Gene 7377 (Tetrahymena)

7377

Species: Tetrahymena
Alias: TTHERM_00622900, 214, 87.m00157, 7377, 3814.m00864, PreTt07377
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
7377.AA Protein None 550 None Fasta, JSON
7377.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
7377.NA RNA None 1653 None Fasta, JSON

Protein domain

Protein domains of 7377.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 7377.AA ULK 12-267 40 1e-142 480.42 In-house 1-324 (324) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-324/324
Sequence Identity: 40% (133 aa)

WENRKFIGEGSFG-KVYRATNTKT---KQDVAVKVLD---MKNFKQ----QDMIASLKNEIQIMKQLK---SPN--IVRLLDCSGNT--KETFIFMEYCE
.. .. .|.|||| |||...| ||   .|.||.|. |   |...|.    | |. .|||||||||.||   .||  ||.|.|.. ..  . ..|.||||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLKHYIEKKGG--------KLKEKQAIDILKQFMNGFKEMHEKGYIHRDIKPQNILLSRET-------------FKIADFGFATKVDP--RGKQFMKE
||||..||.|...        .| |..|| ..||..|||||.|....|||||||||||..  .             .|||||||| .||     .| ...
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

YV------GTPLYMAPQLLE----NMPYT-AKSDVWSIGMTFYEIIFGKTP---WPARDLY----SFLRN-------IKTTPLRFP---YDKPIGKDTKD
.|      |||||||||.|.    ..||. .|.|.||.|. |||...||.|   | ..|.|    . ..|       ||..|..||   .|..| ...||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FISRCLVIDENKRMSWDEIFKHPIL
.|.|.|..||..|.||.|||.||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 7377.AA ULK 12-267 39 3.6e-140 471.96 In-house 1-329 (329) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-329/329
Sequence Identity: 39% (131 aa)

WENRKFIGEGSFGKVYRATNTKTK----QDVAVKVLD---MKNFKQ----QDMIASLKNEIQIMKQLK----SPN----IVRLLDCSGNTKE--TFIFME
.. .. .|.|||||||...| |||    ..||.|..|   |.....    | |. .|||||.|||.||    ..|    ||.|.|.. ....  ..|.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCEGGDLKHYIEKKGG---------KLKEKQAIDILKQFMNGFKEMHEKGYIHRDIKPQNILLSRE-------------TFKIADFGFATKVDPR--GKQ
||.||||..||.|...         .| |..|| ..||..|||||.|....|||||||||||..               ..|||||||| .||     .|
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FMKEYV------GTPLYMAPQLLE----NMPYT-AKSDVWSIGMTFYEIIFGKTP---WPARDLY-----SFLRN-------IKTTPLRFP---YDKPIG
 |. .|      |||||||||.|.    ..||. .|.|.||.|. |||...||.|   | ..|.|     . ..|       ||..||.||   .|..| 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

KDTKDFISRCLVIDENKRMSWDEIFKHPIL
...||.|.|.|..||..|.||.|.|.||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 7377.AA S_TKc 12-267 33 1.1e-92 315.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-231/231
Sequence Identity: 33% (90 aa)

WENRKFIGEGSFGKVYRATNTKTKQDVAVKVLDMKNFKQQDMIASLKNEIQIMKQLKSPNIVRLLDCSGNTKETFIFMEYCEG--GDLKHYIEKKGGK--
.|  . ||.|.|||||.....||.. ||.|...           ....||||.|. . ||||.|.|.  . .. ...||||.|  |||..||.|.|..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LKEKQAIDILKQFMNGFKEMHEKGYIHRDIKPQNILLSRETFKIADFGFATKVDPRGKQFMKEYVGTPLYMAPQLLENMPYTA-KSDVWSIGMTFYE
   . | .|  ...|  .. . .|..| ||||.||.||||.. . ||.|||.|...        . ..||| |||| .|   .|.  |.|.||.| ..||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

IIFGKTPWPARDLYSFLRNIKTTPLRFPYDKPIGKDTKDFISRCLVIDENKRMSWDEIFK-------HPIL
 . |..|.|  ...  ...|.             .. ||||..||. | .||..  |...       || .
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 7377.AA Pkinase 12-267 32 1.1e-84 292.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

