Gene SNRK (Sea Urchin)

SNRK

Species: Sea Urchin
Alias: SNRK, SPU_004413, Spk112
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: SNRK

Sequence

Name Sequence Type Origin Length Description Download
SNRK.AA Protein None 201 None Fasta, JSON
SNRK.kin_dom Protein Kinase Domain None 180 None Fasta, JSON

Protein domain

Protein domains of SNRK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SNRK.AA SNRK 18-198 86 1.3e-148 489.99 In-house 1-181 (254) Show / Hide 
Range on Protein: 18-198
Range on HMM: 1-181/254
Sequence Identity: 86% (156 aa)

YDLEETLGRGHFAIVKLARHIFTGEKVAVKVIDKLKLDAVSKAHLFQEVKCMKLVQHPNVVRLYEVIDTQTKLYLILELGDGGDMYDYIMKHENGLDDDI
||||.||||||||.||||||.|||||||||||||.|.|.||||||||||.|||||||||.||||||||||||||||||||||.||||||||||.||..|.
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

ARTYFRQIVEAISYCHKRRVVHRDLKPENVIFFKKQGVVKLTDFGFSNRFMPGEKLETSCGSLAYSAPEILLGDSYDAPAV
||.||.||..||.|||...|||||||||||.||.|||.||||||||||.||||||||||||||||||||||||||||||||
ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAV
Kinase SNRK.AA CAMKL 18-198 41 8.70000000001e-104 332.1 In-house 1-217 (297) Show / Hide 
Range on Protein: 18-198
Range on HMM: 1-217/297
Sequence Identity: 41% (90 aa)

YDLEETLGRGHFAIVKLARH-IFTGEKVAVKVID--KLKLDAVSKAH-----------LFQEVKCMKLVQ---HPNVVRLYEVIDTQTK------LYLIL
|....|||.|.|. ||||.| ..||||||.|.||  |...| ..|..           ...|...||...   |||...|||||.|...      .||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELGDGGD--MYDYIMKHEN---GLDDDIARTYFRQIVEAISYCHKRRVVHRDLKPENVIFFKKQG-VVKLTDFGFSNRFMP-----GEKLETSCGSLAYS
|. .||.  ..||| ||..    .. . || ||||||.|..|||....||||.||||. . ...  ..|..|||||| ..|     |.||.|.|||..| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEILLG--DSYDAPAV
||||..|  ..||.|.|
APEIFQGNNKPYDGPKV
Kinase SNRK.AA CAMK 23-198 26 1.2e-85 275.87 In-house 1-315 (425) Show / Hide 
Range on Protein: 23-198
Range on HMM: 1-315/425
Sequence Identity: 26% (83 aa)

TLGRGHFAIVKLARHIFTG------------EKVAVKVIDKLKLD--------------------------AVSKAHLFQEVKCMKLVQ-------HPNV
||||| |..|||..|. |.            .|||.|.||| ||.                          ..... ...|...||..|       |||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLYEVID------------TQTK--------LYLIL---ELGDGG----DMYDYIMKHENG--------------LDDDIARTYFRQIVEAISYCHKRR
..||||..            | .|        .|...   |. .||    |..||| .|...              .. . ||.|||||..|. |||.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VVHRDLKPENVIFFKKQ----------------GVVKLTDFGFSNRFMP------------------------GEKLETSCGSLAYSA-PEILLG-----
.|||||||||. . ..                 . .|..||||.|.|.|                        |.|..|.||...| | ||.|.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------DSYDAPAV
          |. |..
MQNATDEEKPYYGPKC
Kinase SNRK.AA MARK 18-198 45 1.4e-81 266.47 In-house 1-187 (262) Show / Hide 
Range on Protein: 18-198
Range on HMM: 1-187/262
Sequence Identity: 45% (86 aa)

YDLEETLGRGHFAIVKLARHIFTGEKVAVKVIDKLKLDA-VSKAHLFQEVKCMKLVQHPNVVRLYEVID--TQTK-LYLILELGDGGDMYDYIMKHENG-
| .  |.| | .| ||||.|. ||.|||.|...| ||.   ..  .. |.. ||...|||...|..||.  | .. .|||.|.  ||..|||| .|.|| 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LDDDIARTYFRQIVEAISYCHKRRVVHRDLKPENVIFFKKQG--VVKLTDFGFSNRFMPGEKLETSCGSLAYSAPEILLGDSYDAPAV
|  . ||..|||||.|..|||....||||.||||.    ..|   .|..|||||....||.||.| ||...| ||||.|.  ||.|.|
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENIL-IDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKV
Kinase SNRK.AA AMPK 18-198 41 3.7e-76 225.6 In-house 1-181 (254) Show / Hide 
Range on Protein: 18-198
Range on HMM: 1-181/254
Sequence Identity: 41% (76 aa)

YDLEETLGRGHFAIVKLARHIFTGEKVAVKVIDKLKLDAVS-KAHLFQEVKCMKLVQHPNVVRLYEVI-DTQTKLYLILELGDGGDMYDYIMKHENGLDD
| ...|.|.| |  ||.. || ||||||.|...| |.  .. .  .  |.. .||. ||....||||| .|.| .....|   ||. .||| || . |. 
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKH-GRLQE

DIARTYFRQIVEAISYCHKRRVVHRDLKPENVIFFKKQGVVKLTDFGFSNRFMPGEKLETSCGSLAYSAPEILLGDSYDAPAV
. |. .| ||. ...|||.  .|||||||||. .  ..  .|. ||| ||    ||.| |.|||  | |||.  |  |  | |
REACRFFQQIISGVEYCHRHMIVHRDLKPENLLLD-HNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEV
Kinase SNRK.AA QIK 18-198 42 2.2e-72 246.78 In-house 1-199 (272) Show / Hide 
Range on Protein: 18-198
Range on HMM: 1-199/272
Sequence Identity: 42% (85 aa)

YDLEETLGRGHFAIVKLARHIFTGEKVAVKVIDKLKLDAVSKAHLFQEVKCMKLVQHPNVVRLYEVIDTQTKLYLILELGDGGDMYDYIMKHEN------
||.| |.|.| ||.||||||. | .|||.|.||| .||.     .. ||. ||. .||....||.|. |.  .|.. |   .|.|.||..||        
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

-------------GLDDDIARTYFRQIVEAISYCHKRRVVHRDLKPENVIFFKKQGVVKLTDFGFSNRFMPGEKLETSCGSLAYSAPEILLGDSYDAPAV
              .  . ||  | ||. |. ||||| .|||||| || | . ..  .|. |||||| | .|. |.| ||| .| |||...| .|| | |
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAEN-ILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKV
Kinase SNRK.AA NuaK 18-198 40 2e-67 176.1 In-house 1-180 (252) Show / Hide 
Range on Protein: 18-198
Range on HMM: 1-180/252
Sequence Identity: 40% (74 aa)

YDLEETLGRGHFAIVKLARHIFTGEKVAVKVIDKLKLDAVSK-AHLFQEVKCMKLVQHPNVVRLYEVIDTQTKLYLILELGDGGDMYDYIMKHENGLDDD
|....|||.| .  ||||. ..|| .||.| | | | ..     |  .|.. |  ..||...  |||   . |. ...|   ||..|||| . .  |   
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKS-LPER

IARTYFRQIVEAISYCHKRRVVHRDLKPENVIFFKKQGVVKLTDFGFSNRFMPGEKLETSCGSLAYSAPEILLGDSYDAPAV
 ||  ||||| |. |||| |..||||| || |   ... .|  ||| || .  .. |.| |||  |  |||  |  |  | |
EARHFFRQIVSAVHYCHKHRICHRDLKLEN-ILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEV
Kinase SNRK.AA TSSK 18-194 34 1.9e-65 213.72 In-house 1-206 (289) Show / Hide 
Range on Protein: 18-194
Range on HMM: 1-206/289
Sequence Identity: 34% (71 aa)

YDLEETLGRGHFAIVKLARHIFTGEK----------------VAVKVIDKLKL-DAVSKAHLFQEVKCMKL-VQHPNVVRLYEVIDTQT-KLYLILELGD
|......|.| .| |..|..  .  |                ||.|.||. |  . . .  |  | ..|.  ..|||....|| ..|.  | |...|...
YNVGKKIGHGSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIKIIDRKKAPTDYLNKFLPREIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAE

GGDMYDYIMKH-----ENGLDDDIARTYFRQIVEAISYCHKRRVVHRDLKPENVIFFKKQGVVKLTDFGFSNRFMPGE------KLETSCGSLAYSAPEI
.||. .|| ..      ..|... ||. |||.|.|. ||| . ||||||| ||.. .|  . .|||||||........      ...| ||| ||.||||
HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKH-WNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEI

LLGDSYD
|.|  ||
LRGIPYD
Kinase SNRK.AA RAD53 18-190 33 2.3e-63 187.39 In-house 1-200 (305) Show / Hide 
Range on Protein: 18-190
Range on HMM: 1-200/305
Sequence Identity: 33% (68 aa)

YDLEETLGRGHFAIVKLARHIFTGEKVAVKVIDKLK-----LDA-VSKAHLFQEVKCMKLVQHPNVVRLYEVIDT-QTKLYLILELGDGGDMYDYIMKHE
|.. ..||.|.|..||||    |..|||.| ||| |      ..  ..  .  ||. .| ..||...|.|...|| |. .|..||| .||. .. |  ..
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

N---GLDDDIARTYFRQIVEAISYCHKRRVVHRDLKPENVIFF-KKQG----------------VVKLTDFGFSNRFMPGEK--LETSCGSLAYSAPEIL
    |.| |....||.|...|..| | .  .||||||||. .  ....                ..|.|||| | .|. ||.  . | ||...| |||..
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLS-KFV-GEGSFMKTMCGTPQYVAPEVI

LG
..
TS
Kinase SNRK.AA Pkinase 18-197 31 2.9e-61 214.66 Pfam 1-193 (293) Show / Hide 
Range on Protein: 18-197
Range on HMM: 1-193/293
Sequence Identity: 31% (61 aa)

YDLEETLGRGHFAIVKLARHIFTGEKVAVKVIDKLKLDAVSKAHLFQ--EVKCMKLVQHPNVVRLYEVIDTQTKLYLILELGDGG----DMYDYIM-KHE
| .....|.| |. |....|. ||..||||.|.| . .   . ...   |.. || ..|||.||||..  . ...|...|. .||    | .|||. . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NGL--DDDIARTYFRQIVEAISYCHKRRVVHRDLKPENVIFFKKQGVV----KLTDFGFSNR--FMPGEKLETSCGSLAYSAPEILL-GDSYDAPA
...  ... .. |..||.... |||.....|||||||| |.....|..    |..|||..      ... . | ||.. | |||... |  |. ..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPEN-ILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV
Kinase SNRK.AA CAMK1 18-194 35 3.7e-60 173.53 In-house 1-194 (276) Show / Hide 
Range on Protein: 18-194
Range on HMM: 1-194/276
Sequence Identity: 35% (69 aa)

YDLEETLGRGHFAIVKLARHIFT---GEKVAVKVID-KLKLDAVSK---AHLFQEVKCMKLV---QHPNVVRLYEVIDTQTKLYLILELGDGGDMYDYIM
| . ...||| |..|.|. |. |   |...|.|.|| |  ..  .    . | .|.  || |   .|||.. .||. .. ...||..||  ||.  | |.
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

KHENGLDDDIARTYFRQIVEAISYCHKRRVVHRDLKPENVIFFKK--QGVVK--LTDFGFSNRFMPGE-KLETSCGSLAYSAPEILLG---DSYD
. .|   .| ||.  .||..|. |.|.. .|||||||||  .  |  .  .|  . ||| | .| ..| ...| ||.. | |||.| .   . ||
EKGNYTEKD-ARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYD
Kinase SNRK.AA S_TKc 18-198 25 1.2e-41 145.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-198
Range on HMM: 1-231/231
Sequence Identity: 25% (65 aa)

YDLEETLGRGHFAIVKLARHIFTGEKVAVKVIDKLKLDAVSKAHLFQEVKCMKLVQHPNVVRLYEVIDTQTKLYLILELGDG--GDMYDYIMKHENG---
|.. ...|.| |. |...||. ||..||.|.|.          |. .|....|  .|||.|.||.|... ..||...|. ||  ||..||| |.  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDDDIARTYFRQIVEAISYCHKRRVVHRDLKPENVIFFKKQGVVKLTDFGFSNRFMPGEKLETSCGSLAYSAPEILLGDSYDA---------------
  ..   || |..||..|. |||.....||||||||. . .   ..|..|||.. ..       | ||.. | |||.|   .|.                
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

----------------------------------------------------PAV
                                                    | .
LCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase SNRK.AA Pkinase_Tyr 18-142 28 4e-19 65.38 Pfam 1-137 (270) Show / Hide 
Range on Protein: 18-142
Range on HMM: 1-137/270
Sequence Identity: 28% (39 aa)

YDLEETLGRGHFAIVKLARHI----FTGEKVAVKVIDKLKLDAVS--KAHLFQEVKCMKLV-QHPNVVRLYEVID-TQTK--LYLILELGDGGDMYDYIM
  . ..||.|.|  |....       |. .||||.. | . .     .. ...|.| ||   .|||.|||| |.   .    .|...|.  .||..||  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KH---ENGLDDDIARTYFRQIVEAISYCHKRRVVHRDL
||   .. |.      . .|| .. .| . .. .||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase SNRK.AA TyrKc 18-198 17 2.6e-10 -55.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-198
Range on HMM: 1-280/280
Sequence Identity: 17% (51 aa)

YDLEETLGRGHFAIVKLARHIFTGEKVAVKVIDKLKLDAVSKAHLFQEVKCMKLV--QHPNVVRLYEVIDTQ-------TKLYLILELGDGGDMYDYIMK
  |...||.|.| .| ... .   ..||||.. . .     .. . .| . |. .  .|||.|||| |. .|         |....|. ..||  ||. |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HENGLDDDIARTYFRQIVEAISYCHKRRVVHRDLKPENVIFFKKQGVVKLTDFGFSNRFMPGE-------KLETS----CGS----LAYSAPEIL-----
|.. |  .    .  || .  .| |.....||||   |.   ... .|| .||| | |.   .       .  ..    .|     .   ||| .     
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

------------------LGDSYDAP--------------------------------------------------------------AV
                  .|..                                                                    
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF