Gene NDR (Sea Urchin)

NDR

Species: Sea Urchin
Alias: NDR, Spk010, SPU_012503
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: AGC
Family: NDR
Subfamily: NDR

Sequence

Name Sequence Type Origin Length Description Download
NDR.AA Protein None 459 None Fasta, JSON
NDR.kin_dom Protein Kinase Domain None 297 None Fasta, JSON

Protein domain

Protein domains of NDR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NDR.AA NDR 83-379 54 2.5e-239 746.93 In-house 1-350 (350) Show / Hide 
Range on Protein: 83-379
Range on HMM: 1-350/350
Sequence Identity: 54% (192 aa)

FESIKVIGRGAFGEVRLVQKKDTGHIYAMKILRKCDMHEKEQVAHVRAERDILVEAD--NPWVVKMYYSFQDPYNLYLIMEFLPGGDMMT---LLMKRET
||.||.||.||||||.||.||||||||||||.||..|..|.|||||||||||..|||  ||||||.||||||. .|||.||..|||||||   |||| ..
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LSEEVTLFYIAETIMAINSIHKLNFIHRDIKPDNLLLDARGHIKLSDFGLCTG---------------------LKKSHRTEFYRDLSQVRPNDFSATTC
..|... |||||...||.|.||...|||||||||.|.|..|||||.|||||||                     ....|....|......|| ||.....
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

-KPMDSKR-----------------LAESWKRNRRALAYSTVGTPDYIAPEVFLQ-TGYSHVCDWWSLGVVMYEMLIGYPPFCSETPQETYRKVMHWRET
 .||..|.                  ..|||.|||.|||||||||||.|||||.| |||.. |||||||..|||||.|||||||.|||||..|.|.|..|
SNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQT

L-----QFPAEIPISNEAKGMIQRFCC-EADRRVGKNG--VDEIKSHAFF
.     .||.|...| ||. .|.|.|| ..|.|.|..|  ||||||| ||
WDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase NDR.AA AGC 83-379 31 3.1e-187 489.4 In-house 1-395 (395) Show / Hide 
Range on Protein: 83-379
Range on HMM: 1-395/395
Sequence Identity: 31% (130 aa)

FESIKVIGRGAFGEVRLVQKK------DTGHIYAMKILRKCD--------MHEKEQVAH-------VRAERDILVEAD----------NPWVVK-MYYSF
|| .||||.|.||.|.||.||      |||..||||.|.| .        | |. ...|       |..||.||....          .|..|| ..|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDPYN--LYLIMEFLP---------GG-DMMTLLM---KRETLSEEVTLFYIAE-------TIMAINSIHK-LNFIHRD-IKPDNLLLDARGHIKLSDFG
||. .  ||..||..|         || .... |.   |. ...||.. ||.||       ...|. ..|. ...|||| .||.|.|||..|||||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCTG----------------LKKSHRTEFYRDLSQVRPNDFSATTCKPMDSKRLAESWKRNR-----------RALAYSTVG--TPDYIAPEVFLQTGYS
||.                 ... |.... . .|     ...     .  . . ...|.||.           |..... .|  ||.|.|||..    |.
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KS-----NMD-----T-NK-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YG

HVCDWWS--LGVVMYEMLIGYPPFCSETPQ----------ETYRKVM------HWRETL------QFPAEIPISNEAKGMIQRFCC-EADRRVGKN----
. |||||  ||..|||||.|||||....||          |.. |.|      .|....      |||..  .|.|||  |....| . ..| | .    
KACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDF

---GVDEIKSHAFF
   |..|||.| .|
GDKGAEEIKNHPWF
Kinase NDR.AA DMPK 83-228 49 9.1e-111 274.91 In-house 1-147 (270) Show / Hide 
Range on Protein: 83-228
Range on HMM: 1-147/270
Sequence Identity: 49% (73 aa)

FESIKVIGRGAFGEVRLVQKKDTGHIYAMKILRKCDMHEKEQVAHVRAERDILVEADNPWVVKMYYSFQDPYNLYLIMEFLPGGDMMTLLMKRE-TLSEE
|| .||||||.|||| .|. | |. .||||.. | .|  ....| .. ||||.| .. .|... .| |||. .||..||. ||||. ||. . |  ..|.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

VTLFYIAETIMAINSIHKLNFIHRDIKPDNLLLDARGHIKLSDFGLC
 . ||.|| ..||.|||.. ..|||||||| ||| .||||| ||| |
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSC
Kinase NDR.AA S_TKc 83-379 30 1.2e-98 334.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 83-379
Range on HMM: 1-231/231
Sequence Identity: 30% (96 aa)

FESIKVIGRGAFGEVRLVQKKDTGHIYAMKILRKCDMHEKEQVAHVRAERDILVEADNPWVVKMYYSFQDPYNLYLIMEFLPG--GDMMTLLMKRET---
.| ...||.||||.|.....|.||.|.|.||..           |.| |..|| . . |..||.|..|||  .||..||...|  ||..... || .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSEEVTLFYIAETIMAINSIHKLNFIHRDIKPDNLLLDARGHIKLSDFGLCTGLKKSHRTEFYRDLSQVRPNDFSATTCKPMDSKRLAESWKRNRRA
   ..| .. ||..... |.. .|....||||.||.|.|||   |||..||||.. |                                           
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

LAYSTVGTPDYIAPEVFLQTGYSH-VCDWWSLGVVMYEMLIGYPPFCSETPQETYRKVMHWRETLQFPAEIPISNEAKGMIQRFCC-EADRRVGKNGVDE
  .. .|||.|.||||.   ||..  |||||.|...|||| |||||.  ..|....|..              | ||| .|.. .. . ..| .   . .
--TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

----IKSHAFF
    ||.| .|
DEWDIKCHPWF
Kinase NDR.AA RSK 86-379 33 6e-98 331.7 In-house 1-278 (278) Show / Hide 
Range on Protein: 86-379
Range on HMM: 1-278/278
Sequence Identity: 33% (105 aa)

IKVIGRGAFGEVRLVQKK---DTGHIYAMKILRKCDMHEKEQ-VAHVRAERDILVEAD-NPWVVKMYYSFQDPYNLYLIMEFLPGGDMMTLLMKRET---
.|| |.|..|.| |..|.   |||.|||||.|.|  .  ..  ..|...||.|| .    | .|. .|.||..  ||||||...||.. | | |...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSEEVTLFYIAETIMAINSIHKLNFIHRDIKPDNLLLDA---RGHIKLSDFGLCTGLKKSHRTEFYRDLSQVRPNDFSATTCKPMDSKRLAESWKRNR-R
.||.   ||.|| ..|.  .|.. .||||.||.| |.|    .|||||.|||.|  .                                      |..  
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF--------------------------------------RCDHN

ALAYSTVGTPDYIAPEVFL----QTGYSHVCDWWSLGVVMYEMLIGYPPFCS---ETPQETYRKVMHWRETLQFPAEIPISNEAKGMIQR-FCCEADRRV
 .... ..| .|.|||.      | |... ||||||||.||||| |.||| .   ....|. ..... . .| .|.   .|.|||  |.. .. .  .| 
QWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRL

G--KNGVDEIKSHAFF
|  .....|||.|..|
GCGPQDAEEIKQHPWF
Kinase NDR.AA AktR 83-379 34 2.1e-89 303.32 In-house 1-268 (268) Show / Hide 
Range on Protein: 83-379
Range on HMM: 1-268/268
Sequence Identity: 34% (106 aa)

FESIKVIGRGAFGEVRLVQKK-DTGHIYAMKILRKCDMHEKEQVAHVRAERDILV-EADNPWVVKMYYSFQDPYNLYLIMEFLPGGDMMTLLMKRETLSE
|. .|..|.||||.| ||||| |.. .||||...| .. |..|  |.. ||.|.  ....|  ||..|.||. ..|..|||. |||.. . | |....||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EVTLFYIAETIMAINSIHKL-NFIHRDIKPDNLLLDARGHIKLSDFGLCTGLKKSHRTEFYRDLSQVRPNDFSATTCKPMDSKRLAESWKRNRRALAYST
|...||.|. . |.   |.  | | ||.||.|.|||  ||.|..||||                                         .. .. .||| 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK------------------------------------LQFMMHYDEKAYSF

VGTPDYIAPEVFLQ-TGYSHVCDWWSLGVVMYEMLIGYPPFCSETPQETYRKVMHWRETLQFPAEIPISNEAKGMIQR--FCCEADRRVG--KNGVDEIK
.||| |.|||. ..  |.   .|||..|.. |||..|.||| ..  .. . |    .  ..||  ...|...|  |||  .|     | |  .|| .|||
CGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIK

SHAFF
|| .|
SHPWF
Kinase NDR.AA MAST 83-227 45 6.6e-76 231.22 In-house 1-148 (337) Show / Hide 
Range on Protein: 83-227
Range on HMM: 1-148/337
Sequence Identity: 45% (68 aa)

FESIKVIGRGAFGEVRLVQKKDTGHIYAMKILRKCDMHEKEQVAHVRAERDILVEADNPWVVKMYYSFQD--PYNLYLIMEFLPGGDMMTLLMKRE-TLS
|| ||.|..||.| | ||..|.|. ..|||.... |.  | || .|..||.||....||.||||.||||      |...||.. |||  .||     .. 
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EEVTLFYIAETIMAINSIHKLNFIHRDIKPDNLLLDARGHIKLSDFGL
|. . .|||||. ..  .|.   .|||.||||.|.|. ||||| ||||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase NDR.AA MAST 83-227 47 2.8e-73 235.48 In-house 1-145 (334) Show / Hide 
Range on Protein: 83-227
Range on HMM: 1-145/334
Sequence Identity: 47% (69 aa)

FESIKVIGRGAFGEVRLVQKKDTGHIYAMKILRKCDMHEKEQVAHVRAERDILVEADNPWVVKMYYSFQDPYNLYLIMEFLPGGDMMTLLMKRETLSEEV
|| ||.|..||.| | || .|.|. ..|||...| ||  | .| .|..||.|| ...||.||||.||||   .|...||.. |||  .||    .. |. 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

TLFYIAETIMAINSIHKLNFIHRDIKPDNLLLDARGHIKLSDFGL
. .|||||....  .|.   .|||.||||.|.|. ||||| ||||
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase NDR.AA Akt 83-228 45 5.5e-73 232.62 In-house 1-148 (264) Show / Hide 
Range on Protein: 83-228
Range on HMM: 1-148/264
Sequence Identity: 45% (68 aa)

FESIKVIGRGAFGEVRLVQKKDTGHIY-AMKILRKCDMHEKEQVAHVRAERDILVEADNPWVVKMYYSFQDPYNLYLIMEFLPGGDMMTLLMKRETLSEE
|. .||.|.|.|| | ||.||||. .| |||.|.|    .| ||.|. .|| ||.  ..| .|...||||.. .||..|.. .||.  ..| .... ||.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

VTLFYIAETIMAINSIHKLNFIHRD-IKPDNLLLDARGHIKLSDFGLC
 . ||.|| | ||   |. | | ||  || |.|.|. |||.| |||||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase NDR.AA Pkinase 83-379 25 2.6e-70 244.68 Pfam 1-293 (293) Show / Hide 
Range on Protein: 83-379
Range on HMM: 1-293/293
Sequence Identity: 25% (84 aa)

FESIKVIGRGAFGEVRLVQKKDTGHIYAMKILRKCDMHEKEQVAHVR-AERDILVEADNPWVVKMYYSFQDPYNLYLIMEFLPGG----DMMTLLM--KR
.. ...||.|.||.|.. ..|.||.|.|.||..|.. .......|.| .|  |. . . | .|..|..|.|. ..|..||...||    | .....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

ETL--SEEVTLFYIAETIMAINSIHKLNFIHRDIKPDNLLLDARGHI----KLSDFGLCTGLKKSHRTEFYRDLSQVRPNDFSATTCKPMDSKRLAESWK
 ..  ||..  ||. ... ... .|. ..||||.||.|.|.| .|||    |..||||.  ..                                     
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------------------------------

RNRRALAYSTVGTPDYIAPEVFL-QTGYSHVCDWWSLGVVMYEMLIGYPPFCSE------TPQETYRKVMHWRETLQFPAEIPIS---------------
  .   ... .|||.|.|||| . ...|.. .|.||.|...|||| |.|||...      .... ....|. .   ..| ...||               
Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHN

--NEAKGMIQRFCC-EADRRVGKNGVDEIKSHAFF
   |.|  | . .|    .| .    ..|. | .|
WSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase NDR.AA GEK 83-233 53 3.9e-68 227.72 In-house 1-152 (269) Show / Hide 
Range on Protein: 83-233
Range on HMM: 1-152/269
Sequence Identity: 53% (81 aa)

FESIKVIGRGAFGEVRLVQKKDTGHIYAMKILRKCDMHEKEQVAHVRAERDILVEADNPWVVKMYYSFQDPYNLYLIMEFLPGGDMMTLLMK-RETLSEE
|| .|||||||||||  |. |.|...|||||| | .|  .  .|  | |||.||. |. |. .. | |||  .|||.|..  |||..||| |  . | |.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

