RSK1

Species: Sea Urchin
Alias: RSK1, Spk023, SPU_011714
External Links: Sea Urchin Project Link
Annotation: Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: RSKb,

Classification

Group: AGC
Family: RSK
Subfamily: RSKp90

Sequence

Name Sequence Type Origin Length Description Download
RSK1.AA Protein None 457 None Fasta, JSON
RSK1.kin_dom2 Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of RSK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RSK1.AA RSK 1-45 51 8.7e-26 89.11 In-house 220-271 (271) Show / Hide
Range on Protein: 1-45
Range on HMM: 220-271/271
Sequence Identity: 51% (27 aa)

AKLGM-------PQFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF
.||||       ..|.|.||..||||...|.|.|||||||||...||.|..|
IKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF

Kinase RSK1.AA AGC 2-45 30 6.4e-24 57.34 In-house 337-395 (395) Show / Hide
Range on Protein: 2-45
Range on HMM: 337-395/395
Sequence Identity: 30% (18 aa)

KLGMP----------QFLSAEAQSLLRMLFKRNPQNRLGAGPN-----GINDIKSHAFF
|. .|          ...| ||..|...|....| .|||.|.|     |...||.| .|
KVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF

Kinase RSK1.AA RSK 1-45 44 3.1e-21 74.6 In-house 230-278 (278) Show / Hide
Range on Protein: 1-45
Range on HMM: 230-278/278
Sequence Identity: 44% (22 aa)

AK--LGMP--QFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF
.|  |.||  |.||.||..|.|....|.|..|||.||.....||.|..|
GKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase RSK1.AA Ciliate-E2 9-45 21 1.4e-08 25.59 In-house 329-365 (365) Show / Hide
Range on Protein: 9-45
Range on HMM: 329-365/365
Sequence Identity: 21% (9 aa)

LSAEAQSLLRM----LFKRNPQNRLGAGPNGINDIKSHAFF
.| |.. |..     .....|..|..    |...|. | .|
WSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF

Kinase RSK1.AA Ciliate-E2-Unclassified 9-45 18 1e-06 18.8 In-house 317-352 (352) Show / Hide
Range on Protein: 9-45
Range on HMM: 317-352/352
Sequence Identity: 18% (7 aa)

LSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF
.| ||. ... |..........  . ....|. | .|
WSPEAKDFINDLLQKMLKKNPNKRI-TFEQILNHPWF

Kinase RSK1.AA MSK 10-40 29 7.4e-05 12.34 In-house 247-277 (277) Show / Hide
Range on Protein: 10-40
Range on HMM: 247-277/277
Sequence Identity: 29% (9 aa)

SAEAQSLLRMLFKRNPQNRLGAGPNGINDIK
|..|. |.. |  ..|. |||... . . .|
SPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK

Kinase RSK1.AA CAMKL 6-45 22 0.000717 8.07 In-house 264-297 (297) Show / Hide
Range on Protein: 6-45
Range on HMM: 264-297/297
Sequence Identity: 22% (9 aa)

PQFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF
. ..| ....|.| . ..||  |       | .|..| ..
WYHVS-DCRDLIRKMLQVNPEKRP-----TIHQIMNHPWM

Kinase RSK1.AA CAMK 6-45 22 0.003563 5.28 In-house 392-425 (425) Show / Hide
Range on Protein: 6-45
Range on HMM: 392-425/425
Sequence Identity: 22% (9 aa)

PQFLSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF
. |.|.|...|.| . ...|..|.      | ....| ..
H-FVSQECKDLIRKMLQVDPEKRM-----TIEQCLNHPWM

Kinase RSK1.AA Pkinase 9-45 18 0.005794 11.56 Pfam 262-293 (293) Show / Hide
Range on Protein: 9-45
Range on HMM: 262-293/293
Sequence Identity: 18% (7 aa)

LSAEAQSLLRMLFKRNPQNRLGAGPNGINDIKSHAFF
.| |...... .....|. |..     . .|. | .|
WSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF

Kinase RSK1.AA RSK 143-397 55 1.9e-182 612.43 In-house 4-271 (271) Show / Hide
Range on Protein: 143-397
Range on HMM: 4-271/271
Sequence Identity: 55% (149 aa)

XQDIGLGSYS---VCKRCTHKATGQDYAVKIIKKNTKDVR-----EEIEILLRYGHHSNVITLRDVFDDGQNVYMVMELMRGGELLDRLLKQKFLSEREA
 ..|| ||.|   |||.|.||.|.|.||.|||||.|.||.     ||..|.||||||.....|..||.|...|||.|..||||.|.|||||||..||||.
HECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREV

CEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRADNGMLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVILYTMLAGFT
...|......|..||.|..|||||||.||||.||...||...|.|||||||.|..||||||.|||||..||||||.||.|.|||.||.||..|.||.|.|
KFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCT

PFVHKPDDSSKVILARIQEGKYTMNGGNWDNISDRAKDLISRMLHVDPFQRPST-----KQVLQHTWF
||..||.|. ..|..||..|...|..||||.|||.||||...|||.||..|...     .|..||.||
PFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF

Kinase RSK1.AA RSK 142-397 42 1.1e-150 506.95 In-house 1-278 (278) Show / Hide
Range on Protein: 142-397
Range on HMM: 1-278/278
Sequence Identity: 42% (120 aa)

XXQD--IGLGSYSVCKRCTHKATGQDYAVKIIKKNTKDVR--------EEIEILLRYGHHSNVITLRDVFDDGQNVYMVMELMRGGELLDRLLKQKF---
  ..  .| |....|..|||..||| ||.|..||.. ..|        .|..||.|...| ...|| ..|.... .|..||..|||||...|.|.|.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSEREACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRAD-NGMLMTPCYTANFVAPEVLK---KQG-YDAACDIWSLG
.||.|||..| ... ....||||...||||||.||||.||. ..|.... ||||.||.|.| |...||.|||....|||.||   .|| .|.|||.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VILYTMLAGFTPFVHKPDD-SSKVILARIQEGKYTMNGGNWDNISDRAKDLISRMLHVDPFQRPS-----TKQVLQHTWF
|..|.||.|..|| . |.| ..|.|..|||.||......||...|. |||||..|||.|| .|..     .....|| ||
VLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase RSK1.AA CAMK1 146-397 38 1.8e-111 325.31 In-house 7-276 (276) Show / Hide
Range on Protein: 146-397
Range on HMM: 7-276/276
Sequence Identity: 38% (105 aa)

IGLGSYSVCKRCTHKAT---GQDYAVKII--KKNTKD--------VREEIEILLRYG--HHSNVITLRDVFDDGQNVYMVMELMRGGELLDRLLKQKFLS
|| |. |. ..|||| |   |..||.|.|  ||..|         .. ||||. . .  .| |.| . .....   .|.||||. ||||.|| .. .. .
IGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKGNYT

EREACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPG-TLR--IADFGFAKQMRADNGMLMTPCYTANFVAPEVLKK---QGYDAACDIWSLGV
|..|..||  .     ..|.. .||||||| |.||.|.  ... ...  ||||| .|.   |.... |.| |  .||||||.    ..|| |||.|| ||
EKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDK--DEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGV

ILYTMLAGFTPFVHKPDDS-SKVILARIQEGKYTMNGGNWDNISDR-AKDLISRMLHVDPFQRPSTKQVLQHTWF
|.|..| |. ||    |..  . ... | ...|..    ||||||  |||.|. || ||| .|.. .|.|.| |.
ITYILLCGYPPFY---DENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI

Kinase RSK1.AA AGC 146-397 22 4.90000000001e-108 279.87 In-house 7-395 (395) Show / Hide
Range on Protein: 146-397
Range on HMM: 7-395/395
Sequence Identity: 22% (88 aa)

IGLGSYSVCKRCTHK------ATGQDYAVKIIKKNT----------KDVREE------------IEILLRYGH---------HSNVIT-LRDVFDDGQN-
|| ||.. .  . .|      .||. ||.|..|| .          . .  |             .|| .. |         | ...  |   | | .. 
IGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHT

-VYMVMELMR---------GG-ELLDRLL---KQKFLSEREACEIMLT-------VTRTMDFLHQ-QKVVHRD-LKPSNILYADETYSPGTLRIADFGFA
 .|.|||.|          || ||. .|    |.. ..| .|. ..         ..  ...||. ....||| ||| |||  ..    | ....|||..
YLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIKLTDFGLC

KQMRAD-----------------------------------------------------NGMLMTPCYTANFVAPEVLKKQGYDAACDIWS--LGVILYT
|... |                                                     .  .  || |....|||.|    |. |||.||  ||...| 
KEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGLGCLMYE

MLAGFTPFVHKPDD-------SSKVILARIQEGKYTMNGGNW------------DNISDRAKDLISRMLHVDPFQRPS----------TKQVLQHTWF
||.| .|| .....       . . .  .|..|.|..| .              ...|. |||||...|..|| .|.           .... .| ||
MLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF

Kinase RSK1.AA CAMK 145-397 24 1.2e-103 334.94 In-house 1-425 (425) Show / Hide
Range on Protein: 145-397
Range on HMM: 1-425/425
Sequence Identity: 24% (106 aa)

DIGLGSYSVCKRCTHKATG------------QDYAVKIIKK--------------------------------NTKDVREEIEILLRYG------HHSNV
 .| ||... |.|.|| |.            | .|.|||.|                                . | || ||||. .        .| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLRDVFDDGQN-------------------VYMVM---ELMRGGEL----LDRLLKQKF---------------LSEREACEIMLTVTRTMDFLHQQKV
| | .|..|...                   .||||   |.. ||||    .|.. ...                ..||||. ..  .   ....|....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNILYADETYSP-------------GTLRIADFGFAKQMRADNG-----------------------MLMTPCYTANFVA-PEVLKK------
||||||| |||. |   .              ... |.|||||.... ...                       .. |.| |  ..| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QGYDAACDIWSLGVILYTMLAGFTPFVHKPDD----------SSKVILARIQEGKYTMNGGN------------WDNISDR--------AKD
        ..|. .||.||.|||||.|| |. || .. |.          . . .. .|..|||..                ||.|||         .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISRMLHVDPFQRPSTKQVLQHTWF
||..|| ||| .|.. .|.|.| |.
LIRKMLQVDPEKRMTIEQCLNHPWM

Kinase RSK1.AA MAPKAPK 140-397 37 1e-99 309.45 In-house 1-292 (292) Show / Hide
Range on Protein: 140-397
Range on HMM: 1-292/292
Sequence Identity: 37% (111 aa)

XXXXQDIGLGSYSVCKRCTHKATGQDYAVKIIKKN-----TKDVREEIEILLRYGHHSNVITLRDVFDD----GQNVYMVMELMRGGELLDRLLK--QKF
    . .|.|.|    .|.|| ||| |||||...      .| .| | |.. .   | |.. . |.| .     .. |.|||.|.||||...  .  .| 
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQK-ARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKH

LSEREACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQ--------MRADNGMLMTPCYTANFVAPEVLKKQG----YDAA
 .|||| .||  ..   ||||.    |||||| |||. | |..  .. . ||||||.         .. .  |||||||. ..||||.  .     ||  
FTEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTD-TNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKEAHTYDKS

CDIWSLGVILYTMLAGFTPFVHKPD--DSSKV-----------ILARIQEGKYTMNGGNWDNISDRAKDLISRMLHVDPFQRPSTKQVLQHTWF
||.||||||.| ||.|. ||. . .  | |.              .|||||.|.     |..||. |||||...| .|| || ...||..| | 
CDMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI

Pkinase RSK1.AA Pkinase 140-397 32 2.1e-96 331.4 Pfam 1-293 (293) Show / Hide
Range on Protein: 140-397
Range on HMM: 1-293/293
Sequence Identity: 32% (98 aa)

XXXXQDIGLGSYSVCKRCTHKATGQDYAVKIIKKNTKDVRE--------EIEILLRYGHHSNVITLRDVFDDGQNVYMVMELMRGG----ELLDRLL--K
    . || ||......|.|| ||. .||||||| ...  .        ||.|..|  .| |...|.|.| |....|||||...||    .| |..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QKFL--SEREACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQM-RADNGMLMTPCYTANFVAPEVLK-KQGYDAACDIWS
.. .  ||.|.. .|. . | ....|.....||||||.|||. .. . . ...|.|||.|||.    |. ..|.| | ...||||..  |.|. ..|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVILYTMLAGFTPFVHK----PDDSSKVILARIQEGKYTMNGGNWDNIS-----------------DRAKDLISRMLHVDPFQRPSTKQVLQHTWF
.|.||| || | .|| ..    . .. .....|| ....  .  .|..||                 . .||.|...|..|| .||. .|.||| ||
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase RSK1.AA S_TKc 144-397 34 1.1e-95 325.07 SMART 5-231 (231) Show / Hide
Range on Protein: 144-397
Range on HMM: 5-231/231
Sequence Identity: 34% (94 aa)

QDIGLGSYSVCKRCTHKATGQDYAVKIIKKNTKDVREEIEILLRYGHHSNVITLRDVFDDGQNVYMVMELMRG--GELLDRLLKQKF------LSEREAC
. || |.......|.|| ||. .|.||||   ...| ||.|| .  || |...| |||.| ...|||||.. |  |.|.|.. |..       ..| .|.
RKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

EIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRADNGMLMTPCYTANFVAPEVLKKQGYDA-ACDIWSLGVILYTMLAGFT
 .|  . . ....|.....||||||.|||  .      .. |.|||.|.|.       .| | | ...|||||   ||.  .||.||.|.||| ||.| .
FYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

PFVHKPDDSSKVILARIQEGKYTMNGGNWDNISDRAKDLISRMLHVDPFQRPSTKQVLQ-------HTWF
||        .... .|               |. |||.|...|..|| .||.  ..||       | ||
PFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase RSK1.AA MSK 141-397 35 2.3e-88 298.83 In-house 1-277 (277) Show / Hide
Range on Protein: 141-397
Range on HMM: 1-277/277
Sequence Identity: 35% (100 aa)

XXXQ-DIGLGSYSVCKRCTHKATGQDYAVKIIK--------KNTKDVREEIEILLRYGHHSNVITLRDVFDDGQNVYMVMELMRGGELLDRLLKQKFLSE
      .| |....|..|.|. ||. ||.||..        | .  .. |. .|..   | |. .| ..| |    |.|||. .||||. .. | .  .|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

REACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRAD-NGMLMTPCYTANFVAPEVLK----KQG-YDAACDIWSLGVI
 |. .||. .    |..|| ...|||||| |||..||. . |.... |||||.   .| .  . .||.|  . |||.|.    ..| ||.|||.||||||
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDN-GHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVI

LYTMLAGFTPFV---HKPD---DSSKVILARIQEGKYTMNGGNWDNISDRAKDLISRMLHVDPFQRPSTKQVLQHTWF
||||| |  ||    .  .    |.. |  ||..|.    |  | |.|  |||||...| .||  |...   ..| | 
LYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK

Kinase RSK1.AA Ciliate-E2 140-397 25 2e-76 260.21 In-house 1-365 (365) Show / Hide
Range on Protein: 140-397
Range on HMM: 1-365/365
Sequence Identity: 25% (98 aa)

XXXXQDIGLGSYSVCKRCTH-----------------------KATGQDYAVKIIKKN-TKDVREEIEIL---------------LRYGHHSNVITLRDV
    . || |.... ..|..                       |.... ||.||.|||  . .  || |.               |.   | |.| . ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FD--DGQNVYMVMELMRGGELLDRLL--KQKF---------LSEREACEIMLTVTR---------------TMDFLHQQK-VVHRDLKPSNILYADETYS
|   | .|.|.|||.  ||.|.|..   |.|.         ..|.|...||  ...                . .||... ..|||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PGTLRIADFGFAKQMRADNG-------------------------------MLMTPCYTANFVAPEVLK---------KQGYDAACDIWSLGVILYTMLA
   . |.|||..|.   ||                                |  | |.|....|||.|.         ..||| .||||||||||| || 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GFTPFVHKPDDSSKVILARIQEGKYTMNGG--------------NWDNISDRAKDLISR----MLHVDPFQRPS-TKQVLQHTWF
| .||           .  |...|.  .                .|...|. .||||..    || .|| .|..  .|.|.| ||
GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase RSK1.AA CAMKL 146-397 30 3.1e-75 239.5 In-house 7-297 (297) Show / Hide
Range on Protein: 146-397
Range on HMM: 7-297/297
Sequence Identity: 30% (92 aa)

IGLGSYSVCKRCTH-KATGQDYAVKIIKKNTKD-------------------VREEIEI--LLRYGHHSNVITLRDVFDDGQN------VYMVMELMRGG
.| ||... | .|| . ||. .|.|||.|. .                    .| ||.|  .|. | | |.| | .|... ..      .|.|||.  ||
LGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGG

E--LLDRLLKQKF----LSEREACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRA----DNGMLMTPCYTANFVAPEV
|  |.|.. |..     ..|.||. .   .   ....|....||||.|| |||  .   .  .. |.||||. ..|     .. .|.| | . .. |||.
EMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEI

LKK--QGYD-AACDIWSLGVILYTMLAGFTPFVHKPD-----DSSKVILARIQEGKYTMNGGNWDNISDRAKDLISRMLHVDPFQRPSTKQVLQHTWF
...  . ||  . ||||.|||||.|. |  ||   ..     |     . .| .| | ..   |  .| ...|||..|| |.| .||. .|...| |.
FQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase RSK1.AA Ciliate-E2-Unclassified 140-397 25 1.3e-67 230.95 In-house 1-352 (352) Show / Hide
Range on Protein: 140-397
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)

XXXXQDIGLGSYSVCKRCTHKATGQDYAVKIIKKNTKDV-----------REEIEILLRY-----------------GHHSNVITLRDVFDDGQNVYMVM
    . || |.... ..| || ..| || |..||. ..            .|..|.  .                    | ... . ..| | ||.|.||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

ELMRGGELLDRLLKQKF-----------------LSEREAC-----EIMLTVTRTMDFLHQQK-VVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRA
|...||.|.. . |.|.                 ..|..|.      ..  .    ..||... ..|||.||.|||. .. .  . ..|.|||..|.   
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQ

DNG---------------MLMTPCYTANFV----APEVLKKQGYD----AACDIWSLGVILYTMLAGFTPFVHKPDDSSKV-------------ILARIQ
.|.               |. | | | |.     |||||..|.||     .||||||||||| || |  ||  . ......             ..  |.
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

EGKYTMNGGNW----DNISDRAKDLIS----RMLHVDPFQRPSTKQVLQHTWF
....  .  .|    ...|. |||.|.    .|| ..| .|.. .|.|.| ||
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase RSK1.AA Pkinase_Tyr 167-327 26 1.5e-19 66.79 Pfam 32-205 (270) Show / Hide
Range on Protein: 167-327
Range on HMM: 32-205/270
Sequence Identity: 26% (48 aa)

AVKIIKKNTKDV-------REEIEILLRYGHHSNVITLRDVFD-DGQN--VYMVMELMRGGELLDRLLK----QKFLSEREACEIMLTVTRTMDFLHQQK
|||..| .. .         .|..|.  .||| |.. |  |   .|.   .|.|||.| .| ||| | |    .. |.  . ... . . . |..|....
AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN

VVHRDLKPSNILYADETYSPGTLRIADFGFAKQM-------RADNGMLMTPCYTANFVAPEVLKKQGYDAACDIWSLGVILY
 .||||   |.| ..    ... .|.||| |. .       |.  |  .    .    |||...   .  . |.|| || ..
CIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTTKSDVWSFGVLMW

Kinase RSK1.AA TyrKc 144-397 21 2.7e-16 40.65 SMART 5-280 (280) Show / Hide
Range on Protein: 144-397
Range on HMM: 5-280/280
Sequence Identity: 21% (63 aa)

QDIGLGSYSVCKRCTHKATGQDYAVKIIK--KNTKDVREEIEILLRYG-HHSNVITLRDVFDDG-------QNVYMVMELMRGGELLDRLLKQK-FLSER
. .| | . .  ..| |   .. ||| .|  .  .| ..|..|. ..| || |.. |  |  ..       . ...|||.| .| |.|.| | .  |. .
KKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

EACEIMLTVTRTMDFLHQQKVVHRDLKPSNILYADETYSPGTLRIADFGFAKQMRAD------NGMLMT----PC---YTANFVAPEVLKKQGYDAACDI
. ..... . . |..||.....||||   |.|....     | .|.||| ..    |        . ..     .         |||....  .  . |.
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSLGVILYTMLA-GFTPFVH---KPDDSSKVILARIQEGKYTMNGGNWDN--------ISDRAKDLISRMLHVDPFQRPSTKQVLQHTWF
|| || .. ..  | .|      . . | . .......|.. .     .|         .|   .....  | || .||. ...  |  |
WSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQP---PNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF