ROCK

Species: Sea Urchin
Alias: Spk004, SPU_024526, ROCK
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: DMPK
Subfamily: ROCK

Sequence

Name Sequence Type Origin Length Description Download
ROCK.AA Protein None 1540 None Fasta, JSON
ROCK.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of ROCK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ROCK.AA DMPK 72-334 66 6e-290 728.1 In-house 1-270 (270) Show / Hide
Range on Protein: 72-334
Range on HMM: 1-270/270
Sequence Identity: 66% (179 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYE--IPEK
|...||||||.||||.|||......|||||...|.||.||...|..|||||||.|.||.||.|||||||||.||||||.|||||||..|||.||  |||.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

WARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLKSQAGN--GQYGRECDWWSVGVFIYEM
.||||.||.|||...||.||..|||.||||||||..||.||||||.||.|.|||||||..|||||||||||||... ..  |.||.|||||||||..|||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LVGDTPFYADSLVGTYSKIMDH-RNSLEFPDDIS--ISGPAKDLICKFLTDRDTRLGKNGIDEIKLHRFF
|.|.|||||||||.||.|||.| .|.|.|||| .  .|  ||||||..|.||..|||.||....| |.||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF

Kinase ROCK.AA ROCK 72-334 85 1.5e-214 719.06 In-house 1-263 (263) Show / Hide
Range on Protein: 72-334
Range on HMM: 1-263/263
Sequence Identity: 85% (226 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYEIPEKWA
|.|||||||||||||..||...||||||||.||||||||||||||.||||||||||||||||||||||||..|||||||||||||||||||||..|||||
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDVPEKWA

RFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLKSQAGNGQYGRECDWWSVGVFIYEMLVGD
||||.|||||||||||||||||||||||||||..||||||||||||.|...||||.||||||||||||||||||...|.|||||||||||||||||||||
RFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGD

TPFYADSLVGTYSKIMDHRNSLEFPDDISISGPAKDLICKFLTDRDTRLGKNGIDEIKLHRFF
||||||||||||||||||.|||.||||..|| .||||||||||||..|||.||.|.|| |.||
TPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF

Kinase ROCK.AA AGC 72-334 31 5.6e-177 462.26 In-house 1-395 (395) Show / Hide
Range on Protein: 72-334
Range on HMM: 1-395/395
Sequence Identity: 31% (128 aa)

FQMIKVIGRGAFGEVKVVRER------TSKKVYAMKCLSKFE--------MIKRSDSAF-------YWEERDIMAHAN----------SEWIVQ-LHYAF
|...||||.|.||.|  ||..      ...|.||||.|.| .        |...  ...        ||||.|....|          . .||. |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDEKY--LYMVMDYMP--------GGDLVNLMSNY------EIPEKWARFYTAE-------VVLALDAIHS-MGFIHRD-VKPDNMLLDSSGHLKLADFG
||...  ||.||.|||        ||..  .....        .|..||||.||       .||||. .|| ||.|||| .||.|.|||. ||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TCMRMERDG-------------------------------------------------MVRSDTAVG--TPDYISPEVLKSQAGNGQYGRECDWWS--VG
 | .. .||                                                 ..|  | .|  ||.|..||.|        ||..|||||  .|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--------YGKACDWWSFGLG

VFIYEMLVGDTPFYADSLV----------GTYSKIMDHR----NSLEFP--------DDISISGPAKDLICKFLT-DRDTRLGKN-------GIDEIKLH
...||||.| .|||.|. .           .. |||..|    . ..||        .| ..|  ||||| |.|. |.. ||| .       |..||| |
CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

RFF
 .|
PWF

Kinase ROCK.AA GEK 72-334 56 7.89999999999e-141 474.16 In-house 1-269 (269) Show / Hide
Range on Protein: 72-334
Range on HMM: 1-269/269
Sequence Identity: 56% (152 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYE--IPEK
|...||||||||||| ||. . ...||||| | |.||.||.. | . ||||.. .  . || .||||||||.|||.||||  ||||. |.| .|  .||.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

WARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLKS-QAGNGQYGRECDWWSVGVFIYEML
 |||| ||.|.|.|..| ....|||.||||.|||  ||..||||| |.||..||||.|  |||||||||||.|.  . |.|.||.||||||.||..||||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

VGDTPFYADSLVGTYSKIMDHRNSLEFPDDIS---ISGPAKDLICKFLTDRDTRLGKNGIDEIKLHRFF
 |.|||||.||| ||.|||.|.. ..||..     .|  |||||.. .  ...|||.|||.. | | ||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF

Kinase ROCK.AA CRIK 72-334 44 1.1e-122 393.08 In-house 1-272 (272) Show / Hide
Range on Protein: 72-334
Range on HMM: 1-272/272
Sequence Identity: 44% (123 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYE--IPEK
|    .||.| ||.|.||||.    .|||| . | ..  . . .|  ||||||. .||.|. || |||||.  || .| |.|||||  ||. ..    | 
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

WARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLKSQAGN----GQYGRECDWWSVGVFIY
 |||| || ..|.  .| ||..|||.||.| |.|  || ||||||    |.|...| |   ||||||. |||| .  |     | || .|||||.|.  |
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMLVGDTPFYADSLVGTYSKIMD------HRNSLEFPDDISISGPAKDLICKFLTDRDTRLGKNGIDEIKLHRFF
|| .| |||  |. . |||.||.       .  | ||||  .|  . |||   |...  ||   .   .. | ||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRL---KYEQLCCHPFF

Kinase ROCK.AA S_TKc 72-334 33 1.4e-98 334.76 SMART 1-231 (231) Show / Hide
Range on Protein: 72-334
Range on HMM: 1-231/231
Sequence Identity: 33% (93 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPG--GDLVNLMSNYE----
......||.||||.|. .|.. .....|.|...             . |..|. . . ..||.|...||| ..|||||.|..|  |||  .. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLKSQAGNGQYGR-ECDWWSVG
   .|| .||||......||. .||.|.||||.||.| |||.  |.|..||| . ..        .| .|||.|..||||       .||. .|||||.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCG

VFIYEMLVGDTPFYADSLVGTYSKIMDHRNSLEFPDDISISGPAKDLICKFLT-DRDTRLGKNGIDE----IKLHRFF
. .||||.| .||.   .  .. ||.              | .|||.|.| |. | . |..   . .    ||.| .|
CILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase ROCK.AA RSK 75-334 37 4e-91 309.03 In-house 1-278 (278) Show / Hide
Range on Protein: 75-334
Range on HMM: 1-278/278
Sequence Identity: 37% (106 aa)

IKVIGRGAFGEVKVVRER---TSKKVYAMKCLSKFEMIKRS-DSAFYWEERDIMAHAN-SEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYEI---
.|| |.|..|.| ..|.     ....|||| |.| ....|  | .  ..||.|... . .  ||.||||||.|..||..|.|..||.|    .. ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

-PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDS---SGHLKLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLK-SQAGNGQYGRECDWWSVG
  |. |.|| ||.|||.. .|. |.|||| ||.|.|.|.   .||.|| ||| |  .  |   . .| ..| .|. ||.||  . ..| ... ||||| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLG

VFIYEMLVGDTPFYA---DSLVGTYSKIMDHRNSLEFPDDISISGPAKDLICKFLT-DRDTRLG--KNGIDEIKLHRFF
| .||||.| .||..   ..   .  .|.  . ||..| . ..| .||||| | |. |   |||  .....||| | .|
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase ROCK.AA Akt 72-334 40 1.7e-87 279.77 In-house 1-264 (264) Show / Hide
Range on Protein: 72-334
Range on HMM: 1-264/264
Sequence Identity: 40% (109 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVY-AMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYEI-PEK
|...||.|.|.|| |  |..  ..|.| ||| |.|   |..   .    || |  | |.  ||.|||.||....||.||||..||.| ....  .. .|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

WARFYTAEVVLALDAIHSMGFIHRD-VKPDNMLLDSSGHLKLADFGTCMRM-ERDGMVRSDTAVGTPDYISPEVLKSQAGNGQYGRECDWWS-VGVFIYE
 |||| ||..||... ||.. | ||  || | |.|. ||..|.||| | ..   |. .  .|  ||| |..||.|.   ||| ... .|||. .|...||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDK-TKTFCGTPEYLAPEILN---GNG-HTKAVDWWGSLGCVMYE

MLVGDTPFYADSLVGTYSKIMDHRNSLEFPDDISISGPAKDLICKFLT-DRDTRLG--KNGIDEIKLHRFF
|. |  |||..     . ||.   . ..||| . ||  .|||| . |. |.. |||  .|...||| | .|
MMCGRPPFYNQDHHQMFKKIK--NQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF

Kinase ROCK.AA NDR 72-214 51 1e-82 254.87 In-house 1-149 (350) Show / Hide
Range on Protein: 72-214
Range on HMM: 1-149/350
Sequence Identity: 51% (77 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHAN--SEWIVQLHYAFQDEKYLYMVMDYMPGGDLVN---LMSNYEI
|..||.||.|||||| .||.. ....|||| . | ||...   |    |||||| |.  ..|.| | |.|||..||| ||.|.||||.     | ....|
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

-PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFG
 .| ||||| || |.|....|.||.||||.|||| |.|. ||.|| |||
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG

Kinase ROCK.AA Pkinase 72-334 29 7.8e-71 246.44 Pfam 1-293 (293) Show / Hide
Range on Protein: 72-334
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYW-EERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGG----DLVNLMS---N
.. ...||.|.||.|.  ... . |..|.|...| .  .  | .  .  |  ||.. |.. ||.|...|.|....||||.|..||    ||  ..|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

YEI--PEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHL----KLADFGTCMRMERDGMVRSDTAVGTPDYISPEVLKSQAGNGQYGRECDW
  .  .|. ..||  ... .|. .||||.||||.||.| |.|. ||.    |..||| .  ..    .  .| .|||.|..|||..   |.  ||...|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVDM

WSVGVFIYEMLVGDTPFYAD------SLVGTYSKIMDHRNSLEFPDDISIS-----------------GPAKDLICKFLT-DRDTRLGKNGIDEIKLHRF
||.|. .|||| | .||. .      .    . .||. ... ..| ..|||                  ..||.|.. |. |   |..   ...|. | .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPW

F
|
F

Kinase ROCK.AA MAST 72-214 43 9.3e-68 205.85 In-house 1-147 (337) Show / Hide
Range on Protein: 72-214
Range on HMM: 1-147/337
Sequence Identity: 43% (65 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKR--SDSAFYWEERDIMAHANSEWIVQLHYAFQD--EKYLYMVMDYMPGGDLVNLMSNYE--
|  ||.|..||.| |  |. ..... .||| . .  .|..   |..|   ||.| . .  ...| . |.||   .|||.|||.|| |||   |...|   
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFV--ERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNC

IPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFG
 ||  |..|.|| ||.|. .||.| .|||.||||||.|| ||.||.|||
MPEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG

Kinase ROCK.AA MAST 72-214 44 9.7e-66 210.78 In-house 1-144 (334) Show / Hide
Range on Protein: 72-214
Range on HMM: 1-144/334
Sequence Identity: 44% (65 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKR--SDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNY-EIPE
|  ||.|..||.| |  |. ..... .||| . | .||..   |. .   ||.| | . ....| . |.|| ..||.|||.|| |||.  |...|   .|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQV--ERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDE

KWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFG
  |..|.||.||.|. .||.| .|||.||||||.||.|| ||.|||
WMAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG

Kinase ROCK.AA NDR 230-334 44 2.4e-53 162.55 In-house 241-350 (350) Show / Hide
Range on Protein: 230-334
Range on HMM: 241-350/350
Sequence Identity: 44% (50 aa)

AVGTPDYISPEVLKSQAGNGQYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHRNSL-----EFPDDISISGPAKDLICKFLT-DRDTRLGKN
.||||||. |||.. . |   |. .|||||.|.  |||||| .||..|.   |. |||. .. .     .|| .. .|  |.||| .... |.|.|||..
TVGTPDYMAPEVFQQKTG---YNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSH

G--IDEIKLHRFF
|  .|||| | ||
GKGVDEIKSHPFF

Kinase ROCK.AA MAST 231-334 43 6.4e-36 106.74 In-house 229-337 (337) Show / Hide
Range on Protein: 231-334
Range on HMM: 229-337/337
Sequence Identity: 43% (49 aa)

VGTPDYISPEVLKSQAGNGQYGRECDWWSVGVFIYEMLVGDTPFYADSLVG-TYSKIMDHRNSLEFPDD--IS----ISGPAKDLICKFLT-DRDTRLGK
.||||||.|||.    | | ||   ||||.|. .|| ||| .|| .|.    . ..|  | . .|.|..  .     .|  |.||| |.|. .  .||| 
CGTPDYIAPEVI---LGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGA

NGIDEIKLHRFF
|| |||| |.||
NGADEIKQHPFF

Kinase ROCK.AA MAST 231-334 41 6.5e-34 106.46 In-house 225-334 (334) Show / Hide
Range on Protein: 231-334
Range on HMM: 225-334/334
Sequence Identity: 41% (47 aa)

VGTPDYISPEVLKSQAGNGQYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHR-NSLEFPDD------ISISGPAKDLICKFLTD-RDTRLGK
.||||||.|||.. |   | .|   ||||.|. .|| ||| .||  |.   ....|  .. |  |.|..      . .| .|.||| |.|.    .||| 
CGTPDYIAPEVILGQ---GTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGA

N-GIDEIKLHRFF
| | ||.| |.||
NNGADEVKQHPFF

Kinase ROCK.AA TyrKc 72-313 20 2.9e-12 -24.42 SMART 1-280 (280) Show / Hide
Range on Protein: 72-313
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHA--NSEWIVQLHYAFQDE-------KYLYMVMDYMPGGDLVNLMS
 ...|..|.||||||   . .   .| | |.| .         .|. .|  || .   . . ||.|. .  ..       . |..|| |||.||| .   
ITLGKKLGEGAFGEVYKGTWK--IQV-AVKMLKEDA-----REDFM-REARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NYE--IPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERD-------GMVRSDTAVGTPD-----YISPEVLKSQAGN
...  .. |    .   .    . .||...||||    | |... .. | .||| .   . |        . |. .  |. .       .||..      
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NY

GQYGRECDWWSVGVFIYEML-VGDTPFYA-----DSLVGTYSKIMDHRNSLEFPDD-----------------------ISISGPAKDLICKFL
| .  . | || || ..|..  |..| .       |    . ... ... .. |..                          . |    |....
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase ROCK.AA Pkinase_Tyr 72-87 50 0.001913 12.29 Pfam 1-16 (270) Show / Hide
Range on Protein: 72-87
Range on HMM: 1-16/270
Sequence Identity: 50% (8 aa)

FQMIKVIGRGAFGEVK
 ...|..|.||||||.
ITFGKKLGEGAFGEVY

Kinase ROCK.AA Pkinase_Tyr 132-159 38 0.004536 11.02 Pfam 66-96 (270) Show / Hide
Range on Protein: 132-159
Range on HMM: 66-96/270
Sequence Identity: 38% (12 aa)

IVQLHYAFQ-DEKY--LYMVMDYMPGGDLVN
||.|. .   ...   .|.|| |||.||| .
IVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

Kinase ROCK.AA Pkinase_Tyr 186-214 37 0.020521 8.8 Pfam 128-156 (270) Show / Hide
Range on Protein: 186-214
Range on HMM: 128-156/270
Sequence Identity: 37% (11 aa)

HSMGFIHRDVKPDNMLLDSSGHLKLADFG
.|...||||.   | |...... | .|||
ESKNCIHRDLAARNCLVTENNVVKICDFG

Pkinase_C ROCK.AA Pkinase_C 354-399 31 5.5e-09 34.93 Pfam 1-46 (46) Show / Hide
Range on Protein: 354-399
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

ELISDVDTSNFDEIEPEDHPEES-FQSPKTFAGNNLPFIGFTYNKSN
.. |. ||||||. . . .|...   ..  ..|...||.||||  ..
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD

S_TK_X ROCK.AA S_TK_X 337-397 25 1.7e-07 32.16 SMART 1-79 (79) Show / Hide
Range on Protein: 337-397
Range on HMM: 1-79/79
Sequence Identity: 25% (20 aa)

DMWTYDNIRN----TVPPVVPELI----SDVDTSNFDEIEPEDHPEESFQSPKTFAGNNLP----------FIGFTYNK
. .  |...|    . || .|..     |. ||||||. ..|  | .. ..|  ..... .          |.||||. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF

Rho_Binding ROCK.AA Rho_Binding 1056-1074 42 4.316682 2.74 Pfam 1-19 (72) Show / Hide
Range on Protein: 1056-1074
Range on HMM: 1-19/72
Sequence Identity: 42% (8 aa)

LQQDYHQLSNEKESLAAQL
|  |  .|.|||| |  ..
LTKDVANLANEKEELNNKM

Rho_Binding ROCK.AA Rho_Binding 1137-1205 41 2.2e-07 27.58 Pfam 1-72 (72) Show / Hide
Range on Protein: 1137-1205
Range on HMM: 1-72/72
Sequence Identity: 41% (30 aa)

LNNRIMTLNTEKDELNKKLKESSEA-QEAMETK--HQEMEKQMEQNKKLLGEEKLKKEQAVSKLAEIMNRKD
|   .  |  || ||| |.|.  |  | . |..   ... .| | ..  |  |.. | ||| ||||||||||
LTKDVANLANEKEELNNKMKKQQEELQKLKEEEQQMNQIKAQFEKCRAKLQTERTLKTQAVNKLAEIMNRKD

PH ROCK.AA PH 1314-1516 9 2.9e-07 31.39 SMART 1-82 (82) Show / Hide
Range on Protein: 1314-1516
Range on HMM: 1-82/82
Sequence Identity: 9% (19 aa)

GRLEGWLSLPGKNLRRHGWKKHFVEVSSKKILFYESEDQKAQKKPYLVLAIDKLFHVRAVTQGDVIRAEARDIPRIFQLLYAGEGENRRMVPDEANENPG
  .||||.  .    . .|||... . .. ...|...      ||  .. ....  ||  .                                       
VIKEGWLYKKS----K-RWKKRWFVLFNDCLYYYKDK------KPKGSIPLSDC-TVRE-P---------------------------------------

QDDEEGTIVHKNHKFTVVHFHMPTTCECCSKTLSHLVRPPPALECKLCRLKVHKEHYDKQEEFCPPCKVNIDAETAKHMLLMANSKEEQQRWIGKLGKQI
                                                                   ..    .    ... ..|.||.|.|.  . | |
-----------------------------------------------------------------CFEIHH-DR---TYYFQCESEEEMQEWMQAIQKAI

QDK
.. 
HNN

C1 ROCK.AA C1 1426-1477 24 3.1e-07 31.28 SMART 1-61 (61) Show / Hide
Range on Protein: 1426-1477
Range on HMM: 1-61/61
Sequence Identity: 24% (15 aa)

HKFTVVHFHMPTTCECCSKTLSHLVRP---PPALECKLCRLKVHKEHYDKQEE-------FC
|..  . |  ||.|. | |..... ..   .....|  |..|.|| . ||  .        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC

PH ROCK.AA PH 1314-1392 20 1.9e-05 22.29 Pfam 1-63 (92) Show / Hide
Range on Protein: 1314-1392
Range on HMM: 1-63/92
Sequence Identity: 20% (16 aa)

GRLEGWLSLPGKNLRRHGWKKHFVEVSSKKILFYESEDQKAQKKPYLVLAIDKLFHVRAVTQGDVIRAEARDIPRIFQL
 ..||||.. |   .| .|||... . ......|....    ..|  .. ....  |. |. .        . | .||.
VIKEGWLHKKG---KRKSWKKRWFVLFNNCLYYYKDDK----YRPKGSIPLSDC-QVTKVPDN--------KRPHCFQI

C1_1 ROCK.AA C1_1 1426-1468 22 0.000959 17.4 Pfam 1-43 (55) Show / Hide
Range on Protein: 1426-1468
Range on HMM: 1-43/55
Sequence Identity: 22% (10 aa)

HKFTVV-HFHMPTTCECCSKTLSH-LVRPPPALECKLCRLKVHKE
|.. .  .| .|| |. | . ... | .  ... |  | ...|..
HHWVHHWNFKQPTFCCHCGEFCWGWLGH--QGWKCQWCHYNCHHR

PH ROCK.AA PH 1490-1514 20 0.376647 6.8 Pfam 68-92 (92) Show / Hide
Range on Protein: 1490-1514
Range on HMM: 68-92/92
Sequence Identity: 20% (5 aa)

KHMLLMANSKEEQQRWIGKLGKQIQ
.  .. |.| || ..|.  . . . 
RTYYFQAESEEEMNDWMQAIQSACR