Gene BARK (Sea Urchin)

BARK

Species: Sea Urchin
Alias: Spk006, SPU_001621, BARK, SpGPRK1
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: GRK
Subfamily: BARK

Sequence

Name Sequence Type Origin Length Description Download
BARK.AA Protein None 549 None Fasta, JSON
BARK.kin_dom Protein Kinase Domain None 299 None Fasta, JSON

Protein domain

Protein domains of BARK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS BARK.AA RGS 54-175 21 2.7e-32 114.51 SMART 1-121 (121) Show / Hide 
Range on Protein: 54-175
Range on HMM: 1-121/121
Sequence Identity: 21% (27 aa)

TFEKIF-GQKLGYLLFKDYCENCADVQVQQLQFYEAIKDYEKLDTLDERLEEARRIFDNYIMKEVLS-CTHQFSKSAVENVRQRLTNQEAKPDLFSDYIT
.|....  .. |...|......  .. .. |.|..|.....|... .|| . ||.|.| ||... .. . ...... .|...|.|.|    ||.| .. .
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMED-EERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCN--PHPDCFDEAQR

EILNSLKGEIFQKFLESDKFTRFC
.. . .... ...||.||...|..
HVYQLMEKDSYPRFLRSDYYKRYL
RGS BARK.AA RGS 54-174 22 2.1e-28 95.69 Pfam 1-124 (124) Show / Hide 
Range on Protein: 54-174
Range on HMM: 1-124/124
Sequence Identity: 22% (28 aa)

TFEKIFGQKL-GYLLFKDYCENCADVQVQQLQFYEAIKDYEKL--DTLDERLEE-ARRIFDNYIMKEVLSCTHQFSKSAVENVRQRLTNQEAKPDLFSDY
.|....  .  | .||....|.    .   ..|..|..|..|   |. .....  ||.|...||. .  .  |. .....|.....|....  ||.| ..
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFKKMFSDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQAQPTPDCFDEA

ITEILNSLKGEIFQKFLESDKFTRF
...|.. .... ...||.||.. ||
QRHIYTLMEKDSYPRFLKSDYYQRF
Kinase BARK.AA BARK 193-389 92 2.3e-173 582.25 In-house 1-198 (264) Show / Hide 
Range on Protein: 193-389
Range on HMM: 1-198/264
Sequence Identity: 92% (184 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKSGETLALNERIMLSLVSET-DCPFIVCMTYAFQTPDKLCFILDLMNGGDLHYHLSQHGVF
||||||||||||||||||||||||||||||||||||||||.||||||||||||||||.. ||||||||||||.|||||||||||||||||||||||||||
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVF

SEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDENGHVRISDLGLACDFSSKKPHASVGTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHG
||.|. ||||||||||||||.|.|||||||||||||||||||||||||||||||.||||||||||||||||||.||||||||||||||||||.|||.|
SEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLLRG
Kinase BARK.AA GRK 193-389 60 4.3e-168 534.21 In-house 1-203 (272) Show / Hide 
Range on Protein: 193-389
Range on HMM: 1-203/272
Sequence Identity: 60% (123 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKSGETLALNERIMLSLVSETDCPFIVCMTYAFQTPDKLCFILDLMNGGDLHYHLSQHGV--
|...|..|.||||||..|....||||||.|||||||||.. |||.||||...|..|...||||||||.||..|.|.||.....|||||||||....|.  
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSRDCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGNNE

--FSEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDENGHVRISDLGLACDFSSKK--PHASVGTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKL
  |.||.. ||||||..|||||| |..|||||||.|||||..||||||||||||... ..  .|..||||||||||||....|||.|.||.|||||....
PGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYEM

LHG
..|
IEG
Kinase BARK.AA AGC 193-389 29 5.4e-121 314.15 In-house 1-301 (395) Show / Hide 
Range on Protein: 193-389
Range on HMM: 1-301/395
Sequence Identity: 29% (90 aa)

FSVHRIIGRGGFGEVYGCRKA------DTGKMYAMKCLDKKR-IKMKS--GETLALNE------------RIMLSLVSETD-------CPFIVC-MTYAF
| ....||.|.||.|| .||       ||||.||||.|.||. |..|    .  ...|            | .|.... |        .||||  . |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPDK--LCFILDLMN---------GG-DLHYHLS---QHGVFSEEEVGFYAAE-------IILGLEHMHV-RNVVYRD-LKPANILLDENGHVRISDLG
|..|.  |.|....|.         || .|..||    . |.|.||.. |||||       |.|.||..|  .....|| ||| ||||||.||....| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LACDFSS----------------------------------------------------KKPHASVG--THGYMAPEVLSKGTAYDSSADWFS--LGCML
|.. . .                                                    .. .  .|  |. |||||.|     |. ..|| |  |||..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

FKLLHG
. .| |
YEMLTG
Kinase BARK.AA S_TKc 193-491 26 4.8e-83 283.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 193-491
Range on HMM: 1-231/231
Sequence Identity: 26% (81 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKSGETLALNERIMLSLVSETDCPFIVCMTYAFQTPDKLCFILDLMNG--GDLHYHLSQHGV
. ..|.||.|.||.|| ||. .||. .|.|...            ...|. .|.     ..|.|| . ..||. |.|........|  |||. .. ..| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------FSEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDENGHVRISDLGLACDFSSKKPHASVGTHGYMAPEVLSKGTAYDSSADWFSLGCMLF
      |.| .. ||...|...||..| .....|||||.||||||  |. |.| |||. .     .  .||  |||||||                    
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL--------------------

KLLHGGTHGYMAPEVLSKGTAYDS-SADWFSLGCMLFKLLHGHSPFRQHKTKDKHEIDRMTLTMDVEFPDKMSDEMRALLAGLLQREVASRLGCEGRGA-
                     |.  ..|| |.||.|. .| |  ||.     ..  ....            |.|.. .. ..||.. . |...    . 
--------------------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQD

-TEVREHPFF
  ... ||.|
EWDIKCHPWF
Kinase BARK.AA GRK 193-384 50 6.1e-82 278.53 In-house 1-192 (265) Show / Hide 
Range on Protein: 193-384
Range on HMM: 1-192/265
Sequence Identity: 50% (99 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKSGETLALNERIMLSLVSETDCPFIVCMTYAFQTPDKLCFILDLMNGGDLHYHLSQHG---
|   |. | ||||||  |    |||||| | |.||||| . ||..||||   |  |.    .|.| . ||. | | || .. .|||||| .|.   |   
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVH---SRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGENP

VFSEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDENGHVRISDLGLACDFSSKKP-HASVGTHGYMAPEVLSKGTAYDSSADWFSLGCMLF
 |.|| . ||||||..|||| | ...||||.|| |||||. ||.||||||||      ..    ||| |||||||.     |. | ||..||| ..
GFDEERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQMIRGRVGTVGYMAPEVVKNER-YTFSPDWWGLGCLIY
Kinase BARK.AA Pkinase 193-387 35 1.6e-77 268.68 Pfam 1-206 (293) Show / Hide 
Range on Protein: 193-387
Range on HMM: 1-206/293
Sequence Identity: 35% (76 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKSGETLAL--NERIMLSLVSETDCPFIVCMTYAFQTPDKLCFILDLMNGG----DLHYHLS
. ..|.||.|.||.|| |.. .|||..|.|...|...|..  .|...    .||..| .   .|.|| . ..|...|..........||    ||. ..|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--QHGVF--SEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDENGHV----RISDLGLAC---DFSSKKPHASVGTHGYMAPEVLSKGTAYDSSAD
  .||.|  ||.|. ||. .|. |||..| .....|||||.|||.|.|||.    .|.| |||.     ..  ..  .|| .||||||. .|. |....|
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

WFSLGCMLFKLL
..|.||.|. .|
MWSCGCILYEML
Kinase BARK.AA BARK 390-491 84 1.7e-77 263.8 In-house 163-264 (264) Show / Hide 
Range on Protein: 390-491
Range on HMM: 163-264/264
Sequence Identity: 84% (86 aa)

GTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHGHSPFRQHKTKDKHEIDRMTLTMDVEFPDKMSDEMRALLAGLLQREVASRLGCEGRGATEVREHP
|||||||||||.||||||||||||||||||.|||.|||||||||||||||||||||||.||.||..|.|||.||.|||||.|..||||.||||.||.|||
GTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLLRGHSPFRQHKTKDKHEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCMGRGAQEVKEHP

FF
||
FF
Kinase BARK.AA GRK 390-491 56 2.8e-73 230.23 In-house 168-272 (272) Show / Hide 
Range on Protein: 390-491
Range on HMM: 168-272/272
Sequence Identity: 56% (59 aa)

GTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHGHSPFRQHKTKDKH-EIDRMTLTMDVEFPDKMSDEMRALLAGLLQREVASRLGCEGR--GATEVR
|||||||||||....|||.|.||.|||||......|||||||||.|.|. |.||......|..|||.|.|.. .. .|||.....||||.|.  ||.||.
GTHGYMAPEVLQNERAYDFSPDWWSLGCMIYEMIEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQEVK

EHPFF
|||||
EHPFF
Kinase BARK.AA SGK 193-389 37 1.5e-70 216.93 In-house 1-221 (283) Show / Hide 
Range on Protein: 193-389
Range on HMM: 1-221/283
Sequence Identity: 37% (84 aa)

FSVHRIIGRGGFGEVYGCRKADT------------------GKMYAMKCLDKKRIK-------MKSGETLALNER-IMLSLVSETDCPFIVCMTYAFQTP
|    .|| |.||.||  .. |.                  .|.|||| | |. |         |  . . . ||   |....    ||||   |||||.
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMK---HPFIVNLHYAFQTK

DKLCFILDLMNGGDLHYHLSQHGVFSEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDENGHVRISDLGLAC-DFSSKKPHASV-GTHGYMAPEVL
.|| | .| .|||.. |||   . |.| .. ||||||.. ||. |  ...|||||| |||||  ||... | ||.  .   ..   .  ||  |.|||||
WKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVL

SKGTAYDSSADWFSLGCMLFKLLHG
 | . .| . ||..||| |. ...|
RKQP-HDRTVDWWCLGCVLYEMMYG
Kinase BARK.AA RSK 196-389 38 7.5e-69 235.05 In-house 1-208 (278) Show / Hide 
Range on Protein: 196-389
Range on HMM: 1-208/278
Sequence Identity: 38% (80 aa)

HRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKSG-ETLALNERIMLSLVSETDCPFIVCMTYAFQTPDKLCFILDLMNGGDLHYHLSQHGV-
..  |.||.|.|. |||    |||. |||| |.|. |. .      .. ||  |...    .||||   |||||..||  |.....||.| .||....  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQ--HPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHF

--FSEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDE---NGHVRISDLGLACDF--S-SKKPHASVGTHGYMAPEVLS---KGTAYDSSADWFSL
  |||.|. ||.|||.| .||.| . ...||||| |||.|.   .||....| |... |  . ... .  ..|. |||||.|    .. ..| ..||.||
GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GCMLFKLLHG
|. .. .| |
GVLMYEMLTG
Kinase BARK.AA AktR 193-384 41 2.1e-68 233.57 In-house 1-196 (268) Show / Hide 
Range on Protein: 193-384
Range on HMM: 1-196/268
Sequence Identity: 41% (83 aa)

FSVHRIIGRGGFGEVYGCRKA-DTGKMYAMKCLDKKRIKMKSGETLALNERIMLS-LVSETDCPFIVCMTYAFQTPDKLCFILDLMNGGDLHYHLSQHGV
| |....|.|.||.|| ..|  |..|.|||| ..|| |. .  .  ...||  .  ..   . |||| . |.||| .|| ||.. . ||.| .||.. . 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCC---NHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK

FSEEEVGFYAAEIILGLEHMHVR-NVVYRDLKPANILLDENGHVRISDLGLAC-DFS---SKKPHASVGTHGYMAPEVLSKGTAYDSSADWFSLGCMLF
||||.. ||.|.|.|.||. | . |..|||||| ||||||.|||.|.| ||.   |    . | .  .||. |||||.. |   .. |.|| ..|. ..
FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIY
Kinase BARK.AA Akt 193-341 46 4.5e-67 213.44 In-house 1-148 (264) Show / Hide 
Range on Protein: 193-341
Range on HMM: 1-148/264
Sequence Identity: 46% (70 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMY-AMKCLDKKRIKMKSGETLALNERIMLSLVSETDCPFIVCMTYAFQTPDKLCFILDLMNGGDLHYHLSQHGVF
| . ...|.| || |. ..| ||.|.| ||| | |..| .|     .. || .|  .    .|||| . |.|||.|||.|..| .|||.| |||.. ..|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN---HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

SEEEVGFYAAEIILGLEHMHVRNVVYRD-LKPANILLDENGHVRISDLGLA
||..  ||.|||||..|| | .|..||| ||| |||.|..||... | ||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase BARK.AA RSK 193-389 39 6.9e-63 215.23 In-house 1-201 (271) Show / Hide 
Range on Protein: 193-389
Range on HMM: 1-201/271
Sequence Identity: 39% (83 aa)

FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKSGETLALNERIMLSLVSETDCPFIVCMTYAFQTPDKLCFILDLMNGGDLHYHLSQHG
. .|. ||.| |..|| |.|    ||.. |||| ..|. .. |.    . .|||.|. .   . ||||   |.||.  |.  |.|.| ||||  .|.  .
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYG---HHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQK

VFSEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDEN----GHVRISDLGLACDFSSKKPHASVG-------THGYMAPEVLSKGTAYDSSADWFS
.|||.|| ||.||| | .|. |   .|.|||||.|||.|.     ||..| |.|.|     |.  .  |       |  |||||||..   .| ..||.|
MFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFA-----KQLRDENGMLMTFCYTANYMAPEVLKR-QGHDQACDWWS

LGCMLFKLLHG
.|  ..  |.|
FGVLMYEMLTG
Kinase BARK.AA p70 193-389 34 3e-57 196.5 In-house 1-234 (299) Show / Hide 
Range on Protein: 193-389
Range on HMM: 1-234/299
Sequence Identity: 34% (83 aa)

FSVHRIIGRGGFGEVYGCRKAD---TGKMYAMKCLDKKRIKMKSGETLALN--------------------------ERIMLSLVSETDCPFIVCMTYAF
|   ...|.||.| |.  ||     |||.|||| | |  |      |                              ||  |. |     |||.   |||
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEV---KHPFICDLHYAF

QTPDKLCFILDLMNGGDLHYHLSQHGVFSEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDENGHVRISDLGLACDF--SSKK----------PHA
||  ||  ||. . || | .||  ||.. |. . ||..|||. ||| | . ..|||||| |..|.. |||   | ||       ...           | 
QTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHT

SVGTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHG
 .||. |||||.|.. ....   ||.|||| ..  | |
FCGTIEYMAPEILMR-CGHNHAVDWWSLGCLMYDMLTG
Kinase BARK.AA AGC 390-491 29 3.1e-48 121.69 In-house 267-395 (395) Show / Hide 
Range on Protein: 390-491
Range on HMM: 267-395/395
Sequence Identity: 29% (40 aa)

G--THGYMAPEVLSKGTAYDSSADWFS--LGCMLFKLLHGHSPFRQH-------------KTKDKHEIDRMTLTMDVEFP----------DKMSDEMRAL
|  |. |||||.|     |. ..|| |  |||... .| |..||. .             .. .| ...|.... .|.||          ...|.| . |
GPCTPEYMAPEIL-----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDL

LAGLLQREVASRLGCEGR-----GATEVREHPFF
. .||... . |||| |.     || |...||.|
IKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase BARK.AA GRK 390-491 42 3.7e-34 119.59 In-house 163-265 (265) Show / Hide 
Range on Protein: 390-491
Range on HMM: 163-265/265
Sequence Identity: 42% (44 aa)

GTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHGHSPFRQHKTK-DKHEIDRMTLTMDVEFP-DKMSDEMRALLAGLLQREVASRLGCEGRGATEVRE
|| |||||||.     |. | ||..||| ..    |.||||| | |  . |.|| ..  ..... .| |.| . .   ||. . . ||||.. |. |||.
GTVGYMAPEVVKNER-YTFSPDWWGLGCLIYEMIEGRSPFRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREEGCDEVRQ

HPFF
||||
HPFF
Kinase BARK.AA RSK 390-491 30 1.7e-33 117.64 In-house 170-278 (278) Show / Hide 
Range on Protein: 390-491
Range on HMM: 170-278/278
Sequence Identity: 30% (34 aa)

GTHGYMAPEVLS---KGTAYDSSADWFSLGCMLFKLLHGHSPFRQHKTK-DKHEIDRMTLTMD--VEFP--DKMSDEMRALLAGLLQREVASRLGCEGRG
.|. |||||.|    .. ..| ..||.|||. .. .| |..||..   . ...|| .  .. .  ...|  ...|.|.. |. ..|.|. . ||||  ..
YTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQD

ATEVREHPFF
| |...||.|
AEEIKQHPWF
Kinase BARK.AA Pkinase 390-491 23 9.4e-28 99.22 Pfam 173-293 (293) Show / Hide 
Range on Protein: 390-491
Range on HMM: 173-293/293
Sequence Identity: 23% (30 aa)

GTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHGHSPFRQH----KTKDKHEIDRMTLTMDVEFPDK---------------------MSDEMRALLA
|| .||||||. .|. |....|..|.||.|. .| |. ||..|    .  |. .. ....  ...|.                       .|.|.. .. 
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

GLLQREVASRLGCEGRGATEVREHPFF
..|..  ..|..     |... .||.|
WCLCKDPKKRPT-----AEQILQHPWF
Kinase BARK.AA SGK 390-491 36 3.8e-26 77.33 In-house 187-283 (283) Show / Hide 
Range on Protein: 390-491
Range on HMM: 187-283/283
Sequence Identity: 36% (37 aa)

GTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHGHSPFRQHKTKDKHEIDRMTLTMDVEFPDKMSDEMRALLAGLLQREVASRLGCEGRGATEVREHP
||  |.||||| | . .| . ||..||| |. ...|  ||     ..| .     .  .  .|  || . . |. ||||...  |||   |.. |...||
GTPEYLAPEVLRKQP-HDRTVDWWCLGCVLYEMMYGLPPFYS---RNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHP

FF
||
FF
Kinase BARK.AA p70 390-491 35 8.6e-21 72.1 In-house 200-299 (299) Show / Hide 
Range on Protein: 390-491
Range on HMM: 200-299/299
Sequence Identity: 35% (37 aa)

GTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHGHSPFRQHKTKDKHEIDRMTLTM-DVEFPDKMSDEMRALLAGLLQREVASRLGCEGRGATEVREH
||. |||||.|.. ....   ||.|||| ..  | |  ||     |..  ||        .. | . . ||| |.  || |....|.|     |....||
GTIEYMAPEILMR-CGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKT--IDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEH

PFF
|||
PFF
Kinase BARK.AA Akt 394-491 32 2.1e-20 61.89 In-house 168-264 (264) Show / Hide 
Range on Protein: 394-491
Range on HMM: 168-264/264
Sequence Identity: 32% (33 aa)

YMAPEVLSKGTAYDSSADWFS-LGCMLFKLLHGHSPFRQHKTKDKHEIDRMTLTMDVEFP--DKMSDEMRALLAGLLQREVASRLGCEGRGATEVREHPF
|.|||.|.. . .. ..|| . ||| .. ...|  ||  .. .|.|.     .. .|.||  |. |.| . |. |||..    |||    .| |...||.
YLAPEILNG-NGHTKAVDWWGSLGCVMYEMMCGRPPF--YN-QDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPW

F
|
F
Kinase BARK.AA RSK 390-491 36 3.4e-20 68.9 In-house 167-271 (271) Show / Hide 
Range on Protein: 390-491
Range on HMM: 167-271/271
Sequence Identity: 36% (39 aa)

GTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHGHSPFRQHKTKDKHE--IDRMTLTM---DVEFPDKMSDEMRALLAGLLQREVASRLGCEGRGATE
.|  |||||||..   .| ..||.|.|  ..  |.|. || |.|..|  .  | |  | |       .|. |||   || ..| |  . |||.   |. .
YTANYMAPEVLKR-QGHDQACDWWSFGVLMYEMLTGCTPF-QNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQ

VREHPFF
...||.|
IKQHPWF
Kinase BARK.AA AktR 390-491 27 3.3e-15 55.21 In-house 166-268 (268) Show / Hide 
Range on Protein: 390-491
Range on HMM: 166-268/268
Sequence Identity: 27% (29 aa)

GTHGYMAPEVLSKGTAYDSSADWFSLGCMLFKLLHGHSPFRQHK-TKDKHEIDRMTLTMDVEFPDKMSDEMRALLA-GLLQREVASRLGCEGRGATEVRE
||. |||||.. |   .. |.|| ..|. .. .. |. || ... . . . |.  .    ...| . |.. . |.  .||..    |||    |..|...
GTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKS

HPFF
||.|
HPWF
Kinase BARK.AA TyrKc 193-475 18 1.1e-10 -49.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 193-475
Range on HMM: 1-280/280
Sequence Identity: 18% (59 aa)

FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKSGETLALNERIM--LSLVSET--DCPFIVCMTYAFQTP-------DKLCFILDLMNGGDL
 .  ...|.| ||||| ..      . | |.| .              | .|  ... ..   . | ||..  .  ..       . |. .. .| .|||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

HYHLSQHGV-FSEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDENGHVRISDLGLACDFSSK------KPHASV----GTHG-----YMAPEVLS
. .|  |.  .. ..   ..  |  | |. | .|.. |||   |.|..||..|.||| ||. |  ..      |   ..    |...      ||||.. 
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

KGTAYDSSADWFSLGCMLFKLLHGGTHGY-------MAPEVLSKGTAYDSSADWFSLGC-MLFKLLHGHSPFRQHKTKDKHEIDRMTLTMDVEFPDKMSD
.   . .  | .| | ... ..  |   |       | .. . .        .    .. |                                |   ..|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------F-VCCPD

EMRALLAGLLQR---------EVASRL
||  .     ..         |. ...
EMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase BARK.AA Akt 358-389 33 2e-06 16.33 In-house 168-199 (264) Show / Hide 
Range on Protein: 358-389
Range on HMM: 168-199/264
Sequence Identity: 33% (11 aa)

YMAPEVLSKGTAYDSSADWFS-LGCMLFKLLHG
|.|||.|.. . .. ..|| . ||| .. ...|
YLAPEILNG-NGHTKAVDWWGSLGCVMYEMMCG
Kinase BARK.AA S_TK_X 492-548 17 2.3e-05 22.73 SMART 1-79 (79) Show / Hide 
Range on Protein: 492-548
Range on HMM: 1-79/79
Sequence Identity: 17% (14 aa)

KTTDWNQVYY--QKVQPPLIPPRGEVNAADAFDIGSFDEDDVKGIKVRNLP---------------------FLTFLNLK
. .||...|   ....|| .|.  ||.| ...|.. ||..  ..  .   .                     |. |    
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase BARK.AA Pkinase_Tyr 268-341 29 0.003725 11.31 Pfam 81-158 (270) Show / Hide 
Range on Protein: 268-341
Range on HMM: 81-158/270
Sequence Identity: 29% (23 aa)

KLCFILDLMNGGDLHYHLSQH----GVFSEEEVGFYAAEIILGLEHMHVRNVVYRDLKPANILLDENGHVRISDLGLA
... .. .| .|||. .| .|    . .. ..   ....|  |.|. . .| . |||   |.|..||..|.|.| |||
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase BARK.AA Pkinase_Tyr 193-208 43 0.899233 3.24 Pfam 1-16 (270) Show / Hide 
Range on Protein: 193-208
Range on HMM: 1-16/270
Sequence Identity: 43% (7 aa)

FSVHRIIGRGGFGEVY
 .  . .|.| |||||
ITFGKKLGEGAFGEVY