MSK

Species: Sea Urchin
Alias: SPU_024721, MSK, SPU_024930, Spk026
External Links: Sea Urchin Project Link
Annotation: Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: MSKb,

Classification

Group: AGC
Family: RSK
Subfamily: MSK

Sequence

Name Sequence Type Origin Length Description Download
MSK.AA Protein None 801 None Fasta, JSON
MSK.kin_dom Protein Kinase Domain None 116 None Fasta, JSON
MSK.kin_dom2 Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of MSK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MSK.AA MSK 1-111 56 1.5e-69 234.26 In-house 8-118 (277) Show / Hide
Range on Protein: 1-111
Range on HMM: 8-118/277
Sequence Identity: 56% (63 aa)

AYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNGGELFTHLYQREHFRESEVRIYI
.|||.|..||...|..|||||||.|.|||.|||.||||||.||||.||.....|..|.||||||......|...|.||||||||...||||.|||.|...
GYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDESECRMIM

AEIIIALDCLH
.|...|.|..|
RELVMAVDHMH

Kinase MSK.AA AGC 1-111 37 6.7e-68 173.7 In-house 11-170 (395) Show / Hide
Range on Protein: 1-111
Range on HMM: 11-170/395
Sequence Identity: 37% (60 aa)

AYGKVFLVRKVGNH---NQGKLYAMKVLKKAT-IVQKAK-TAEHTMTE------------RQVLEAVRS---------CPFLVT-LHYAFQTDSK--LNL
..|||.||||....     ||.||||||||.. ||.| | . ||||||            |..|| ...         .||.|  |||.||....  | .
SFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYF

ILD----YVN-----GG-ELFTHLY---QREHFRESEVRIYIAE-------IIIALDCLH
...    |||     || |||.||.   .. .| |...|.|.||       |. ||. ||
VMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLH

Kinase MSK.AA RSK 1-111 57 9.1e-63 214.84 In-house 8-121 (278) Show / Hide
Range on Protein: 1-111
Range on HMM: 8-121/278
Sequence Identity: 57% (66 aa)

AYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNGGELFTHLYQREH---FRESEVR
.||||||.||...|..|..|||||||||.|||..|...||||||..||.....||.|||||||||..|| ||..|..||||||||....|   | |.|..
GYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEAC

IYIAEIIIALDCLH
.|.|||. |...||
FYMAEIVLAVEHLH

Kinase MSK.AA RSK 1-111 37 3e-33 116.08 In-house 11-118 (271) Show / Hide
Range on Protein: 1-111
Range on HMM: 11-118/271
Sequence Identity: 37% (42 aa)

AYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNGGELFTHLYQREHFRESEVRIYI
...||....|.     ...||||..||||.. | .    . .|| .|. . . || |.|||.||.  |. .|.|   ||.||..|     | |.||..| 
SFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIILRYGHH-PFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREVKFYM

AEIIIALDCLH
|||  |...||
AEIALAMEYLH

Kinase MSK.AA AGC 112-158 34 8.6e-26 62.3 In-house 326-395 (395) Show / Hide
Range on Protein: 112-158
Range on HMM: 326-395/395
Sequence Identity: 34% (24 aa)

RIL------TSHPPMP----------NTFSKEVKDFINKLLVKDPTKRLGCN-------GVKDIKSHSFF
.|.      .  ...|            ||.| ||.|.|||.|||.|||||.       |...||.| .|
KIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF

Kinase MSK.AA CAMK 1-111 15 1.7e-18 55.58 In-house 6-196 (425) Show / Hide
Range on Protein: 1-111
Range on HMM: 6-196/425
Sequence Identity: 15% (30 aa)

AYGKVFLVRKV-GN---------HNQGKLYAMKVLKKATIVQ------------------------KAKTAEHTMTERQVLEAVR------SCPFLVTLH
..|||.|..    .          | |. .|.|...|  .                          ..|. .  . | ...  ..      . | .. |.
SFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLY

YAFQ------------TDSK--------LNLIL---DYVNGGEL----FTHLYQREH---------------FRESEVRIYIAEIIIALDCLH
 ...            | ||        . ...   .|. ||||    | .. ....               | |.|.| |.  |. |.. .|
EVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH

Kinase MSK.AA Ciliate-E2 1-111 24 7.1e-18 57.92 In-house 11-177 (365) Show / Hide
Range on Protein: 1-111
Range on HMM: 11-177/365
Sequence Identity: 24% (41 aa)

AYGKVFLV--RKVGNH------------------NQGKLYAMKVLKKATIVQKAKTAEHTM----------TERQVLEAVRSCPFLVTLHYAFQ--TDSK
..|.|...  .||..                   ...|.||||..||  | |. |  .| |           |...||   ..|... ....||  .|..
NFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQI-KQEIHIMREINCFYKKINEKNILE-QLNHPNIIKMYECFQEKDDNN

LNLILDYVNGGELFTHLYQREHFR-----------ESEVR---------------IYIAEIIIALDCLH
. |...|..||.|| ..... ..|           | |..                |||.|| ||  ||
IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH

Kinase MSK.AA RSK 112-158 41 7.1e-16 54.81 In-house 226-278 (278) Show / Hide
Range on Protein: 112-158
Range on HMM: 226-278/278
Sequence Identity: 41% (22 aa)

RILTSH--PPMP--NTFSKEVKDFINKLLVKDPTKRLGCN--GVKDIKSHSFF
||.. .  ..||  .. |.| ||.|.|.| .|| |||||.  ....||.|..|
RIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase MSK.AA Pkinase 1-108 22 3.7e-15 54.66 Pfam 11-122 (293) Show / Hide
Range on Protein: 1-108
Range on HMM: 11-122/293
Sequence Identity: 22% (26 aa)

AYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQ-KAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNGG----ELFTHLY--QREHF--
..|.|.. ...|.     ..|.|..|| ..   | .|. .. .| |..  . ..|. |.|...|...... ....|..||    .||...   ..  |  
SFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

RESEVRIYIAEIIIALD
 | |.. |. .|. .|.
SEWECKFYMYQILRGLE

Kinase MSK.AA S_TK_X 159-221 28 1.2e-14 55.88 SMART 1-79 (79) Show / Hide
Range on Protein: 159-221
Range on HMM: 1-79/79
Sequence Identity: 28% (23 aa)

KGLNWDDVAA--KRVSPPFRPHIN----GELDTSNFAEEFTSLVPADSPADI--PKTADARV---------FRVGYSFIA
.|..||.. .  |.. |||.| |.    .. ||||| .|||. .| ..|.|    ......          || |.....
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFR-GFTYVF

Kinase MSK.AA S_TKc 1-158 22 6.3e-14 27.27 SMART 11-231 (231) Show / Hide
Range on Protein: 1-158
Range on HMM: 11-231/231
Sequence Identity: 22% (54 aa)

AYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNG--GELFTHLYQREH------FR
|.|||...|...    |...|.|..|           ||.. |.|.|.    .|..|.|...||. ..| ....|..|  |.||... .| .      | 
AFGKVYKCRHKK---TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

ESEVRIYIAEIIIALDCLHR---------------------------------------------------------------ILTSHPPMPNTFSK---
| ..| |...|. ||. .|.                                                                |.  || | .  .   
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFK

-----EVKDFINKLLVKDPTKRLGCNGVKD----IKSHSFF
     |.||||.|.|.|||.||...  .      ||.| .|
KIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase MSK.AA RSK 119-158 40 3.4e-12 40.01 In-house 230-271 (271) Show / Hide
Range on Protein: 119-158
Range on HMM: 230-271/271
Sequence Identity: 40% (17 aa)

PMPNTFSKEVKDFINKLLVKDPTKRLGC--NGVKDIKSHSFF
. ... |.| || . ..|  ||..|||.  |||..||.|..|
GNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF

Kinase MSK.AA Ciliate-E2 121-158 38 5.6e-12 37.38 In-house 326-365 (365) Show / Hide
Range on Protein: 121-158
Range on HMM: 326-365/365
Sequence Identity: 38% (16 aa)