WENRKFIGEGSFGKVYRATNTKTKQDVAVKVLDMKNFKQQDMIASLK-NEIQIMKQLKSPNIVRLLDCSGNTKETFIFMEYCEGG----DLKHYIE-KKG
..  . ||.||||.||.... .| . ||||... .. | .  .. .. .|||||| |..||||||.|.  . ..  . |||||||    ||..||. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKL--KEKQAIDILKQFMNGFKEMHEKGYIHRDIKPQNILLS-RETF----KIADFGFATKVDPRGKQFMKEYVGTPLYMAPQLLE-NMPYTAKSDVWSI
|..   |........|   | . .|..| ||||.||.|||.. . .     ||.|||.| ..|   .. |. ..||| |||| ..  . .|. |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GMTFYEIIFGKTPWPAR------DLYSFLRNIKTTPLRFPYDKPIG-------------------KDTKDFISRCLVIDENKRMSWDEIFKHPIL
| ..|| ..|..|.| .      | .  ...|. .||.|......                    .. ||||..||  | .|| ....|..|| .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 7377.AA Ciliate-E2 18-267 26 1.1e-83 284.35 In-house 7-365 (365) Show / Hide 
Range on Protein: 18-267
Range on HMM: 7-365/365
Sequence Identity: 26% (97 aa)

IGEGSFGKVYRATNTKTKQDVAVKVLDMKN----------------FKQQ--DMIASLKNEIQIMK----------------QLKSPNIVRLLDCSG--N
||.|.||.||.... |.....| |. | ..                 |..  ..| ..|.||.||.                ||..|||... .|    .
IGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKD

TKETFIFMEYCEGGDLKHYIEKKGGK----------LKEKQAIDILKQFMN---------------GFKEMHEKG-YIHRDIKPQNILLSRETFKIADFG
..  .. ||||.||||..||...  |          ..||....| ||  .               .....|.|.  |||||||.|||.     ||.|||
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFG

FATKVDPR---------GKQFMKEY----------------------VGTPLYMAPQLLENMP---------YTAKSDVWSIGMTFYEIIFGKTPWPARD
...|.|.           | .|                         .||| ||||. |.. .         |. |.|.||.|...|| .|||.|.    
LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----

LYSFLRNIKTTPLRFPYD----------------KPIGKDTKDFISR----CLVIDENKRMS-WDEIFKHPIL
    ...||  ...||                  | . ...||.|..    .|. |..||.. |..|..||..
----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 7377.AA CAMK 17-267 22 9.6e-81 259.77 In-house 1-425 (425) Show / Hide 
Range on Protein: 17-267
Range on HMM: 1-425/425
Sequence Identity: 22% (97 aa)

FIGEGSFGKVYRATNTKTK------------QDVAVKVLDMKNFK-------------------------QQDMIASLKNEIQIMKQ-------LKSPNI
 .|.||||||.......|.            | ||.|..| |  |                         .. . .....||.|||.       |. |||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLLD--------------------CSGNTKETFIFM---EYCEGG----DLKHYIEKKGG--------------KLKEKQAIDILKQFMNGFKEMHEKG
..|..                    .  ..|. ...|   |||.||    ||  || ..|.              ...|..|  . .|   . . .|...
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

YIHRDIKPQNILLSRE------------------TFKIADFGFATKVDPRGKQF----------------------MKEYVGTPLYMA-PQLLEN-----
 .|||.|| ||||.                    . ||.|||||.|.||  ..|                      ||...||| ||| | .|.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------MPYTAKSDVWSIGMTFYEIIFGKTPWPAR-------------DLYSFLRNIKTTPLRFP--YDKPIG--------------------KDTK
          .|. |.|.||.|   |    |. |. .              ..|  ...|..   .||  | .||                     .. |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFISRCLVIDENKRMSWDEIFKHPIL
|.|...|. | .|||. ... .|| .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 7377.AA Ciliate-E2c 12-267 31 3.4e-77 262.78 In-house 1-310 (310) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-310/310
Sequence Identity: 31% (98 aa)

WENRKFIGEGSFGKVYRATNTK---TKQDV-------AVKVLDMKN-----FKQQDMIASLKNEIQIMKQLKSPNIVRLLDCSGNTKETFIFMEYCEGGD
 .  .  | ||.||||.| . .   . . .       |.| .  ||     ... |   |...||..||....|.|..  |    .|  ...||||.||.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LKHYIEKKGGKLKEKQAIDILKQFMNGFKEMHEK-GYIHRDIKPQNILLSRETFKIADFGFATKVDPRGKQFMK---EYVGTPLYMAPQLLEN-MPYTAK
|. ||..|  |..||| ..  .|  ..||. |.. . .|||||| |||.   . |||||||. ....  .|.      ..|||.||||| ||    || |
LEQYIYHK-PKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEK

SDVWSIGMTFYEIIFGKTPWP-----------------ARD-LYSFLRNIK---------------TTPLRFPYD--KPIGKDTKDFISRCLVIDENKRM
||.|| | | |. .. | ||                    . .     .|.               |....|| .  . | ...|..| . |. ||.|| 
SDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRI

SWDEIFKHPIL
.||||| |...
DWDEIFNHECI
Kinase 7377.AA STE 12-267 26 1.7e-74 253.82 In-house 1-359 (359) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-359/359
Sequence Identity: 26% (98 aa)

WENRKFIGEGSFGKVYRATNTK---------------TKQDVAVKVLDMKNFKQ--------------QDMIASLKNEIQIMKQLK--SPNIVRLLDC--
||. ..||.|.||.||.| | |               |.. .|.|.....| ..              .. . ....||.|||...  .||||. ..|  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----SGNTKETFIFMEYCEGGDLKHYIEKKGGKLK-------------EKQAIDILKQFMNG-FKEMHEKGYIHRDIKPQNILLSRETFKIADFGFATK
     ..|  | .|.|||..|| |   |..|.|..|             |.| . |..|   |  .  |....|||||||.||||     |..|||....
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

VDP---------------RGKQFMKEYVGTPLYMAPQLLENM------PYTAKSDVWSIGMTFYEIIFGKTPW----PARDLYSFLRNI-----------
...                ..|  .  |||| .|||  ....      .|..|.|.||.| |  | . || ||    | | .. ...|.           
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

-KTTPLRFPYD-----------------KPIGKDTKDFISRCLVIDENKRMSWDEIFK--HPIL
 . .| ..| .                 .   .. ||||..||..| ||| . ..  |  || .
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 7377.AA CAMKL 12-267 30 1.3e-73 234.26 In-house 1-297 (297) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-297/297
Sequence Identity: 30% (93 aa)

WENRKFIGEGSFGKVYRATNTKT-KQDVAVKVLDMKNFK-QQDMIAS-----------LKNEIQIMKQLK---SPNIVRLLDCS-------GNTKETFIF
..  | .|.||||||  ||...| .. ||.|..| |  .  . | .            .. ||||||.|.    |||..|...         . |. ...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

MEYCEGGD--LKHYIEKKG---GKLKEKQAIDILKQFMNGFKEMHEKGYIHRDIKPQNILLS-RE--TFKIADFGFATKVDP--RG-KQFMKEYVGTPLY
||||.||.  | .||.|.|   |...|..|  . .| . . . .|..| .|||||| ||||. .   . ||.||||... .|   |  |..|.  |.| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MAPQLLEN--MPYT-AKSDVWSIGMTFYEIIFGKTPWPAR--------DLYSFLRNIKTTPLRFPYDKPIGKDTKDFISRCLVIDENKRMSWDEIFKHPI
||| ...    ||   | |.||.| . | ...|. |. .         .   ... |...  ..|  . .  | .|.|.. |. . .||.. ..| .|| 
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

L
.
M
Kinase 7377.AA Ciliate-E2-Unclassified 12-267 25 2.5e-67 230.02 In-house 1-352 (352) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-352/352
Sequence Identity: 25% (92 aa)

WENRKFIGEGSFGKVYRATNTKTKQDV-------AVKVLDMKNFKQQDMIASLK----NEIQ-------------IMKQLKSPNIVRLLDCSGNTKETFI
 .  | ||.|.|||||.. . |.|  .        ... ..|. ...| . ...    |...             |......|.||....|  ...  .|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

FMEYCEGGDLKHYIEKKGG----------------KLKEKQAI-----DILKQFMNGFKEMHEKG-YIHRDIKPQNILLSRE----TFKIADFGFATKVD
 |||||||||. ||.|...                .. |.||.     ....|  .|.. .|.|.  |||||||.|||.. .      ||.|||.. | .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

PR--------------GKQFMKEYVGTPLYM----APQLLENMPYT----AKSDVWSIGMTFYEIIFGKTPWPARDLYS----------------FLRNI
                 .| |.  .||| ||    || .|..  |      |.|.|| |. .||..||. | .... ..                ...||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KTTPLRFPYDKP------IGKDTKDFIS----RCLVIDENKRMSWDEIFKHPIL
|  .. ||  ..      . .  ||||.    ..|. . |||.....|..||..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 7377.AA CAMK-Unique 12-267 21 8.8e-62 202.65 In-house 1-363 (363) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-363/363
Sequence Identity: 21% (77 aa)

WENRKFIGEGSFGKVYRATNTKTKQDVAVKVLDMKNFKQQDMIA-----------------SLKNEIQIMKQLKSPNIVRLLDC----SGNTK-------
... . ||.|.||.||.... .|.   |.|..  .  .   ...                 .||.|.||.| .. |||..|.|         |       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------ETFIFMEYCEGGDLKHYIEKK-------------------GGKLKE--KQAIDILKQFMNGFKEMHEKGYIHRDIKPQNILLSRE-------
        . .|.||||.||||. .| |                     |.. |   ... |  .     . ||... .|||.|. ||... .       
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

----------TFKIADFGFATKVDPRGKQ-FMKEYVGTPLYMAP--------------QLLENMPYTAKS----DVWSIGMTFYEIIFGKTPWPARDLY-
            |..||| .....   .   |....|||.||||              ..... .|  ..    | ||.| . |. ..|..|  . .   
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------SFLRNIKTTPL-RFP---YDKP--IGKDTKDFISRCLVIDENKRMSWDEIFKHPIL
       . ...|.   . .|.   .. |  |..  |||. .|...| ..| |  |. .|. .
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 7377.AA STE20 12-210 32 4.4e-54 185.99 In-house 1-226 (288) Show / Hide 
Range on Protein: 12-210
Range on HMM: 1-226/288
Sequence Identity: 32% (74 aa)

WENRKFIGEGSFGKVYRATNTKTKQD----VAVKVLDMKNFKQQ-DMIASLKNEIQIMKQLKSPNIVRLLDCSGNT----KETFIFMEYCEGGDLKHYIE
.|. . ||.||.||||.|....|..     ||.|...... . . |.. ....||.||||.|.||||. ...         | .| ||||.|| |   ..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---KKGG-----KLKEKQAIDILKQFMNGFKEMHEKGYIHRDIKPQNILLSRE-TFKIADFGFATKVDP----RGKQFMKEYVGTPLYMAPQLLEN----
   |.|.     ...|.|   |...   | .  |....|||||| .||||. .   |.||||.. ....      ..  .  |||| .||| ...     
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-MPYTAKSDVWSIGMTFYEIIFGKTP
  .|. |.|.|| | |  | . |. |
DKGYDYKCDIWSLGITAIEMAEGEPP
Kinase 7377.AA Pkinase_Tyr 12-224 31 1e-34 118.24 Pfam 1-230 (270) Show / Hide 
Range on Protein: 12-224
Range on HMM: 1-230/270
Sequence Identity: 31% (73 aa)

WENRKFIGEGSFGKVYRATNT----KTKQDVAVKVLDMKNFKQQD-MIASLKNEIQIMKQL-KSPNIVRLLDCSG-NTKE--TFIFMEYCEGGDLKHYIE
 .  | .|||.||.||..| .    .||..||||.|   .  ... ..... .|..||||| . ||||||. .     .    .| |||...|||..|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KK---GGKLKEKQAIDILKQFMNGFKEMHEKGYIHRDIKPQNILLS-RETFKIADFGFATKVDPRGKQFMKEYVGTPL---YMAPQLLENMPYTAKSDVW
|.   ...|. |. ...  |  .|    ..|..||||.   |.|..   . ||.||| |  . . .   ..   |..|    |||  . .. .| |||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SIGMTFYEIIF-GKTP-WPARDLYSFLRNI-K
| | . .||.  |..| .|  . . ... | .
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYE
Kinase 7377.AA TyrKc 12-267 26 4.4e-23 83.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-280/280
Sequence Identity: 26% (78 aa)

WENRKFIGEGSFGKVYRATNTKTKQDVAVKVLDMKNFKQQDMIASLKNEIQIMKQL--KSPNIVRLLDCSGNT-------KETFIFMEYCEGGDLKHYIE
 .  | .||| ||.||..| .   ..||||.|          .. . .|..||..|  . ||||||. .           .  .| |||...||||.|. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KKGGKLKEKQAIDILKQFMNGFKEMHEKGYIHRDIKPQNILLSRET-FKIADFGFATKVDPR------GKQFMKEY-VGTP--L---YMAPQLLENMPYT
|...||. |. ...  |  .|    |.|..||||.   |.|....   ||.||| . ...        ..  .|    |.   |    |||  .    .|
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

