Gene 19075 (Tetrahymena)

19075

Species: Tetrahymena
Alias: PreTt19075, 19075, TTHERM_00716030, 700, 3673.m00038, 113.m00114
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
19075.AA Protein None 425 None Fasta, JSON
19075.kin_dom Protein Kinase Domain None 253 None Fasta, JSON
19075.NA RNA None 1278 None Fasta, JSON

Protein domain

Protein domains of 19075.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19075.AA PAKA 132-384 46 1.1e-167 563.32 In-house 1-260 (260) Show / Hide 
Range on Protein: 132-384
Range on HMM: 1-260/260
Sequence Identity: 46% (122 aa)

YDFLSQIGKGATCKVYRCKNKQTGQE--CAMRVIRMLNPDQIEKTKMEILLMNESKNNNIVQYYKSYIYMDVIFMAIEYMNAGSLTELIYGNFS----FL
|.|...||.||...||...|..|.||  .|.....| |....|....|||.|.|.|..|||.|..||...|......|||..|.||..|. ...    ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

SEQMASYICEQILFGLFFIHRTNQIHRDLKSDNILLNQNGDVKIADFGFATQLTREHFSKKSQVGTPAWMAPELILRKDYSQKVDIWSLGVICIEILEGE
.|....|.|...|.||.|||....||||.|||||||...|.|||.||||..|||.|.......||||.|||||.|.||.|..||||||||...||..|||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYIRDKPAKAMYYITKK-KPHKLDATKFSQEACDFVSTCLNIDPQERPTAQQLISHPFI
|||....|..|||.|... ||...|..|.|||.|||...||..|...|..||.|..|||.
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase 19075.AA STE20 132-384 39 4.90000000001e-130 438.3 In-house 1-288 (288) Show / Hide 
Range on Protein: 132-384
Range on HMM: 1-288/288
Sequence Identity: 39% (114 aa)

YDFLSQIGKGATCKVYRCKNKQTGQE----CAMRVIRMLNP----DQIEKTKMEILLMNESKNNNIVQYYKSYIYM----DVIFMAIEYMNAGSLTELIY
|..| .||.|...|||.. .|.||..    .| ... . ..    |..|  . ||. |...|. |||.|| ||...    | .....||...||||... 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

GNFS--------FLSEQMASYICEQILFGLFFIHRTNQIHRDLKSDNILLNQNGDVKIADFGFATQLTR-----EHFSKKSQVGTPAWMAPELILR----
....         ..|.  .||| ..| || ..|. ..||||.|.|||||...|.||.||||.. |||.     ..| ... |||| |||||.|..    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-KDYSQKVDIWSLGVICIEILEGEPPYIRDKPAKAMYYIT--KKKPHKLD---ATKFSQEACDFVSTCLNIDPQERPTAQQLISHPFI
 |.| .|.||||||  .|| .||||||    | .||..|.  ...| .|     .|.|.| .|||..||..||..||||.|| .||||
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 19075.AA STE 132-384 28 6.5e-110 371.45 In-house 1-359 (359) Show / Hide 
Range on Protein: 132-384
Range on HMM: 1-359/359
Sequence Identity: 28% (105 aa)

YDFLSQIGKGATCKVYRCKNK------QTGQE---------CAMRVIRMLNP-----------------DQIEKTKMEILLMNESK--NNNIVQYYKSYI
......|||||. .||...|.      .||..         .|. .... |                  ..... ..|| .|....    |||.|| .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YM-------DVIFMAIEYMNAGSLTELIYGNFSFLS-------------EQMASYICEQILFG-LFFIHRTNQIHRDLKSDNILLNQNGDVKIADFGFAT
.        | .... |||..|||...|  ... .              |.  .||| ||| | | ..|. . ||||.|..||||     ||..|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLTREHF----------------SKKSQVGTPAWMAPELILR------KDYSQKVDIWSLGVICIEILEGEPPYIRDKPAKAMYYITKK-----------
||| ..                   .. |||| ||||| |..      |.|. |.||||||  .|| ..|.||.   .| .||..|...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----KPHKLDA------------------TKFSQEACDFVSTCLNIDPQERPTAQQLIS--HPFI
    .| .|                    .|.|.| .||.. ||..||..||||.||..  ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 19075.AA S_TKc 132-384 33 8.4e-88 298.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 132-384
Range on HMM: 1-231/231
Sequence Identity: 33% (89 aa)

YDFLSQIGKGATCKVYRCKNKQTGQECAMRVIRMLNPDQIEKTKMEILLMNESKNNNIVQYYKSYIYMDVIFMAIEYMNA--GSLTELIYGNFSF-----
|..| .|||||  |||.|..| ||...|. .|.       |... || .. . .  |||..| ..   | ..|  ||..   |.| ..|  . .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSEQMASYICEQILFGLFFIHRTNQIHRDLKSDNILLNQNGDVKIADFGFATQLTREHFSKKSQVGTPAWMAPELILRKDYSQ-KVDIWSLGVICIEILE
..| .| ... ||. .| ..|. . |||||| .||||..   .||.|||.|.||       ....||| .||||..    |.  |.|.||.|.| .| | 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYIRDKPAKAMYYITKKKPHKLDATKFSQEACDFVSTCLNIDPQERPTAQQLIS-------HPFI
|.||.      ..|. . .           |.||.||.. ||. ||..|||| ..         ||..
GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19075.AA YSK 132-384 36 1.3e-76 230.09 In-house 1-257 (257) Show / Hide 
Range on Protein: 132-384
Range on HMM: 1-257/257
Sequence Identity: 36% (94 aa)

YDFLSQIGKGATCKVYRCKNKQTGQECAMRVIRM-LNPDQIEKTKMEILLMNESKNNNIVQYYKSYIYMDVIFMAIEYMNAGSLTELIYG-NFSFLSEQM
.  .. ||.|    ||   ...|..  |  .|      | ||    ||    . .  .| .|| ||     .    ||   ||.  |.       . |. 
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

ASYICEQILFGLFFIHRTNQIHRDLKSDNILLNQNGDVKIADFGFATQLTREHFSKKSQVGTPAWMAPELILR--KDYSQKVDIWSLGVICIEILEGEPP
 . |   || || ..|  . |||| |. |.||. .||||..||| | |.|         |||| |||||.|      |  |.||||||.  .|.. ||||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YIRDKPAKAMYYITKKKPHKLDATKFSQEACDFVSTCLNIDPQERPTAQQLISHPFI
|   .| ..|  | |..| ||   ..|  . .||  ||| ||..||.|..| .| ||
YCDYHPMRVMFLIPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase 19075.AA MST 132-384 40 7.8e-76 240.5 In-house 1-254 (254) Show / Hide 
Range on Protein: 132-384
Range on HMM: 1-254/254
Sequence Identity: 40% (104 aa)

YDFLSQIGKGATCKVYRCKNKQTGQECAMRVIRMLNPD--QIEKTKMEILLMNESKNNNIVQYYKSYI--YMDVIFMAIEYMNAGSLTELIYGNFSFLSE
.| .  .| |.  .||.  .||||.. |  ..   | |  .|.|   ||  | . |. .||.|| ||.  .   .   .|| ..||.  ..      |.|
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV-NEDLQEIIK---EISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNE

QMASYICEQILFGLFFIHRTNQIHRDLKSDNILLNQNGDVKIADFGFATQLTREHFSKKSQVGTPAWMAPELILRKDYSQKVDIWSLGVICIEILEGEPP
|  . |. . | ||   |.   ||||.|. |||||. |  | |||| . |||     . . .||| ||||| |    |  |.||||||  .||  ||.||
QQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPP

YIRDKPAKAMYYITKKKPHKL-DATKFSQEACDFVSTCLNIDPQERPTAQQLISHPFI
|   .|  ||  | .| | .. | ...|||  |||. || ..|..|.|| || .||||
YSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase 19075.AA Pkinase 132-384 31 1.4e-72 252.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 132-384
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

YDFLSQIGKGATCKVYRCKNKQTGQECAMRVIRMLNPDQIEKTK----MEILLMNESKNNNIVQYYKSYIYMDVIFMAIEYMNAG----SLTELIY----
| ....||.|.  .||.|..| ||.. |. .|.  . .  ..      .|| .|.. .  |||..| .. . | | |  ||.. |    .| ..|     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GNFSFLSEQMASYICEQILFGLFFIHRTNQIHRDLKSDNILLNQNGDV----KIADFGFATQL-TREHFSKKSQVGTPAWMAPELIL-RKDYSQKVDIWS
|.|. .||. .  .. ||| || ..|. . ||||||..|||...||..    ||.|||.| |. .      .. .||| .||||.|. ...|..|||.||
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVICIEILEGEPPYIRD----KPAKAMYYITKKKPHKLDATKF----------------------SQEACDFVSTCLNIDPQERPTAQQLISHPFI
.|.|..| | |.||.  .    . .  |. | .... .|.   .                      |.|..||.. ||. ||..||||.|.  ||..
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 19075.AA KHS 132-384 37 2.6e-69 232.24 In-house 1-258 (258) Show / Hide 
Range on Protein: 132-384
Range on HMM: 1-258/258
Sequence Identity: 37% (98 aa)

YDFLSQIGKGATCKVYRCKNKQTGQECAMRVIRMLNPDQIEKTKMEILLMNESKNNNIVQYYKSYIYMDVIFMAIEYMNAGSLTELIYGNFSFLSEQMAS
|. | ..| |    ||. ...|...  |..||.|   |...  . ||..| . .  ||| |. ||.  | .....||  .||| . ||     |||   .
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQD-IYHVTGPLSELQIA

YICEQILFGLFFIHRTNQIHRDLKSDNILLNQNGDVKIADFGFATQLTREHFSKKSQVGTPAWMAPELI---LRKDYSQKVDIWSLGVICIEILEGEPPY
|.| ..| || ..|   ..|||.|  ||||...||||.|||| ..|.|     .|| .||| |||||      .  | |  |||..|.  ||. |  || 
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPM

IRDKPAKAMYYITK---KKPHKLDATKFSQEACDFVSTCLNIDPQERPTAQQLISHPFI
    | .|.. .||   . |.  | .|.||   .|| ..|  .|. ||||..|..|||.
FDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase 19075.AA PAKB 177-384 42 3.6e-64 219.5 In-house 46-252 (252) Show / Hide 
Range on Protein: 177-384
Range on HMM: 46-252/252
Sequence Identity: 42% (89 aa)

EILLMNESKNNNIVQYYKSYIYMDVIFMAIEYMNAGSLTELIYGNFSFLSEQMASYICEQILFGLFFIHRTNQIHRDLKSDNILLNQNGDVKIADFGFAT
|.  | . . .|||. |.||   |      |.|  |.||  .        || | ..|.|.|  | . |    |||| ||| ||| . | ||  ||||  
EVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHT-RMNEEQIA-TVCRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA

QLTREHFSKKSQVGTPAWMAPELILRKDYSQKVDIWSLGVICIEILEGEPPYIRDKPAKAMYYITKKKPHKL-DATKFSQEACDFVSTCLNIDPQERPTA
|. .|    || |||| |||||.| |  |  .|||||||.  ||  .|||||  ..| .||  |  ..| .| .. | | .  .|.. .|  ||..| ||
QVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPLQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTA

QQLISHPFI
| |  |||.
QELLRHPFL
Kinase 19075.AA CAMK 137-384 19 3.1e-63 202.32 In-house 1-425 (425) Show / Hide 
Range on Protein: 137-384
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

QIGKGATCKVYRCKNKQTG------------QECAMRVIR---MLN-------------------------PDQIEKTKMEILLMNESK-------NNNI
..|.|. .||..|..|.|.            |..|. .|    . .                         |   .. . || .|.  .         ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYYKSYIYMDV-------------------IFMAI---EYMNAG----SLTELIYGNFSF--------------LSEQMASYICEQILFGLFFIHRTNQ
.. |  |  ...                   ..|     ||.  |     | . |  . ..              ..|. |...  ||. .. ..|  | 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKSDNILLNQN-----------------GDVKIADFGFATQLTREHFS-----------------------KKSQVGTPAWMA-PELILRKD----
.||||| .||||..|                 ...||.|||||..... . .                        | ..|||. || ||....|     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YSQKVDIWSLGVICIEILEGEPPYIRDKPAKAMY-------------YITKKKPHKLDAT----------------------KFSQEACD
          |..|.|.||.|||.   | |.||.  |.    .               |.| | .  .                        ..|||. |
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FVSTCLNIDPQERPTAQQLISHPFI
... .|. ||..|.|..|  .||..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 19075.AA Ciliate-E2 132-384 22 5.6e-63 215.03 In-house 1-365 (365) Show / Hide 
Range on Protein: 132-384
Range on HMM: 1-365/365
Sequence Identity: 22% (86 aa)

YDFLSQIGKGATCKVYRCKNKQTGQECA--------------------MRVIRMLNPDQIEKTKMEILLMN----------------ESKNNNIVQYYKS
|.|. .||.|.  .||.||....... |                    .  . .....||| .|.|| .|.                . ...||...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI--YMDVIFMAIEYMNAGSLTELIYGNFSF----------LSEQMASYICEQILF---------------GLFFIHRTN-QIHRDLKSDNILLNQNGDV
..    . |..  || . |.| ..|. |  .          ..|. ..|| .|||                .| ..|  |  ||||.| .|||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADFGFATQLT-----------REHFSKKS---------------------QVGTPAWMAPELILRKD---------YSQKVDIWSLGVICIEILEGEP
||.|||......           .. .   .                     ..|||  |||| . .|.         |. |.||||||||  | | |.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PYIRDKPAKAMYYITKKK-PHKLDAT-----------------KFSQEACDFVST----CLNIDPQERPT-AQQLISHPFI
|.          .. .|. . ...                   | |||. |. .     .|. ||..|.| ..|.. ||..
PF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19075.AA SLK 132-384 33 5.4e-62 207.9 In-house 1-259 (259) Show / Hide 
Range on Protein: 132-384
Range on HMM: 1-259/259
Sequence Identity: 33% (88 aa)

YDFLSQIGKGATCKVYRCKNKQTGQECAMRVIRMLNPDQIEKTKMEILLMNESKNNNIVQYYKSYIYMDVIFMAIEYMNAGSLTELIYGNFSFLSEQMAS
.. .  .| ||  |||. ..|....  | ..| . . ...|   .|| .. | |  |||. |..| | . ..| ||. . | . ...      | |.   
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

YICEQILFGLFFIHRTNQIHRDLKSDNILLNQNGDVKIADFGFATQLTREHFSKKSQVGTPAWMAPELIL---RKD--YSQKVDIWSLGVICIEILEGEP
|.|.... .| ..|. . ||||||  |||. ..|||..|||| . .....   . . .||| |||||...    ||  |  |.||||||.  ||. ..||
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PYIRDKPAKAMYYITKKKPHKLDA-TKFSQEACDFVSTCLNIDPQERPTAQQLISHPFI
|.    | . .  | |  | .|    ..|.|  ||.  ||. ||| |.|..||. |...
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase 19075.AA TyrKc 132-384 24 2.6e-17 57.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 132-384
Range on HMM: 1-280/280
Sequence Identity: 24% (70 aa)

YDFLSQIGKGATCKVYRCKNKQTGQECAMRVIRMLNPDQIEKTKMEILLMNES--KNNNIVQYYKSYIYM--------DVIFMAIEYMNAGSLTELIYGN
  .. ..| || ..||... |   ...|  ...      .|    |. .| .   .. |||. |  ..          . ...  |||  |.| . .  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

FSFLSEQMASYICEQILFGLFFIHRTNQIHRDLKSDNILLNQNGDVKIADFGFATQLTRE--------HFSKKSQVGTP-----AWMAPELILRKDYSQK
   |. .   ..| ||  |  ..|. | |||||   |.|.. |. |||.||| .  .. .          .||.  |.       ||||| |  . .. |
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

VDIWSLGVICIEILE-GEPPYIR-----DKPAKAMYYITKK----KPHK-----LDATKFSQEACDFVSTCLNIDPQERPTAQQLISHPFI
 |.|| || . ||.  |..||        ... .. |. .     .|.            ..|  .  ..| . || .||| ...  | ..
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 19075.AA Pkinase_Tyr 132-328 28 3.5e-15 52.04 Pfam 1-216 (270) Show / Hide 
Range on Protein: 132-328
Range on HMM: 1-216/270
Sequence Identity: 28% (62 aa)

YDFLSQIGKGATCKVYRCKNK----QTGQECAMRVIRMLNPDQ---IEKTKMEILLMNES-KNNNIVQYYKSYI-YMDV--IFMAIEYMNAGSLTELIYG
  |. ..|.||  .||... |    .|....|  ...    ..   .|.   |. .| .  .. |||..|   .   .   |..  |||  |.| .    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---FSFLSEQMASYICEQILFGLFFIHRTNQIHRDLKSDNILLNQNGDVKIADFGFATQLTREHFS-KKSQ--VGTPAWMAPELILRKDYSQKVDIWSL
.      |. ..   .| ||  |. . .. | |||||   |.|.. |. |||.||| |  .. .    .|..       ||||| |  . .. | |.|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVICIEILE-GEPP-Y
|| . ||.  || | |
GVLMWEIFTYGEQPTY
Kinase 19075.AA Pkinase_Tyr 364-384 33 2.510131 1.73 Pfam 252-270 (270) Show / Hide 
Range on Protein: 364-384
Range on HMM: 252-270/270
Sequence Identity: 33% (7 aa)

CLNIDPQERPTAQQLISHPFI
| . ||..||| ...  | ..
CWHYDPEDRPTFSEI--HEQL