Gene SgK495 (Sea Urchin)
SgK495
Sequence
Protein domains of SgK495.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | SgK495.AA | SgK495 | 143-313 | 88 | 3.3e-160 | 498.98 | In-house | 1-171 (171) | Show / Hide |
Range on Protein: 143-313 Range on HMM: 1-171/171 Sequence Identity: 88% (151 aa) NLQHHVIHEKKLSEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNCHTRQITLTNFCLGKHLVSEHDLLKDQRGSPAYISPDVLSGKPYLGKPSDM ||||||||||.|||.|.||||||||.|||.||.|||||||||||||||||||.|||.|||||||||||||||||||||||||||||||||.||.|||||| NLQHHVIHEKRLSERETVYIFHDVVRIVEALHQKNIVHRDLKLGNMVLNCHTHQITITNFCLGKHLVSEHDLLKDQRGSPAYISPDVLSGRPYRGKPSDM WALGVVLFTMLYGQFPFYDSAPQELFRKIKAAEFTIPQDGRVSENTTGLIKSLLVLDASTRLTATQVIESV ||||||||||||||||||||.||||||||||||.||||||||||||..||..|||||...|||||||||.| WALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPQDGRVSENTVCLIRKLLVLDPQQRLTATQVIEAV |
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| Kinase | SgK495.AA | CAMK | 144-311 | 21 | 1.3e-58 | 187.19 | In-house | 151-421 (425) | Show / Hide |
Range on Protein: 144-311
Range on HMM: 151-421/425
Sequence Identity: 21% (59 aa)
LQHHVIHE---------------KKLSEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNCHT----------------RQITLTNFCLGKHLVS--
| ... ....|.|| ..|. ..| |. .|..||||||||. | |. . .| .. | . ... .
LFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGE
---------------------EHDLLKDQRGSPAYIS-PDVLSG-------------KPYLGKPSDMWALGVVLFTMLYGQFPFYDS-------------
| ...|.. |.|.|.. | ||.| ||| |...|||..||.|..|| | .|||..
NNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGM
APQELFRKIKAAEFT-IPQ-------------DGRVSEN--------TTGLIKSLLVLDASTRLTATQVIE
..|||.||...... .| ....|.. ||...|. | . |.|..|. .
NDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN
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| Kinase | SgK495.AA | CAMKL | 144-311 | 28 | 2.7e-41 | 129.46 | In-house | 110-293 (297) | Show / Hide |
Range on Protein: 144-311 Range on HMM: 110-293/297 Sequence Identity: 28% (53 aa) LQHHVIHE----KKLSEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNCHTR-QITLTNFCLGKH---L-VSEHDLLKDQRGSPAYISPDVLSG-- |..... . ....|.|| .| .|| |. .|...|||||.|. | | .. . .| .. | .. . . . ..|| . |||.| .| ...| LFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNN KPYLGKPSDMWALGVVLFTMLYGQFPFYDSAPQ-------ELFRKIKAAEFTIPQDGRVSENTTGLIKSLLVLDASTRLTATQVIE ||| |.. |.|..||.|..|..|..|| | . .|..||. . .| .|| ||...|. . . | |. |. . KPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN |
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| Kinase | SgK495.AA | Trbl | 150-311 | 40 | 1.9e-40 | 125.22 | In-house | 91-252 (256) | Show / Hide |
Range on Protein: 150-311 Range on HMM: 91-252/256 Sequence Identity: 40% (66 aa) HEKKLSEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNCHTR-QITLTNFCLGKHLVSEHDLLKDQRGSPAYISPDVLSGKP-YLGKPSDMWALGV | |.| |.|| .|| ... | |. || ||||| | | .. | . . . | | | | | |||.|| .|. .. | ||. ||| ||| HRKRLCEEEAARLFHQMCQAVAHCHQHGIVLRDLKLRRFVFKDEERTKLQLESLEDSCIMTGEDDSLWDKHGCPAYVSPEILCTQGSYSGKAADMWSLGV VLFTMLYGQFPFYDSAPQELFRKIKAAEFTIPQDGRVSENTTGLIKSLLVLDASTRLTATQVIE .|.||| |..||.||.| || || .| || .| || .|| . | |.||... . MLYTMLVGRYPFHDSEPCNLFTKIRRGQFCIPE--HLSPKARCLIRCLLRREPSERMTAQHILL |
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| Kinase | SgK495.AA | AMPK | 152-312 | 37 | 2.9e-37 | 108.21 | In-house | 95-251 (254) | Show / Hide |
Range on Protein: 152-312 Range on HMM: 95-251/254 Sequence Identity: 37% (60 aa) KKLSEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNCHTRQITLTNFCLGKHLVSEHDLLKDQRGSPAYISPDVLSGKPYLGKPSDMWALGVVLFT ..|.|.|| | ..| || .|. .|||||||. |. |. | .| . | | . . .. ..|| ||| | .| . |||.| | | | ||.|. GRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLD-HNKNIKIVDFGLSN-MMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYA MLYGQFPFYDSAPQELFRKIKAAEFTIPQDGRVSENTTGLIKSLLVLDASTRLTATQVIES || | || |. .|..|||. |..||.. .|.. .|||..| | |.| .. .. MLCGYLPFDDENTPTLYKKIKNGEYYIPKF--LSPEAKDLIKHMLQVDPMKRITIHDIRNH |
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| Kinase | SgK495.AA | GIN4 | 153-315 | 31 | 3.5e-37 | 116.01 | In-house | 130-293 (293) | Show / Hide |
Range on Protein: 153-315 Range on HMM: 130-293/293 Sequence Identity: 31% (52 aa) KLSEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNCHTRQITLTNFCLGKHLVSEHDLLKDQRGSPAYISPDVLSGKPYLGKPSDMWALGVVLFTM .| |.||. .|. .. | | ||.||||| |..| ..| . | . | . .||. ||| | .|.. .| || | .||.|. ||.|| . PLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMA-ALETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFAL LYGQFPFYDS--APQELFRKIKAAEFTIPQDGRVSENTTGLIKSLLVLDASTRLTATQVIESVKT | |. || . ..| |.. .. .| | .| . ||. .||.| |.. .... LTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEKRIKTRDILKHPLI |
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| Kinase | SgK495.AA | MARK | 143-311 | 32 | 1.6e-36 | 117.0 | In-house | 88-258 (262) | Show / Hide |
Range on Protein: 143-311 Range on HMM: 88-258/262 Sequence Identity: 32% (57 aa) NLQHHVIHE--KKLSEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNCHT-RQITLTNFCLGKHLVSEHDLLKDQRGSPAYISPDVLSGKPYLGKP .| .... .|.|.|| ||. .|| |. .|.|||||||.|. | . ... ..| .. | .. . . . .|. |.|.| .| ....||| |.. ELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSIC-IPPGQKLNTFCGTPPYMAPEIFLKKPYDGPK SDMWALGVVLFTMLYGQFPFYDSA--PQELFRKIKAAEFTIPQDGRVSENTTGLIKSLLVLDASTRLTATQVIE |.|.|||||..|. |.||| .. ||..|| . ...|| || ||..||... . | |.... . VDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMK |
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| Kinase | SgK495.AA | Ciliate-E2 | 143-311 | 20 | 1.5e-33 | 112.52 | In-house | 120-361 (365) | Show / Hide |
Range on Protein: 143-311
Range on HMM: 120-361/365
Sequence Identity: 20% (53 aa)
NLQHHVI------------HEKKLSEKEAVYIFHDVVS---------------IVESLHKKN-IVHRDLKLGNMVLNCHTRQITLTNFCLGKHLVSEHD-
.|... . |...|||. ||. ... .|.||.|| |.|||.|. | .. | .. | | | . ...
DLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQN
--------LLKDQR-----------------------GSPAYISPDVLSGKPYLG--------KPSDMWALGVVLFTMLYGQFPFYDSAPQELFRKIKAA
.... . |.| | .| .|.||.| . . .|.|.|||.|. ||.|..|| ...||
RTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQC
EFTIPQD----------------GRVSENTTGLIKS----LLVLDASTRLT-ATQVIE
.. .|. .|... ||| .|. | . |.| . |...
KIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
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| Kinase | SgK495.AA | Pkinase | 146-313 | 22 | 1.2e-32 | 116.47 | Pfam | 92-293 (293) | Show / Hide |
Range on Protein: 146-313 Range on HMM: 92-293/293 Sequence Identity: 22% (46 aa) HHVIH---EKKL--SEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNCHTRQI----TLTNFCLGKHL-VSEHDLLKDQRGSPAYISPDVLSGKPY ...|. .... ||.|. .. ... .| .|...|.|||||. | .. .. .| .. | | |.. ... |.| |..| |. | .| FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY LGKPSDMWALGVVLFTMLYGQFPFYDS------APQELFRKIKAAEFTIPQDGRVS-------------------ENTTGLIKSLLVLDASTRLTATQVI |...|||..|..|. || |..||... .......|. ... . . | |. .||..| .| . |.||.|. YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL ES--V .. . QHPWF |
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| Kinase | SgK495.AA | ULK | 151-305 | 25 | 8.2e-30 | 102.99 | In-house | 120-314 (324) | Show / Hide |
Range on Protein: 151-305 Range on HMM: 120-314/324 Sequence Identity: 25% (49 aa) EKKLSEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNCHTRQ-----------ITLTNFCLGKHLV---SEHDLLKDQR------GSPAYISPDVL .|.|||.||. .|.. .. |||.||.|||.|. | .. .. . . .. |...||. | .... . |.| | .| .| KKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQIL S----GKPYLGKPSDMWALGVVLFTMLYGQFPFYDSAPQELF----RK----------IKAAEFTIP---QDGRVSENTTGLIKSLLVLDASTRLT . .||| . .|.| ||.... ||||. ||. . ..... . || . .| .| .|... ||. .|. | . | . QGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRIS |
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| Kinase | SgK495.AA | RSK | 150-309 | 27 | 2.3e-29 | 103.89 | In-house | 94-272 (278) | Show / Hide |
Range on Protein: 150-309 Range on HMM: 94-272/278 Sequence Identity: 27% (49 aa) HEKK---LSEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNC--HTRQITLTNFCLGKHLVSE-HDLLKDQRGSPAYISPDVLS---GKP-YLGKP .|| .||.|| ... .|. || ||.. |.|||||. |.... . . | || | . | .. . ... ... .|. | .| .. . .| KEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGH-DKA SDMWALGVVLFTMLYGQFPFYD---SAPQELFRKIKAAE--FTIPQDGRVSENTTGLIKSLLVLDASTRLT-----ATQV | | |||....|| |. ||. . ..|....|. .. .|.| . .|.. ||. .| | . ||. | .. CDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEI |
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| S_TKc | SgK495.AA | S_TKc | 23-319 | 20 | 1e-27 | 99.32 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 23-319 Range on HMM: 1-231/231 Sequence Identity: 20% (62 aa) YLLGPRLGTSPVRSIVQCLARKEGTDDFYSLKILTLSENGRENQDERQGKMLLHTEYSLLSLLRDQEGVVHHHGLFQDRAYEIRPGTSTSGRKTSYKKRL | .. .| . .| .| |. . .||. . | ..|. . . .|. .. ||| ..| YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------------EHIRREIQILKK--HHPNIVKLYDVFQD-------------------DHL CLVLDCLVSHDFSSRTVDLVNLQHHVIHEKK------LSEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNCHTRQITLTNFCLGKHLVSEHDLLK ..|.... || .| .. . .. ..| .| .... ... .| .|...|.||||| | |. .| .. | | ..| . YMVMEYCDG--------DLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------T DQRGSPAYISPDVLSGKPYLGKPSDMWALGVVLFTMLYGQFPFYDSAPQELFRKIKAAEFTIPQDGRVSENTTGLIKSLLVLDASTRLTATQVIE---SV . |.| |..| || .| ....|.|..|..|. ||.|. ||. .|..|.||. |. .|. .|. | . |.|| .. . . TFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI KTTLAM | . KCHPWF |
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| TyrKc | SgK495.AA | TyrKc | 23-313 | 15 | 1e-05 | -130.3 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 23-313 Range on HMM: 1-280/280 Sequence Identity: 15% (50 aa) YLLGPRLGTSPVRSIVQCLARKEGTDDFYSLKIL--TLSENGRENQDERQGKMLLHTEYSLLSLL-RDQEGVVHHHGLFQDRAYEIRPGTSTSGRKTSYK || || .... .. .. .| |. .. .. | .... | . . .| .| . | ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-----------FMYI KRLCLVLDCLVSHDFSSRTVDLVNLQHHV-IHEKKLSEKEAVYIFHDVVSIVESLHKKNIVHRDLKLGNMVLNCHTRQITLTNFCLGKHLVSE------H . |..|. ... .|... |..||. |. ... ... . | ||.||..|||| | .. .. . | | . . .. . EPLMIVME----------YMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESK DLLKDQR--GSP-----AYISPDVLSGKPYLGKPSDMWALGVVLFTML-YGQFPFYD-----SAPQELFRKIKAAEFTIPQDG-------RVSENTTGLI | . . |. .| .. . . || |. ||... .. ||| | .. .||.....|. . . . . .. .. DYYRKKEHKGGKTMLPIRWMAPECINYGKF-TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIM KSLLVLDASTRLTATQVIESV |. |.. | | ....| KQCWHEDPEDRPTFSEIHECF |
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