Gene CAMK4 (Sea Urchin)
CAMK4
Sequence
Protein domains of CAMK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | CAMK4.AA | CAMK1 | 4-194 | 59 | 7.79999999999e-158 | 462.43 | In-house | 79-276 (276) | Show / Hide |
Range on Protein: 4-194 Range on HMM: 79-276/276 Sequence Identity: 59% (118 aa) DDFNVYLQLELVTGGELFERIVERGYYSERDAARCVREICQAVSYLHDHDIVHRDLKPENLLYADMGDEAPLK--LADFGLSKIIDQDV-SMKTVCGTPG .| .|| .|||||||||.||||.|.|.|.||......|..|| |.|...|||||||||||||.|. .....| .||||||||.|.|. |||.||||| SDNHFYLVMELVTGGELFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPG YCAPEVLCG---KPYCKAVDMWSVGVITYILLCGFEPFYDDRGDNYIYKKIIRADYAFISPWWDDISDS-AKDFIDRLLVTDPKKRLCAEGALHHPWV |.|||||.. |||.||.||||.||||||||||..||||...||....||....| |.|||||.|||. ||||| .|. |||||...| .|.|||. YVAPEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
|||||||||
| Kinase | CAMK4.AA | CAMK | 3-194 | 31 | 1e-105 | 341.73 | In-house | 117-425 (425) | Show / Hide |
Range on Protein: 3-194 Range on HMM: 117-425/425 Sequence Identity: 31% (98 aa) SDDF-----------NVYLQL---ELVTGGEL----FERIVER---------------GYYSERDAARCVREICQAVSYLHDHDIVHRDLKPENLLYADM .| . ..|. . |...|||| |..|||. |...||.|.|..| ||.|| |.|.|.||||||||||.|. | ND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDN GDE--------------APLKLADFGLSKIIDQ------------------------DVSMKTVCGTPGYCA-PEVLCG--------------KPYCKAV .|. ...|..|||.....|. . |||.||||.|.| |||| | ..| ... NDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKC DMWSVGVITYILLCGFEPFYDDR------------GDNYIYKKIIRADYAFISPW------------WDDISDS--------AKDFIDRLLVTDPKKRLC ||||.|||.||.|||. |||.| |. ...||....| |..|. ||||||. .||.| ..|..||.||. DMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMT AEGALHHPWV .| .| |||. IEQCLNHPWM |
|||||||||
| Kinase | CAMK4.AA | RAD53 | 7-194 | 39 | 2.7e-100 | 299.45 | In-house | 79-305 (305) | Show / Hide |
Range on Protein: 7-194 Range on HMM: 79-305/305 Sequence Identity: 39% (90 aa) NVYLQLELVTGGELFERIVERGY----YSERDAARCVREICQAVSYLHDHDIVHRDLKPENLLYADMGDEA---------------PLKLADFGLSKIID ..|. |||.||||||..|| ... ..| .. . . .| ||.|||| |.|||||||| |... ..| .|..||||||... YYYMVLELMTGGELFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVG QDVSMKTVCGTPGYCAPEVLCGK---------------PYCKAVDMWSVGVITYILLCGFEPFYDDRGD----NYIYKKIIR-ADYAFISPWWDDISDSA . ||| |||| |.||||. .| | |.||.|| |.|.||.|||. || ||... . ....|.. . |.|..| ||.||..| EGSFMKTMCGTPQYVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEA KDFIDRLLVTDPKKRLCAEGALHHPWV ||.|...|. ||.||. ...|| ||| KDLIKWMLCVDPEKRYTIDEALNHPWM |
|||||||||
| Kinase | CAMK4.AA | DCAMKL | 7-194 | 48 | 4.8e-88 | 273.94 | In-house | 89-279 (279) | Show / Hide |
Range on Protein: 7-194 Range on HMM: 89-279/279 Sequence Identity: 48% (93 aa) NVYLQLELVTGGELFERIVERGYYSERDAARCVREICQAVSYLHDHDIVHRDLKPENLLYAD--MGDEAPLKLADFGLSKIIDQDVS-MKTVCGTPGYCA . || .|.|.|| ||. |.| . ..|||||. ....|.| |||. |||||.|||||| . | | |||.|||| .....| . |||||| |.| HYYLVMEYVQGGDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDG-EKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVA PEVLCGKPYCKAVDMWSVGVITYILLCGFEPFY-DDRGDNYIYKKIIRADYAFISPWWDDISDSAKDFIDRLLVTDPKKRLCAEGALHHPWV ||.| . | ||.|..|||.||||||| || |. ..|. ... | .| ||.||||||| | ..|. ||.|| || . |||| PEILMETGYGCKVDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV |
|||||||||
| Kinase | CAMK4.AA | CDPK | 4-194 | 47 | 7.5e-88 | 269.53 | In-house | 72-271 (271) | Show / Hide |
Range on Protein: 4-194 Range on HMM: 72-271/271 Sequence Identity: 47% (96 aa) DDFNVYLQLE--LVTGGELFERIVERGYYSERDAARCVREICQAVSYLHDHDIVHRDLKPENLLYADMGDEA----PLKLADFGLSKIIDQD-----VSM |. |.|. .| ..||||||..|.|.|...|..|| .| | .||.| |.. ||||||||||.|. | . ..|. |.|.||. ||. | DEKNYYIVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKM KTVCGTPGYCAPEVLCGKPYCKAVDMWSVGVITYILLCGFEPFYDDRGDNYIYKKIIRADYAFISPWWDDISDSAKDFIDRLLVTDPKKRLCAEGALHHP .. |||| | ||||| .| | . .| || ||| |||||| ||| . |. |..|. | | | ||.|||.||| | ..|..|||||..|. || || SQRCGTPYYIAPEVLQKK-YNEKCDIWSCGVILYILLCGYPPFYGKN-DQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHP WV |. WF |
|||||||||
| Kinase | CAMK4.AA | PSK | 8-194 | 48 | 7.5e-85 | 271.05 | In-house | 71-258 (258) | Show / Hide |
Range on Protein: 8-194 Range on HMM: 71-258/258 Sequence Identity: 48% (91 aa) VYLQLELVTGGELFERIVERGYYSERDAARCVREICQAVSYLHDHDIVHRDLKPENLLYADMGDEAPLKLADFGL--SKIIDQDVSMKTVCGTPGYCAPE ||. .|. ||||.| ||| .| ..|||| | . . .. ||| | |||||||||||.. |.|. . |||| .. .| |||.|||| | ||| VYMVMEMATGGEMFDRIVAKGRFTERDATRVLQMVLDGMRYLHALRITHRDLKPENLLYYHPGNESKIMITDFGLAYQRKKSNDWMMKTTCGTPEYIAPE VLCGKPYCKAVDMWSVGVITYILLCGFEPFYDDRGDNYIYKKIIRADYAFISPWWDDISDSAKDFIDRLLVTDPKKRLCAEGALHHPWV || ||| ..|||| ||||.|||. |. || || .|..|... | .. | ..|. ||||||.||.... .|. | |. |||| VLLRKPYTQSVDMWAVGVIAYILMSGIMPFDDDC-RTRLYRHILTGKYNYYGQPWPSVSHLAKDFIDKLLEINQGERMTASQAMKHPWV |
|||||||||
| Kinase | CAMK4.AA | MAPKAPK | 9-194 | 39 | 4.5e-83 | 256.98 | In-house | 77-292 (292) | Show / Hide |
Range on Protein: 9-194 Range on HMM: 77-292/292 Sequence Identity: 39% (85 aa) YLQLELVTGGELFERIVE--RGYYSERDAARCVREICQAVSYLHDHDIVHRDLKPENLLYADMGDEAPLKLADFGLSKI------IDQD---VSMKTVCG || .|. |||||..| . .....|| |.. ...||.||..||...| ||||||||.|. |. . .|.|| |||. | ... ....| |. YLVMECMEGGELFQHIQQRGHKHFTEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCY TPGYCAPEVLCGKP----YCKAVDMWSVGVITYILLCGFEPFYDDRG------D---------NYIYKKIIRADYAFISPWWDDISDSAKDFIDRLLVTD || |.||||. | | |||| ||| ||.|||. ||| . | | | ..| . |.| .. |..||. ||| | .||..| TPYYMAPEVVGAFKEAHTYDKSCDMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRD PKKRLCAEGALHHPWV |..|| .| . |||. PTQRLTIEQVMNHPWI |
|||||||||
| Kinase | CAMK4.AA | MAPKAPK | 12-194 | 47 | 5.6e-76 | 255.31 | In-house | 81-268 (268) | Show / Hide |
Range on Protein: 12-194 Range on HMM: 81-268/268 Sequence Identity: 47% (89 aa) LELVTGGELFERIVER--GYYSERDAARCVREICQAVSYLHDHDIVHRDLKPENLLYADMGDEAPLKLADFGLSKIIDQDVSMKTVCGTPGYCAPEVLCG .|. |||||.|| || . || || ...||||| ..|...| ||||||||||| | .....||| ||| | .. ....| | || |.||||| MECMEGGELFHRIQERGDQHFTEREAAQIMKQICQAVQHCHSMNIAHRDLKPENLLYKDTQPNCVLKLTDFGFAKETTRHNTLMTPCYTPYYVAPEVLGP KPYCKAVDMWSVGVITYILLCGFEPFYDDRGDNY---IYKKIIRADYAFISPWWDDISDSAKDFIDRLLVTDPKKRLCAEGALHHPWV | | |||| ||| ||.|||. ||| .| ..| . |.| .| |...|. ||| | .|| ||| .|| |. . |||. EKYDKSCDMWSLGVIMYIMLCGYPPFYSNHGQAISPGMKHRIMNGQYEFPHPEWSCVSEDAKDLIRKLLRTDPTERLTIEEFMNHPWI |
|||||||||
| Kinase | CAMK4.AA | Pkinase | 7-194 | 35 | 4.8e-75 | 260.42 | Pfam | 74-293 (293) | Show / Hide |
Range on Protein: 7-194 Range on HMM: 74-293/293 Sequence Identity: 35% (79 aa) NVYLQLELVTGG----ELFERIV--ERGYY--SERDAARCVREICQAVSYLHDHDIVHRDLKPENLLYA-DMGDEAPLKLADFGLSKI--IDQDVSMKTV ..|. .|.. || .||..| ..| . ||... .....|.... |.|.. |.||||||||.|. .. .|..|..||||.| . .. |.|. HIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF CGTPGYCAPEVLC-GKPYCKAVDMWSVGVITYILLCGFEPFYDD-----RGDNYIYKKIIRADYAFISPWWDDIS-----------------DSAKDFID ||||.|.||||. |..| ..|||||.|.| |..||| ||... . .......| .... | .|||..|| ...||||. CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK RLLVTDPKKRLCAEGALHHPWV ..| |||||. || .|.|||. WCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | CAMK4.AA | CAMK-Unique | 7-194 | 29 | 4.6e-74 | 243.83 | In-house | 109-363 (363) | Show / Hide |
Range on Protein: 7-194 Range on HMM: 109-363/363 Sequence Identity: 29% (75 aa) NVYLQLELVTGGELFERIVE--------------------RGYYSE--RDAARCVREICQAVSYLHDHDIVHRDLKPENLLYADMGD------------- . |. .|...||.||. |.. .|..|| .|... .... .||.|.|. ||||||||.||... .. YMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWS EAPLKLADFGLSKIID-QDVS--MKTVCGTPGYCAP--------------EVLCGKPYCKAV----DMWSVGVITYILLCGFEPFYDDRGDN-------Y .||.||||.. .. .. |.|.|||| |.|| ||. . .| . | || |||.|..||| ||. . | NWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKE IYKKIIRADY-AFISPWWDD---ISDSAKDFIDRLLVTDPKKRLCAEGALHHPWV |...| .|| | ...|.. ||..||||.......||..|. |. .| |.|. IFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
|||||||||
| Kinase | CAMK4.AA | CAMK2 | 9-194 | 49 | 2.9e-69 | 234.31 | In-house | 74-259 (259) | Show / Hide |
Range on Protein: 9-194 Range on HMM: 74-259/259 Sequence Identity: 49% (93 aa) YLQLELVTGGELFERIVERGYYSERDAARCVREICQAVSYLHDHDIVHRDLKPENLLYADMGDEAPLKLADFGLSKIIDQDVS-MKTVCGTPGYCAPEVL || .||||||||| || | |||| ||. |.. | .| . | ..|||||||||||| | | ||||||| .. | ||||| .|||| YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL CGKPYCKAVDMWSVGVITYILLCGFEPFYDDRGDNYIYKKIIRADYAFISPWWDDISDSAKDFIDRLLVTDPKKRLCAEGALHHPWV || |.||.| ||| |||| |. ||.|. .|..| | . || || . ||. |...| .||||. |. || |||. RKDPYGKPVDIWACGVILYILLVGYPPFWDED-QHRLYQQIKAGAYDYPSPEWDTVTPEAKNLINQMLTINPKKRITADEALKHPWI |
|||||||||
| S_TKc | CAMK4.AA | S_TKc | 1-194 | 30 | 1.2e-52 | 182.15 | SMART | 18-231 (231) | Show / Hide |
Range on Protein: 1-194
Range on HMM: 18-231/231
Sequence Identity: 30% (76 aa)
MQSDD-------------------------------------FNVYLQLELVTG--GELFERIVERGY------YSERDAARCVREICQAVSYLHDHDIV
. . ..|. .|.. | |.||..|..||. ..| .|.. ...||.|. |.|.| |.
CRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGII
HRDLKPENLLYADMGDEAPLKLADFGLSKIIDQDVSMKTVCGTPGYCAPEVLCGKPYCK-AVDMWSVGVITYILLCGFEPFYDDRGDNYIYKKIIRADYA
||||||||.| . .|..||||.... .|.|||| |.||||| .| | ..|.||.|.| |..||| ||. .. ..|||
HRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----
FISPWWDDISDSAKDFIDRLLVTDPKKRLCAEGALH-------HPWV
|..|||||...|. ||.||. | ||. |||.
---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| TyrKc | CAMK4.AA | TyrKc | 1-193 | 14 | 5e-06 | -125.04 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-193 Range on HMM: 1-280/280 Sequence Identity: 14% (41 aa) MQSDD-----------------------------------------F-------------------------NVYLQLELVTGGELFERIVERGY-YSER . .. . ... .|.. .| | ... ... . . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK DAARCVREICQAVSYLHDHDIVHRDLKPENLLYADMGDEAPLKLADFGLSKIIDQD----VSMKTVC-----GTPG-----YCAPEVLCGKPYCKAVDMW | |.. .|||.. ..|||| | |... . | .|||||. |. | .| .. |. . .|||.. . . . | | DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW SVGVITY-ILLCGFEPFYDD----RGDNYIYKKIIRADYAFISPWWDD--------ISDSAKDFIDRLLVTDPKKRLCAEGALHHPW | || . |. | .| ... . ..... . .. . | . .| . . . ||..| . . ..|. . SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPP---NDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS-EIHECF |
|||||||||