Gene LKB1 (Sea Urchin)

LKB1

Species: Sea Urchin
Alias: LKB1, SPU_022284, Spk113
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: LKB

Sequence

Name Sequence Type Origin Length Description Download
LKB1.AA Protein None 424 None Fasta, JSON
LKB1.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of LKB1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LKB1.AA LKB 60-320 66 4.2e-241 723.28 In-house 1-265 (265) Show / Hide 
Range on Protein: 60-320
Range on HMM: 1-265/265
Sequence Identity: 66% (177 aa)

YLMGDTLGEGSYGKVKEALDSESLCRRAVKILKKKKLKRIPCGEQNVKREIQLLKRLNHPNIIQLVEVLQNDEKQKMYLFMEYCVSG-LQDMLDAAECKK
|.|||.|||||||||||..||..||||||||.|||||.|||.|.||||.|||.|||..|...|||..|..|.||||||..|||||.| .|.|||...||.
YMMGDVLGEGSYGKVKECMDSYTLCRRAVKIMKKKKLRRIPNGWQNVKKEIQILKRMHHRHVIQLIDVFYNEEKQKMYMVMEYCVCGTMQEMLDMQPCKR

FPIWQANDYFCQLVDGLEYLHSQHVVHKDIKPSNLLLTTAGILKISDFGVAELLDHFTEDDACRTSQGSPAFQPPEIANG-QDVFSGFKVDIWSSGITLY
.|||||..|||||.||.||||||.||||||||.|||||....|||.|||||| |.||..||.|.||||||||||||.||| .|.||||||||||.|.|||
MPIWQAHFYFCQLCDGCEYLHSQRVVHKDIKPGNLLLTHDNTLKICDFGVAEQLHHFQRDDCCTTSQGSPAFQPPECANGNHDTFSGFKVDIWSMGVTLY

NIVTGKFPFEGDNIYRLFENIGKGDYTIPA--DVPPQLTNLLEGMLSIDPDTRLNVHQIKEHVWV
|..|||.||||||.|.|||||||.....|.  |....|.||..|||..|...|...|||..|.|.
NMTTGKYPFEGDNMYKLFENIGKCQWEMPCWYDCDKDLQNLIKGMLQYDHNKRFSCHQIMHHPWF
Kinase LKB1.AA CAMKL 60-320 35 1.7e-129 415.47 In-house 1-297 (297) Show / Hide 
Range on Protein: 60-320
Range on HMM: 1-297/297
Sequence Identity: 35% (107 aa)

YLMGDTLGEGSYGKVKEALD-SESLCRRAVKILKKKKLKRIPCGEQN-----------VKREIQLLKRLN---HPNIIQLVEVLQNDEK----QKMYLFM
| .|.|||.||.|||| |.. .   .. |.||..|||.. .|. ..|           ..||||..|.||   |||||.| ||....|.    .|.||.|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCVSG---LQDMLDAAECKK--FPIWQANDYFCQLVDGLEYLHSQHVVHKDIKPSNLLLTTAG--ILKISDFGVAELLD-H-FTEDDACRTSQGSPAFQ
||| .|   |.|.... ....  .| ..|  ||.|.|....|.||...|| |||| |.||.  |   .||.||| . . . . |.... ..|. |||...
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPEIANG-QDVFSGFKVDIWSSGITLYNIVTGKFPFEGDN---------IYRLFENIGKGDYTIPADVPPQLTNLLEGMLSIDPDTRLNVHQIKEHVWV
.||| .| .. . |.|||||| |..||..|.|..||..|.          ... ...| . ..|. .|. .. .|. .||  .|. | ..|||..| |.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase LKB1.AA CAMK 65-320 25 8.9e-104 335.33 In-house 1-425 (425) Show / Hide 
Range on Protein: 65-320
Range on HMM: 1-425/425
Sequence Identity: 25% (108 aa)

TLGEGSYGKVKEALDSESL------------CRRAVKILKKKKLKR------------------------IPCGEQNVKREIQLLKR-------LNHPNI
|||.||.||||.. . ..              . |.||..|||||                          |. ..||.|||...|.       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQLVEVLQNDE-----------------KQKMYLFM---EYCVSG-----LQDMLDAAEC-------------KKFPIWQANDYFCQLVDGLEYLHSQHV
|.| || ....                 ...||..|   |||  |     | |.. . .|             ..|. ..|  || |......|.||...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHKDIKPSNLLLTTA-----------------GILKISDFGVAELLDH---------------------FTEDDACRTSQGSPAFQP-PEIANGQ-----
|| |.|| |.||..                  . .||.||| |  .|.                     .||.. ..|. |.|.. . ||. ||.     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------DVFSGFKVDIWSSGITLYNIVTGKFPFEGD-------------NIYRLFENIGKGDYT-IPADVPP-----------------------QLTN
           |.|.|.|| |. ||  ..|..||.||             |.|.|||.| ||.|. .|  ..|                       .  .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLEGMLSIDPDTRLNVHQIKEHVWV
|. .||  ||. |....|...| |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase LKB1.AA S_TKc 60-320 28 9.7e-85 288.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 60-320
Range on HMM: 1-231/231
Sequence Identity: 28% (79 aa)

YLMGDTLGEGSYGKVKEALDSESLCRRAVKILKKKKLKRIPCGEQNVKREIQLLKRLNHPNIIQLVEVLQNDEKQKMYLFMEYCVS---GLQDMLDAAEC
| .....|.|..|||. . . ..  . |.||.|           ....||||.||. .||||..| .| |.   ...|..||||      | |...   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

KK----FPIWQANDYFCQLVDGLEYLHSQHVVHKDIKPSNLLLTTAGILKISDFGVAELLDHFTEDDACRTSQGSPAFQPPEIANGQDVFSGFKVDIWSS
..    ||  .|  |..|....|||.||....| |.||.|.||..   .||.|||.| .|         .|  |.| . .||.      ....|.|.|| 
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GITLYNIVTGKFPFEGDNIYRLFENIGKGDYTIPADVPPQLTNLLEGMLSIDPDTRLNVHQIKE-------HVWV
|..||  ..|. ||.  .....|..||          .|.. ......|  ||. |. . .. .       | |.
GCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LKB1.AA CAMKK 60-320 24 1.3e-81 258.69 In-house 1-396 (396) Show / Hide 
Range on Protein: 60-320
Range on HMM: 1-396/396
Sequence Identity: 24% (96 aa)

YLMGDTLGEGSYGKVKEALDSES-LCRRAVKILKK----KKLKR----------------------IPCGEQNVKREIQLLKRLNHPNIIQLVEVLQNDE
|  ....|.|..|||| | ...      |.||..|    ||||.                      .. ....|..||  .|..|||||..|.||... .
YELMKEIGQGQFGKVKLAYNEYDTQKHYAIKIFNKKYVFKKLKKKQQFYRDPPKRMTNMNQNGEMQMMNPFDCVYQEIAIMKKCNHPNIVKLYEVIDDPQ

KQKMYLF-MEYCVSG-LQDMLDAAE-----------------------CKKFPIWQ---------------------ANDYFCQLVDGLEYLH-SQH---
 .| |.  ||||  | ...  .  .                       ....   |                     |  || . . |||||| .|    
NDKIYMVQMEYCERGQIMWWPYWKQDYQPNWPYQYTELYSNRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACS

----------------VVHKDIKPSNLLLTTAG---ILKISDFGVAELLDHFTED-DAC--------RTSQGSPAFQPPEIANG-QDV------------
                ..|.||||.|.|..  |    .||.||||.  ... ... . |           .| |||..||      ..            
YIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFRF

-FSGFKVDIWSSGITLYNIVTGKFPFEGDNIYRLFE---NIGKGDYTIPA-------------DVPPQLTNLLEGMLSIDPDTRLNVHQIKEHVWV
 ..|...|||. |.||| .|.|| || ..|.  |..    | . . . |              .....| .|...||  .|..|....|||.| ||
IYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTKRITIPQIKVHPWV
Kinase LKB1.AA AMPK 60-320 36 8.4e-80 236.61 In-house 1-254 (254) Show / Hide 
Range on Protein: 60-320
Range on HMM: 1-254/254
Sequence Identity: 36% (96 aa)

YLMGDTLGEGSYGKVKEALDSESLCRRAVKILKKKKLKRIPCGEQNVKREIQLLKRLNHPNIIQLVEVLQNDEKQKMYLFMEYCVSG-LQDMLDAAECKK
|..|.|.|||..|||| .         |.||| |.|.|     |  ..|||..|| ..||.|||| ||.   ... ....|||   | | |    .  ..
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVER-IQREIHILKLFRHPHIIQLYEVIIETPTD-IFMVMEYVSGGELFDYI--VKHGR

FPIWQANDYFCQLVDGLEYLHSQHVVHKDIKPSNLLLTTAGILKISDFGVAELLDHFTEDDACRTSQGSPAFQPPEIANGQDVFSGFKVDIWSSGITLYN
 .. .|  .| | . |.||.|   .|| | || ||||     .|| |||   |    .. .  .|. |||    ||.  |.    | .|||||.|. || 
LQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFG---LSNMMKDGEFLKTACGSPCYAAPEMISGK-LYCGPEVDIWSCGVILYA

IVTGKFPFEGDNIYRLFENIGKGDYTIPADVPPQLTNLLEGMLSIDPDTRLNVHQIKEHVWV
 . |. ||. .|.  |. .| .|.|.||... |.  .|...||  ||  |...|.|..| | 
MLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase LKB1.AA Pkinase 60-320 28 1.5e-72 252.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 60-320
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

YLMGDTLGEGSYGKVKEALDSESLCRRAVKILKKKKLKRIPCGEQNVKR--EIQLLKRLNHPNIIQLVEVLQNDEKQKMYLFMEYCVSGLQDMLDAA---
|  | ..|.||.|.|... .  . .. ||||.||.  .. .. .|.  |  |||..||||||||..| .. ..  |...|. ||||  ||   .| .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYI

---ECKKF--PIWQANDYFCQLVDGLEYLHSQHVVHKDIKPSNLLLTTAGIL----KISDFGVAELLDHFTEDDACRTSQGSPAFQPPEIANGQDVFSGF
   . ..|  . |.. .|. |.. ||||.||. ..| |.||.|.|.   | .    ||.|||.|...|    .  . |  |.| . .||. .  .   | 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR-GGQYYGP

KVDIWSSGITLYNIVTGKFPFEGD------NIYRLFENIGKGDYTIPADVP---------------------PQLTNLLEGMLSIDPDTRLNVHQIKEHV
|||.|| |..||  ..|..|| |.      . . ....|.....  . . .                     . .  .....|  ||  |.. .||..| 
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

WV
|.
WF
Kinase LKB1.AA Meta 104-320 36 2.9e-66 190.36 In-house 67-287 (287) Show / Hide 
Range on Protein: 104-320
Range on HMM: 67-287/287
Sequence Identity: 36% (83 aa)

QNVKREIQLLKRLNHPNIIQLVEVLQNDEKQKMYLFMEYCVSGLQDMLDAAECKKFPIWQANDYFCQLVDGLEYLHSQHVVHKDIKPSNLLLTTAGILKI
. | .||  || |.|||.. |||||       .|. .||   |    . .   . ..  ||  ||  .| |||||| | ..|.|||||||||.  |  ||
DRVYQEIAILKKLDHPNVVKLVEVLDDPNEDYLYMVFEYVEKG--PVMEVPCDNPLSEDQAWSYFRDIVCGLEYLHYQKIIHRDIKPSNLLLNDDGHVKI

SDFGVAELLDHFTEDDACRTS---QGSPAFQPPE-IANGQDV-FSGFKVDIWSSGITLYNIVTGKFPFEG--DNIYRLFENIGKGDYTIPA--DVPPQLT
 ||||    . |  ||| . .    |.|||  || . ..|   ..|  .|.|. |.|||  | |. ||    . |  |.. |     . |   ..   | 
ADFGVS---NEFEGDDAFLCNGSTAGTPAFMAPEACSEEQNHFYCGRALDVWAMGVTLYCFVFGQCPFIDKTNYIMCLHDKIKNHPVMFPEQPEISEDLK

NLLEGMLSIDPDTRLNVHQIKEHVWV
 .  .||  .| .|. ...||.| ||
DCIKRMLDKNPEHRIMIPEIKTHPWV
Kinase LKB1.AA Ciliate-E2 60-320 22 5.3e-61 208.15 In-house 1-365 (365) Show / Hide 
Range on Protein: 60-320
Range on HMM: 1-365/365
Sequence Identity: 22% (84 aa)

YLMGDTLGEGSYGKVKEALDSESLCRRA----------------VKILKKKKLKRIPCGEQNVKREIQLLK----------------RLNHPNIIQLVEV
|     .|.|..|.|... . .  .. |                ||| .. .   .. . ...|.||....                .|||||||...|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LQNDEKQKMYLFMEYCVSG-LQD-----------------MLDAAECKKFPIWQAN-------DYFCQLVDGLEYLHSQH-VVHKDIKPSNLLLTTAGIL
 |.  ....|| ||||  | |.|                  ..  |.|..   ...        |.......||||||.. ..| ||||.|.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KISDFGVAELLDHFTED-----------------------------DACRTSQGSPAFQPPEIANGQDVF-------SGFKVDIWSSGITLYNIVTGKFP
||.||| .  .| . ..                             .  .|  |.| ...||| ||..          ..|.|||| |..||  ..||.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEGDNIYRLFENIGKGDYTIP------------------ADVPPQLTNLLEG----MLSIDPDTRLN-VHQIKEHVWV
|        ...| .... .|                   .....  .|.      ||  ||. |..   ||..| | 
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase LKB1.AA ULK 60-320 27 8e-54 185.12 In-house 1-324 (324) Show / Hide 
Range on Protein: 60-320
Range on HMM: 1-324/324
Sequence Identity: 27% (89 aa)

YLMGDTLGEGSYG-KVKEALDSES---LCRRAVKILKKKKLKRIPCG------EQNVKREIQLLKRLN---HPN--IIQLVEVLQNDEKQKMYLFMEYCV
| . . ||.||.| || .. . ..       |.|.  |||.. ..         |. |.|||..| |.   |||  |..| ......     |..|||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

SG-LQDMLDAA-------ECKKFPIWQANDYFCQLVDGLEYLHSQHVVHKDIKPSNLLLTTA------------GILKISDFGVAELLDHF-TEDDACRT
 | |.. .          | |...  .|  .| |.. |. .||.. ..| ||||.|.|..              |.|||.||| |  .|    |.. | |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

SQ------GSPAFQPPEIANGQ--DVFSG-FKVDIWSSGITLYNIVTGKFPFEGDNIYRLF----ENIGKG------DYTIPADVP---------PQLTN
        |.| .  |.| .||      . .|.|||| |. .| ...|| ||... .. ..    . | .|       .. | . |         |.. .
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LLEGMLSIDPDTRLNVHQIKEHVWV
|. .|| .|.. | . ..| .| |.
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase LKB1.AA MARK 60-207 42 1.2e-40 130.73 In-house 1-151 (262) Show / Hide 
Range on Protein: 60-207
Range on HMM: 1-151/262
Sequence Identity: 42% (64 aa)

YLMGDTLGEGSYGKVKEALDSESLCRRAVKILKKKKLKRIPCGEQNVKREIQLLKRLNHPNIIQLVEVLQNDEKQK-MYLFMEYCVSG-LQDMLDAAECK
| |. |.|.|||.||| |..  .  . |.||..|.|| . |.  .||.|||...|.|.|||||.| .| . |..|.  || |||. .| | | . |..  
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLND-PQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNG

KFPIWQANDYFCQLVDGLEYLHSQHVVHKDIKPSNLLLTTAG--ILKISDFG
. .   |  .| |.| ...|.||...|| |||| |.|.   |    ||.|||
RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFG
Kinase LKB1.AA QIK 163-320 34 7.7e-37 128.72 In-house 119-272 (272) Show / Hide 
Range on Protein: 163-320
Range on HMM: 119-272/272
Sequence Identity: 34% (54 aa)

QANDYFCQLVDGLEYLHSQHVVHKDIKPSNLLLTTAGILKISDFGVAELLDHFTEDDACRTSQGSPAFQPPEIANGQDVFSGFKVDIWSSGITLYNIVTG
.|   | |.. . .|.|....|| |.|  |.||      || |||      .|...    |  |||..  ||.  |.. . | |||||| |. ||  |.|
EARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFS---NWFKQGQLLMTWCGSPPYAAPEMFEGKE-YDGPKVDIWSMGVVLYVLVCG

KFPFEGDNIYRLFENIGKGDYTIPADVPPQLTNLLEGMLSIDPDTRLNVHQIKEHVWV
..|| |...  | . .  | . ||  ..  .  |   || .||. |... ||..| | 
ALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase LKB1.AA MARK 226-320 38 1.9e-29 93.57 In-house 167-262 (262) Show / Hide 
Range on Protein: 226-320
Range on HMM: 167-262/262
Sequence Identity: 38% (37 aa)

GSPAFQPPEIANGQDVFSGFKVDIWSSGITLYNIVTGKFPFEGDN--IYRLFENIGKGDYTIPADVPPQLTNLLEGMLSIDPDTRLNVHQIKEHVWV
|.|.. .||| ....   |.|||||| |. || .|.|.|||.||.  .  |...| .|.|.||  |.... ||.  .| ..|. |  ...| .| |.
GTPPYMAPEIFLKKP-YDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase LKB1.AA TyrKc 60-318 23 5.8e-17 51.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 60-318
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

YLMGDTLGEGSYGKVKEALDSESLCRRAVKILKKKKLKRIPCGEQNVKREIQLLKRL--NHPNIIQLVEVLQNDEK-----QKMYLFMEYCVSG-LQDML
  .|..|||| .|.| ..  .      ||| ||. .       ..   ||......|  .||||..|. |   ..      . ... |||.  | |.| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

DAAECKKFPIWQANDYFCQLVDGLEYLHSQHVVHKDIKPSNLLLTTAGILKISDFGVAELLDHF------TEDDACRTSQGSP-----AFQPPEIANGQD
 . . | ..  .  ..  |  .| |||||....| |.   | |..  .. |||||| .  ...       ..    ....|.         .||    ..
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NY

VFSGFKVDIWSSGITLYNIVT-GKFPFEG-----DNIYRLFENIGKGDY-TIPAD--------VPPQLTNLLEGMLSIDPDTRLNVHQIKEHV
    .| |.|| |.... | | |. | .|      . ....|.. .|..  .|..         |. . .. .     ||. | .  .|.|  
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LKB1.AA QIK 60-146 34 2.9e-14 51.8 In-house 1-83 (272) Show / Hide 
Range on Protein: 60-146
Range on HMM: 1-83/272
Sequence Identity: 34% (30 aa)

YLMGDTLGEGSYGKVKEALDSESLCRRAVKILKKKKLKRIPCGEQNVKREIQLLKRLNHPNIIQLVEVLQNDEKQKMYLFMEYCVSG
| .. |.| | .. || |       . |.||. | .| .     | ..||.|..|.|.||.|| | .|.    .. ||. .||| .|
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENL--QKCYREVQIMKMLYHPHIIKLYQVME--TDDMMYIVTEYCSNG
Kinase LKB1.AA Pkinase_Tyr 60-209 29 2.2e-12 42.57 Pfam 1-158 (270) Show / Hide 
Range on Protein: 60-209
Range on HMM: 1-158/270
Sequence Identity: 29% (47 aa)

YLMGDTLGEGSYGKVKEALDS----ESLCRRAVKILKKKKLKRIPCGE---QNVKREIQLLKRL-NHPNIIQLVEVLQNDEKQ-KMYLFMEYCVSG-LQD
  .| .||||..|.|...       .  .  |||.||          .   .   ||....| | .||||..|. |   .... ..|. |||.  | | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

MLDAA--ECKKFPIWQANDYFCQLVDGLEYLHSQHVVHKDIKPSNLLLTTAGILKISDFGVA
 | .   . ..... .  ..  |  .|.|||.|.. .| |.   | |.|  .. ||.||| |
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase LKB1.AA Meta 60-98 46 3e-08 19.86 In-house 1-39 (287) Show / Hide 
Range on Protein: 60-98
Range on HMM: 1-39/287
Sequence Identity: 46% (18 aa)

YLMGDTLGEGSYGKVKEALDSESLCRRAVKILKKKKLKR
| . . .| ||||.|| |   |     | ||| ||||..
YRLMEEIGKGSYGVVKLAYNEEDHHHYAMKILSKKKLLK