AKSDVWSIGMTFYEII-FGKTPWPA-----RDLYSFLRNIKTTPLRFPYDKP-------IGKDTKDFISRCLVIDENKRMSWDEIFKHPIL
 |||||| | . .||  .|..|.|       . .  ....|.   . . . .         ..  . ...|   | ..| .  ||  | ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 7377.AA STE20 241-267 37 0.000162 12.76 In-house 262-288 (288) Show / Hide 
Range on Protein: 241-267
Range on HMM: 262-288/288
Sequence Identity: 37% (10 aa)

KDFISRCLVIDENKRMSWDEIFKHPIL
.||...||..| .|| . ..  ||| .
HDFVDKCLQKDPEKRPTASQLLKHPFI
EFh 7377.AA EFh 302-330 34 0.000135 22.52 SMART 1-29 (29) Show / Hide 
Range on Protein: 302-330
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

NVNHIFDKFDKDKGGSLDEQEFFQFIVSI
 .. .|..||||. | .| .|| ... |.
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 7377.AA efhand 302-330 31 0.00041 19.47 Pfam 1-29 (29) Show / Hide 
Range on Protein: 302-330
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

NVNHIFDKFDKDKGGSLDEQEFFQFIVSI
 .. .|..||||. | .| .|| ... ..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 7377.AA efhand 338-366 27 0.000662 18.71 Pfam 1-29 (29) Show / Hide 
Range on Protein: 338-366
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

ESKAIFRVVDTSNDKKISLQEFASIFCQY
| |..|...|. .| .|...|| ... . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 7377.AA EFh 338-366 31 0.00868 13.12 SMART 1-29 (29) Show / Hide 
Range on Protein: 338-366
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

ESKAIFRVVDTSNDKKISLQEFASIFCQY
| |..||..|. .| .|...||  ..   
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 7377.AA efhand 392-420 41 2e-05 24.31 Pfam 1-29 (29) Show / Hide 
Range on Protein: 392-420
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

NLKEIFSNFDKDKLGTLDKQEFEKLIRVV
 |||.|. ||||. |..|..|| .... .
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 7377.AA EFh 392-420 37 2.3e-05 25.06 SMART 1-29 (29) Show / Hide 
Range on Protein: 392-420
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

NLKEIFSNFDKDKLGTLDKQEFEKLIRVV
 .||.|. ||||. |..|..|| .... .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 7377.AA EFh 428-456 37 5.8e-07 30.38 SMART 1-29 (29) Show / Hide 
Range on Protein: 428-456
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

EIQKCFEKFDKDKDNQVSFDEFKNALTYG
|....|..||||.| ...|.||| ...  
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 7377.AA efhand 428-454 37 5.8e-07 29.9 Pfam 1-27 (29) Show / Hide 
Range on Protein: 428-454
Range on HMM: 1-27/29
Sequence Identity: 37% (10 aa)

EIQKCFEKFDKDKDNQVSFDEFKNALT
|... |..||||.| ...|.||.....
ELKEMFKEFDKDGDGYIDFEEFCEMMK
Efhand 7377.AA efhand 488-516 34 0.00018 20.78 Pfam 1-29 (29) Show / Hide 
Range on Protein: 488-516
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

DIKVIFRNFDQTKDSYLDINEFKKFIKII
..| .|. ||. .| |.|..||....| .
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 7377.AA EFh 488-516 41 0.001391 19.15 SMART 1-29 (29) Show / Hide 
Range on Protein: 488-516
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

DIKVIFRNFDQTKDSYLDINEFKKFIKII
..| .|| ||. .| |.| .|||...| .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 7377.AA efhand 524-549 42 5.8e-05 22.58 Pfam 1-26 (29) Show / Hide 
Range on Protein: 524-549
Range on HMM: 1-26/29
Sequence Identity: 42% (11 aa)

EYNYIFKLFDTDNDDKISFQEFSKFF
| . .||.||.|.| .|.|.|| ...
ELKEMFKEFDKDGDGYIDFEEFCEMM
EFh 7377.AA EFh 524-550 34 0.014848 11.24 SMART 1-29 (29) Show / Hide 
Range on Protein: 524-550
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

EYNYIFKLFDTDNDDKISFQEFSKFF--V
| . .|..||.|.| .|.|.|| ...  .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL