Gene PKA (Sea Urchin)

PKA

Species: Sea Urchin
Alias: PKA, SPU_016045, Spk013
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: PKA

Sequence

Name Sequence Type Origin Length Description Download
PKA.AA Protein None 233 None Fasta, JSON
PKA.kin_dom Protein Kinase Domain None 180 None Fasta, JSON

Protein domain

Protein domains of PKA.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PKA.AA PKA 1-180 70 1.2e-147 496.77 In-house 77-263 (263) Show / Hide 
Range on Protein: 1-180
Range on HMM: 77-263/263
Sequence Identity: 70% (131 aa)

MVLDYIPGGEMFSHLRRIGRFSEPHSRFYAA-QIVLAFEYLHHLDLIYRDLKPENILIQENGYIAVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSK-GY
||..|.|||||||.||. ||||.||..|||| |||||.||||....|||||||||||| .||.| .|||||||.|..|||||||||||||||||.|| |.
MVMEYVPGGEMFSYLRKSGRFSNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDDRTWTLCGTPEYLAPEIIQSKNGH

NKAVDWWALGVLIYEMAAGYPPFFAD--QPIQIYEKIVSGKVRFPSHFSADL---KDILRSLLQVDLTKRYGNLKAGVADIKLHKWF
.|.|||||||.|||||.||||||...  .|.||||||..||..||.||. |.   || ...||||||||||||.|.|| ||| ||||
GKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase PKA.AA AGC 1-180 34 3.8e-132 343.65 In-house 110-395 (395) Show / Hide 
Range on Protein: 1-180
Range on HMM: 110-395/395
Sequence Identity: 34% (99 aa)

MVLDYIP---------GG-EMFSHLR---RIGRFSEPHSRFYAAQ-------IVLAFEYLHH-LDLIYRD-LKPENILIQENGYIAVTDFGFAKRVKG--
.|..|.|         || |.|.||.   . |||.|...|||||.       ||||.||||  .. |.|| |||||||. |.|.|  ||||..|....  
FVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDG

---------------------------------------------------RTWTLCG--TPEYLAPEIILSKGYNKAVDWWA--LGVLIYEMAAGYPPF
                                                   ||||.||  ||||.||||.    |.||.|||.  ||.|.||| .|||||
EKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPF

FAD----------QPIQIYEKIV------SGKVRFP----------SHFSADLKDILRSLLQVDLTKRYGNLKA-----GVADIKLHKWF
..|          .| ....||       . ||.||          ..|| ..||... ||..| .|| |...      |. .|| |.||
YGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKA.AA Akt 1-180 48 4.1e-96 307.73 In-house 77-264 (264) Show / Hide 
Range on Protein: 1-180
Range on HMM: 77-264/264
Sequence Identity: 48% (92 aa)

MVLDYIPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHHLDLIYRD-LKPENILIQENGYIAVTDFGFAK-R-VKG--RTWTLCGTPEYLAPEIILS
.|.||..||| |.||.| .||||.  |||.|.|.|| |.||. . |||| |||||||. ..|.|..|||| .|   .|   .| |.|||||||||||.. 
FVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNG

KGYNKAVDWWA-LGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP--SHFSADLKDILRSLLQVDLTKRYGNLKAGVADIKLHKWF
.|. ||||||. ||...|||  | |||....  | ..|| ...|.||  . .| . ||....||. | .|| |. . .. .|| | ||
NGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKA.AA SGK 1-180 47 3.5e-94 291.22 In-house 102-283 (283) Show / Hide 
Range on Protein: 1-180
Range on HMM: 102-283/283
Sequence Identity: 47% (87 aa)

MVLDYIPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHHLDLIYRDLKPENILIQENGYIAVTDFGFAK---RVKGRTWTLCGTPEYLAPEIILSKG
.|.||. |||||.||.| ..|.|. .|||||.||.| |||| .| |||||||||||    |..  |||| .|     .  | | ||||||||||... ..
FVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQP

YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSADLKDILRSLLQVDLTKRYGNLKAGVADIKLHKWF
. ..|||| || . |||  | |||.     | |..| ... ..|  .|.| .|..  ||| | .|| |  |.. ..|| | .|
HDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase PKA.AA AktR 2-180 46 3.6e-86 292.58 In-house 79-268 (268) Show / Hide 
Range on Protein: 2-180
Range on HMM: 79-268/268
Sequence Identity: 46% (89 aa)

VLDYIPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHHL-DLIYRDLKPENILIQENGYIAVTDFGFAK----R-VKGRTWTLCGTPEYLAPEIILS
...|.||||.|.||.....|||  .|||.|||.||.||||   . |||||||||||. |.|..  |||| .|    .    .. ..||||||.|||.|. 
IMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITK

-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK-VRFPSH--FSADLKDILR-SLLQVDLTKRYGNLKAGVADIKLHKWF
 ||.||.|||||.|..|||| .|.|||....  |...|| .   ..|| .  ||  .||..   ||. . .|| |  ..|  .|| |.||
KKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKA.AA RSK 1-180 41 2.9e-77 262.99 In-house 78-278 (278) Show / Hide 
Range on Protein: 1-180
Range on HMM: 78-278/278
Sequence Identity: 41% (83 aa)

MVLDYIPGGEMFSHLRRIGR---FSEPHSRFYAAQIVLAFEYLHHLDLIYRDLKPENILIQE---NGYIAVTDFGFAKRV----KGRTWTLCGTPEYLAP
....|..|||.| ||.. ..   |||   .||.|.|||| |.|| .. |.|||||||||  .   .| | .|||||.|      ...| | |.| ||.||
LIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAP

EIIL----SKGYNKAVDWWALGVLIYEMAAGYPPFFA---DQPIQIYEKIVSGK--VRFP--SHFSADLKDILRSLLQVDLTKRYGNLKAGVADIKLHKW
|..      .|..||.||| ||||.||| .|.||| .   ... .| ..| .||  ...|  .  |.. ||..| .|..|  ||.|  . ....|| |.|
EMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPW

F
|
F
Kinase PKA.AA Ciliate-E2b 1-180 35 2.8e-72 218.97 In-house 77-272 (272) Show / Hide 
Range on Protein: 1-180
Range on HMM: 77-272/272
Sequence Identity: 35% (72 aa)

MVLDYIPGGEMFSHLRRIG--RFSEPHSRFYAAQIVLAFEYLHHLDLIYRDLKPENILIQENGYIAVTDFGFAKRVK---G---RTWTLCGTPEYLAPEI
...... |.|.|. .| ||   .|.  |.|| |.|.|..||||..  ||||.|||||.. ..||.   |.| ||  .   .   || |..|||.|.||||
FMMEFCNGMELFDVIREIGRLLLSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEI

IL-----SKGYNKAVDWWALGVLIYEMAAGYPPFF--ADQPIQIYEKIVSG--KVRFPSHFSADLK--DILRSLL----QVDLTKRYGNLKAGVADIKLH
|       |||. .|| |..|.  ||.  ||.|.   .. |..||..|...  .. |||...  ..  ..  ..|    .|.| ..|. ||.       |
IQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKS-------H

KWF
.||
PWF
Kinase PKA.AA PKG 8-180 46 7e-71 241.79 In-house 84-260 (260) Show / Hide 
Range on Protein: 8-180
Range on HMM: 84-260/260
Sequence Identity: 46% (82 aa)

GGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHHLDLIYRDLKPENILIQENGYIAVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGYNKAVDWW
|||. . ||  |.| .. .|||.| .| ||.|||   .|||||||||..  ..||.   ||||||...  ..||| |||||| |||||| ||   .||.|
GGELWTILRDRGHFDDKTTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYW

ALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSADLKDILRSLLQVDLTKRYGNLKAGVADIKLHKWF
|||.|..|   | ||| .  |...|  | .|  .. ||.. .   ... ..|     | | |..| |..||| ||||
ALGILMCELLTGNPPFSGSDPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase PKA.AA p70 2-180 39 2.2e-70 240.11 In-house 106-299 (299) Show / Hide 
Range on Protein: 2-180
Range on HMM: 106-299/299
Sequence Identity: 39% (76 aa)

VLDYIPGGEMFSHLRRIGRFSEPHSRFYAAQIVLAFEYLHHLDLIYRDLKPENILIQENGYIAVTDFGFAKRV--KGRT-----------WTLCGTPEYL
.|.|..||| | || | | . |   .||.. |..| |.|| .. |||||||||..  . | .  ||||  |    .|             .|.|||.|| 
ILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCGTIEYM

APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--VRFPSHFSADLKDILRSLLQVDLTKRYGNLKAGVADIKLHKWF
||||.. .|.|.|||||.||.|.| |  | ||| .. . .. .||  ||  .. |   ... .|... ||  . |.| |     .|||. |..|
APEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase PKA.AA Pkinase 1-180 31 3.4e-64 224.39 Pfam 77-293 (293) Show / Hide 
Range on Protein: 1-180
Range on HMM: 77-293/293
Sequence Identity: 31% (71 aa)

MVLDYIPGG----EMFSHLR--RIGRF--SEPHSRFYAAQIVLAFEYLHHLDLIYRDLKPENILIQENGYI----AVTDFGFA----KRVKGRTWTLCGT
||..| .||    . |....  | |.|  || . .||. ||. . ||.|    |.|||||||||| .||.|     ..|||.|       .. ..|.|||
MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT

PEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFAD------QPIQIYEKIVSGKVRFPSHFS---------------------ADLKDILRSLL
|.|.|||.|. ...| ..||.|..|...|||. |.|||  .       ..|....| .....|..  .                      ..||.....|
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

QVDLTKRYGNLKAGVADIKLHKWF
..| .||..      ..|. |.||
CKDPKKRPT-----AEQILQHPWF
Kinase PKA.AA Ciliate-E2-Unclassified 1-180 27 5.5e-63 215.58 In-house 98-352 (352) Show / Hide 
Range on Protein: 1-180
Range on HMM: 98-352/352
Sequence Identity: 27% (72 aa)

MVLDYIPGGEMFSHLRRI-----------------GRFSEPHSR-----FYAAQIVLAFEYLHHLD-LIYRDLKPENILIQENG---YIAVTDFGFAKRV
.|..|..||... ...                    .|.| ...     ||.|||....|||||    |.||.||||||...||   || ..|||..|. 
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

KGR------------------TWTLCGTPEYL----APEIILSKGYN----KAVDWWALGVLIYEMAAGYPPFFADQPIQ----------------IYEK
.                    .|| ||||.|.    |||.. ...|.    ...|.|.|||..|||  ||.||.. . .|                .|..
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

IVSGKVRFPS--------HFSADLKDILR----SLLQVDLTKRYGNLKAGVADIKLHKWF
|  ... ||.        | |   ||...    ..|.... ||.     .  .|. | ||
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-----TFEQILNHPWF
Kinase PKA.AA S_TKc 1-180 30 5.6e-45 156.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-180
Range on HMM: 1-231/231
Sequence Identity: 30% (78 aa)

M---------------------------------------------------------------VLDYIPG--GEMFSHLRRIGR------FSEPHSRFY
                                                                |..|..|  |..|..... ||      |.| | |||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

AAQIVLAFEYLHHLDLIYRDLKPENILIQENGYIAVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNK-AVDWWALGVLIYEMAAGYPPFFADQPIQ
..||..| ||.| .  |.|||||||||. |   | ..|||.|...     |.||||.|.|||..   ||.| ..|||..|...|||..|||||   |. .
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQM

IYEKIVSGKVRFPSHFSADLKDILRSLLQVDLTKRYGNLKAGV--ADIKLHKWF
...||.          | ..||..| .||.| .||..  .|     |||.| ||
MFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKA.AA S_TK_X 181-233 20 7.6e-14 53.24 SMART 1-79 (79) Show / Hide 
Range on Protein: 181-233
Range on HMM: 1-79/79
Sequence Identity: 20% (16 aa)

QSTDWIAIYQ--QRVDAPFVPRVK----GPGDASQFD-EYEEEALKISLTEK-------------------CVKEFADF
 ..|| ..|.  ... .||.|..|    .|.|.|.|| |..||. . . ...                   .   ...|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKA.AA TyrKc 1-167 14 8.3e-07 -112.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-167
Range on HMM: 1-280/280
Sequence Identity: 14% (41 aa)

MVLD---------------------------------------------------------------------------YIPGGEMFSHLRRIGR-FSEP
 .|.                                                                           | |.|   ..||. .. .. .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

HSRFYAAQIVLAFEYLHHLDLIYRDLKPENILIQENGYIAVTDFGFAKRVKGR-------TWTLC----GTPE-----YLAPEIILSKGYNKAVDWWALG
.   .. ||    ||||.  .| |||   |.|. ||. . ..||| .. ..                  |.        .||| |  . .. . | |. |
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG

VLIYEMAA-GYPPFFA-----DQPIQIYEKIVSG-KVRFPSH--------FSADLKDILRSLLQVDLTKR------YGNL
|...|.   | .|          .....|.. .|   . | .         .... .| ..  . |  .|      .  .
VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF