1557

Species: Tetrahymena
Alias: TTHERM_01298440, PreTt01557, 314.m00018, 746, 1557
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
1557.AA Protein None 268 None Fasta, JSON
1557.kin_dom Protein Kinase Domain None 214 None Fasta, JSON
1557.NA RNA None 807 None Fasta, JSON

Protein domain

Protein domains of 1557.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1557.AA STE7-Unclassified 75-227 42 2.4e-91 309.78 In-house 127-301 (301) Show / Hide
Range on Protein: 75-227
Range on HMM: 127-301/301
Sequence Identity: 42% (74 aa)

QLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKTQQLCMTYVGTTLYMSPERLIGN-----QYGLRSDIWSVGLVIIELATGLYPYD
|...||..||...|..||||||.|||.|..|.||..|||...|||.|.   .| ||.. ||||||..|.     .|...|||||.||.|.|.||| |||.
QVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRPSYSVKSDIWSLGLTIWECATGKYPYE

------VKNKS-------IVQFVSNILQSKEPTLPDNG---KYSAALMDFVKKCVAKEQKDRLDISDLLK-HEWI
      ..|..       .....|.|.....|.|||..   ..|...|||..||..|....| ||..||. |.||
YNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPWI

Kinase 1557.AA STE7 75-227 39 3e-80 272.92 In-house 118-288 (288) Show / Hide
Range on Protein: 75-227
Range on HMM: 118-288/288
Sequence Identity: 39% (68 aa)

QLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKTQQLCMTYVGTTLYMSPERLIG--NQYGLRSDIWSVGLVI-IELATGLYPYD--
...|||..||....  |||.||.|||.|.||.||| ||||..||. . .  .|.||.  ||.|||. |  ..|. |||.||.|. . ||.||| |||.  
AVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLGITMGIEMATGRYPYPNW

--------VKNKS------IVQFVSNILQS-KEPTLPDNGKYSAALMDFVKKCVAKEQKDRLDISDLLK-HEWI
        ..|..      | .....|... . |.||   |.|. ..|||.||  |....| ....|.| |..|
NTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP---KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI

Kinase 1557.AA STE 71-227 31 8.7e-62 211.59 In-house 155-359 (359) Show / Hide
Range on Protein: 71-227
Range on HMM: 155-359/359
Sequence Identity: 31% (67 aa)

FILKQLLKG-LEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEK---------------TQQ-LCMTYVGTTLYMSPERLIG------NQYGL
.|..|.||| |..||. .  .|||||| |||.     |||.|||...||..               |.|  . | |||  .|.||.. .      ..|. 
YICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDT

RSDIWSVGLVIIELATGLYPY-DVKNKSI-------------VQFVSNILQSKEPTLPD-----------------NGKYSAALMDFVKKCVAKEQKDRL
..||||.|..|||.||| .|. | .. .              .... .|.. . |.|||                   |.|  . ||..||  |. ..| 
KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP

DISDLLK--HEWI
. |.|||  |..|
TASQLLKSEHPFI

Kinase 1557.AA Pkinase 8-227 23 5.4e-50 177.21 Pfam 53-293 (293) Show / Hide
Range on Protein: 8-227
Range on HMM: 53-293/293
Sequence Identity: 23% (60 aa)

LLTQYTHPNLITCFGAYYEEGTIKIILELMDFG----SIRNLIDMLKEINYCYLSKILCNQKYQYHFFILKQLLKGLEFLHKERHQVHRDIKPENILINK
..    ||| ........... | ...|... |    .   .|           .. .    ..   |...|.|.|||..|. .  .|||.|||||||..
IMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-------WRHGCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDN

RGNV----KLTDFGISKQL-EKTQQLCMTYVGTTLYMSPERLI-GNQYGLRSDIWSVGLVIIELATGLYPYDVK----NKSIVQFVSNILQSKEPTLPDN
.|..    |..|||..||. .  .. ..|..||  ||.|| .  |. || ..|.||.|....|...|  |.. .    |    ... .   ....  .  
NGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWP

GKYS-------------------AALMDFVKKCVAKEQKDRLDISDLLKHEWI
 ..|                    .. ||.|.| .|  |.|. . ..|.|.|.
WWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 1557.AA YSK 71-227 38 1.6e-46 137.84 In-house 103-257 (257) Show / Hide
Range on Protein: 71-227
Range on HMM: 103-257/257
Sequence Identity: 38% (62 aa)

FILKQLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKTQQLCMTYVGTTLYMSPERLIG--NQYGLRSDIWSVGLVIIELATGLYPY
.||. .||||..||.||  .|||||  |.|... |.||| |||.. |.  ||.   | |||  .| ||       .|    ||||.|   .|.|.|. ||
IILREILKGLDYLHSER-KIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPY

DVKNKSIVQFVSNILQSKEPTLPDNG-KYSAALMDFVKKCVAKEQKDRLDISDLLKHEWI
  .   .|   ..|  .. |.|   | .|| .. .||  |  |. ..|.  ..||||. |
CDYHPMRV--MFLIPKNNPPKL--EGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI

Kinase 1557.AA STE20 71-227 39 8.6e-44 151.81 In-house 121-288 (288) Show / Hide
Range on Protein: 71-227
Range on HMM: 121-288/288
Sequence Identity: 39% (67 aa)

FILKQLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEK----TQQ-LCMTYVGTTLYMSPERLIG-----NQYGLRSDIWSVGLVIIE
.|....|.||..||.. |..|||||  |||....|.|||.||| . ||.|    |.|    | |||  .|.|| . .     ..|. ..||||.|  .||
YICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIE

LATGLYPYDVKNKSIVQFVSNIL--QSKEPTLPD--NGKYSAALMDFVKKCVAKEQKDRLDISDLLKHEWI
.|.|  ||   . . ..    |.  | . ||| |    |.|  . |||.||  |. ..|   |.||||..|
MAEGEPPY--FDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI

Kinase 1557.AA Ciliate-E2 6-227 21 2.3e-43 146.68 In-house 83-365 (365) Show / Hide
Range on Protein: 6-227
Range on HMM: 83-365/365
Sequence Identity: 21% (65 aa)

KVLLTQYTHPNLITCFGAYY--EEGTIKIILELMDFGSIRNLID-----MLKEINYCYLSKILCNQKYQYHFFILK-----------QLLKGLEFLHKER
| .| |  |||.| .. ...   . .| ...|. . |. . .|       ..||.  .  .. ...  ..   ||.           .....||.||.. 
KNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKN

HQVHRDIKPENILINKRGNVKLTDFGISKQLEK-------------------------------TQQLCMTYVGTTLYMSPERLIGNQ---------YGL
. .||||||||||.     .|..|||.||.. .                                |..  |..||  ||.|| | | .         |. 
NIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY

RSDIWSVGLVIIELATGLYPYDVKNKSIVQFVSNILQSKEPTLP----------------DNGKYSAALMDFVKK----CVAKEQKDRLD-ISDLLKHEW
 .||||.| .. |. .| .|.            .. . ..  .|                .. | |   .|. ||    .  |... |.. ....|.|.|
KCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPW

I
.
F

Kinase 1557.AA MEK5 76-227 39 4.5e-42 146.09 In-house 102-254 (254) Show / Hide
Range on Protein: 76-227
Range on HMM: 102-254/254
Sequence Identity: 39% (62 aa)

LLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKTQQLCMTYVGTTLYMSPERLIGNQYGLRSDIWSVGLVIIELATGLYPYDVKNKSI
. |||..|   .  .|||.|| |.|.| .|..|| |||.| ||   . .  ||.||  || |||. |.|||. ||.||.|. ..|.||| .||   ..  
IVKGLNYLWNLKI-MHRDVKPSNMLVNTQGQIKLCDFGVSTQL--VNSITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYPQIQRDQ

-----VQFVSNILQSKEPTLPDNGKYSAALMDFVKKCVAKEQKDRLDISDLLKHEWI
     .| .  | . . | ||  .|.|.  ..|. .|. |  |||    ||..| .|
GELMPIQLLQCIVDEHPPRLP-VDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI

Kinase 1557.AA ULK 72-227 28 1.6e-41 144.23 In-house 131-324 (324) Show / Hide
Range on Protein: 72-227
Range on HMM: 131-324/324
Sequence Identity: 28% (56 aa)

ILKQLLKGLEFLHKERHQVHRDIKPENILINKRGN------------VKLTDFGISKQLE---KTQQLCMTYV------GTTLYMSPERLIGN----QYG
..||.. |. .||| .  .||||||.||||..               .|..||| .|...   . ||.|.|.|      || |||.|. | |.    .|.
FFKQICNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYY

-LRSDIWSVGLVIIELATGLYP-----YDVKNKSIVQFVSN------ILQSKEPTLPDNG---KYSAALMDFVKKCVAKEQKDRLDISDLLKHEWI
   .||||.| .. |. .| ||     .| ... | . . |      . . .    |...   | |  . |. ...  ...||| .. ....|.|.
DYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF

Kinase 1557.AA Ciliate-E2-Unclassified 8-227 25 5.1e-41 140.02 In-house 70-352 (352) Show / Hide
Range on Protein: 8-227
Range on HMM: 70-352/352
Sequence Identity: 25% (74 aa)

LLTQ--YTHPNLITCFGAYYE--EGTIKIILELMDFGSIRNLIDMLKE---INYCYLSKILCNQKYQ-YHF-----------FILKQLLKGLEFLHKERH
.. |  . ||...     |..  . .| |..|... |. .. |   |    .      . | ....|  .|           |...|.|.|||.||.. .
IMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQK-----GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN

QVHRDIKPENILINKRG---NVKLTDFGISKQLEKT---------------QQLCMTYVGTTLYM----SPERLIGNQYGLR----SDIWSVGLVIIELA
 .||||||||||... |   ..|..||||||....                ||.. | .||  ||    .|| | |..|. .    .||||.| .. |. 
IIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEML

TGLYPYDVKNKSI--------------VQFVSNILQSKEPTLPDN-----GKYSAALMDFVK----KCVAKEQKDRLDISDLLKHEWI
.| ||.. .|. .               |. .||.| .    . .      . |    ||..    |.  | .. |......|.| |.
FGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

S_TKc 1557.AA S_TKc 2-227 20 7.7e-37 129.62 SMART 1-231 (231) Show / Hide
Range on Protein: 2-227
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

LNDFKVL-----------------------------------LTQYTHPNLITCFGAYYEEGTIKIILELMDF--GSIRNLIDMLKEINY-CYLSKILCN
    ...                                   | .  |||.......... . . ...|..|   |. . .|.  .   . ....   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

QKYQYHFFILKQLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKTQQLCMTYVGTTLYMSPERLIGNQYGL-RSDIWSVGLVIIELA
       |...|....||..|.  . .|||.||||||...  ..|..|||...||       .|..||  ||.|| |   .||  ..|.||.| ...|..
-------FYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TGLYPYDVKNKSIVQFVSNILQSKEPTLPDNGKYSAALMDFVKKCVAKEQKDRLDISDLLK-------HEWI
.|  |..      .| . ...             |  . ||..||  |. ..|. . ..|.       |.|.
CGYPPFP-----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 1557.AA MEK1 15-167 40 4.7e-35 116.9 In-house 57-195 (297) Show / Hide
Range on Protein: 15-167
Range on HMM: 57-195/297
Sequence Identity: 40% (62 aa)

PNLITCFGAYYEEGTIKIILELMDFGSIRNLIDMLKEINYCYLSKILCNQKYQYHFFILKQLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGI
| ..  .||.|..| | | .| || ||.  ..   . |    | |.                |.|| .|. . . .|||.|| |||.| || .|| |||.
PYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILGKVSVA------------VLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGV

SKQLEKTQQLCMTYVGTTLYMSPERLIGNQYGLRSDIWSVGLVIIELATGLYP
| ||     .   .|||  ||||||| |  | ..|||||.|| ..|.| | ||
SGQL--IDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYP

Kinase 1557.AA STE7-Unclassified 14-51 43 1.9e-16 54.53 In-house 64-104 (301) Show / Hide
Range on Protein: 14-51
Range on HMM: 64-104/301
Sequence Identity: 43% (18 aa)

HPNLITCFGAYYEEGT---IKIILELMDFGSIRNLIDMLKE
||......||||.|..   |.|..|.||.||..|.||..|.
HPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKIDIYKK

Kinase 1557.AA STE7 14-52 31 5.9e-13 43.81 In-house 58-98 (288) Show / Hide
Range on Protein: 14-52
Range on HMM: 58-98/288
Sequence Identity: 31% (13 aa)

HPNLITCFGAYYEEGT--IKIILELMDFGSIRNLIDMLKEI
.|. ....||.| ||   |.|..|.||.|.........|..
CPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKV

TyrKc 1557.AA TyrKc 2-227 16 1.4e-11 -35.5 SMART 1-280 (280) Show / Hide
Range on Protein: 2-227
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)

LNDFKVL------------------------------------LTQY--THPNLITCFGAYYEE-------GTIKIILELMDFGSIRNLIDMLKEINYCY
.   |.|                                    ....   |||.. ..|.  ..       . . |..|.|. |. .. .   ..     
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----

LSKILCNQKYQYHFFILKQLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKT-------QQLCMTY--VGTTL----YMSPERLIGN
        . .    .  |  .| |.||.  . .|||.   |.|..... || .||| |. ..         .   ..    | |.     |.|| .  .
-------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

QYGLRSDIWSVGLVIIELAT--GLYPYDVKN--KSIVQFVSNILQSKEPTLPDNGK------YSAALMDFVKKCVAKEQKDRLDISDLLKHEWI
 .   ||.|| | .. |. |  .  ....    .|  . . .. | . .  |.|.        .... .  |.| . . .||   |..  || .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 1557.AA STE 14-47 34 8.6e-08 23.73 In-house 89-129 (359) Show / Hide
Range on Protein: 14-47
Range on HMM: 89-129/359
Sequence Identity: 34% (14 aa)

HPNLITCFGAYYEEG-------TIKIILELMDFGSIRNLID
||| ....|.|. ||       .. |..|.|| ||.. .|.
HPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIK

Kinase 1557.AA MEK1 175-227 32 4.4e-07 19.69 In-house 246-297 (297) Show / Hide
Range on Protein: 175-227
Range on HMM: 246-297/297
Sequence Identity: 32% (17 aa)

IVQFVSNILQSKEPTLPDNGKYSAALMDFVKKCVAKEQKDRLDISDLLKHEWI
|  ..  | . . |.|| .. .|  ..|||.||. |. ..| |.  |. | .|
IFEMLDYIVNEPPPKLP-HRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI

Kinase 1557.AA Pkinase_Tyr 8-44 24 0.000653 13.87 Pfam 56-96 (270) Show / Hide
Range on Protein: 8-44
Range on HMM: 56-96/270
Sequence Identity: 24% (10 aa)

LLTQY-THPNLITCFGAYY-EEGT--IKIILELMDFGSIRN
...|.  |||.. . |. . ...   | |..|.|  |. ..
IMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

Kinase 1557.AA STE20 7-51 18 0.011931 5.86 In-house 56-116 (288) Show / Hide
Range on Protein: 7-51
Range on HMM: 56-116/288
Sequence Identity: 18% (11 aa)

VLLTQYTHPNLITCFGAYYEE----GTIKIILELMDFGSIRNLID------------MLKE
. . |. ||| .. .|.|. .      . |. |... ||.. ...             ..|
SIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNE

Kinase 1557.AA Pkinase_Tyr 78-121 31 0.024323 8.55 Pfam 122-164 (270) Show / Hide
Range on Protein: 78-121
Range on HMM: 122-164/270
Sequence Identity: 31% (14 aa)

KGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKT
||.|.|. ... .|||.   |.|... . || .||| .. ....
KGMEYLE-SKNCIHRDLAARNCLVTENNVVKICDFGLARDIYND