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGM

ISG-------------------------------------------------KKLIKECVG--TPLYMAPQLLENTPYTSKSDLWS--IGMMFYEMLFGK
 .|                                                 ... .  .|  || ||||  |    |.   | ||   | ..||||.|.
NDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGY

TPWPAR----------DINSYLRNMK------NSPLRFP--------YDKPIGKNTKDFITRCLTINEKSRIS----------WEEVFQHPIL
.|  .           . .    . .      | ...||        .|. . .. ||.|...|. . . |.            ||. .||  
PPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 5688.AA Ciliate-E2c 10-265 29 8.9e-60 204.91 In-house 1-310 (310) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-310/310
Sequence Identity: 29% (93 aa)

WDNSGFLGEGSYGKVYKG---KDVKTGELV------------AVKCMDMSQFTDQFMKESLENEIGVMKILHSNNVVRMLHCEQDKKTTYIILELCPDGD
 |    || ||||||||.   .|...  ..            . |  |......   |||. .||  || . . .....    | .|  |.|.| |..|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LRKFIHSNGGHLNETLSLEILNQLMFGFKELVDH-GFIHRDIKPENTLIKNKVYKVADFGFACKADISGKKLIKE----CVGTPLYMAPQLLEN-TPYTS
| ..| ..   .||   |   .|.  .||.| .  . .|||||||| ||.| . | |||||. . .. . . ..     |.|||.||||| ||    ||.
LEQYIYHK-PKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQD-DNIQNTQGFNTCCGTPMYMAPQILEGKNYYTE

KSDLWSIGMMFYEMLFGKTPWP---------------ARDIN---SYLRNMK---------------NSPLRFPYD--KPIGKNTKDFITRCLTINEKSR
|||.|| | . |.||. | ||                   .|       . .               . ...|| .  . | . .|..| . |   |. |
KSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKR

ISWEEVFQHPIL
|.|.|.| |...
IDWDEIFNHECI
Kinase 5688.AA CAMK-Unique 10-265 19 6.5e-56 182.97 In-house 1-363 (363) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-363/363
Sequence Identity: 19% (70 aa)

WDNSGFLGEGSYGKVYKGKDVKTGELVAVKCMDMSQFTDQFMKE-----------------SLENEIGVMKILHSNNVVRMLHC----EQDKK-------
...   .|.|..|.||...| .|| . |.|           .|.                 .|..|....| .  .| .. ..      .|.|       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------TTYIILELCPDGDLRKFIHSN-------------------GGHLNE--TLSLEILNQLMFGFKELVDHGFIHRDIKPENTLIKNKVY-----
          ||..|.|..||| . | ..                    ||..|  .... |  .|    . . . . .|||.|.|| .... .      
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

------------KVADFGFACKADISGKK-LIKECVGTPLYMAP--------------QLLENTPYTSKS----DLWSIGMMFYEMLFGKTPWPARDIN-
            |..||| .|. . . .  .... .|||.||||              ..... .| ...    |.||.| . |.||.|..|  . ... 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------SYLRNMKNSPL-RFP---YDKP--IGKNTKDFITRCLTINEKSRISWEEVFQHPIL
       . ... .   . .|.   .. |  |... |||...|.|.  ..|.| .|  .|. .
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 5688.AA STE 10-265 21 1.4e-54 187.62 In-house 1-359 (359) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-359/359
Sequence Identity: 21% (77 aa)

WDNSGFLGEGSYGKVYKGKDVK---------------TGELVAVKCMDMSQF--------------TDQFMKESLENEIGVMKILH--SNNVVRMLHCEQ
|.. ...|.|..|.|||....|               |||..|.| |....               ...  ......|| .|| ..  . |.|. . |. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DK-------KTTYIILELCPDGDLRKFIHSNGGHLN-------------ETLSLEILNQLMFG-FKELVDHGFIHRDIKPENTLIKNKVYKVADFGFACK
..        . .|..|... | |...|....|...             |..   |. |.  |  . | .|. ||||||| | |.     | .|||.. .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

ADI---------------SGKKLIKECVGTPLYMAPQLLEN------TPYTSKSDLWSIGMMFYEMLFGKTPWPA-RDINSYLRNMKN------------
 .                ....  . .|||| .|||  ...       .|. |.| ||.| .  ||. || ||    .   ... ..|            
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

---SPLRFPYD-----------------KPIGKNTKDFITRCLTINEKSRISWEEVFQ--HPIL
    | ..| .                 .   .. |||| .||... . | . ..  .  || .
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 5688.AA CAMKL 10-265 26 4.7e-50 157.84 In-house 1-297 (297) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-297/297
Sequence Identity: 26% (78 aa)

WDNSGFLGEGSYGKVYKGKD-VKTGELVAVKCMDMSQFT-DQFMKES-----------LENEIGVMKILH---SNNVVRMLHCEQDKKT------TYIIL
..    ||.||.|||  ...   ||| ||.| .| .  . |..||             .. ||  || |.     |....... .....       |...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCPDGD--LRKFIHSNG---GHLNETLSLEILNQLMFGFKELVDHGFIHRDIKPENTLIK-NK--VYKVADFGFACKAD-I-SG-KKLIKECVGTPLYM
|.|. |.  |  .| ..|   | . |     .  |.. . . . .|| .|||||||| |.  |.  . |..||||. . . .  |  .. |.. |.| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APQLLEN--TPYT-SKSDLWSIGMMFYEMLFGKTPWPAR--------DINSYLRNMKNSPLRFPYDKPIGKNTKDFITRCLTINEKSRISWEEVFQHPIL
|| ...   .||   | | ||.| . | |..|. |. .         .|  ...  .    ..|  . .    .|.| . |. | . |.. ... .|| .
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 5688.AA Pkinase_Tyr 16-135 29 1.2e-19 67.12 Pfam 7-137 (270) Show / Hide 
Range on Protein: 16-135
Range on HMM: 7-137/270
Sequence Identity: 29% (39 aa)

LGEGSYGKVYKGKDV----KTGELVAVKCMDMSQFTDQ-FMKESLENEIGVMKIL-HSNNVVRMLHCEQ-DKKT--TYIILELCPDGDLRKFIHSN---G
||||..|.||||.      .|.  ||||..   . ...  ..|.. .|. .|| | |  |.||.. .   ...    ||..|..| |||... ...   .
LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

GHLNETLSLEILNQLMFGFKELVDHGFIHRDI
..|.    |..  |   |   | ....||||.
QPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 5688.AA TyrKc 10-265 22 1.7e-15 27.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

WDNSGFLGEGSYGKVYKGKDVKTGELVAVKCMDMSQFTDQFMKESLENEIGVMKIL--HSNNVVRMLHCEQDK-------KTTYIILELCPDGDLRKFIH
      |||| .|.||||.     . ||||..  .       .| . .|. .|. |  |  |.||.. .  ..       .  .|..|..| |||.....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SNGGHLNETLSLEILNQLMFGFKELVDHGFIHRDIKPENTLIKNKV-YKVADFGFACKADIS-----GKKLIKE----CVGTPL---YMAPQLLENTPYT
.....|.    |..  |   |   | ....||||.   | |....   |..||| . . .        |. ..     .  |.|    |||  .    .|
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

SKSDLWSIGMMFYEML-FGKTPWPAR----DINSYLRNMKNSPLRFPYDKP--------IGKNTKDFITRCLTINEKSRISWEEVFQHPIL
.||| || | . .|.. .|..|.|        |. ...   .  | |  .           .   . ...|   . ..| . .|.  | ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Efhand 5688.AA efhand 300-328 24 0.01265 14.02 Pfam 1-29 (29) Show / Hide 
Range on Protein: 300-328
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

NTEQIFYKFDSDHQGGLNPQEFHLLLQNI
  ...| .|| |. | .. .||  .....
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 5688.AA EFh 300-328 24 0.016038 10.97 SMART 1-29 (29) Show / Hide 
Range on Protein: 300-328
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

NTEQIFYKFDSDHQGGLNPQEFHLLLQNI
  ...| .|| |. | ....||  .....
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 5688.AA efhand 336-363 28 0.000562 18.97 Pfam 1-28 (29) Show / Hide 
Range on Protein: 336-363
Range on HMM: 1-28/29
Sequence Identity: 28% (8 aa)

ESEHLFQIVDSSKDGRISLQEFKAIFNE
| . .|...|  .||.|...||.... .
ELKEMFKEFDKDGDGYIDFEEFCEMMKK
EFh 5688.AA EFh 336-364 31 0.00326 16.55 SMART 1-29 (29) Show / Hide 
Range on Protein: 336-364
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

ESEHLFQIVDSSKDGRISLQEFKAIFNEW
| . .|...|  .||.|...|||... . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 5688.AA efhand 390-418 37 2e-06 28.13 Pfam 1-29 (29) Show / Hide 
Range on Protein: 390-418
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

SLKQIFQNFDKDKQGTLDLQEFQKLIRVV
 ||..|. ||||. |..|..||..... .
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 5688.AA EFh 390-418 34 3e-06 27.79 SMART 1-29 (29) Show / Hide 
Range on Protein: 390-418
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

SLKQIFQNFDKDKQGTLDLQEFQKLIRVV
 .|..|. ||||. |..|..||..... .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 5688.AA efhand 426-452 40 6.1e-05 22.49 Pfam 1-27 (29) Show / Hide 
Range on Protein: 426-452
Range on HMM: 1-27/29
Sequence Identity: 40% (11 aa)

EIVPVFKKFDTNGDNQVSFEEFYRVLA
|.  .||.||..|| ...|||| ....
ELKEMFKEFDKDGDGYIDFEEFCEMMK
EFh 5688.AA EFh 426-454 34 0.000425 20.86 SMART 1-29 (29) Show / Hide 
Range on Protein: 426-454
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

EIVPVFKKFDTNGDNQVSFEEFYRVLAYG
|.  .|..||..|| ...|||| ....  
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 5688.AA efhand 486-514 37 1.3e-05 24.91 Pfam 1-29 (29) Show / Hide 
Range on Protein: 486-514
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

NLKQIFNNFDKSKDGKLNLEEFTKLVLVI
 ||..|. ||| .||....||| ...  .
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 5688.AA EFh 486-514 34 0.001011 19.61 SMART 1-29 (29) Show / Hide 
Range on Protein: 486-514
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

NLKQIFNNFDKSKDGKLNLEEFTKLVLVI
 .|..|. ||| .||....||| ...  .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 5688.AA efhand 522-549 42 0.001242 17.71 Pfam 1-28 (29) Show / Hide 
Range on Protein: 522-549
Range on HMM: 1-28/29
Sequence Identity: 42% (12 aa)

EIKTIFDLFNSDGDNEITFEEFSNTLAN
|.| .|..|  ||| .|.|||| . ...
ELKEMFKEFDKDGDGYIDFEEFCEMMKK
EFh 5688.AA EFh 522-549 42 0.030579 8.71 SMART 1-28 (29) Show / Hide 
Range on Protein: 522-549
Range on HMM: 1-28/29
Sequence Identity: 42% (12 aa)

EIKTIFDLFNSDGDNEITFEEFSNTLAN
|.| .|..|  ||| .|.||||   ...
EFKEMFRMFDKDGDGYIDFEEFKDMMKS