MAPKAPK2

Species: Sea Urchin
Alias: SPU_020465, MAPKAPK2, Spk069
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: MAPKAPK
Subfamily: MK2

Sequence

Name Sequence Type Origin Length Description Download
MAPKAPK2.AA Protein None 240 None Fasta, JSON
MAPKAPK2.kin_dom Protein Kinase Domain None 155 None Fasta, JSON

Protein domain

Protein domains of MAPKAPK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAPKAPK2.AA MAPKAPK 6-168 80 1.6e-133 449.85 In-house 105-268 (268) Show / Hide
Range on Protein: 6-168
Range on HMM: 105-268/268
Sequence Identity: 80% (132 aa)

EAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNSLLKLTDFGFAKETT-TTNLQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
|||.|...|.|||.|.| |||||||||||||||.|..||..||||||||||||| ...|.||||||||||||||||||||||||||||||||||.|||.|
EAAQIMKQICQAVQHCHSMNIAHRDLKPENLLYKDTQPNCVLKLTDFGFAKETTRHNTLMTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIMLCGYP

PFYSNHGMAISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMNSPWV
|||||||.|||||||.||.|||||||.||||.||||||.||.|||||||.|||.|.||||.||.
PFYSNHGQAISPGMKHRIMNGQYEFPHPEWSCVSEDAKDLIRKLLRTDPTERLTIEEFMNHPWI

Kinase MAPKAPK2.AA MAPKAPK 6-168 57 3.2e-133 415.0 In-house 104-292 (292) Show / Hide
Range on Protein: 6-168
Range on HMM: 104-292/292
Sequence Identity: 57% (109 aa)

EAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNSLLKLTDFGFAKE-------TT---TTNLQTPCYTPYYVAPEVLGPEK----YDKSCDMWS
||..|.. |..||..|| ||||||||||||.|..|...|. .||.|||||||       ||   |..|.||||||||.||||.|..|    |||||||||
EASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKEAHTYDKSCDMWS

LGVIMYILLCGFPPFYSNHG-MAISPG-----------MKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMNSPWV
|||||||.|||.||||||.| ...|..           |..||..|||||||.|||..||.||.||.||||.|| .||.|...||.||.
LGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI

Kinase MAPKAPK2.AA CAMK1 6-168 44 4.7e-90 261.96 In-house 109-276 (276) Show / Hide
Range on Protein: 6-168
Range on HMM: 109-276/276
Sequence Identity: 44% (76 aa)

EAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNSLLK--LTDFGFAKETTTT--NLQTPCYTPYYVAPEVLGP---EKYDKSCDMWSLGVIMYI
.|..|.. | .||...| ..|.|||||||||||.|  ..| .|  . ||| .| .     ...|.| ||.|||||||     . |||.||||| ||| ||
DARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYI

LLCGFPPFYSNHGMAISPGMKRRIRNGQYEFPDPEWSQVSED-AKNLIKKLLRTDPAERLSIQEFMNSPWV
||||.||||.. . .    . . | ...|||| |.|  .|.  ||..||..|  || .|...... | ||.
LLCGYPPFYDENVDNE---LFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI

Kinase MAPKAPK2.AA CAMK 6-168 30 1.7e-83 268.8 In-house 180-425 (425) Show / Hide
Range on Protein: 6-168
Range on HMM: 180-425/425
Sequence Identity: 30% (76 aa)

EAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNS--------------LLKLTDFGFAKETTTTN-------------------------LQTP
||. ..| | .|||..| .||.||||||||.|. |. ..|               .|..|||||.. .  .                         ..|.
EARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTF

CYTPYYVA-PEVLGP--------------EKYDKSCDMWSLGVIMYILLCGFPPFYSNHGMAIS---------PGMKRRIRNGQYEFPDPE---------
| ||.|.| ||||                . |...|||||.|||.||.|||.||||. ... |          . ....|..|.|.||.|.         
CGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYG

---WSQVSED--------AKNLIKKLLRTDPAERLSIQEFMNSPWV
   |. .|..        .|.||.|.|..|| .|..|.. .| ||.
PEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase MAPKAPK2.AA CDPK 5-168 42 3.6e-67 205.11 In-house 103-271 (271) Show / Hide
Range on Protein: 5-168
Range on HMM: 103-271/271
Sequence Identity: 42% (74 aa)

TEAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNS----LLKLTDFGFAKETTT------TNLQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV
.|||.|.| | .|| . |  || ||||||||.|.    ..|     .|. |.| .|.           . . | ||||.|||||    |...|| ||.||
KEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSCGV

IMYILLCGFPPFYSNHGMAISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMNSPWV
|.|||||| ||||    . |       ...|.|.| .|||. .|..||.||.|.| .||  |.| |. .. ||.
ILYILLCGYPPFYGKNDQEIM----EKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF

Kinase MAPKAPK2.AA RAD53 17-168 38 1.1e-65 194.47 In-house 121-305 (305) Show / Hide
Range on Protein: 17-168
Range on HMM: 121-305/305
Sequence Identity: 38% (71 aa)

AVHHLHVMNIAHRDLKPENLLYR-DRTPN--------------SLLKLTDFGFAKETTTT-NLQTPCYTPYYVAPEVLGPE---------------KYDK
||  || ..|.|||||||| |.  .. ..              .|.|.|||| .| .  .  ..| | || ||||||.  .                | |
AVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKGHNCYHENEERQVQVGYTK

SCDMWSLGVIMYILLCGFPPFYSNHGMA--ISPGMKRRIRN-GQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMNSPWV
..|.||.|.| ||.|||.||| | .  .    . ..  |.| | |.|| |.|. .|| ||.|||..|  || .|..| | .|.|| 
KVDCWSMGCILYICLCGYPPF-SDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHPWM

Kinase MAPKAPK2.AA Pkinase 6-168 32 2.9e-61 214.65 Pfam 109-293 (293) Show / Hide
Range on Protein: 6-168
Range on HMM: 109-293/293
Sequence Identity: 32% (61 aa)

EAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYR-DRTPNSLLKLTDFGFAK---ETTTTNLQTPCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILL
|.  ... | ... ..| |.| ||||||||.|.  . .... .|..|||.||   .   . ..|.| ||.|.||||.   ..|....||||.|.|.|..|
ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML

CGFPPFYSNH----GMAISPGMKRRIRNGQYEFPDPEWSQVS-----------------EDAKNLIKKLLRTDPAERLSIQEFMNSPWV
|| |||. .|    . .    | .||. ....|. |.|. .|                 |..| .||..|. ||..|..... ...||.
CGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase MAPKAPK2.AA MSK 3-168 37 4.4e-59 198.38 In-house 99-277 (277) Show / Hide
Range on Protein: 3-168
Range on HMM: 99-277/277
Sequence Identity: 37% (68 aa)

RLTEAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNSLLKLTDFGFAKETTTT---NLQTPCYTPYYVAPEVLG----PEK-YDKSCDMWSLGV
...|...|.|..  || |.|   | ||||||||.|. |...|  .||.|||||.....     ...||.|  | |||.|     ..  ||..||.|||||
DESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGV

IMYILLCGFPPFY--SNHGM---AISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMNSPWV
|.| .| |  ||   .  .    . .    .||. |.  ||  .|...|.|||.||..||  ||. ||. ..   . | 
ILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK

Kinase MAPKAPK2.AA RSK 5-168 41 7.9e-59 201.75 In-house 104-278 (278) Show / Hide
Range on Protein: 5-168
Range on HMM: 104-278/278
Sequence Identity: 41% (75 aa)

TEAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPN-SLLKLTDFGFAKE-TTT--TNLQTPCYTPYYVAPEVLG---PEK-YDKSCDMWSLGVIM
.||... . |  || |||   | |||||||| || |.. |   .|||||||.|.        ..|.|||  |.|||.|    ... .||.|| |||||.|
DEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLM

YILLCGFPPFYS---NHGMAISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLS-----IQEFMNSPWV
| .| |.|||..   |.   |.    .||..|.. .. |.|. .|..||.||.|.|  ||. ||.     ..|  ..|| 
YEMLTGCPPFQGPNDNNRKEIM----KRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase MAPKAPK2.AA CAMK-Unique 3-168 29 1.2e-58 192.17 In-house 155-363 (363) Show / Hide
Range on Protein: 3-168
Range on HMM: 155-363/363
Sequence Identity: 29% (61 aa)

RLTEAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTP-------------NSLLKLTDFGFAKETTTTNLQ----TPCYTPYYVAP----------
| .... |.... .|| ..|  .| |||||.||.... . .             |. .||.||| ...  .        | | ||.|.||          
RCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQE

----EVLGPEKYDKSC----DMWSLGVIMYILLCGFPPFYSNHGM----AISPGMKRRIRNGQY-EFPDPEWSQ---VSEDAKNLIKKLLRTDPAERLSI
    ||..  .||  |    | ||||||||..||| |||...        .  .  ..|. |.| .|. . |.    .|. ||...|... .||. |.|.
MTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSA

QEFMNSPWV
 |   ..|.
KELLEHQWI

Kinase MAPKAPK2.AA Ciliate-E2 10-168 29 1.5e-55 189.13 In-house 165-365 (365) Show / Hide
Range on Protein: 10-168
Range on HMM: 165-365/365
Sequence Identity: 29% (65 aa)

IVRSIGQAVHHLHVMN-IAHRDLKPENLLYRDRTPNSLLKLTDFGFAK------------------------ETTTTNL---------QTPCYTPYYVAP
....| .|...||  | | |||.||||.|.        .|..|||..|                        ..|....         .| |.||.|.||
YIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAP

EVLGPEK---------YDKSCDMWSLGVIMYILLCGFPPFYSNHGMAISPGMKRRIRNGQYEFPDPE--------------WSQVSEDAKNLIKK----L
|.|. .|         ||..||.||||||.|..|.| |||             . | .....|| ||              | ..|...|.||||    .
EILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRM

LRTDPAERLS-IQEFMNSPWV
|  || .|.. ... .| || 
LQKDPEKRITGWEQILNHPWF

S_TKc MAPKAPK2.AA S_TKc 1-168 21 8.2e-23 83.02 SMART 1-231 (231) Show / Hide
Range on Protein: 1-168
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

M------------------------------------------------------------------------------------------IRLTEAAEI
                                                                                           .   .|. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

VRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNSLLKLTDFGFAKETTTTNLQTPCYTPYYVAPEVLGPEKYDK-SCDMWSLGVIMYILLCGFPPFYSN
.. | .|. ..| ..| ||||||||.|  .      .|..|||.|..       | | ||.|.|||||   .|.| .||.||.|.|.|..||| |||.  
MYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--

HGMAISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMN-------SPWV
        | ..|.              |..||..|.|.|. ||..|... | ..        ||.
----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF