Gene SIK (Sea Urchin)

SIK

Species: Sea Urchin
Alias: SIK, SPU_019413, Spk104
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: QIK

Sequence

Name Sequence Type Origin Length Description Download
SIK.AA Protein None 903 None Fasta, JSON
SIK.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of SIK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SIK.AA QIK 26-274 69 2.5e-197 661.84 In-house 1-272 (272) Show / Hide 
Range on Protein: 26-274
Range on HMM: 1-272/272
Sequence Identity: 69% (188 aa)

YDIDRTIGKGNFAVVKLAKHRITKSQVAIKIIDKSRLDESNLKKVYREVQIMKMLSHPNVIKLYQVMETKSMLYLVTEYASNGEMFDT---HGR------
|||.||||||||||||||.|||||..|||||||||.|||.||.|.||||||||||.||..|||||||||..|.|.||||.|||||||.   |||      
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------MSEKEAKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNMNIKIADFGFSNFFVPGEHLATWCGSPPYAAPEVFEGQKYDGPQLD
              |.|.||...| ||..||.|||||..|||||||||.||| |||||||||||||.| .|. |.||||||||||||.|||..||||..|
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

IWSLGVVLYVLVCGALPFDANTLPQLKERVLAGKFRIPFFMSQECEHLIRHMLVINPAKRLSIDQIKNHKWF
|||.|||||||||||||||  ||..|..||| |||||||||||.||||||||||..|..|..|.||..|.| 
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase SIK.AA CAMKL 26-274 47 2.5e-159 512.26 In-house 1-297 (297) Show / Hide 
Range on Protein: 26-274
Range on HMM: 1-297/297
Sequence Identity: 47% (142 aa)

YDIDRTIGKGNFAVVKLAKH-RITKSQVAIKIIDKSRLD--------------ESNLKKVYREVQIMKMLS---HPNVIKLYQVMETKSM------LYLV
|.| .|.|||.|..||||.| |.|. .||||||||...               ||.. ...||.||||||.   |||.||||.|.||...      .|||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

TEYASNGE--MFDT---H----GRMSEKEAKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNM--NIKIADFGFSNFFVP-----GEHLATWCGSPPY
.||.|.||  .||    |    |||.|.||.. | ||..||.|||....||||.|.||.||| |.  ||||.||||||.. |     |. | |.||||||
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

AAPEVFEG--QKYDGPQLDIWSLGVVLYVLVCGALPFDANTLP---------QLKERVLAGKFRIPFFMSQECEHLIRHMLVINPAKRLSIDQIKNHKWF
.|||.|.|  ..||||. ||||.||.||..|||.||||. |..          .|.... ....|....| .|..|||.||. || || .|.||.||.|.
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase SIK.AA MARK 26-274 49 3.2e-150 494.07 In-house 1-262 (262) Show / Hide 
Range on Protein: 26-274
Range on HMM: 1-262/262
Sequence Identity: 49% (130 aa)

YDIDRTIGKGNFAVVKLAKHRITKSQVAIKIIDKSRLDE-SNLKKVYREVQIMKMLSHPNVIKLYQVME--TKSM-LYLVTEYASNGEMFD-----THGR
| . .|||.|..|.|||| |. |. .|||||..| .|..  ..|.|.||..|||.|.|||.|||..|.|  |..  .||. ||||.||..|     ..||
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

MSEKEAKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNM--NIKIADFGFSNFFVPGEHLATWCGSPPYAAPEVFEGQKYDGPQLDIWSLGVVLYVLV
..|.||.. | ||. ||.|||....||||.|.||.|.| |.  ||||.|||||. . ||. | | ||.|||.|||.|....||||  ||||||||||..|
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

CGALPFDANT--LPQLKERVLAGKFRIPFFMSQECEHLIRHMLVINPAKRLSIDQIKNHKWF
|| .|||. |  . .|....|.||..||...| ||..||. .|..|| .| .|..| .|.|.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase SIK.AA AMPK 26-274 50 1e-146 438.54 In-house 1-254 (254) Show / Hide 
Range on Protein: 26-274
Range on HMM: 1-254/254
Sequence Identity: 50% (128 aa)

YDIDRTIGKGNFAVVKLAKHRITKSQVAIKIIDKSRL-DESNLKKVYREVQIMKMLSHPNVIKLYQVM-ETKSMLYLVTEYASNGEMFD---THGRMSEK
| |. |||.| |  ||...| .|. .|||||..| .. |..  ... ||..|.|.. ||..|.||.|  ||.. ...|.||.|.|| ||    |||..|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EAKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNMNIKIADFGFSNFFVPGEHLATWCGSPPYAAPEVFEGQKYDGPQLDIWSLGVVLYVLVCGALPF
||.. | |||..|||||.  .|||||| |||||| |.||||.||| ||    || | | |||| |||||. .|..| ||. |||| ||.||...|| |||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

DANTLPQLKERVLAGKFRIPFFMSQECEHLIRHMLVINPAKRLSIDQIKNHKWF
|    |.|  ....|.. || |.|.|.. ||.|||  .| ||..|..|.||.||
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase SIK.AA CAMK 31-274 30 2.8e-138 448.52 In-house 1-425 (425) Show / Hide 
Range on Protein: 31-274
Range on HMM: 1-425/425
Sequence Identity: 30% (130 aa)

TIGKGNFAVVKLAKHRITK------------SQVAIKIIDKSRLD--------------------------ESNLKKVYREVQIMKMLS-------HPNV
|.|.|.|..|||..|. |.             .||||||||..|.                          ....|.|.||..|||.|.       |||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYQVME------------TKSM--------LYLVT---EYASNGEMFDT-------H---------------GRMSEKEAKKKFMQIIAAVEYCHKRH
||||.|.|            | |.        .|.|.   ||.|.||.||        |               ||..|.||.. | ||. ||.|||...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VVHRDLKAENLLLDGNM-----------------NIKIADFGFSNFFVP------------------------GEHLATWCGSPPYAA-PEVFEG-----
.|||||| ||.||| |.                 ||||.||||.|.| |                        |. . |.||.|.|.| |||..|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------QKYDGPQLDIWSLGVVLYVLVCGALPFDAN-------------TLPQLKERVLAGKFR-IPFFMS-----------------------QECE
        ..|.||. |.||.||.||...|| .||..              ....|.|....||.. .|...|                       ||| 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

HLIRHMLVINPAKRLSIDQIKNHKWF
.|||.||. .| ||..|.|..||.|.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase SIK.AA NuaK 26-274 45 2.1e-123 326.43 In-house 1-252 (252) Show / Hide 
Range on Protein: 26-274
Range on HMM: 1-252/252
Sequence Identity: 45% (115 aa)

YDIDRTIGKGNFAVVKLAKHRITKSQVAIKIIDKSRL-DESNLKKVYREVQIMKMLSHPNVIKLYQVMETKSMLYLVTEYASNGEMFD---THGRMSEKE
|.. .| ||| .  ||||  . |  .|||| | |..  ||  . .. ||..||  | ||..|. | | | |. . .| |||| ||..|     ....|.|
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

AKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNMNIKIADFGFSNFFVPGEHLATWCGSPPYAAPEVFEGQKYDGPQLDIWSLGVVLYVLVCGALPFD
|.. | ||. || ||||  ..||||| || ||| | |.|||||| ||..  .. | | |||| || ||. .|| | ||  | |||||.||..| | .|||
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

ANTLPQLKERVLAGKFRIPFFMSQECEHLIRHMLVINPAKRLSIDQIKNHKWF
 .   .|.  .  |... |   |. |. |||.|| .|| .| .| .| .| | 
GHDFKHLVKQISQGAYYEPCKPSDACM-LIRWMLMVNPRRRATIYDICHHWWV
Kinase SIK.AA NIM1 26-274 43 4.1e-115 339.6 In-house 1-258 (258) Show / Hide 
Range on Protein: 26-274
Range on HMM: 1-258/258
Sequence Identity: 43% (111 aa)

YDIDRTIGKGNFAVVKLAKHRITKSQVAIKIID--KSRLDESNLKKVYREVQIMKMLSHPNVIKLYQVMETKSMLYLVTEYASNGEMF---DTHGRMSEK
| .   || |||  |||. |  ||  |||||.|  |  .|   ..   ||.| |  . |||...|| | || . ..||.|||. || .    . | ..| 
YRFCGEIGRGNFSKVKLGVHQLTKEKVAIKIMDLDKTKMDQKTQRMLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLREI

EAKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNMNIKIADFGFSNFFVP----GEHLATWCGSPPYAAPEVFEGQKYDGPQLDIWSLGVVLYVLVCG
..|  | ||. ||   | | .||||.|||| ..  |  .|..|||||         .. | | |||||||||| |  . | |.  |.| ||. ||  . |
HCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPELFQDEHYIGEYVDVWALGILLYFMMTG

ALPFDANTLPQLKERVLAGKFRIPFFMSQECEHLIRHMLVINPAKRLSIDQIKNHKWF
  || | | | .|  .|.|.. || . |  |  ||| ||   |. |  |||..|| | 
VMPFRAETVPKMKKCILKGQYQIPDYVSLPCHRLIRGMLKHIPTQRYTIDQMMNHQWM
Kinase SIK.AA BRSK 26-274 50 5.9e-106 358.3 In-house 1-254 (254) Show / Hide 
Range on Protein: 26-274
Range on HMM: 1-254/254
Sequence Identity: 50% (128 aa)

YDIDRTIGKGNFAVVKLAKHRITKSQVAIKIIDKSRLD--ESNLKKVYREVQIMKMLSHPNVIKLYQVMETKSMLYLVTEYASNGEMFD---THGRMSEK
| ...| |||    |||  | .|   |||||| | .|   || |.|| ||. |||.  ||.|.|.| | |.|  |||. |. | ||.||     ||.  |
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPK

EAKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNMNIKIADFGFSNFFVPGEHLATWCGSPPYAAPEVFEGQKYDGPQLDIWSLGVVLYVLVCGALPF
||.| | ||| |...|| . . ||||| ||||||.  ||||||||     | .  | | |||| || |||  | |||| . |.|| ||.|| |  |||||
EARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPF

DANTLPQLKERVLAGKFRIPFFMSQECEHLIRHMLVINPAKRLSIDQIKNHKWF
| . | || |.|  | | .| |  . |  | | |. ..|.||.|. .|. | |.
DDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase SIK.AA SNRK 26-274 45 1.1e-98 323.81 In-house 1-254 (254) Show / Hide 
Range on Protein: 26-274
Range on HMM: 1-254/254
Sequence Identity: 45% (116 aa)

YDIDRTIGKGNFAVVKLAKHRITKSQVAIKIIDKSRLDESNLKKVYREVQIMKMLSHPNVIKLYQVMETKSMLYLVTEYASNGEMFD---THGR-MSEKE
||...|.|.| |||||||.|  |  .||.|.||| ..||    ....||. ||.  |||...|| |..|.  |||. |    ..|.|    | . ..|. 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

AKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNMN-IKIADFGFSNFFVPGEHLATWCGSPPYAAPEVFEGQKYDGPQLDIWSLGVVLYVLVCGALPF
|.| | ||. |..|||..|||||||| || .    .  .|. |||||| | |||.| | |||  |.|||.  | .|| | .|||||||.||.|||| .||
ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF

DANTLPQLKERVLAGKFRIPFFMSQECEHLIRHMLVINPAKRLSIDQIKNHKWF
.         ...  |. .|  .|.||  ||  ||| .| || |...|..| | 
QEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase SIK.AA S_TKc 26-274 35 1.4e-98 334.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-274
Range on HMM: 1-231/231
Sequence Identity: 35% (95 aa)

YDIDRTIGKGNFAVVKLAKHRITKSQVAIKIIDKSRLDESNLKKVYREVQIMKMLSHPNVIKLYQVMETKSMLYLVTEYASN--GEMFD---THGR----
|.| |.|||| |..|....|. |. .||||||.         ....||.||.|.  |||..||| |... . ||.|.||...  |..||    .||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MSEKEAKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNMNIKIADFGFSNFFVPGEHLATWCGSPPYAAPEVFEGQKYDGPQLDIWSLGVVLYVLV
  ..| .|.. . ||. |.||||.....||||| ||.|||   .|||.|||.. ..       | ||.| | ||||.   .|...  |.||.|..|| ..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

CGALPFDANTLPQLKERVLAGKFRIPFFMSQECEHLIRHMLVINPAKRLSIDQIKN-------HKWF
||  ||.  .. .. ....          |.|. ..||..|. .|.||... .. .       | ||
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SIK.AA TSSK 26-274 37 2e-98 323.68 In-house 1-289 (289) Show / Hide 
Range on Protein: 26-274
Range on HMM: 1-289/289
Sequence Identity: 37% (108 aa)

YDIDRTIGKGNFAVVKLAKHRITKSQ----------------VAIKIIDKSRLDESNLKK-VYREVQIMKM-LSHPNVIKLYQVMETKS-MLYLVTEYAS
|. ...||.|..| |..| .. .|                  |||||||. .  . .|.|   || |||.. | |||.|..|.  || . . |.| |||.
YNVGKKIGHGSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIKIIDRKKAPTDYLNKFLPREIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAE

NGEMFD---TH------GRMSEKEAKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNMNIKIADFGFSNFFVPGE------HLATWCGSPPYAAPEVF
.| ...   ..      |...|..|.| | |...||.||| ..||||||| ||.||| . |||..||||.. . ...       . | |||  |||||..
HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEIL

EGQKYDGPQLDIWSLGVVLYVLVCGALPFDA--NTLPQLKERVL--AGKFRI--PFFMSQECEHLIRHMLVINPAKRLSIDQIKNHKWF
 | .||. . |.||.||.||..||| .|||     .... ...     .|..    . |||| .|||||| ..| .|..|..|..| | 
RGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM
Kinase SIK.AA Pkinase 26-274 34 1.1e-96 332.32 Pfam 1-293 (293) Show / Hide 
Range on Protein: 26-274
Range on HMM: 1-293/293
Sequence Identity: 34% (102 aa)

YDIDRTIGKGNFAVVKLAKHRITKSQVAIKIIDKSRLDESNLKKVYR--EVQIMKMLSHPNVIKLYQVMETKSMLYLVTEYASNG----EMF-----DTH
| | |.||.|.|..|....|. |  .||.|||.|.. ... ..   |  |.||||.|.|||...|| ..|.|. .|.|.||. .|    . |     . |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRM--SEKEAKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNMNI----KIADFGFSNF--FVPGEHLATWCGSPPYAAPEVFEGQKYDGPQLDIWSL
|..  ||.|.|. . ||. ..||||.. ..||||| ||.|.| |..|    ||.|||.. .    ... . | ||.|.|.||||  |..|.||  |.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVLYVLVCGALPFDAN------TLPQLKERVLAGKFRIPFF---------------------MSQECEHLIRHMLVINPAKRLSIDQIKNHKWF
|..|| ..|| .||.        .  |. .|.. .... ...                     .|.|| ..|. .|  .|.||....||..|.||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SIK.AA Pkinase_Tyr 26-108 29 1e-18 63.98 Pfam 1-92 (270) Show / Hide 
Range on Protein: 26-108
Range on HMM: 1-92/270
Sequence Identity: 29% (27 aa)

YDIDRTIGKGNFAVVKLAKHR----ITKSQVAIKIIDKSRLDESN--LKKVYREVQIMKML-SHPNVIKLYQVME-TKSM--LYLVTEYASNG
  .....|.|.| .|.... .     || .||.|.. |   ....  ...  ||..||| | .|||...|| |    .    .|.|.||. .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG
Kinase SIK.AA TyrKc 26-274 23 9e-18 64.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-274
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

YDIDRTIGKGNFAVVKLAKHRITKSQVAIKIIDKSRLDESNLKKVYREVQIMKML--SHPNVIKLYQVMETK-------SMLYLVTEYASNGEMFD---T
   ....| |.| .| ... .    |||.| . ..      ..  .|| .||..|  .|||...|| |  ..         |..|.||...|   |    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HGR-MSEKEAKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDGNMNIKIADFGFSNFFVPG-------EHLATW---CGS--PPYA--APEVFEGQKYDG
|..  . |.  .   || .  || |.....|||| | | |.. |  .||.||| | .   .       .   .    .|    |.   |||..   |.  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-

PQLDIWSLGVVLY-VLVCGALPFDA-----NTLPQLKERVLAGKFRIPFFM---------SQECEHLIRHMLVINPAKRLSIDQIKNHKWF
.. |.|| ||... ..  |. |         .  .. |.| .|. . .            ..|   ...     .|..| .  .|  |. |
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase SIK.AA Pkinase_Tyr 134-165 46 2.7e-05 18.57 Pfam 125-156 (270) Show / Hide 
Range on Protein: 134-165
Range on HMM: 125-156/270
Sequence Identity: 46% (15 aa)

EYCHKRHVVHRDLKAENLLLDGNMNIKIADFG
|| . .. .|||| | | |.. |. .||.|||
EYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase SIK.AA Pkinase_Tyr 202-235 24 0.497734 4.11 Pfam 196-232 (270) Show / Hide 
Range on Protein: 202-235
Range on HMM: 196-232/270
Sequence Identity: 24% (9 aa)

DIWSLGVVLYVLVC-GALP-FDANTLPQLKERV-LAG
|.|| ||... ..  |. | .   .  ...|..   |
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG
UBA_CAMKL SIK.AA UBA_CAMKL 299-336 39 2.2e-14 49.65 In-house 1-41 (41) Show / Hide 
Range on Protein: 299-336
Range on HMM: 1-41/41
Sequence Identity: 39% (16 aa)

NEQALRLMQSL--GIDQQKTIDSLRRDAY-DHYTAIYYLLV
.|.....|...  |.| ...|.||| . | .| ||.||||.
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL