Gene MAPKAPK5b (Sea Urchin)
MAPKAPK5b
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| MAPKAPK5b.AA | Protein | None | 652 | None | Fasta, JSON |
| MAPKAPK5b.kin_dom | Protein Kinase Domain | None | 88 | None | Fasta, JSON |
Protein domains of MAPKAPK5b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| WD40 | MAPKAPK5b.AA | WD40 | 61-100 | 30 | 6.3e-11 | 34.06 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 61-100
Range on HMM: 1-39/39
Sequence Identity: 30% (12 aa)
MSSAGQLKGHGGPVSGVKFAHRNPFTVFSSSRDGTVRCWD
. || ..|. ..... .. ..|.|||||.| ||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
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| WD40 | MAPKAPK5b.AA | WD40 | 60-100 | 33 | 2.2e-09 | 38.42 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 60-100 Range on HMM: 1-46/46 Sequence Identity: 33% (16 aa) TMSSAGQLKGHGG--PVSGVKFAHRN-----PFTVFSSSRDGTVRCWD | . .||| | .|..|.. . . | ..|.| |||.|.|| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MAPKAPK5b.AA | WD40 | 152-193 | 28 | 2.3e-09 | 38.35 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 152-193 Range on HMM: 1-46/46 Sequence Identity: 28% (14 aa) STNLLGTYKESHSD--DITQVKFHPTK-----SSSLATGSTDGLVCVFD . ... |.| |.. ..| |..||. .. ||.|| || ....| T-KCVHTFK-GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MAPKAPK5b.AA | WD40 | 153-193 | 29 | 2.7e-08 | 26.47 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 153-193 Range on HMM: 1-39/39 Sequence Identity: 29% (12 aa) TNLLGTYKESHSDDITQVKFHPTKSSSLATGSTDGLVCVFD ... |. |.. .| ...|| .. ||.|| || ....| WKCKHTF--GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| Kinase | MAPKAPK5b.AA | MAPKAPK | 374-484 | 50 | 1.4e-70 | 217.56 | In-house | 185-292 (292) | Show / Hide |
Range on Protein: 374-484 Range on HMM: 185-292/292 Sequence Identity: 50% (62 aa) VLEAQKRQRREQKNLIQTSPRPYTYDKGCDMWSLGVIIYIMLCGYPPFYPDTPSRQLSKD-----------MRHKIMAGQYEFPTEEWSLISDEAKDVVK |..|.| ..|||| |||||||||.|||||||||||........|.| |.|.|..||||||.|||| ||.||||... VVGAFK--------------EAHTYDKSCDMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIR RLLRVDPTERLTIEELCSHPWL .|||.|||.|||||....|||. KLLRRDPTQRLTIEQVMNHPWI |
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| Kinase | MAPKAPK5b.AA | MAPKAPK | 374-484 | 54 | 1.3e-67 | 226.68 | In-house | 177-268 (268) | Show / Hide |
Range on Protein: 374-484 Range on HMM: 177-268/268 Sequence Identity: 54% (60 aa) VLEAQKRQRREQKNLIQTSPRPYTYDKGCDMWSLGVIIYIMLCGYPPFYPDTPSRQLSKDMRHKIMAGQYEFPTEEWSLISDEAKDVVKRLLRVDPTERL ||...| |||.|||||||||.|||||||||||. ......|..|.|.||.||||||..||| .|..|||....|||.|||||| VLGPEK------------------YDKSCDMWSLGVIMYIMLCGYPPFYS-NHGQAISPGMKHRIMNGQYEFPHPEWSCVSEDAKDLIRKLLRTDPTERL TIEELCSHPWL ||||...|||. TIEEFMNHPWI |
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| Kinase | MAPKAPK5b.AA | CAMK | 398-484 | 40 | 1.2e-46 | 147.85 | In-house | 311-425 (425) | Show / Hide |
Range on Protein: 398-484 Range on HMM: 311-425/425 Sequence Identity: 40% (46 aa) YDKGCDMWSLGVIIYIMLCGYPPFYPDTPSRQLS--------KDMRHKIMAGQYEFPTEE------------WSLISDE--------AKDVVKRLLRVDP |.. |||||.||| ||||||||||| |. ..... ... .|||.|.|.|| .. |. |||| .|| ....|.||| YGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDP TERLTIEELCSHPWL ..|.|||. .|||. EKRMTIEQCLNHPWM |
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| Kinase | MAPKAPK5b.AA | RAD53 | 398-484 | 45 | 6.2e-46 | 134.48 | In-house | 218-305 (305) | Show / Hide |
Range on Protein: 398-484 Range on HMM: 218-305/305 Sequence Identity: 45% (41 aa) YDKGCDMWSLGVIIYIMLCGYPPFYPDTPSRQ--LSKDMRHKIMA-GQYEFPTEEWSLISDEAKDVVKRLLRVDPTERLTIEELCSHPWL | | .|.||.|.| ||.||||||| . .. | ... ..| | |.||...|. ||.|||| .|..| |||..|.||.|. .|||. YTKKVDCWSMGCILYICLCGYPPF--SDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHPWM |
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| Kinase | MAPKAPK5b.AA | CAMK1 | 398-484 | 52 | 3e-45 | 129.47 | In-house | 193-276 (276) | Show / Hide |
Range on Protein: 398-484 Range on HMM: 193-276/276 Sequence Identity: 52% (46 aa) YDKGCDMWSLGVIIYIMLCGYPPFYPDTPSRQLSKDMRHKIMAGQYEFPTEEWSLISDE-AKDVVKRLLRVDPTERLTIEELCSHPWL ||| ||||| ||| ||.|||||||| .. .| . ||. ..||||. .| |||. ||| .| .| |||..|.|.|. |||. YDKACDMWSIGVITYILLCGYPPFYDENVDNELFE----KIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | MAPKAPK5b.AA | CAMK-Unique | 398-484 | 41 | 1.2e-38 | 125.02 | In-house | 266-363 (363) | Show / Hide |
Range on Protein: 398-484 Range on HMM: 266-363/363 Sequence Identity: 41% (41 aa) YDKGC----DMWSLGVIIYIMLCGYPPFYPDTPSR---QLSKDMRHKIMAGQY-EFPTEEWSL---ISDEAKDVVKRLLRVDPTERLTIEELCSHPWL || | | |||||| |.||||.|||.... | | . .|..|.| .|... |.. ||.||||.||... ||| |....|| .|.|. YDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
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| Kinase | MAPKAPK5b.AA | CDPK | 398-484 | 43 | 2.8e-36 | 108.91 | In-house | 190-271 (271) | Show / Hide |
Range on Protein: 398-484 Range on HMM: 190-271/271 Sequence Identity: 43% (38 aa) YDKGCDMWSLGVIIYIMLCGYPPFYPDTPSRQLSKDMRHKIMAGQYEFPTEEWSLISDEAKDVVKRLLRVDPTERLTIEELCSHPWL |.. || ||.||| ||.|||||||| .. .. |.. |.|.| .||. ||||||| ....| .|| |.. .. ||| YNEKCDIWSCGVILYILLCGYPPFYGKND-----QEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | MAPKAPK5b.AA | Ciliate-E2 | 396-484 | 32 | 4.5e-31 | 103.91 | In-house | 264-365 (365) | Show / Hide |
Range on Protein: 396-484 Range on HMM: 264-365/365 Sequence Identity: 32% (37 aa) YT-------YDKGCDMWSLGVIIYIMLCGYPPFYPDTPSRQLSKDMRHKIMAGQYEFPTEE--------------WSLISDEAKDVVKR----LLRVDPT |. ||. ||.||||||.|.||.|.||| .|. ....|| .| | .|.|.|| |. .| .|| YDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPE ERLT-IEELCSHPWL .|.| .|.. |||. KRITGWEQILNHPWF |
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| Kinase | MAPKAPK5b.AA | RSK | 397-484 | 38 | 9.3e-30 | 105.18 | In-house | 188-278 (278) | Show / Hide |
Range on Protein: 397-484 Range on HMM: 188-278/278 Sequence Identity: 38% (36 aa) TYDKGCDMWSLGVIIYIMLCGYPPFYPDTPSRQLSKDMRHKIMAGQYEFPTEEWSLISDEAKDVVKRLLRVDPTERLT-----IEELCSHPWL ..|| || |||||..| || |.|||. | .. .|. .|. |.. .. ..|. .|.|||| ....| .|| ||. .||. .|||. GHDKACDWWSLGVLMYEMLTGCPPFQG--PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | MAPKAPK5b.AA | Pkinase | 398-484 | 33 | 2.6e-29 | 104.72 | Pfam | 189-293 (293) | Show / Hide |
Range on Protein: 398-484 Range on HMM: 189-293/293 Sequence Identity: 33% (35 aa) YDKGCDMWSLGVIIYIMLCGYPPFYPD--TPSRQLSKDMRHKIMAGQYEFPTEEWSLIS-----------------DEAKDVVKRLLRVDPTERLTIEEL |.. .||||.|.|.|.||||.|||. . ... . | .|| ....|. ..|. || .|.||..|..|..||..|.|.|.. YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI CSHPWL . |||. LQHPWF |
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| Kinase | MAPKAPK5b.AA | MNK | 436-484 | 46 | 2.3e-17 | 56.3 | In-house | 244-292 (292) | Show / Hide |
Range on Protein: 436-484 Range on HMM: 244-292/292 Sequence Identity: 46% (23 aa) HKIMAGQYEFPTEEWSLISDEAKDVVKRLLRVDPTERLTIEELCSHPWL | | |.|||| .||. ||.|||| . .|| |. .||. ... ||| HCIQEGHYEFPEKEWHHISEEAKDLISNLLVRDAKQRLSAAQVLNHPWV |
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| Kinase | MAPKAPK5b.AA | MNK | 398-421 | 87 | 1.7e-14 | 46.25 | In-house | 195-218 (292) | Show / Hide |
Range on Protein: 398-421 Range on HMM: 195-218/292 Sequence Identity: 87% (21 aa) YDKGCDMWSLGVIIYIMLCGYPPF ||| ||.||||||.|||||||||| YDKRCDLWSLGVILYIMLCGYPPF |
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| S_TKc | MAPKAPK5b.AA | S_TKc | 220-484 | 16 | 7e-09 | -46.71 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 220-484
Range on HMM: 1-231/231
Sequence Identity: 16% (56 aa)
GTNSEYL--------YCLTHTE-----TIRIFDAVESSEITKFDSVRESLKEDRCK-VDYLVDCFYHSGLKSLVVLGGTVGG---DLHLLTVGKDR----
. . . |. .|.. | | . .. . .. ||. ... . | |.|.. ..| . ..| ||. . . . |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR
-----------------LHFVHSLKGTHK------------------GVVRCLHWDNQTETLVTGGEDSIVSAWQPDRNANQSSSKKGSPAQTSRIRQGR
| . ||.. | |. | |
FPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-----------------------------------------------
RAEKRGSPVKVLEAQKRQRREQKNLIQTSPRPY------TYDK-GCDMWSLGVIIYIMLCGYPPFYPDTPSRQLSKDMRHKIMAGQYEFPTEEWSLISDE
. . | |.| ||.||.|.|.|.||||||||. . | .||. |.|
------------------------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG--------------SPE
AKDVVKRLLRVDPTERLTIEELCS-------HPWL
||| ....|..||..|.|. |. |||.
AKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| WD40 | MAPKAPK5b.AA | WD40 | 298-338 | 24 | 1.1e-05 | 26.1 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 298-338
Range on HMM: 1-46/46
Sequence Identity: 24% (12 aa)
RLHFVHSLKGTHKG--VVRCLHWDNQT------ETLVTGGEDSIVSAWQ
||..| |.| |.|. |. . |..|. |. . |
T-KCVHTFK-GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
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| WD40 | MAPKAPK5b.AA | WD40 | 299-338 | 21 | 2.7e-05 | 17.87 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 299-338 Range on HMM: 1-39/39 Sequence Identity: 21% (9 aa) LHFVHSLKGTHKGVVRCLHWDNQ-TETLVTGGEDSIVSAWQ .|.. |.. |.|. |. |..|..|. . | WKCKHTF--GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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| WD40 | MAPKAPK5b.AA | WD40 | 200-239 | 22 | 0.003027 | 16.26 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 200-239 Range on HMM: 1-46/46 Sequence Identity: 22% (11 aa) EDALVTTLN-SES--SVSHIDWCGTN-----SEYLYCLTHTETIRIFD . .| |.. .. .|....|. .. ..||.. ||||.| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
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| WD40 | MAPKAPK5b.AA | WD40 | 200-239 | 25 | 0.157559 | 7.02 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 200-239 Range on HMM: 1-39/39 Sequence Identity: 25% (10 aa) EDALVTTLNSESSVSHIDWCGTNSEYLYCLTHTETIRIFD . . |. ...|. ..|. .. || . . ||||.| WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
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