CASK

Species: Sea Urchin
Alias: SPU_016934, SPU_028366, Spk060, CASK
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: CASK

Sequence

Name Sequence Type Origin Length Description Download
CASK.AA Protein None 788 None Fasta, JSON
CASK.kin_dom Protein Kinase Domain None 289 None Fasta, JSON

Protein domain

Protein domains of CASK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CASK.AA CASK 1-119 50 8.8e-86 278.36 In-house 117-291 (330) Show / Hide
Range on Protein: 1-119
Range on HMM: 117-291/330
Sequence Identity: 50% (88 aa)

SHYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKEN-------------------------------------SAPVKLGGFGIAIPLPSS---------
.||||||.|||.|||..|.||||..|||...|.|.|                                     ||||||.|||.|| |. .         
CHYMRQILEALMYCHQWDHIHRDVRPHCRVMASKDNRQRITVEEALAHPWLRERDKFAPKVHLLETVEELKKFSAPVKLCGFGVAIQLSHKFTSFYSDPN

----------GLIAGGRIGTPHFMAPEVVRREPYGKPVDIWGCGVMLFILLSGSLPFFGTKDRLFDMITKGRYNM
          .. |.||.|.|||||||||||||||.|.|||||||||||||||.|||||||||||.||.||||.|
TKHITDFADEDPMACGRVGCPHFMAPEVVRREPYGCPCDIWGCGVMLFILLSGCLPFFGTKDRLFEMIMKGRYDM

Kinase CASK.AA CASK 120-222 73 6.7e-78 252.34 In-house 129-231 (330) Show / Hide
Range on Protein: 120-222
Range on HMM: 129-231/330
Sequence Identity: 73% (76 aa)

KPRQWDHISGDAKELIRSMLSVDPRQRITVEEALAHPWLRERDKFAPKVHLLETVEELKKFNARRKLKGAVLAAVASHKFTSFYSDPNTKHITDFADEDP
...|||||..|.....|.|.|.|.|||||||||||||||||||||||||||||||||||||.|..||.|...|...||||||||||||||||||||||||
YCHQWDHIHRDVRPHCRVMASKDNRQRITVEEALAHPWLRERDKFAPKVHLLETVEELKKFSAPVKLCGFGVAIQLSHKFTSFYSDPNTKHITDFADEDP

TSS
...
MAC

Kinase CASK.AA CAMK 1-158 28 3.9e-74 238.07 In-house 182-425 (425) Show / Hide
Range on Protein: 1-158
Range on HMM: 182-425/425
Sequence Identity: 28% (70 aa)

SHYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENS--------------APVKLGGFGIAIPLPSS-----------------------GLIAGGRIG
..|.||| .|..|||...|.|||.||  .|| .....              ...|.  || |. ....                       |     . |
RRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCG

TPHFMA-PEVVRR--------------EPYGKPVDIWGCGVMLFILLSGSLPFFG--------------TKDRLFDMITKGRYNMKPRQ-----------
||..|| |||...              ..||...|.| |||.|.|.|.| .|| |              .  .|| .|.||.|.. | .           
TPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPE

-WDHISGD--------AKELIRSMLSVDPRQRITVEEALAHPWL
 ||.|| .        .| |||.|| ||| .|.|.|..|.|||.
WWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase CASK.AA CAMK1 1-158 37 2.1e-65 189.06 In-house 111-276 (276) Show / Hide
Range on Protein: 1-158
Range on HMM: 111-276/276
Sequence Identity: 37% (63 aa)

SHYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENSAPVK--LGGFGIAIPLPSSGL-IAGGRIGTPHFMAPEVVRR---EPYGKPVDIWGCGVMLFIL
.| |.|| .|. |.|...| |||.||   |...|.. ...|  .  ||..  . ...  .   . ||| ..||||. .   .||.|..|.|..|| ..||
RHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIF-DHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYIL

LSGSLPFFGTK-D-RLFDMITKGRYNMKPRQWDHISGD-AKELIRSMLSVDPRQRITVEEALAHPWL
| |  ||..   |  ||..|.|. |..   .||.||   ||..|. || ||| .|.|.|..|.|||.
LCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI

Kinase CASK.AA CDPK 3-158 39 3.4e-59 180.29 In-house 108-271 (271) Show / Hide
Range on Protein: 3-158
Range on HMM: 108-271/271
Sequence Identity: 39% (65 aa)

YMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENSA----PVKLGGFGIAIPLPSS----GLIAGGRIGTPHFMAPEVVRREPYGKPVDIWGCGVMLFIL
.||||. |. |||.| |.|||.||  .|. .|....    ..|.  .|..   ...    .     |.|||. .|||| ..  | . .||| ||| |.||
IMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSCGVILYIL

LSGSLPFFGT-KDRLFDMITKGRYNMKPRQWDHISGDAKELIRSMLSVDPRQRITVEEALAHPWL
|.|. ||.|      .... ||.|... ..||||| .|| ||| || .|| .|.. ..||.||| 
LCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF

Kinase CASK.AA CAMK2 1-158 47 1.9e-56 190.07 In-house 101-259 (259) Show / Hide
Range on Protein: 1-158
Range on HMM: 101-259/259
Sequence Identity: 47% (76 aa)

SHYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENSAPVKLGGFGIAIPLPSSGLIAGGRIGTPHFMAPEVVRREPYGKPVDIWGCGVMLFILLSGSLP
|| ..||.|.. .|| |.|.|||.||  .||| |   | |||  ||.|| .        |  ||| ...|||.|..||||||||| |||.|.||| |  |
SHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPP

FFGT-KDRLFDMITKGRYNMKPRQWDHISGDAKELIRSMLSVDPRQRITVEEALAHPWL
|.   . ||.  |  | |.     || .  .||.|| .|| ..|..||| .||| |||.
FWDEDQHRLYQQIKAGAYDYPSPEWDTVTPEAKNLINQMLTINPKKRITADEALKHPWI

Kinase CASK.AA CAMK-Unique 3-158 25 2.1e-51 167.88 In-house 162-363 (363) Show / Hide
Range on Protein: 3-158
Range on HMM: 162-363/363
Sequence Identity: 25% (51 aa)

YMRQIMEALRYCHDNDIIHRDIKPHCVLLATKEN-------------SAPVKLGGFGIAIPLPSSGLIA--GGRIGTPHFMAP--------------EVV
.|... .|. | |..||.|||.|.  ... . ..                .||  ||..  . ..   .    ..||| .|||              ||.
IMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVI

RREPYGKPV----DIWGCGVMLFILLSGSLPFFGTKDR---------LFDMITKGRY-NMKPRQWDH---ISGDAKELIRSMLSVDPRQRITVEEALAHP
 . .|. ..    ||| .||.....|.|..|| .. .          .|. |.||.| | . ..|.    ||  || ..   . ||| .|.. .|.| |.
NMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQ

WL
|.
WI

Kinase CASK.AA Pkinase 2-158 32 3.2e-50 177.96 Pfam 112-293 (293) Show / Hide
Range on Protein: 2-158
Range on HMM: 112-293/293
Sequence Identity: 32% (60 aa)

HYMRQIMEALRYCHDNDIIHRDIKPHCVLLA-TKENSAPVKLGGFGIAIPL-PSSGLIAGGRIGTPHFMAPEVVR-REPYGKPVDIWGCGVMLFILLSGS
.||.|| ..| |||.. |||||.||  .|.  . ...|.||.. ||.|  .   ..  . .. |||..|||||.| ...||..||.|.||..|...|.| 
FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR

LPFFGT-------KDRLFDMITKGRYNMKPRQWDHIS-----------------GDAKELIRSMLSVDPRQRITVEEALAHPWL
.|| |        .. ....| ....     .|. ||                  ..|..|...| .|| .|.| |..| |||.
PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase CASK.AA Ciliate-E2 2-158 24 3.2e-49 167.12 In-house 164-365 (365) Show / Hide
Range on Protein: 2-158
Range on HMM: 164-365/365
Sequence Identity: 24% (54 aa)

HYMRQIMEALRYCHDND-IIHRDIKPHCVLLATKENSAPVKLGGFGIAI----------------PLPSSG----------------LIAGGRIGTPHFM
.|...|..||.|.| .  ||||||||  .|.        .|.  ||..                  ..  .                 ..   .|||..|
FYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYM

APEVVRREP---------YGKPVDIWGCGVMLFILLSGSLPFFGTKDRLFDMITKGRYNMKPR--------------QWDHISGDAKELIRS----MLSV
|||......         |.. .||| .||.|...|.| .||       .. | .. ..  .                |...| ..| ||.     || .
APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQK

DPRQRIT-VEEALAHPWL
|| .|||  |..| |||.
DPEKRITGWEQILNHPWF

Kinase CASK.AA CAMKL 2-158 36 1.8e-48 152.75 In-house 131-297 (297) Show / Hide
Range on Protein: 2-158
Range on HMM: 131-297/297
Sequence Identity: 36% (64 aa)

HYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENSAPVKLGGFGIA---IPL-PSSGLIAGGRIGTPHFMAPEVVRR--EPYG-KPVDIWGCGVMLFIL
.| |||..|. |||...|.||||||  .||  . |.  .|.  || .   .|    .|     . |.|..||||.. .  .||  ..|||| |||.|. .
RYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAM

LSGSLPFFGT---------KDRLFDMITKGRYNMKPRQWDHISGDAKELIRSMLSVDPRQRITVEEALAHPWL
. | ||| .          . .|. .| .| |  .|. | |.| |.. |||.|| |.| .|.|... . |||.
VCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-Y--YPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase CASK.AA RSK 1-158 30 4.4e-45 156.08 In-house 107-278 (278) Show / Hide
Range on Protein: 1-158
Range on HMM: 107-278/278
Sequence Identity: 30% (52 aa)

SHYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENS-APVKLGGFGIAIPLPSS-GLIAGGRIGTPHFMAPEVVR---REP-YGKPVDIWGCGVMLFIL
. ||..|  |... |. .|||||.||  .|.. .. . . .||  || .  .. . .  .   ..| ..||||...   ..  ..| .|.|  || .. .
CFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEM

LSGSLPFFG----TKDRLFDMITKGRYNMKPRQWDHISGDAKELIRSMLSVDPRQRIT-----VEEALAHPWL
|.| .|| |    ... ... | ||.....   |. .| .||.||| || .|| .|..     .|| ..|||.
LTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase CASK.AA RAD53 63-158 38 6e-41 119.35 In-house 188-305 (305) Show / Hide
Range on Protein: 63-158
Range on HMM: 188-305/305
Sequence Identity: 38% (45 aa)

GTPHFMAPEVVR---R------------EPYGKPVDIWGCGVMLFILLSGSLPFF-GTK-----DRLFDMITK-GRYNMKPRQWDHISGDAKELIRSMLS
||| . ||||..   .            . |.| ||.|  |. |.|.|.| .||  . .     . ||. |.. |.|.  . .|| ||  || ||..|| 
GTPQYVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLC

VDPRQRITVEEALAHPWL
|||  |.|..||| |||.
VDPEKRYTIDEALNHPWM

Kinase CASK.AA S_TKc 1-158 25 9e-16 54.38 SMART 19-231 (231) Show / Hide
Range on Protein: 1-158
Range on HMM: 19-231/231
Sequence Identity: 25% (62 aa)

SH------------------------------------------------------------------------------YMRQIMEALRYCHDNDIIHR
 |                                                                              ||.|| .|| |||.. ||||
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHR

DIKPHCVLLATKENSAPVKLGGFGIAIPLPSSGLIAGGRIGTPHFMAPEVVRREPYGK-PVDIWGCGVMLFILLSGSLPFFGTKDRLFDMITKGRYNMKP
|.||  .|| .      .|.. ||.|  |          .|||..|||||.   .||| ..|.| ||..|...|.|  ||  . ...|..|         
DLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------

RQWDHISGDAKELIRSMLSVDPRQRITVEEALA-------HPWL
      | .||..|| .| .||..|.|. |||.       |||.
------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase CASK.AA RAD53 3-35 42 2.8e-10 26.29 In-house 114-146 (305) Show / Hide
Range on Protein: 3-35
Range on HMM: 114-146/305
Sequence Identity: 42% (14 aa)

YMRQIMEALRYCHDNDIIHRDIKPHCVLLATKE
| .|. .|..| ||| |.|||.||  .|.....
YFYQMCDAVKYLHDNGICHRDLKPENILCNHQD

L27 CASK.AA L27 296-350 32 6.7e-10 40.13 SMART 1-62 (62) Show / Hide
Range on Protein: 296-350
Range on HMM: 1-62/62
Sequence Identity: 32% (20 aa)

VHVTTEQVLELFRQHNQDS----QDAYELQAILSD---PYFRALLQAHDVVAHEVYSDHAIR
 .   ..|||  ..| |..    .|. ||. ||..   | |.|||..||.||...| .. ..
AVQRVYEVLEELQSHLQHHEDMQEDLQELRQILQSMFMPHFHALLKIHDKVACTKYQPPPPP

L27 CASK.AA L27 292-350 37 4.5e-07 29.57 Pfam 1-56 (56) Show / Hide
Range on Protein: 292-350
Range on HMM: 1-56/56
Sequence Identity: 37% (22 aa)

SLQSVHVTTEQVLELFRQHNQDSQDAYELQAILSDPYFRALLQAHDVVAHEVYSDHAIR
 .| |  ..||  .|  .|    .|. ||| ||..| ...|||.||.||..|| . . .
AVQRVLELLEQLQSLSEHH---PEDLQELQQILQSPHMHSLLQVHDKVACKVYDPPSPE

PDZ CASK.AA PDZ 385-463 25 1.7e-22 79.68 Pfam 1-86 (86) Show / Hide
Range on Protein: 385-463
Range on HMM: 1-86/86
Sequence Identity: 25% (22 aa)

LVQFQKN-SEEPLGITLKMNEDR----RCIVARIMHG-GMIHRQATLHVGDEIREINNASVANQTVDQLQKLLRELKG-SITFKIV
.|...|. . ..||...|...|      ......|.| |...|.  .|.|| | .||. ...| |.|. ...... || ... .| 
QVTLEKQDKRGGLGFSIKGGNDQRHDQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ

PDZ CASK.AA PDZ 394-466 20 1.2e-13 52.61 SMART 1-80 (80) Show / Hide
Range on Protein: 394-466
Range on HMM: 1-80/80
Sequence Identity: 20% (17 aa)

EPLGITLKMNEDRRCIVARIMHGGMIHRQAT-----LHVGDEIREINN-ASVANQTVDQLQKLLRELKG-----SITFKIVPSY
..||....      ........||  ..  .     |..||.| |.|.  .| | | .| ...|.. .|     ..|.....  
GGLGFSIVG----GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG

SH3 CASK.AA SH3 475-542 33 1.6e-15 58.79 SMART 1-58 (58) Show / Hide
Range on Protein: 475-542
Range on HMM: 1-58/58
Sequence Identity: 33% (23 aa)

IYVRAQFDYDPGQDDLIPCQQAGLSFRCGDILQIISKDDHNWWQARKEGEPLNGTAGLIPSPELQEWR
 ||||..||..       ..   |||. |||.....||| .||..|. .   .|  |..||  ..| .
PYVRALYDYQA-------QNPDELSFKKGDIITVLEKDDDGWWKGRCNR---TGQEGWFPSNYVEEID

SH3_2 CASK.AA SH3_2 476-541 26 7.7e-13 47.86 Pfam 1-68 (68) Show / Hide
Range on Protein: 476-541
Range on HMM: 1-68/68
Sequence Identity: 26% (20 aa)

YVRAQFDYDP-GQDDLIPCQQAGLSFRCGDILQII---SKDDHNWWQA-RK--EGEPLNGTA--GLIPSPELQEW
|.|. .||.|    . ..   ..|.|. ||.. .|   .||..|||.. ..  .     |..  |..||  ..|.
YYRVHCDYVPATYCNENH--EPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWG-----GRRMRGWFPSQWVEEC

SH3_1 CASK.AA SH3_1 498-535 41 4.1e-08 30.47 Pfam 14-49 (49) Show / Hide
Range on Protein: 498-535
Range on HMM: 14-49/49
Sequence Identity: 41% (16 aa)

LSFRCGDILQIISKDDH-NWWQARKEGEPLNGTAGLIPS
|||. |||...|.|.|  .|| .|  .    |  |..||
LSFKKGDIIHVIEKSDDWDWWKGRCNNT---GQEGWFPS

SH3_1 CASK.AA SH3_1 478-489 41 3.0158 4.09 Pfam 1-12 (49) Show / Hide
Range on Protein: 478-489
Range on HMM: 1-12/49
Sequence Identity: 41% (5 aa)

RAQFDYDPGQDD
.| .||.. |.|
VALYDYQAQQPD

Guanylate_kin CASK.AA Guanylate_kin 599-775 35 2.9e-75 259.0 Pfam 1-198 (198) Show / Hide
Range on Protein: 599-775
Range on HMM: 1-198/198
Sequence Identity: 35% (70 aa)

MRKTLVLLGAHGVG---RRHIKNTLITSHPNKY-A-YPIPHTTRRCKSDEENGKNYFFV-SHEEMMNDIANNKYLEYGT-HEDAMYGTKLDTIREIHNRS
.....||.|..|||   ..|||..|...||.|  . |..|||||    .|..|| |.|| |.|||.|.|.|....|... ... ||||.. |||.||   
QMRPIVLSGPSGVGYEVKSHIKKALWDEHPHKFDGRYCVPHTTRPPRPGEVDGKHYHFVSSREEMWNMIQNHEFIEWAQVFNGNMYGTSKETIRQIHEQG

LI---AILDVE-PQALKVLRCA-EFAPFVVFIAAPTLTGMNDV----HDSSLERLAKESELLRQAYGHF-----FDLTIVNNDIDDTIRTLENAMEEI
 |   .|||.. .|..|.|| . |..|..|||..|..... .      ....| ..|..| ..|...|      ||. |||.|.|...  |. ..|. 
KIMQLCILDIDTWQGVKQLRKTYELHPIMVFIKPPSMQELQRRLRCRNTEQEEKINKRMEAAEQEMQHYDEPGMFDYIIVNDDFDKAYWHLKEILEAE

GuKc CASK.AA GuKc 599-776 32 9.1e-67 229.04 SMART 1-203 (203) Show / Hide
Range on Protein: 599-776
Range on HMM: 1-203/203
Sequence Identity: 32% (66 aa)

MRKTLVLLGAHGVGRRHIKNTLITSHPN--KYAYPIPHTTRRCKSDEENG--KNYFFVS-HEEMMNDIANNKYLEYGTHEDA-MYGTKLDTIREIHNRSL
.|...||.|..|||....|..|.  .|.  |.....|||||  .. |.||  . |.||| .|||...|..||.||.|..... .|||...|.|..|..  
HRRPIVLSGPSGVGKSTLKHMLMQEYPDYPKFEFSVPHTTRPPRPGEVNGCVVDYHFVSLKEEMEQMIKHNKFLEWGEYHGNLYYGTSKETVRQVHEQGK

IAILDVEPQALKVLRCA----EFAPFVVFIAAPT----LTGMND---VHDSSLERLAKESEL-LRQAYGHF------FDLTIVNNDIDDTI-RTLENAME
..|||..||....|| |    .| |.|.||..|.    .. ..      ....||..|...   .. ..|       ||..|||.|..|.. . | ..||
HCILDIDPQGVRQLRYARRYSYFYPIVIFIKPPSMEELEERLRQPCQRGTETEERIQKRLAHQAQKEMQHYPKCHHEFDYVIVNDDLEDACYKELKEIME

EIC
. .
QEQ