VTLFYIAETIMAINSIHKLNFIHRDIKPDNLLLDARGHIKLSDFGLCTGLKK
.  ||||| .|||.|.|.|...||||||||.||| .|||.| ||| |  ..|
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNK
Kinase NDR.AA DMPK 280-379 44 9.4e-63 153.48 In-house 162-270 (270) Show / Hide 
Range on Protein: 280-379
Range on HMM: 162-270/270
Sequence Identity: 44% (48 aa)

VGTPDYIAPEVF--LQTG----YSHVCDWWSLGVVMYEMLIGYPPFCSETPQETYRKVMHW-RETLQFPAEIP--ISNEAKGMIQRFCCEADRRVGKNGV
|||||||.|||   . ..    |   |||||.||.||||| |  ||  ..  ||| | |.  .. |.||.. .  .| ||| .|... |....| |.||.
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGY

DEIKSHAFF
...| | ||
EDFKCHPFF
Kinase NDR.AA ROCK 83-228 47 9.5e-61 205.57 In-house 1-145 (263) Show / Hide 
Range on Protein: 83-228
Range on HMM: 1-145/263
Sequence Identity: 47% (70 aa)

FESIKVIGRGAFGEVRLVQKKDTGHIYAMKILRKCDMHEKEQVAHVRAERDILVEADNPWVVKMYYSFQDPYNLYLIMEFLPGGDMMTLLMKRETLSEEV
|. ||||||||||||.|| .| . ..||||.| | .|  .   |    ||||.  |  .|.|...| |||.  ||..|...||||.. |. . . ..|  
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYD-VPEKW

TLFYIAETIMAINSIHKLNFIHRDIKPDNLLLDARGHIKLSDFGLC
. || .| ..|...|| . |||||.||||.|||  ||.|| ||| |
ARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTC
Kinase NDR.AA MAST 280-379 42 1.3e-40 121.36 In-house 229-337 (337) Show / Hide 
Range on Protein: 280-379
Range on HMM: 229-337/337
Sequence Identity: 42% (46 aa)

VGTPDYIAPEVFLQTG-YSHVCDWWSLGVVMYEMLIGYPPFCSETPQE-TYRKVMHWRETLQFPAE------IPISNEAKGMIQRF-CCEADRRVGKNGV
.|||||||||| | .| |.   ||||.|..||| |.|.|||  .||.| .  .. .  . . .| |       ..| ||.  |...       | | ||.
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGA

DEIKSHAFF
||||.|.||
DEIKQHPFF
Kinase NDR.AA ROCK 280-379 48 5.9e-39 130.13 In-house 160-263 (263) Show / Hide 
Range on Protein: 280-379
Range on HMM: 160-263/263
Sequence Identity: 48% (50 aa)

VGTPDYIAPEVFLQTG----YSHVCDWWSLGVVMYEMLIGYPPFCSETPQETYRKVMHWRETLQFPAEIPISNEAKGMIQRFCCEADRRVGKNGVDEIKS
|||||||.|||    |    | . ||||| || .||||.|  ||  ..   || |.|  .. |.|| .. ||..|| .|..|  ....|.|.||||.|| 
VGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQ

HAFF
| ||
HKFF
Kinase NDR.AA GEK 280-379 46 2.5e-38 125.99 In-house 162-269 (269) Show / Hide 
Range on Protein: 280-379
Range on HMM: 162-269/269
Sequence Identity: 46% (50 aa)

VGTPDYIAPEVF--LQTG---YSHVCDWWSLGVVMYEMLIGYPPFCSETPQETYRKVMHWRETLQFPAEIP---ISNEAKGMIQRFCCEADRRVGKNGVD
|||||||.||.   .. |   |   ||||||||.||||| |  || .|   ||| |.|.... .|||..     .|.||| .|..  |....|.|.||..
VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQ

EIKSHAFF
. | |.||
DFKKHPFF
Kinase NDR.AA MAST 280-379 39 1e-36 115.68 In-house 225-334 (334) Show / Hide 
Range on Protein: 280-379
Range on HMM: 225-334/334
Sequence Identity: 39% (43 aa)

VGTPDYIAPEVFLQTG-YSHVCDWWSLGVVMYEMLIGYPPFCSETPQETYRKVMHWR-ETLQFPAE------IPISNEAKGMIQRF-CCEADRRVGKN-G
.|||||||||| |..| ..   ||||.|..||| |.|.|||. .||.|.. .. . .     .| .      . .| ||.  |...  .    | | | |
CGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGANNG

VDEIKSHAFF
.||.|.| ||
ADEVKQHPFF
Kinase NDR.AA Akt 276-379 35 1.4e-27 85.2 In-house 159-264 (264) Show / Hide 
Range on Protein: 276-379
Range on HMM: 159-264/264
Sequence Identity: 35% (39 aa)

AYSTVGTPDYIAPEVFLQTGYSHVCDWWS-LGVVMYEMLIGYPPFCSETPQETYRKVMHWRETLQFPAEIPISNEAKGMIQRFCCEADR--RVG--KNGV
...  ||| |.|||. ...|..  .|||. ||.|||||. | ||| ..  .. . | .   . ..||  . ||.|.|  | . ... |.  | |  .|..
TKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKN--QPVKFPDKDWISPECKDLISG-LLNKDPKKRLGGGPNDA

DEIKSHAFF
.|||.| .|
QEIKRHPWF
Kinase NDR.AA TyrKc 83-379 19 4.1e-11 -43.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 83-379
Range on HMM: 1-280/280
Sequence Identity: 19% (64 aa)

FESIKVIGRGAFGEVRLVQKKDTGHIYAMKILRKCDMHEKEQVAHVRAERDILVEA--DNPWVVKMYYSFQDP-------YNLYLIMEFLPGGDMMTLLM
 . .|..|.||||||.. . |      | | |...       ..  . |  |. .   ..| .|..|    ..         |...||. |.||    | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KRET-LSEEVTLFYIAETIMAINSIHKLNFIHRDIKPDNLLLDARGHIKLSDFGLCTGLKKS-HRTEFYRDLSQVRPNDFSATTCKPMDSKRLAESWKRN
|..  |. .  | .        . .|. |.||||.   | |.......| |||||.  ..   ..                                   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----------------------------------

RRALAYST---VGTPD-----YIAPEVFLQTGYSHVCDWWSLGVVMYEML-IGYPPFCS-----ETPQETYRKVMHWRETLQFPAE--------IPISNE
 .   |..    |. .       |||..    ...  | || ||.|.|..  | .|         ..|| ...|.. .. .  |..         |    
ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-GYRMPQPPNDYPMSFVCCPDEMY

AKGMIQRFCCE-ADRRVGKNGVDEIKSHAFF
   .... . | .. |   . .     | .|
Q--IMKQCWHEDPEDRPTFSEI-----HECF
Kinase NDR.AA Pkinase_C 397-442 27 7.1e-08 31.01 Pfam 1-46 (46) Show / Hide 
Range on Protein: 397-442
Range on HMM: 1-46/46
Sequence Identity: 27% (13 aa)

NIKSFEDTSNFDAFPEIELKPIT-PPQATGEHMKDWVFINYTFKRFE
..|| .|||||| . . |  . | |..     .... |...|.....
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase NDR.AA Pkinase_Tyr 155-228 28 5.8e-05 17.43 Pfam 81-158 (270) Show / Hide 
Range on Protein: 155-228
Range on HMM: 81-158/270
Sequence Identity: 28% (22 aa)

NLYLIMEFLPGGDMMTLLMK----RETLSEEVTLFYIAETIMAINSIHKLNFIHRDIKPDNLLLDARGHIKLSDFGLC
..|..||. |.||. . | |    .. |. .  | . ..  .. .  .  |.||||.   | |..  ...| .||||.
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase NDR.AA S_TK_X 380-440 24 0.00019 14.33 SMART 1-79 (79) Show / Hide 
Range on Protein: 380-440
Range on HMM: 1-79/79
Sequence Identity: 24% (20 aa)

HGVDWEHIR-----ERPAAIPTNIK----SFEDTSNFD-AFPEIELKPITPPQA--TGEHMKDW--------VFINYTFKR
.|.||....       |  .| .||    | .||||||  |.| . .  ||..   .. .  .          |...|...
RGIDWDKLYNQQKEIEPPFKP-KIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase NDR.AA Pkinase_Tyr 287-331 29 0.001681 12.48 Pfam 182-228 (270) Show / Hide 
Range on Protein: 287-331
Range on HMM: 182-228/270
Sequence Identity: 29% (14 aa)

APEVFLQTGYSHVCDWWSLGVVMYEMLI-GYPP-FCSETPQETYRKV
|||..    ...  | || ||.|.|..  |  | .   ...| |...
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase NDR.AA Pkinase_Tyr 83-99 47 0.015742 9.19 Pfam 1-17 (270) Show / Hide 
Range on Protein: 83-99
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

FESIKVIGRGAFGEVRL
 . .|..|.||||||..
ITFGKKLGEGAFGEVYK