PNTFSKEVKDFINK----LLVKDPTKRLGCNGVKDIKSHSFF
..  |.|.||.|.|    .|.||| ||..  | ..|. | .|
WKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF

Kinase MSK.AA MSK 112-153 37 5.8e-12 36.73 In-house 230-277 (277) Show / Hide
Range on Protein: 112-153
Range on HMM: 230-277/277
Sequence Identity: 37% (18 aa)

RILTSHPPMP----NTFSKEVKDFINKLLVKDPTKRLGCN--GVKDIK
||... .. |    ...|.. ||.| .|| ||| ||||.|  ..  .|
RICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK

Kinase MSK.AA CAMK1 1-111 22 7.1e-12 30.74 In-house 11-125 (276) Show / Hide
Range on Protein: 1-111
Range on HMM: 11-125/276
Sequence Identity: 22% (27 aa)

AYGKVFLVRKVGN-HNQGKLYAMKVLKKATIVQKAKTAEHTM-------TERQVLEAV--RSCPFLVTLHYAFQTDSKLNLILDYVNGGELFTHLYQREH
| ..|.|. .  .    || ||.|...|     |  .....|       .| ...  |   ..|. . ..  ...|... |....|.|||||    ....
AFSEVYLCTHKETQT-NGKQYAIKCIDK-----KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKGN

FRESEVRIYIAEIIIALDCLH
. | . |  . .|. |.  .|
YTEKDARHIMKQILSAVEYMH

Kinase MSK.AA CAMKL 1-112 21 2.8e-09 25.63 In-house 11-145 (297) Show / Hide
Range on Protein: 1-112
Range on HMM: 11-145/297
Sequence Identity: 21% (29 aa)

AYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQKAKTAEH-----------TMTERQVLEAVR--SCPFLVTLHYAFQTDSK------LNLILDYVNGGE-
..||| | . . .   |. .|.|...|  |  . ..  .              | | .. ..    |  . |.  ..|...      ..|.. |. ||| 
SFGKVKLATHIRTT--GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEM

-LFTHLYQREH----FRESEVRIYIAEIIIALDCLHR
 || .. ...|    . |.| | |   |. |.. .|.
DLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHS

Kinase MSK.AA CAMK 121-158 31 1e-08 23.44 In-house 392-425 (425) Show / Hide
Range on Protein: 121-158
Range on HMM: 392-425/425
Sequence Identity: 31% (12 aa)

PNTFSKEVKDFINKLLVKDPTKRLGCNGVKDIKSHSFF
. ..|.|.||.|.|.|..||.||. .   .....| ..
H-FVSQECKDLIRKMLQVDPEKRMTI---EQCLNHPWM

Kinase MSK.AA Pkinase_C 178-223 31 2.8e-08 32.42 Pfam 1-46 (46) Show / Hide
Range on Protein: 178-223
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

HINGELDTSNFAEEFTSLVPADSP--ADIPKTADARVFRVGYSFIAPS
......||||| .|||.  | |.|   .    .| . | .|... .|.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPF-RGFTYVNPD

Kinase MSK.AA Pkinase 110-158 25 3.7e-08 29.92 Pfam 231-293 (293) Show / Hide
Range on Protein: 110-158
Range on HMM: 231-293/293
Sequence Identity: 25% (17 aa)

LHRILTSHPPMPNTFS-----------------KEVKDFINKLLVKDPTKRLGCNGVKDIKSHSFF
....| .. | ... |                 .| ||||...| |||.||..    ..|. | .|
MGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF

Kinase MSK.AA CAMK1 125-144 47 4.9e-08 19.38 In-house 245-265 (276) Show / Hide
Range on Protein: 125-144
Range on HMM: 245-265/276
Sequence Identity: 47% (10 aa)

SKE-VKDFINKLLVKDPTKRL
|.. .||||...|..||.||.
SDQEAKDFIKHMLEVDPKKRY

Kinase MSK.AA CAMKL 117-158 28 9.7e-08 20.62 In-house 260-297 (297) Show / Hide
Range on Protein: 117-158
Range on HMM: 260-297/297
Sequence Identity: 28% (12 aa)

HPPMPNTFSKEVKDFINKLLVKDPTKRLGCNGVKDIKSHSFF
.|| ..  | ...|.| |.|...|.||  .   ..|..| ..
YPPIWYHVS-DCRDLIRKMLQVNPEKRPTI---HQIMNHPWM

Kinase MSK.AA MAPKAPK 8-113 27 5.3e-07 17.24 In-house 15-122 (292) Show / Hide
Range on Protein: 8-113
Range on HMM: 15-122/292
Sequence Identity: 27% (31 aa)

VRKVGNHNQGKLYAMKVLKKA--TIVQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQT----DSKLNLILDYVNGGELFTHLYQ--REHFRESEVRIY
|..  .   |. || |.|..    . |||        |   .  .  .|  | ..  |      |... |..   .||||| |  |  . || | |..  
VQTCVHKRTGQEYAVKILEDQPGHSRQKA------RREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHFTEREASQI

IAEIIIALDCLHRI
. .|  |.| ||..
MKDICSAVDFLHSM

Kinase MSK.AA CDPK 125-144 55 6e-06 14.4 In-house 241-260 (271) Show / Hide
Range on Protein: 125-144
Range on HMM: 241-260/271
Sequence Identity: 55% (11 aa)

SKEVKDFINKLLVKDPTKRL
|.| || |.|.|..|| ||.
SDEAKDLIRKMLCYDPKKRM

Kinase MSK.AA MAPKAPK 125-144 65 9e-06 13.31 In-house 262-281 (292) Show / Hide
Range on Protein: 125-144
Range on HMM: 262-281/292
Sequence Identity: 65% (13 aa)

SKEVKDFINKLLVKDPTKRL
|.|.|| | |||..|||.||
SEEAKDLIRKLLRRDPTQRL

Kinase MSK.AA MSK 269-530 53 2.4e-173 582.16 In-house 1-277 (277) Show / Hide
Range on Protein: 269-530
Range on HMM: 1-277/277
Sequence Identity: 53% (147 aa)

MKSA-PIGDGSFSICRRCTHRKTEKEYAVKIVS-------RRVACT--QEITTLQLCQKHPNIVHLKEEFKDKLHTYIIMELCKGGELLGRIRKKKHFDE
.|.. ..|.|.|.|||.|.|..|.|.||.||.|       |..|..  .|...|..||.|||||.|...|.|..|||..||.|.||||...|||..||||
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

LEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDAELKIIDFGFARITNSN--QPLKTPCFSLHFAAPEVLKRAYEQDGEYDASCDVWSLGVIL
 |..||||.||.|||.||..||.|||||||||||.|..|....|.|||||||.....  ...|.|||.||..|||.|.|.|.|||.||..||.|||||||
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

YTMLSGRVPFQ--DPSIS-KSNSASDIMKRIKHGNFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLTTDDLLQNEWI
||||.|.||||  ..... ..||...|||||..|.|||.|..|...|..|||||..|||.||..||...||...||.
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK

Kinase MSK.AA RSK 269-530 39 7.79999999999e-147 494.1 In-house 1-278 (278) Show / Hide
Range on Protein: 269-530
Range on HMM: 1-278/278
Sequence Identity: 39% (113 aa)

MKSA-PIGDGSFSICRRCTHRKTEKEYAVKIVSRRVACT---------QEITTLQLCQKHPNIVHLKEEFKDKLHTYIIMELCKGGELLGRIRKKKH---
.| . ..| |....||.|||..|...||.|.........         .|.. |..||.||.||.|.. |......|.|||.|.||||. ...|.||   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDD-AELKIIDFGFARI-TNS-NQPLKTPCFSLHFAAPEVLKRAYEQDGEYDASCDVWSL
|.| ||...|...|.||...|..||.||||||||||..|.| . ...|..||||...  .. ||...|.|......|||.||||. |.| .|..||.|||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSL

GVILYTMLSGRVPFQDPSISKSNSASDIMKRIKHGNFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLT-----TDDLLQNEWI
||..|.||.|..|||  . .  |....|||||..|.||.....|...|..|||||...|..||..||.     .....|..|.
GVLMYEMLTGCPPFQG-PND--NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase MSK.AA CAMK1 265-530 37 3.6e-120 351.03 In-house 1-276 (276) Show / Hide
Range on Protein: 265-530
Range on HMM: 1-276/276
Sequence Identity: 37% (108 aa)

YELDMKSAPIGDGSFSICRRCTHRKT---EKEYAVKIVS-RRVACT----------QEITTLQLCQ--KHPNIVHLKEEFKDKLHTYIIMELCKGGELLG
||.. .   || |.||. ..|||..|   .|.||.|. . ...  .          .||  .. .   .||||. ..| . .. | |..|||..||||. 
YEFGKE---IGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFD

RIRKKKHFDELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDAELK--IIDFGFARITNSNQ-PLKTPCFSLHFAAPEVLKRAYEQDGEYDA
|| .|... | .|. ||....||| ||||.|||||||||||.|. | ..|...|  |.||| ..|....   .||.| .. . |||||..    |  || 
RIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK--DKPYDK

SCDVWSLGVILYTMLSGRVPFQDPS-ISKSNSASDIMKRIKHGNFSFDGEEWNSVSTP-AKDLIKGLLTVDPSRRLTTDDLLQNEWI
.||.|| |||.|..| |  ||.| . ...      ... || . . |.  .|...|   |||.||..|.|||. |.| .. |.  ||
ACDMWSIGVITYILLCGYPPFYDENVDNE------LFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI

Kinase MSK.AA CAMK 273-530 25 2.4e-114 369.99 In-house 1-425 (425) Show / Hide
Range on Protein: 273-530
Range on HMM: 1-425/425
Sequence Identity: 25% (109 aa)

PIGDGSFSICRRCTHRKTE------------KEYAVKIVSRR---------------------------------VACTQEITTLQLCQK------HPNI
 .| |||.. ..|.|..|             ...|.||....                                     .||  ....|.      ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VHLKEEFKD-------------------KLHTYIIM---ELCKGGEL----LGRIRKKKH---------------FDELEASMIMRKLVSAVDYMHSRGI
..| | . |                   . | |..|   |.| ||||    . .|.....               |.| ||. ..| ..|||.|.||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENILFTDDSDD--------------AELKIIDFGFARITNS------------------------NQPLKTPCFSLHFAA-PEVLKR------
|||||||||||..|..||              . .||||||||.. ..                        .|..||.| .....| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

---AYEQDGEYDASCDVWSLGVILYTMLSGRVPFQDPSISKSN-------SASDIMKRIKHGNFSFD-----------GEEWNS---------VSTPAKD
    .|.   |. .||.||.|||||.||.|. ||.... .          . ......|. |...|.           |.|| .         ||. .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIKGLLTVDPSRRLTTDDLLQNEWI
||...|.|||..|.| .. |. .|.
LIRKMLQVDPEKRMTIEQCLNHPWM

Kinase MSK.AA MAPKAPK 268-530 38 4.7e-105 326.24 In-house 1-292 (292) Show / Hide
Range on Protein: 268-530
Range on HMM: 1-292/292
Sequence Identity: 38% (112 aa)

DMKSAPIGDGSFSICRRCTHRKTEKEYAVKIVSRR-----VACTQEITTLQLCQKHPNIVHLKEEFKD----KLHTYIIMELCKGGELLGRIRK--KKHF
 . .  .| |.    ..|.|..|..||||||.  .         .|  ..  || |||||.. . |..    .   |..||. .||||. .| .  .|||
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHF

DELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDAELKIIDFGFARI-------TNS--NQPLKTPCFSLHFAAPEVLKRAYEQDGEYDASC
 | ||| ||.   ||||..||..| ||||||||||.|| .... .|. |||||         | .  .. |.|||..  ..||||. .   .   || ||
TEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFK-EAHTYDKSC

DVWSLGVILYTMLSGRVPFQ----DPSISKS------NSASDIMKRIKHGNFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLTTDDLLQNEWI
| ||||||.| ||.|  ||.    |  .|..          .  .||. | ..|  |||  .|  |||||. || .||. |||. ..... ||
DMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI

Kinase MSK.AA AGC 273-530 23 1e-104 271.08 In-house 6-395 (395) Show / Hide
Range on Protein: 273-530
Range on HMM: 6-395/395
Sequence Identity: 23% (93 aa)

PIGDGSFSICRRCTHR------KTEKEYAVKIVSRRV----------ACTQ-E------------ITTLQLCQK---------HPNIVH-LKEEFKDKLH
.|| |||. .. . ..       |.| ||.|... ..          ..|. |               |..|..         ||.||. |.  |.|| |
VIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDH

--TYIIMELCK---------GG-ELLGRIR---KKKHFDELEASMIMRK-------LVSAVDYMHS-RGIVHRD-LKPENILFTDDSDDAELKIIDFGFA
   |..||...         || ||. ...   |...||| .|  ..         .|.|..|.|| .||.||| |||||||...|     .|. |||..
TYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLTDFGLC

RITNS------------------------------------------------------NQPLKTPCFSLHFAAPEVLKRAYEQDGEYDASCDVWS--LG
 . ..                                                      .. .  || . .. |||.|         |. .|| ||  ||
KEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL---------YGKACDWWSFGLG

VILYTMLSGRVPFQDPSIS----KSNSASDIMKRIKHGN-FSFDGEEWN-----------SVSTPAKDLIKGLLTVDPSRRLT----------TDDLLQN
...| ||.|. ||.. .      . ..  .....|..|. |........           ..|  ||||||.||..||..||.          .... . 
CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

EWI
.| 
PWF

Kinase MSK.AA S_TKc 268-530 34 3.8e-98 333.27 SMART 1-231 (231) Show / Hide
Range on Protein: 268-530
Range on HMM: 1-231/231
Sequence Identity: 34% (95 aa)

DMKSAPIGDGSFSICRRCTHRKTEKEYAVKIVSRRVACTQEITTLQLCQKHPNIVHLKEEFKDKLHTYIIMELCKG--GELLGRIRKKKH------FDEL
  .  .|| |.|. ...|.|.|| ...|.||..      .||  |.   .|||||.|.. | |  | |..||.| |  |.|. .|.|...      |.| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

EASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDAELKIIDFGFARITNSNQPLKTPCFSLHFAAPEVLKRAYEQDGEYDA-SCDVWSLGVILYT
.|  .|. ...|..|.||.||.||||||||||...     ..||.|||.||.       .| | .... |||||         |.  .||.||.|.||| 
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYE

MLSGRVPFQDPSISKSNSASDIMKRIKHGNFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLTTDDLLQ-------NEWI
||.|. ||.            ..|.|.              | .|||.|...|..||..|.|  ..||        .|.
MLCGYPPFP--------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase MSK.AA CDPK 318-530 41 2.2e-94 289.88 In-house 60-271 (271) Show / Hide
Range on Protein: 318-530
Range on HMM: 60-271/271
Sequence Identity: 41% (93 aa)

HPNIVHLKEEFKDKLHTYIIME--LCKGGELLGRIRKKKHFDELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDA----ELKIIDFGFARI
||||. . | . |. . ||.||  .|.||||. .|  |.||.| ||. |||...||| |.||..|||||||||||||. ..||.    ..|.||.| ...
HPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKK

TNSN-----QPLKTPCFSLHFAAPEVLKRAYEQDGEYDASCDVWSLGVILYTMLSGRVPFQDPSISKSNSASDIMKRIKHGNFSFDGEEWNSVSTPAKDL
 ..|     . ... |   .  |||||.      . |. .||.||.|||||..|.|. ||         . ..||. .| |..||.|.||...|  ||||
FDQNQKIEDKKMSQRCGTPYYIAPEVLQ------KKYNEKCDIWSCGVILYILLCGYPPFY------GKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDL

IKGLLTVDPSRRLTTDDLLQNEWI
|. .|..||  |.. .. ||  |.
IRKMLCYDPKKRMSAQQALQHPWF

Kinase MSK.AA RSK 265-530 40 4.7e-94 318.76 In-house 1-271 (271) Show / Hide
Range on Protein: 265-530
Range on HMM: 1-271/271
Sequence Identity: 40% (113 aa)

YELDMKSAPIGDGSFS---ICRRCTHRKTEKEYAVKIV---SRRVA---CTQEITTLQLCQKHPNIVHLKEEFKDKLHTYIIMELCKGGELLGRIRKKKH
|||  .   || ||||   .|..|.|. |...||.||.   .| |.   |. |.  .     ||.|| |.. | |  . |.||....||.|..|. |.| 
YELHEC---IGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKM

FDELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDAE-LKIIDFGFA-RITNSNQPLKTPCFSLHFAAPEVLKRAYEQDGEYDASCDVWSLG
| | |.. .|. . .|..| || |||||||||||||. |.| ... .|| |||||      |  |.|.| .  . |||||||     | .|..||.||.|
FSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQ----G-HDQACDWWSFG

VILYTMLSGRVPFQDPSISKSNSASDIMKRIKHGNFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLTT-----DDLLQNEWI
|..|.||.|. |||       ..  .| .||| | ||. .  |...| .||||. ..|..|| .||..      . .|  |.
VLMYEMLTGCTPFQN---KPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF

Kinase MSK.AA Pkinase 265-530 33 5.1e-89 306.85 Pfam 1-293 (293) Show / Hide
Range on Protein: 265-530
Range on HMM: 1-293/293
Sequence Identity: 33% (103 aa)

YELDMKSAPIGDGSFSICRRCTHRKTEKEYAVKIVSRRVACT---------QEITTLQLCQKHPNIVHLKEEFKDKLHTYIIMELCKGG----ELLGRIR
|..  |   || |||. ...|.|..|.|..||||...| .           .||  .. . .||||| |.. | || | |..||.| ||    .|  .|.
YHIGRK---IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--KKKHF--DELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFT-DDSDDAELKIIDFGFARI--TNSNQPLKTPCFSLHFAAPEVLKRAYEQDGEYD
  ... |  .| |. ..|. ......|.||.||.||||||||||.  ..  || .||.|||.|.   . .|. ..|.| .....||||..     . .|.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYG

ASCDVWSLGVILYTMLSGRVPFQDP-SISKSNSASDIMKRIKHGNFSFDGEEWNSVS-----------------TPAKDLIKGLLTVDPSRRLTTDDLLQ
 ..|.||.|.||| ||.|| ||..     . ..   ...||... ..|| ..|.|.|                  ..||.||..|..||..|.| ...||
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

NEWI
 .|.
HPWF

Kinase MSK.AA CAMKL 267-530 32 4.2e-87 278.01 In-house 1-297 (297) Show / Hide
Range on Protein: 267-530
Range on HMM: 1-297/297
Sequence Identity: 32% (100 aa)

LDMKSAPIGDGSFSICRRCTH-RKTEKEYAVKIVSRRVAC--------------------TQEITTLQLCQ--KHPNIVHLKEEFKDKLH------TYII
 ..    .| |||.  . .|| | |....|.||. .. ..                    ..||  ... .  |||||..| | . .. |       |..
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MELCKGGE--LLGRIRKKKH----FDELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDAELKIIDFGFARI-----TNSNQPLKTPCFSLH
||.| |||  |. .|.|..|    ..| ||  . | .||||.|.||.||||||.||||||.... .   .|||||||. .      ...| ||| | |..
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

FAAPEVLKR-AYEQDGEYDASCDVWSLGVILYTMLSGRVPFQDPSIS--KSNSASDIMKRIKHGNFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLTTDD
..|||....   . ||      |.||.|||||.|. |..|| |....  . .     ...|. | . ..   |..|| ...|||...|.|.|..| | ..
YMAPEIFQGNNKPYDGPK---VDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQ

LLQNEWI
... .| 
IMNHPWM

Kinase MSK.AA Ciliate-E2 274-530 25 3.1e-77 262.89 In-house 7-365 (365) Show / Hide
Range on Protein: 274-530
Range on HMM: 7-365/365
Sequence Identity: 25% (97 aa)

IGDGSFSICRRCTHRKTE-----------------------KEYAVKIVSRR--VACTQEITTL--------QLCQ--------KHPNIVHLKEEFK--D
|| |.|.. ..|...|.                        |.||.||.. .   .  |||  .        .. .        .||||. ..| |.  |
IGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYECFQEKD

KLHTYIIMELCKGGELLGRIRKKKH-----------FDELEASMIMRKLVS---------------AVDYMHSRG-IVHRDLKPENILFTDDSDDAELKI
. . |..||.|.||.|. .|...|.           |.| |.. ||.....               |. |.||.. |.|||.|||||||        .||
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKI

IDFGFARITNSNQP---------LKTPCF------------------------SLHFAAPEVLK-RAYE--QDGE-YDASCDVWSLGVILYTMLSGRVPF
||||.... . ..          ...  .                        .... |||.|.   |.  |... || .||.|||||||| ||.|. ||
IDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

QDPSISKSNSASDIMKRIKHGNFSFDGEE--------------WNSVSTPAKDLIKG----LLTVDPSRRLT-TDDLLQNEWI
              .. || ....|. .|              |...|  .|||||     .| .||. |.|  ...|...|.
--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase MSK.AA TyrKc 268-529 20 2.2e-12 -22.39 SMART 1-280 (280) Show / Hide
Range on Protein: 268-529
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

DMKSAPIGDGSFSICRRCTHR-----KTEKEYAVKIVSRRVACTQEITTLQLC-QKHPNIVHLKEEFKDK-------LHTYIIMELCKGGELLGRIRKKK
  .   .| | | . ...| .     |. ||.|      | .  .|.  .     .||||| |     ..          .|.||....| |. ..||..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

HFDELEASMIMRKLVS-------AVDYMHSRGIVHRDLKPENILFTDDSDDAELKIIDFGFARITNSN------QPLKTP-----C---FSLHFAAPEVL
.         |..|.|         .| ||....||||   |.| ...      || ||| .|   .       .  ...     .   . .   |||..
PK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

KRAYEQDGEYDASCDVWSLGVILYTMLS-GRVPFQDPSISKSNSASDIMKRIKHGNFSFDGEE-----WNSVSTPAK--DLIKGLLTVDPSRRLTTDDLL
     ..|..    |||| || .. ... |  |  ..      |........|.|.     ..        |  |..  ...|     ||. | |  .. 
-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEI-

QNEW
  ..
HECF

Kinase MSK.AA APH 378-411 22 9.3e-05 17.11 Pfam 170-204 (248) Show / Hide
Range on Protein: 378-411
Range on HMM: 170-204/248
Sequence Identity: 22% (8 aa)

RGIVHRDLKPENILFTDDSDDAELK--IIDFGFARI
....|.|..| |.....  .| .    .||...|..
PCWCHGDFHPGNVMWDP-RPDGGRVTGVIDWDDACW

Kinase MSK.AA Pkinase_Tyr 333-385 28 0.000109 16.5 Pfam 81-137 (270) Show / Hide
Range on Protein: 333-385
Range on HMM: 81-137/270
Sequence Identity: 28% (16 aa)

HTYIIMELCKGGELLGRIRK----KKHFDELEASMIMRKLVSAVDYMHSRGIVHRDL
. ||.||....| ||   ||    |....  .   . .   .. .| .|....||||
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

Kinase MSK.AA CDPK 269-300 34 0.000598 8.24 In-house 1-35 (271) Show / Hide
Range on Protein: 269-300
Range on HMM: 1-35/271
Sequence Identity: 34% (12 aa)

MKS-APIGDGSFSICRRCTHR-KTEKEY-AVKIVS
.|   ..| |.|.  |...|. ||  |  |.||..
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIP