Gene 18758 (Tetrahymena)

18758

Species: Tetrahymena
Alias: 18758, PreTt18758, TTHERM_01502010, 427.m00006, 65
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: STE11-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
18758.AA Protein None 645 None Fasta, JSON
18758.kin_dom Protein Kinase Domain None 264 None Fasta, JSON
18758.NA RNA None 1938 None Fasta, JSON

Protein domain

Protein domains of 18758.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18758.AA STE11-Unclassified 379-642 43 6.5e-176 590.71 In-house 1-308 (308) Show / Hide 
Range on Protein: 379-642
Range on HMM: 1-308/308
Sequence Identity: 43% (135 aa)

WKSGDFIGAGSFGQVFTAMNCNTGEIFVVKKIMVHGQSKLDKEFLDE----QEKELRIMQTLSHKHIIQYKGHE--RQQDCLCIFLEYMSEGNIDQMLKK
|..|.|||.||||||...|||||||...||.|..|...........|    ..||......|.||.|.||.|.|  ...||..||.|||..|.|..||.|
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

FGPLEEQTIKVYARQILSGIQYLHSQKVIHKDIKGANILVGSDGIVKLSDFGCAK---------------------QLELTLNSNKEMNKTLKGSVP---
.|...|..||.|..|||.|..||||...||.||||||||...|||.||.||||||                     ......||.....|...|...   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

WMSPEIVT---QTKYDTKADIWSFGCTILEMAQAEAPWSNYQFDNPIAAIMKIGLSDEIPQIPETIS-----------PDLNQFIRKCLQRDPSKRPTAT
||.||...   ||....|.||||.|||..|||....||||.|.||...|||||..|..||||||. |           .....|.|||.|.||.|||||.
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTAN

ELLNDSFL
.||...|.
QLLQHPFI
Kinase 18758.AA STE11 379-642 39 9.1e-157 527.1 In-house 1-303 (303) Show / Hide 
Range on Protein: 379-642
Range on HMM: 1-303/303
Sequence Identity: 39% (119 aa)

WKSGDFIGAGSFGQVFTAMNCNTGEIFVVKKIMVHGQSK---LDKEFLDE------QEKELRIMQTLSHKHIIQYKGHER---QQDCLCIFLEYMSEGNI
|..|..|| |.||.|...||..|||...||.|.......    .......      ...|...|..|.||.|..| |...   |.|...||.||...| .
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

DQMLK-KFGP--LEEQTIKVYARQILSGIQYLHSQKVIHKDIKGANILVGSDGI-VKLSDFGCAKQLELTLNSNKEMNK------TLKGSVP--------
 .||. |.||  ..|..|..| .|||.|.|||||...||.||||||||. |||. .||.||||||.|.  ......||.      ...|..         
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMSPEIVTQTK---YDTKADIWSFGCTILEMAQAEAPWSNYQFDNPIAAIMKIGLS-DEIPQIPETIS------PDLNQFIRKCLQRDPSKRPTATELLN
||.||...|..   |..||||||.|||..|||..  ||.||.. |..||..||| . . .|.||| .|      .....|.|.|...||.||||| .||.
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDH-NHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQ

DSFL
..|.
HPFI
Kinase 18758.AA STE 379-642 29 8.3e-110 371.11 In-house 1-359 (359) Show / Hide 
Range on Protein: 379-642
Range on HMM: 1-359/359
Sequence Identity: 29% (108 aa)

WKSGDFIGAGSFGQVFTAMNCN---------------TGEIFVVKKIMVHGQSKLDKE-------------FLDEQEKELRIMQTLS--HKHIIQYKGHE
|.  ..|| |.||.|..||| .               ||||. .|.. .  ... | |              ... .||..||. ..  |..|..| |..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

RQQ-------DCLCIFLEYMSEGNIDQMLK-KFGPLE-------------EQTIKVYARQILSG-IQYLHSQKVIHKDIKGANILVGSDGIVKLSDFGCA
 .        | |.|..|||. | .|...| |.|...             |. |....|||| |  .||||...|| |||.||||.     |||.|||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KQLELTLN------------SNKEMNKTLKGSVPWMSPEIVTQ------TKYDTKADIWSFGCTILEMAQAEAPWSN-YQFDNPIAAIMKIGLSD-----
.||. ..             .......|. |.  ||.||...|       .||||.||||.||||.|||  . ||.. . . .  ....... ..     
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

-----EIPQIPETIS-------------------PDLNQFIRKCLQRDPSKRPTATELLN--DSFL
     ..|..|...|                   |....||.||||.||.|||||..||.   .|.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 18758.AA S_TKc 379-642 27 3.7e-91 310.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 379-642
Range on HMM: 1-231/231
Sequence Identity: 27% (78 aa)

WKSGDFIGAGSFGQVFTAMNCNTGEIFVVKKIMVHGQSKLDKEFLDEQEKELRIMQTLSHKHIIQYKGHERQQDCLCIFLEYMSE--GNIDQMLKKFGP-
.. .. || |.||.|. . . .||.|. .|.|             .  ..|..|..   |..|...... .  |.|....||..   |.  ...|| |. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LEEQTIKVYARQILSGIQYLHSQKVIHKDIKGANILVGSDGIVKLSDFGCAKQLELTLNSNKEMNKTLKGSVPWMSPEIVTQTKYDT-KADIWSF
     . | ... |..||.....|.||...|| |.| .|||. .   .|..||| |.||           .|. |.  .|.||..   .|.. |.|.||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GCTILEMAQAEAPWSNYQFDNPIAAIMKIGLSDEIPQIPETISPDLNQFIRKCLQRDPSKRPTATELLN-------DSFL
||.. ||.  . |..       .....|. .           ||.. .|||||||.||.||||| |.|.       . ..
GCILYEMLCGYPPFP------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18758.AA Pkinase 379-642 27 2.2e-83 288.1 Pfam 1-293 (293) Show / Hide 
Range on Protein: 379-642
Range on HMM: 1-293/293
Sequence Identity: 27% (82 aa)

WKSGDFIGAGSFGQVFTAMNCNTGEIFVVKKIMVHGQSKLDKEFLDEQEK--ELRIMQTLSHKHIIQYKGHERQQDCLCIFLEYMSEG----NIDQMLK-
.. |  ||.||||.|. ... .||.|..||.| ..   . ..... .  .  |..||. |.|..|.....  .  | ... .||.  |        ... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR---HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KFGPL--EEQTIKVYARQILSGIQYLHSQKVIHKDIKGANILVGSDGIV----KLSDFGCAKQLELTLNSNKEMNKTLKGSVPWMSPEIVT-QTKYDTK
 . |..  .|...| |..|||.|..|.||...|| |.| .|||. ..| .    |..|||.|||..   . |.. ..|. |. ..|.||..  ...|..|
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

ADIWSFGCTILEMAQAEAPWSNY----QFDNPIAAIMKIGLSDEIPQIPETIS-------------------PDLNQFIRKCLQRDPSKRPTATELLNDS
.|.||.||.. ||.  . |...       ..... | .|.  .   ..|...|                   ... .||..||..||.|||||...|.. 
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

FL
..
WF
Kinase 18758.AA MEKK15 379-642 39 4.4e-79 269.04 In-house 1-264 (264) Show / Hide 
Range on Protein: 379-642
Range on HMM: 1-264/264
Sequence Identity: 39% (105 aa)

WKSGDFIGAGSFGQVFTAMNCNTGEIFVVKKIMVHGQSKL--DKEFLDEQEKELRIMQTLSHKHIIQYKGHERQQDCLCIFLEYMSEGNIDQMLKKFGPL
|| |. .| | .| |.  .  ||| .  ||.. .    |.  .....  || |  ...|| || |. | |   ..  . ||....  | |  .. .||||
WKKGNILGKGAYGTVYCGL-TNTGQLIAVKQVELDEIDKEKAKQQYRKLQE-EVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPL

EEQTIKVYARQILSGIQYLHSQKVIHKDIKGANILVGSDGIVKLSDFGCAKQLELT-LNSNK-EMNKTLKGSVPWMSPEIVTQTKYDTKADIWSFGCTIL
.|     | .||| |.||||   |.|.||||.|... . ||.|| |||||| | .  .|  . .| | ..|   || ||..  | |  |.|||| |||. 
DEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVF

EMAQAEAPWSNYQFDNPIAAIMKIGLS-DEIPQIPETISPDLNQFIRKCLQRDPSKRPTATELLNDSFL
|||    || . .   ..||.  ||   | .||.|.  | |  .|.| || ||   |||| .||  .|.
EMATRKPPWADMD---RMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase 18758.AA STE20 379-642 33 3e-73 249.66 In-house 1-288 (288) Show / Hide 
Range on Protein: 379-642
Range on HMM: 1-288/288
Sequence Identity: 33% (100 aa)

WKSGDFIGAGSFGQVFTAMNC-NTGEI----FVVKKIMVHGQ---SKLDKEFLDEQEKELRIMQTLSHKHIIQYKGHERQQ----DCLCIFLEYMSEGNI
..  . || ||.|.|..| ..  |||.      .||. .  .   .    . ... .|| .||. . |..|..| |         |.| |  ||.. | .
YELLEKIGQGSYGKVYKA-YHKPTGEYCNQRVAIKKMNLEKCDNEQ----DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSL

DQMLK---KFG------PLEEQTIKVYARQILSGIQYLHSQKVIHKDIKGANILVGSDGIVKLSDFG-CAKQLELTLNSNKEMN---KTLKGSVPWMSPE
 ...|   | |      |..|. | .  |..| | .||||...|| |||..|||...|| |||.||| ||.  ..       |.   .|. |.  ||.||
TDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHG-R-D-TMQFKRNTFVGTPYWMAPE

IVTQ-----TKYDTKADIWSFGCTILEMAQAEAPWSNYQFDNPIAAIMKIGLSDE-IP--QI--PETISPDLNQFIRKCLQRDPSKRPTATELLNDSFL
.. .      .||.|.||||.| |..|||  | | ...   .|  |...|  ...  |  .   |.. ||....|. ||||.||.|||||..||. .|.
VIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDM---HPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 18758.AA MEKK2 379-642 37 4.6e-72 245.71 In-house 1-262 (262) Show / Hide 
Range on Protein: 379-642
Range on HMM: 1-262/262
Sequence Identity: 37% (100 aa)

WKSGDFIGAGSFGQVFTAMNCNTGEIFVVKKIMVHGQSKLDKEFLDEQEKELRIMQTLSHKHIIQYKGHERQQD--CLCIFLEYMSEGNIDQMLKKFGPL
|. |  .| | ||.|.      ||    ||.. .  ..   .   .  | |..... | |. |.|| |  |..    | ||.|||. | .   || .|.|
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

EEQTIKVYARQILSGIQYLHSQKVIHKDIKGANILVGSDGIVKLSDFGCAKQLELTLNSNKEMNKTLKGSVPWMSPEIVTQTKYDTKADIWSFGCTILEM
 |.  . | |||| |..|||.. ..|.||||||||  | | |||.||| .| |     .   | |.  |   |||||..    |  |||.|| |||. ||
TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITGM-KSVTGTPYWMSPEVINGEGYGRKADVWSIGCTVVEM

AQAEAPWSNYQFDNPIAAIMKIGLSDEIPQIPETISPDLNQFIRKCLQRDPSKRPTATELLNDSFL
     || .|     .||| ||   .  ||.|. .| .  .|...| ..    || | |||   | 
LTEKPPWAEYEA---MAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase 18758.AA ASK 385-642 35 7.4e-67 221.35 In-house 2-254 (254) Show / Hide 
Range on Protein: 385-642
Range on HMM: 2-254/254
Sequence Identity: 35% (94 aa)

IGAGSFGQVFTAMNCNTGEIFVVKKIMVHGQSKLDKEFLDEQEKELRIMQTLSHKHIIQYKGHERQQDCLCIFLEYMSEGNIDQMLK-KFGPLE--EQTI
.| |..| |. . . .|    ..| | ..     |...      |. . ..| |. |.|| |   ... . ||.| .  | . ..|. |.||..  |.|.
LGKGTYGIVYAGRDMHTQVRIAIKEIPER-----DSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTM

KVYARQILSGIQYLHSQKVIHKDIKGANILVGS-DGIVKLSDFGCAKQLELTLNSNKEMNKTLKGSVPWMSPEIVTQTK--YDTKADIWSFGCTILEMAQ
. |..||| |..||| ....|.|||| |.||    |.||.|||| .| |   .|    . .| .| . .| ||.. | .  |   |||||||||..||| 
NFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRL-AGINP---CTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMAT

AEAPWSNYQFDNPIAAIMKIGLSDEIPQIPETISPDLNQFIRKCLQRDPSKRPTATELLNDSFL
.  |.  . ...| ||. |.|.  . |.||| .| .  .||..| . || ||..| .||.| ||
GKPPF--HELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase 18758.AA ULK 379-642 25 1.6e-61 210.72 In-house 1-329 (329) Show / Hide 
Range on Protein: 379-642
Range on HMM: 1-329/329
Sequence Identity: 25% (86 aa)

WKSGDFIGAGSFGQVFTAMNCNT----GEIFVVKKIMVHGQSKLDKEFLDE---------QEKELRIMQTLS--------HKHIIQYKGHERQQ--DCLC
.   . .| ||||.|. . | .|    .|....|.|    ...  .....|          ..| .||..|         |..|....   . .  ... 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMI----DKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIY

IFLEYMSEGNIDQMLKKFGP----------LEEQTIKVYARQILSGIQYLHSQKVIHKDIKGANILVGSD------------GIVKLSDFGCAKQLELT-
|..||   |. .| .|| ..          |.|| .. . .|||.| ..||....|| ||| .|||.  .            |..|..||| ||...   
IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN

LNSNKEMNKT----LKGSVPWMSPEIVT----QTKYD-TKADIWSFGCTILEMAQAEAPWSNYQFDNPI-AAIMK-IGLSDEIP--------QIP-----
.. . .|  .    |.|.   |.|.|.     | .|.  |.||||.|| . ||   . |.... |   .   |.| | . ...|        |.|     
MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

ETISPDLNQFIRKCLQRDPSKRPTATELLNDSFL
 .|||.. ..||..||.|...| . .||.|  ..
PQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 18758.AA ULK 379-642 25 1.8e-59 203.9 In-house 1-324 (324) Show / Hide 
Range on Protein: 379-642
Range on HMM: 1-324/324
Sequence Identity: 25% (84 aa)

WKSGDFIGAGSFG-QVFTAMNCNT---GEIFVVKKIMVHGQSKLDKE-----FLDEQEKELRIMQTLS---HKH--IIQYKGHERQQDC--LCIFLEYMS
.   . .| |||| .|. . | .|   .... .|.|   ...|  .|     ... ...| .||..|    |..  |....   . ...  ..|..||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

EGNIDQMLKKFGP---------LEEQTIKVYARQILSGIQYLHSQKVIHKDIKGANILVGSD------------GIVKLSDFGCAKQLELTLNSNKEMNK
 |. .| .|| ..         |.|| .. . .||..| ..||....|| ||| .|||.  .            |..|..||| ||...   | .. |..
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN-NMEQQMCQ

TLK------GSVPWMSPEIVT----QTKYD-TKADIWSFGCTILEMAQAEAPWSNYQFDNPI-AAIMKI---G------LSDEIPQIP-----ETISPDL
|..      |.   |.|.|.     | .|.  |.||||.|| . ||   . |.... | . .   |.|    |        ..  |.|       |||..
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

NQFIRKCLQRDPSKRPTATELLNDSFL
 ..||..||.|...| . .|..|  ..
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 18758.AA STE-Unique 456-642 29 2.6e-55 190.07 In-house 371-616 (616) Show / Hide 
Range on Protein: 456-642
Range on HMM: 371-616/616
Sequence Identity: 29% (74 aa)

IFLEYMSEGNIDQMLKKFGP---------LEEQTIKVYARQILSGIQYLHSQK--VIHKDIKGANILVGSDG-----IVKLSDFGCAKQLELT-------
||.|| . |  .| .|  |.         ..|  .. |..||| |  |||||.  .|| |.| .||.  .||      ||..||| |... .        
IFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNN

---------------------------LNSNKEMNKTLKGSVPWMSPEIVTQT-----KYDTKADIWSFGCTILEMAQAEAPWSNYQFDNPIAA-IMKIG
                           || |   .|.. |   .|.||...        ||||.||||.||....|.    ||....   .. | |  . 
SKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRY---HMQAYIEMCI

LSDEIPQ------IPETISPDLNQFIRKCLQRDPSKRPTATELLNDSFL
..  .|       ||.  .|...|||.||| |.|..||.| .|| . .|
HIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase 18758.AA Pkinase_Tyr 428-639 27 7.7e-36 122.0 Pfam 52-269 (270) Show / Hide 
Range on Protein: 428-639
Range on HMM: 52-269/270
Sequence Identity: 27% (63 aa)

KELRIMQTL-SHKHIIQYKGHER-QQDC--LCIFLEYMSEGNIDQMLKK----FGPLEEQTIKVYARQILSGIQYLHSQKVIHKDIKGANILVGSDGIVK
.|..|| .| .|..|... |    |..   ..| .|||  |. .  |.|     .||  ...  ...|| .| .||.|.. || |.   |.||.....||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

LSDFGCAKQLELTLNSNK-EMNKTLKGSVPWMSPEIVTQTKYDTKADIWSFGCTILEMAQ-AEAP----WSNYQFDNPIAAIMKIGLSDEIPQIPETISP
 .||| |. .  .  ..   . .  |  ..||.||     |. || |.|||| .. |.    | |    .||..       . .|. . .   .||  ..
ICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE------VYEYIYEDGYRMPCPENCPD

DLNQFIRKCLQRDPSKRPTATELLND
.. . ...| . ||..||| .|....
EIYDLMKQCWHYDPEDRPTFSEIHEQ
Kinase 18758.AA TyrKc 379-641 25 1.2e-31 112.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 379-641
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

WKSGDFIGAGSFGQVFTAMNCNTGEIFVVKKIMVHGQSKLDKEFLDEQEKELRIMQTL--SHKHIIQYKGHERQQ-------DCLCIFLEYMSEGNIDQM
 . |. .| | ||.|. ..      | |  | . ..        . .  .|.|||  |  .|..|..  |  .||       . |.| .|||. |. .. 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKKFGP-LEEQTIKVYARQILSGIQYLHSQKVIHKDIKGANILVGSDGIVKLSDFGCAKQLELT---LNSNKEMNKT-----LK--GSVPWMSPEIVTQT
|.| .| |  ..   .. || .| .||||...|| |.   |.|||....|| |||| .. ..        .|.. ..      |    . ||.||     
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYG

KYDTKADIWSFGCTILEMA-QAEAPWSN---YQFDNPIAAIMKIGLSDEIPQIPET--------ISPDLNQFIRKCLQRDPSKRPTATELLNDSF
|. || |.|||| .. |.    . |...      . . . ...   . . . .|.          .... | ...| ..||..||| .|.  . |
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase 18758.AA STE-Unique 380-453 29 5e-07 20.38 In-house 1-75 (616) Show / Hide 
Range on Protein: 380-453
Range on HMM: 1-75/616
Sequence Identity: 29% (22 aa)

KSGDFIGAGSFGQVFTAMNCNTGEIFVVKKIMVHGQSKLDKEFLDEQ-EKELRIMQTLSHKHIIQYKGHERQQDC
   ..|| |||| |. . | ...    .|.|.. . .   .| | ..  .|. ||  |.|  |. | || ..  |
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWGGC