Gene 8696 (Tetrahymena)
8696
Sequence
Protein domains of 8696.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 8696.AA | ULK | 18-275 | 40 | 4e-142 | 478.45 | In-house | 1-324 (324) | Show / Hide |
Range on Protein: 18-275 Range on HMM: 1-324/324 Sequence Identity: 40% (133 aa) VVVNNVLGKGAFG-KVYRGFCVEDE--NKLVAAKAIPIKSISDSGKM------LELIKREIAILQKVS---SPF--IVSLYDVARTS--NNLYMFLEYCH ..|..||||.|| |||.|...... |..||.| |..|..... .. ..|.|.|| |..| .|. || |||. .|| ||.|...||| YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN DGDLKEYLKKK-------EGKRLSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLSNGI-------------AKISDFGFSRVVEKDD---PALLS .|||..|.||. |.|||||.||..||..|..|||||.||.||||||||.||...||. .||.||||...|.... . . GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT RL------GSPLYMTPQILD----GVPFN-FKCDVWSVGVVFFEMLYGTTP---WIGDSQV----KLLQN-------IKSIPLKFP---ENPIRSKEVKD . |.|||| |||| . |.. .|||.||.|..|.||||| .| | .|. ||..| || |..|| ..|..|.|.|| CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD LLRGMLKVKEEERMSWEEIFNHPLI |.|.||...|..|.|||||||||.. LIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | 8696.AA | ULK | 18-275 | 40 | 5.8e-141 | 474.59 | In-house | 1-329 (329) | Show / Hide |
Range on Protein: 18-275 Range on HMM: 1-329/329 Sequence Identity: 40% (132 aa) VVVNNVLGKGAFGKVYRGFCVEDE---NKLVAAKAIPIKSISDSGKM------LELIKREIAILQKVS----SPF----IVSLYDVARTS--NNLYMFLE ..|..||||.|||||.|...... |..||.| |...... . .. ..|.|.|| |..| ... || |||. .|| ||.|...| YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME YCHDGDLKEYLKKK--------EGKRLSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLSNGI-------------AKISDFGFSRVVEKD---DP || .|||..|.||. |.|||||.||..||..|..|||||.||.||||||||.||...||. .||.||||...|..| . YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ ALLSRL------GSPLYMTPQILD----GVPFN-FKCDVWSVGVVFFEMLYGTTP---WIGDSQV-----KLLQN-------IKSIPLKFP---ENPIRS ... . |.|||| |||| . |.. .|||.||.|..|.||||| .| | .|. ||..| ||..||.|| ..|..| MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS KEVKDLLRGMLKVKEEERMSWEEIFNHPLI .|.|||.|.||...|..|.||||.||||.. PECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 8696.AA | CAMK | 23-275 | 22 | 2.6e-85 | 274.75 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 23-275
Range on HMM: 1-425/425
Sequence Identity: 22% (97 aa)
VLGKGAFGKVYRGFCVEDEN-----------KLVAAKAIPIKSISD------------------------SGKMLELIKREIAILQK-------VSSPFI
.||.|.||||.... .. . . ||.| |. | ..| ..|... ..|||.|..| .. | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VSLYDVAR------------TSNN--------LYMFL---EYCHDG----DLKEYLKKKEG-------------KRLSEPEALIFFRHIVEGFKELQKHK
..||.| | .. .||.. ||| | || .|...... .|..| || .|| |... . . .|.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
IIHRDIKPANIML-SN-----------------GIAKISDFGFSRVVEK-----------------------DDPALLSRLGSPLYMT-PQILDG-----
|.|||.|| ||.| .| . ||.||||...... ... . . |.| || | .| |
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
---------VPFNFKCDVWSVGVVFFEMLYGTTPWIGD-------------SQVKLLQNIKSIPLKFPENPIRS----------------------KEVK
. ..|||.||.||. . || |. |. || .. .|...|.. ||. .. .|.|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK
DLLRGMLKVKEEERMSWEEIFNHPLI
||.|.||.| |.||. |.. ||| .
DLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 8696.AA | S_TKc | 18-275 | 32 | 2.7e-84 | 287.29 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 18-275 Range on HMM: 1-231/231 Sequence Identity: 32% (89 aa) VVVNNVLGKGAFGKVYRGFCVEDENKLVAAKAIPIKSISDSGKMLELIKREIAILQKVSSPFIVSLYDVARTSNNLYMFLEYCHD--GDLKEYLKKKEGK . ...|||||||||.. .. ...|| | |. | |.|||.||.| |.|| |||| .. ..|||..||| |||..|.||. .. YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH R----LSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLSNGIAKISDFGFSRVVEKDDPALLSRLGSPLYMTPQILDGVPFNF-KCDVWSVGVVFF . ..| .| ... |... . . .|.|||||.||.||.|.. ||.|||..|.. . |.| || | .| .... |||.||.|.... GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY EMLYGTTPWIGDSQVKLLQNIKSIPLKFPENPIRSKEVKDLLRGMLKVKEEERMSWEEIFN-------HPLI |||.| .|. . .....|. |.|.||..|..|.. |.|.. |... || . EMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 8696.AA | Ciliate-E2c | 21-275 | 33 | 4.9e-82 | 278.85 | In-house | 4-310 (310) | Show / Hide |
Range on Protein: 21-275 Range on HMM: 4-310/310 Sequence Identity: 33% (102 aa) NNVLGKGAFGKVYRGFCVEDENKLVAA---------KAIPIKSI----SDSGKMLELIKREIAILQKVSSPFIVSLYDVARTSNNLYMFLEYCHDGDLKE || ||.| .||||.. .||.. . | .. |.. . . .| |.||| .. . .| |. || |....| ..||| .|.|. NNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGTLEQ YLKKKEGKRLSEPEALIFFRHIVEGFKELQKH-KIIHRDIKPANIMLSNGIAKISDFGFSRVVEKDDPALLS----RLGSPLYMTPQILDGVPFNF-KCD |...| ...| . | | |. .||.| | .|.||||||.|| . ||. || |||||. . | . |.|.|| |||| | . | | YIYHKP--KPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKSD VWSVGVVFFEMLYGTTPWI------------------GDSQVKLLQNIK---------------SIPLKFPEN--PIRSKEVKDLLRGMLKVKEEERMSW .|| ||. ..||. || ......| |.|. ...|||| .|.|||.|.. || | || | .| IWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRIDW EEIFNHPLI .|||||..| DEIFNHECI |
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| Kinase | 8696.AA | AGC | 18-275 | 23 | 5.3e-80 | 205.72 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 18-275 Range on HMM: 1-395/395 Sequence Identity: 23% (93 aa) VVVNNVLGKGAFGKVYRGFCVE-----DENKLVAAKAIPIKS-ISDSGK-MLELIKRE------------IAILQKVS----------SPFIVS-LYDVA . |.|||.||||| .. | .|. | | . | | . | |.| ...| ||.|.. .||||. |. FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF RTSNN--LYMFLEYCH----------DGDLKEYLKKK-EGKRLSEPEALIFFR-------HIVEGFKELQK-HKIIHRD-IKPANIMLSN-GIAKISDFG . .. ||. .||. ...| .|... .|..|..| ... .|| .. | . ..||||| .|| ||.| . | |..||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG FSRVVEKDD--------------------------------------------------PALLSRLG--SPLYMTPQILDGVPFNFKCDVWS--VGVVFF .. .. .|. . | .| || | || .. || || .|.... LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY EMLYGTTPWIGDSQV----------KLLQNIK------SIPLKFPEN--------PIRSKEVKDLLRGMLKVKEEERMS----------WEEIFNHPLI |||.| .| ||. . .. |.|. . ..||| . . |.| |||....|.. |.| ||| ||| EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | 8696.AA | Ciliate-E2 | 18-275 | 22 | 2.5e-77 | 263.24 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 18-275
Range on HMM: 1-365/365
Sequence Identity: 22% (87 aa)
VVVNNVLGKGAFGKVYRGFCVEDENKL-----------------VAAKAIPIKSISDSG-KMLELIKREI-------------AILQKVSSPFIVSLYDV
.....|.|.||.||.. .. .. |..| . .|... .. .... ..... ||.....|.|. .|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
AR--TSNNLYMFLEYCHDGDLKEYLKKK----------EGKRLSEPEALIFFRHIVE---------------GFKELQKHK-IIHRDIKPANIMLSNGIA
. ||.|. .||| |||..|.|.. . |...| |.. ....|.. ....| . . |||||||| ||..
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I
KISDFGFSRVVEKD----------DPALLSR----------------------LGSPLYMTPQILDGVP---------FNFKCDVWSVGVVFFEMLYGTT
||.|||.|. . .| . . .|.| || |.|| | . ..|||.||.||...|||.| .
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP
PWIGDSQVKLLQNIKSIPLKFP----------------ENPIRSKEVKDLLRG----MLKVKEEERMS-WEEIFNHPLI
|. .|.|| ...|| .. |.|.|||.. ||....|.|.. ||.|.||| .
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 8696.AA | CAMKL | 17-275 | 32 | 8.7e-74 | 234.81 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 17-275 Range on HMM: 1-297/297 Sequence Identity: 32% (97 aa) FVVVNNVLGKGAFGKVYRGFCVEDENKLVAAKAIPIKSISDSGKMLEL-----------IKREIAILQKVS---SPFIVSLYDVARTSNN------LYMF . .. .||||.|||| . . .. || | | .| |.. .|. |.|||.|..... | |..||.| |... .|.. YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV LEYCHDGD--LKEYLKKKEGKR--LSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLS-NG--IAKISDFGFSRVVEK----DDPALLSRLGSPLY .||| |. | .|..|....| ..|.|| .|| ||.. . . .|.|.|||||| ||.|. || .||.||||| .. .. | . ||| | MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY MTPQILDG--VPFN-FKCDVWSVGVVFFEMLYGTTPWIGDS-------QVKLLQNIKSIPLKFPENP-IRSKEVKDLLRGMLKVKEEERMSWEEIFNHPL | | |. | |.. .| |.|| ||. . |..|. |. .|. . .| ... . ..| . | ...||.|.||.|. |.|.. ..| ||| MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW I M |
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| Kinase | 8696.AA | Pkinase | 18-275 | 27 | 2e-73 | 255.05 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 18-275 Range on HMM: 1-293/293 Sequence Identity: 27% (81 aa) VVVNNVLGKGAFGKVYRGFCVEDENKLVAAKAIPIKSISDSGKMLEL-IKREIAILQKVSSPFIVSLYDVARTSNNLYMFLEYCHDG----DLKEYLKKK .. ..|.|.||.||.. . .. .|| | |. ...... .. . . .||.|......|.|| |||. ......|| .||| | ||..|.. . YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW EGKRL--SEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLS-NGIA----KISDFGFSRVV-EKDDPALLSRLGSPLYMTPQILD-GVPFNFKCDVW ..... || |. ... |..| . . ...|||||.||.||... || ||.|||..... . .. . .. |.| || | .. | . |.|.| RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW SVGVVFFEMLYGTTPWIGD------SQVKLLQNIKSIPLKFPENPIRS-------------------KEVKDLLRGMLKVKEEERMSWEEIFNHPLI |.|....||| | .|. |. .| .....|.. ||.|.. .| .| ||.....|... ..| ..|.|..|| . SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 8696.AA | Ciliate-E2-Unclassified | 19-275 | 26 | 4.4e-70 | 239.14 | In-house | 2-352 (352) | Show / Hide |
Range on Protein: 19-275 Range on HMM: 2-352/352 Sequence Identity: 26% (93 aa) VVNNVLGKGAFGKVYRGFCVEDENKLVAAKAIPIKSISDSGKML----ELIKREIAILQK------------------VSSPFIVSLYDVARTSNNLYMF .. ..|.|.|||||. |.....|...|. . .|..... | |.. .... .| .|||| .... .. .|.|. KIIKQIGQGGFGKVYK--CQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LEYCHDGDLKEYLKKKEG---------------KRLSEPEAL-----IFFRHIVEGF-KELQKHKIIHRDIKPANIMLSNG----IAKISDFGFSRVVEK .||| .|||..|.||... |...| .|. .|..|..|. . .|..|||||||| ||...|. ||.|||.|. .. MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ D---------------DPALLSRLGSPLYM----TPQILDGVPFN----FKCDVWSVGVVFFEMLYGTTPWIGDSQVK----------------LLQNIK . . . .. |.| || | .|.| . .|||.||.||...|||.|. | . .. . |.|||| NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK SIPLKFPENP------IRSKEVKDLLR----GMLKVKEEERMSWEEIFNHPLI ...||. | . |.|.||... |||.. ..|...|.|.|||.. QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 8696.AA | MARK | 19-275 | 33 | 2.6e-56 | 182.63 | In-house | 2-262 (262) | Show / Hide |
Range on Protein: 19-275 Range on HMM: 2-262/262 Sequence Identity: 33% (90 aa) VVNNVLGKGAFGKVYRGFCVEDENKLVAAKAIPIKSISDSGKMLELIKREIAILQKVSSPFIVSLYDVAR--TSNN-LYMFLEYCHDGDLKEYLKKKEGK . ..|.|...||. . . . . || | .. ....| .| . ..|||.|..|.. | |..|..| |... .|. .||. |.| .|.|.... KMLKTIGHGSYAKVKLACHKHTG-RKVAIKIYEKFKLNDPQWM-KNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNG RLSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIML-SNG--IAKISDFGFSRVVEKDDPALLSRL-GSPLYMTPQILDGVPFN-FKCDVWSVGVVFF ||.|.|| .|| ||.. . . .. |.|||||| ||.. .|| .||.|||||. .. . .|.. |.| || |.|. . | . .| |.|| ||| . RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPG--QKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLY EMLYGTTPWIGDS--QVKLLQNIKSIPLKFPENPIRSKEVKDLLRGMLKVKEEERMSWEEIFNHPLI |. |. |. ||. ...| ..| . ..| . ||| ..|.. .|.| |||.. ||| .|| . FMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | 8696.AA | RSK | 21-275 | 30 | 8.8e-53 | 181.67 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 21-275 Range on HMM: 1-278/278 Sequence Identity: 30% (86 aa) NNVLGKGAFGKVY--RGFCVEDENKLVAAKAIPIKSISDSGKMLELIKREIAILQKVS-SPFIVSLYDVARTSNNLYMFLEYCHDGDLKEYLKKKEGK-R |||.|..|||. | .| ... | | . . | . | .. ..|. ||. . .||||.|... .| ||. .|||. |.| . |.|.. . LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC LSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLSN----GIAKISDFGFSRV-VEKDDPALLSRLGSPLYMTPQILD----GVPFNFKCDVWSVGV .|| || . .. || . | ...|||||.|| ||.. . | |..||||.. . .. . . .. || | .| .. . ||.|| || FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV VFFEMLYGTTPWIG---DSQVKLLQNIKSIP--LKFPENPIRSKEVKDLLRGMLKVKEEERMS-----WEEIFNHPLI . .||| | .| | ... .....|.. |..|... |.| |||.|.||.. .. | . ||| .|| . LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | 8696.AA | Pkinase_Tyr | 18-173 | 29 | 1.7e-29 | 100.48 | Pfam | 1-165 (270) | Show / Hide |
Range on Protein: 18-173 Range on HMM: 1-165/270 Sequence Identity: 29% (49 aa) VVVNNVLGKGAFGKVYRGFCV---EDENKLVAAKAIPIKSISDSGK--MLELIKREIAILQKV-SSPFIVSLYDVAR-TSNN--LYMFLEYCHDGDLKEY .. . .||.||||.||.| . .... || | . | ... . .... |..|. . . | ||.|| | . .|. .||. |||..| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY LKKK--EGKRLSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLS-NGIAKISDFGFSRVVEKDD |.|. ....|. .. | . . | .| | ...||||. |.... |...||.||| .| ...|| LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDD |
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| Kinase | 8696.AA | TyrKc | 18-275 | 27 | 1.7e-21 | 78.63 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 18-275
Range on HMM: 1-280/280
Sequence Identity: 27% (81 aa)
VVVNNVLGKGAFGKVYRGFCVEDENKLVAAKAIPIKSISDSGKMLELIKREIAILQKV--SSPFIVSLYDVARTS-------NNLYMFLEYCHDGDLKEY
.. . .|| ||||.||.| || | . . .| . ||. |. |. . | || || |.... |.. .||. ||||.|
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY
LKKKEGKRLSEPEALIFFRHIVEGFKELQKHKIIHRDIKPANIMLSNG-IAKISDFGFSRVVEKDDPALLSRLGSPLYMTPQ---ILDG-VP--------
|.|...| |. .. | | | .| | ....||||. |...... ..|||||| || .. || . | | ... .. .|
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMAPEC
-----FNFKCDVWSVGVVFFEML-YGTTPWIG-----DSQVKLLQNIKSI-PLKFPEN------PIRSKEVKDLLRGMLKVKEEERMSWEEIFNHPLI
|..| |||| ||. .|.. || .|. | | .....|. .. |.| .. ..|. .. . . . |.| . .|| | ..
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | 8696.AA | Pkinase_Tyr | 190-221 | 41 | 1.398901 | 2.59 | Pfam | 186-218 (270) | Show / Hide |
Range on Protein: 190-221 Range on HMM: 186-218/270 Sequence Identity: 41% (14 aa) ILDGVPFNFKCDVWSVGVVFFEMLY-GTTP-WIG | .|. |. | |||| ||. .|.. | .| . | INYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPG |
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