Gene 6603 (Tetrahymena)

6603

Species: Tetrahymena
Alias: PreTt06603, 888, 6603, 16.m00259, TTHERM_00193200
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
6603.AA Protein None 629 None Fasta, JSON
6603.kin_dom Protein Kinase Domain None 252 None Fasta, JSON
6603.NA RNA None 1890 None Fasta, JSON

Protein domain

Protein domains of 6603.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6603.AA ULK 40-292 37 1.4e-127 430.13 In-house 1-324 (324) Show / Hide 
Range on Protein: 40-292
Range on HMM: 1-324/324
Sequence Identity: 37% (123 aa)

YVLERKIGSGQFG-DVFKGYNKVN---NQDIAIKVVKRELLKGKFNE--------LLENEIRVLRTCN---NEN--IIKLYDIKKTA--NNFYLMLEYCN
|.| ...|.|.||  |.||.|| .   ||..|.|.. .  .. | ||        ||.|||..... .   ..|  |.||||...|.  ||.|...||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

EGDLMQYQK---------EKKYLTEDEAIEFLIQILNAFKTLVKNKIMHRDFKLANILKHNGN-------------IKIADFGFAKLLGND----NLTST
 ||| || |         |||.|.|.|||.|..||.|.|| |.|..|.||| |..||| |||.             .||||||||| . |.    ... |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

ML------GSPLNMAPEVLD----GQDYNNK-ADIWSIGTVFYELLFGRPP----YTAGN--MIDLIKN-------IRNKPLEIPK--KINKISDVTEDI
..      |.|| |||..|     ...|... .||||.|..|||.|.|..|    ..  .  ...||.|       |.|.|...||  |..|||. ..|.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

IRKMLVVDPRKRIEWDQLFSHKIN
||.||..|...||.|...|.|.. 
IRRMLQYDEKDRISWEEIFNHPWF
Kinase 6603.AA ULK 40-292 37 1.3e-125 423.64 In-house 1-329 (329) Show / Hide 
Range on Protein: 40-292
Range on HMM: 1-329/329
Sequence Identity: 37% (124 aa)

YVLERKIGSGQFGDVFKGYNKVN----NQDIAIKVVKRELLKGKFNE--------LLENEIRVLRTCN--------NENIIKLYDIKKTA--NNFYLMLE
|.| ...|.|.|| |.||.|| .    |...|.|.. .. .. | ||        ||.|||..... .        ..||.||||...|.  ||.|...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCNEGDLMQYQK----------EKKYLTEDEAIEFLIQILNAFKTLVKNKIMHRDFKLANILKHNGN-------------IKIADFGFAKLLGND----N
||| |||.|| |          |||.|.|.|||.|..||||.|| |.|..|.||| |..||| |||.             .||||||||| . ||    .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LTSTML------GSPLNMAPEVLD----GQDYNNK-ADIWSIGTVFYELLFGRPP----YTAGN---MIDLIKN-------IRNKPLEIPK--KINKISD
.. |..      |.|| |||..|     ...|... .||||.|..|||.|.|.||    ..  .   ...||.|       |...||..||  ....||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

VTEDIIRKMLVVDPRKRIEWDQLFSHKIN
 ..|.||.||..|...||.|..||.|.. 
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 6603.AA Ciliate-E2 40-292 27 2.7e-78 266.4 In-house 1-365 (365) Show / Hide 
Range on Protein: 40-292
Range on HMM: 1-365/365
Sequence Identity: 27% (102 aa)

YVLERKIGSGQFGDVFKGYN-KVNN-------------------QDIAIKVVKRELLKGKFNELLENEIR--------------VLRTCNNENIIKLYDI
| . .|||.|.||.|.|. . ||..                   ..| |. .|.   ..... . |. |               .|.. |. ||||.|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

KK--TANNFYLMLEYCNEGDLMQYQKEK-----------KYLTEDEAIEFLIQILN---------------AFKTLVKNK-IMHRDFKLANILKHNGNIK
 .  . ||.|| .|||. |||..| |..           ||.|| |....  |||.               |.. | ... |.||| |. |||     ||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGFAKLLGND--------------------------------NLTSTMLGSPLNMAPEVLDGQD---------YNNKADIWSIGTVFYELLFGRPPY
|.|||..| . .|                                |.. | .|.|  ||||.| |..         |. |.||||.| ..||.|||.||.
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

TAGNMIDLIKNIRNKPLEIPKK---------------INKISDVTEDIIRK----MLVVDPRKRIE-WDQLFSHKIN
        ...| ......|..                .|.|. . |.|.|    ||..|| |||  |.|.. |.. 
--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 6603.AA S_TKc 40-295 33 2.8e-76 260.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-295
Range on HMM: 1-231/231
Sequence Identity: 33% (90 aa)

YVLERKIGSGQFGDVFKGYNKVNNQDIAIKVVKRELLKGKFNELLENEIRVLRTCNNENIIKLYDIKKTANNFYLMLEYCNE--GDLMQYQKEKKY----
| . ||||.| || |.|...|  ..  |||..|         | ...||..|.  . .||.||||.  . ...|. .|||.   |||..| |....    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LTEDEAIEFLIQILNAFKTLVKNKIMHRDFKLANILKHNGNIKIADFGFAKLLGNDNLTSTMLGSPLNMAPEVLDGQDYNN-KADIWSIGTVFYELLF
  ..| .|  .. ||..| . . ...|.||| | .|||  . .|||.|||.|..|      .|. |.|  ||||||    |.  |.|.||.| ..||.| 
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GRPPYTAGNMIDLIKNIRNKPLEIPKKINKISDVTEDIIRKMLVVDPRKRIEWDQLFS----HKINNFL
|.||.   .|  ..|.|.             |.   |.|||.|..||.||.   ...      |.  ..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6603.AA AGC 40-281 21 1.5e-72 186.02 In-house 1-374 (395) Show / Hide 
Range on Protein: 40-281
Range on HMM: 1-374/395
Sequence Identity: 21% (81 aa)

YVLERKIGSGQFGDVFKGYNK-----VNNQDI-AIKVVKREL---------LKGKFNEL-------LENEIRVLRTCN----------NENIIK-LYDIK
. . . || | || |.    |     . .... |.||.| .          ..   .|        . .| ..| .||          . .|.| |.   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KTANN--FYLMLEYCN---------EG-DLMQYQK---EKKYLTEDEAIEFLIQ-------ILNAFKTLVK-NKIMHRD-FKLANIL-KHNGNIKIADFG
.. ..   |. .||..          | .|.....    .....|..|  .. .       |. |.  | . ..| |||  |. |||  ..|.||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKLLGNDN---------------------------------------------------LTSTMLG--SPLNMAPEVLDGQDYNNKADIWS--IGTVFY
..| . ||.                                                   .|.|. |  .|  ||||.|    |.  .|.||   | ..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLFGRPPYTAG-------------NMIDLIKNIR---NKPLEIPKKI-------NKISDVTEDIIRKMLVVDPRKRI
|.|.|.||...               | ..|.| |   |.....| .         ..|.   |.|.|.|..||.||.
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRL
Kinase 6603.AA Ciliate-E2-Unclassified 40-292 26 3.7e-72 246.02 In-house 1-352 (352) Show / Hide 
Range on Protein: 40-292
Range on HMM: 1-352/352
Sequence Identity: 26% (94 aa)

YVLERKIGSGQFGDVFKGYNKVNNQD------IAIKVVKRELLKGK----FNELLENEIR-------------VLRTCNNENIIKLYDIKKTANNFYLML
| . ..||.|.||.|.| ..| ..|       . |...|. . . |    .... .|..               |. .....|.|....... .|.|. .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYCNEGDLMQYQKEK-----------------KYLTEDEAI-----EFLIQILNAFKTLVKNK-IMHRDFKLANILKHNG----NIKIADFGFAKLLGND
|||. |||.|| |..                 | .|| .|.      .. |||.... | ... | ||| |. ||| .|.    .|||.|||..| ....
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

----------------NLTSTMLGSPLNM----APEVLDGQDYNNK----ADIWSIGTVFYELLFGRPPYTAGNMID----------------LIKNIRN
                ....|. |.|  |    |||||.|| |...    .|||| | ..||.|||..|. . | ..                |..|| .
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

KPLEIPKKIN-----KISDVTEDIIR----KMLVVDPRKRIEWDQLFSHKIN
|....||  .     ..|.  .|.|.    |||...| ||| ..|.. | . 
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 6603.AA Ciliate-E2c 40-292 32 1.4e-70 240.78 In-house 1-310 (310) Show / Hide 
Range on Protein: 40-292
Range on HMM: 1-310/310
Sequence Identity: 32% (100 aa)

YVLERKIGSGQFGDVFKGYNKV------NN---------QDIAIKVVKRELLKGKFNE-LLENEIRVLRTCNNENIIKLYDIKKTANNFYLMLEYCNEGD
.  .   |||..| |.|.|.        ||           .. |.  . . . |  .  . .||  ... |. .||| || |.| ...|| .||||.|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LMQYQKEKKYLTEDEAIEFLIQILNAFKTLVKN-KIMHRDFKLANILKHNGNIKIADFGFAKLLGNDNLTSTM-----LGSPLNMAPEVLDG-QDYNNKA
| || ..| ...|.. .   .||..||| | |. .| ||| | .||| ||| ||||||||.|   .|| . |       |.|. |||..| | . |  |.
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS

DIWSIGTVFYELLFGRPPYT-----------------AGN-MIDLIKNIR---------------NKPLEIPKK-INKISDVTEDIIRKMLVVDPRKRIE
|||| | . |. |. ..|                    .| |  |...|.               ....  |.   ..||  . ..|.|||.||. |||.
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID

WDQLFSHKIN
||..| | ..
WDEIFNHECI
Kinase 6603.AA Pkinase 40-289 32 3.2e-69 241.09 Pfam 1-290 (293) Show / Hide 
Range on Protein: 40-289
Range on HMM: 1-290/293
Sequence Identity: 32% (94 aa)

YVLERKIGSGQFGDVFKGYNKVNNQDIAIKVVKRELLKGKFNELLEN--EIRVLRTCNNENIIKLYDIKKTANNFYLMLEYCNEG----DLMQYQK--EK
|...|||||| || |.|...| ...  |.|..|..  | .... . .  ||.... .| .||..|||.  . .. |. .|||. |    ||. | .  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KYL--TEDEAIEFLIQILNAFKTLVKNKIMHRDFKLANILKH-NGNI----KIADFGFAKL--LGNDNLTSTMLGSPLNMAPEVLD-GQDYNNKADIWSI
. .  .|.|.. .. ||| . . . ...|.||| |..||| . ||.|    ||.|||.||.  . |.  ..|  |.|  |||||.  ||.|  |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GTVFYELLFGRPPYTAG------NMIDLIKNIRNKPLEIP-KKINKIS-----------------DVTEDIIRKMLVVDPRKRIEWDQLFSH
| ..||.|.||||.         ... .|..|. .||. .  . . ||                 .   |.|...| .|| ||. ..|.. |
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH
Kinase 6603.AA CAMK 45-281 22 9.2e-69 220.46 In-house 1-414 (425) Show / Hide 
Range on Protein: 45-281
Range on HMM: 1-414/425
Sequence Identity: 22% (94 aa)

KIGSGQFGDVFKGYNKVNN------------QDIAIKVVKRELLKGKF--------------------------NELLENEIRVLRTCN-------NENI
..|.|.|| |.....| ..            |  |||..... ||.|                            . ...||.......        .||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYDIKK------------TANN--------FYLML---EYCNEG----DLMQYQKEK---------------KYLTEDEAIEFLIQILNAFKTLVKNK
||||..              | ..        .|. .   |||  |    || .| .|.               ...||.||  .  ||. | . . ...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IMHRDFKLANILK-HN-----------------GNIKIADFGFAKLLGN------------------------DNLTSTMLGSPLNMA-PEVLDGQD---
|.||| |. |||  .|                 .||||.|||||. .                          . . .|. |.|  || |||| |.    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YNNKADIWSIGTVFYELLFGRPPYTAG-------------NMIDLIKNIRNKPLE-IPKKINKIS--------------------DVTE
           |. |.|.||.| . | .| |.||. .              |. .| ..|..   . .|... .||                    .   
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DIIRKMLVVDPRKRI
| |||||.||| ||.
DLIRKMLQVDPEKRM
Kinase 6603.AA CAMKL 40-290 28 4.8e-58 183.77 In-house 1-295 (297) Show / Hide 
Range on Protein: 40-290
Range on HMM: 1-295/297
Sequence Identity: 28% (85 aa)

YVLERKIGSGQFGDVFKGYN-KVNNQDIAIKVVKRELLKGKFNEL-------------LENEIRVLRTCN---NENIIKLYDIKKTANN------FYLML
| ... .| | || |  . . . ...  |||..... .. . . .             .. ||. ..  |    .||||||..  | ..      .|| .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCNEGD--LMQYQKEKKY----LTEDEAIEFLIQILNAFKTLVKNKIMHRDFKLANILKH-NG--NIKIADFGFAKLLGN-----DNLTSTMLGSPLNM
|||  |.  |..| .....    ..|.||  .  ||. | . . ...| ||| |. |||   ||  ||||.||||. .  .     ... .|  |||  |
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLDG--QDYN-NKADIWSIGTVFYELLFGRPPYT-------AGNMIDLIKNIRNKPLEIPKKINKISDVTEDIIRKMLVVDPRKRIEWDQLFSHK
|||.. |  ..|.  |.||||.| . | ...|. |           . | . ... ..  . | . ...|   .|.|||||.|.| ||.  .|. .|.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP
Kinase 6603.AA NEK 40-292 30 8.9e-57 194.94 In-house 1-286 (286) Show / Hide 
Range on Protein: 40-292
Range on HMM: 1-286/286
Sequence Identity: 30% (89 aa)

YVLERKIGSGQFGDVFKGYNKVNNQD-----IAIKVVKRELLKGKFNELLE-NEIRVLRTCNNENIIKLYDIKKT--ANNFYLMLEYCN-EGDLMQY---
| . .|||.|.|| |.|   | ...       ..| .. . .. |  . .  ||.|.|.  ...||.| ||       | ..   |||. .|||.|    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

QKEKK----YLTEDEAIEFLIQILNAFKTLVKN-----KIMHRDFKLANI-LKHNGN----IKIADFGFAKLLGNDN-LTST-MLGSPLNMAPEVLDGQD
 |..|    |. |..  ...||.. | | . ..     ||.||| | .|| |  |.|    .|| ||| .|.|.... . .| . | |  |.|||. .. 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNNKADIWSIGTVFYELLFG--RPPYTAG--NMIDLIKNIRNKPLEIPKKIN-K--ISDVTEDIIRKMLVVDPRKRIEWDQLFSHKIN
||||.||||.| | ||.     ..|  |   ||  |...|..   . ...|. .   |.   ..|..|| .|| .|   .|.... . 
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG--PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 6603.AA STE 40-292 22 1.4e-55 190.96 In-house 1-359 (359) Show / Hide 
Range on Protein: 40-292
Range on HMM: 1-359/359
Sequence Identity: 22% (82 aa)

YVLERKIGSGQFGDVFKGYNK------VNNQD---------IAIKVVKRELLK---------------GKFNELLENEIRVLRTCN--NENIIKLYDIKK
. . .|||.| || |.|..|.       ...          .|||... |  .                .  . ...||.... ||   .||.| |.   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TA-------NNFYLMLEYCNEGDLMQYQKEK--------------KYLTEDEAIEFLIQILNA-FKTLVKNKIMHRDFKLANILKHNGNIKIADFGFAKL
         .. .. .||.. | | .  |.|              ... |.. . .. ||| .  . | ...|.||| | ||||     .|..|||... 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

LGNDNL-----------------TSTMLGSPLNMAPEVLDG------QDYNNKADIWSIGTVFYELLFGRPPYTA-GNMIDLIKNIRN------------
| ...                  . |. |.|  |||||...      ..|. |.||||.| .  |.. |.||.    .|  .   ..|            
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

---KPLEIPKKIN----------------KISDVTEDIIRKMLVVDPRKRIEWDQLFS--HKIN
   .|  .| ..                 | |.   | |.| |. ||.||   .|| .  |.  
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 6603.AA TyrKc 40-291 20 8.7e-19 69.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-291
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YVLERKIGSGQFGDVFKGYNKVNNQDIAIKVVKRELLKGKFNELLENEIRVLRTC--NNENIIKLYDIKKTA-------NNFYLMLEYCNEGDLMQYQKE
 .|..|.|.|.|| |.||  |   .. |.|..| .       | . .|.|...    ...||..|| .  .           .. .||.  ||| .| ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KKY-LTEDEAIEFLIQILNAFKTLVKNKIMHRDFKLANILKHNGN-IKIADFGFAKLLGND-------NLTSTMLGSPLN-------MAPEVLDGQDYNN
..  |. .. ..| .|| .    | .... |||    |.| .... .||.||| .. ...|          ... ..  .       ||||...   .. 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KADIWSIGTVFYELL-FGRPPYTA-----GNMIDLIKNIRNKPLEIPKKINK--------ISDVTEDIIRKMLVVDPRKRIEWDQLFSHKI
| |.|| | . .|.. .| .||        . ...|.....   . ...            .|   .|...    || .|    ..  ...
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG--YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase 6603.AA Pkinase_Tyr 40-124 23 5.3e-13 44.67 Pfam 1-94 (270) Show / Hide 
Range on Protein: 40-124
Range on HMM: 1-94/270
Sequence Identity: 23% (23 aa)

YVLERKIGSGQFGDVFKGYNK----VNNQDIAIKVVKRELLKGK---FNELLENEIRVLRTC-NNENIIKLYDIKK-TANN--FYLMLEYCNEGDL
 .. .|.|.|.||.|.||. |     .... |.|.. .|    .     .... |......  ...||..|| .          |. .||.  |||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase 6603.AA Pkinase_Tyr 169-235 32 0.000109 16.51 Pfam 144-216 (270) Show / Hide 
Range on Protein: 169-235
Range on HMM: 144-216/270
Sequence Identity: 32% (24 aa)

LKHNGNIKIADFGFAKLLGNDNLT-STMLGSPLN---MAPEVLDGQDYNNKADIWSIGTVFYELLF-GRPP-Y
...|. .||.||| |... ||     .  |..|    ||||..    .. | |.|| | . .|..  |. | |
VTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY