Gene Mnk (Sea Urchin)
Mnk
Sequence
Protein domains of Mnk.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Mnk.AA | MNK | 135-422 | 72 | 1.7e-235 | 788.6 | In-house | 1-292 (292) | Show / Hide |
Range on Protein: 135-422 Range on HMM: 1-292/292 Sequence Identity: 72% (212 aa) DLTGELLGSGSYASVRTCRQISSGKEYAVKMMEKR-PGNSRTKIFREVETLYHCQGHNNILQLIEYFEDDDRFYLIFEKMYGGALLQHIEQRGTFTEQEA ||.|.||.|.||||.||..|.||||||||...|. ||.||...||||||.||||||.|||||||.|||||||||.||||.||.|||||.||..|||.|| KLTDEHLGEGAYASVQTCVNIQSGKEYAVKIIDKQGPGHSRKRVFREVETFYHCQGHRNILQLIEWFEDDDRFYLVFEKMRGGPLLQHIQQRKHFTEHEA SQVIRDIASALSFLHNKGIAHRDLKPENILCESMYSISPIKICDFGLGSG---IHLSSQYNTPVTTPELLTPVGSAEFMAPEIVEAFIYDLQATVYDKRC ||||.||||||.|.||||||||||||||||||......|.|||||.|||| |||......|.||||||||.|||||||||.|.||.| ..|..||||| SQVIKDIASALDFMHNKGIAHRDLKPENILCEHPNHVCPVKICDFDLGSGRPPIHLNHDCSQPITTPELLTPCGSAEFMAPEVVDAFVY-DEAHYYDKRC DLWSLGVILYILLCGHPPFVGSCG-EDCGWDRGEACQDCEELLLHCIQSGEYDFHGAEWEHISAGAKDLISHLLVRDAKQRYTAGMVLNHPWV |||||||||||.|||.|||||.|| |||||||||||.||...|.||||.|.|.|...||.|||..||||||.|||||||||..|..||||||| DLWSLGVILYIMLCGYPPFVGHCGDEDCGWDRGEACRDCQNMLFHCIQEGHYEFPEKEWHHISEEAKDLISNLLVRDAKQRLSAAQVLNHPWV |
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| Kinase | Mnk.AA | MAPKAPK | 135-422 | 55 | 4.8e-217 | 679.17 | In-house | 1-292 (292) | Show / Hide |
Range on Protein: 135-422 Range on HMM: 1-292/292 Sequence Identity: 55% (163 aa) DLTGELLGSGSYASVRTCRQISSGKEYAVKMMEKRPGNSRTKIFREVETLYHCQGHNNILQLIEYFED----DDRFYLIFEKMYGGALLQHIEQ--RGTF |..|.||.|.|..|.||.....|.|||||..|..||.||.|..||||...|||||.||.|.|..||. |..|||..|.|.||.|.|||.| ...| KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHF TEQEASQVIRDIASALSFLHNKGIAHRDLKPENILCESMYSISPIKICDFGLGSGIHLSSQYNTPVTTPELLTPVGSAEFMAPEIVEAFIYDLQATVYDK ||.||||...||.||..|||...|||||||||||||.......|.|.||||....|||.....||.|||||.||......||||.|.||. .|..||| TEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFK---EAHTYDK RCDLWSLGVILYILLCGHPPFVGSCG-EDCGWDRGEACQDCEELLLHCIQSGEYDFHGAEWEHISAGAKDLISHLLVRDAKQRYTAGMVLNHPWV .||.||||||.||.|||.|||...|| |||.|||||||.||.... |.||.|.|.|. .||.|||. |||||..||.||..||.|. .|.||||. SCDMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI |
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| Kinase | Mnk.AA | CAMK | 140-422 | 26 | 3.3e-110 | 356.43 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 140-422
Range on HMM: 1-425/425
Sequence Identity: 26% (112 aa)
LLGSGSYASVRTCRQISSG------------KEYAVKMMEKR----------------------------PGNSRTKIFREVETLYHCQG------HNNI
||.||.. |. |...... ...|.|...|. ...| ...||.| . ..|| | ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
LQLIEYFED-------------------DDRFYLIF---EKMYGGAL----LQHIEQR---------------GTFTEQEASQVIRDIASALSFLHNKGI
..|.|..|| |...|... | . || | ...| .. | |||.||....| |.||. ..|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
AHRDLKPENILCESMYSISP--------------IKICDFGLGSGIHLSSQYN---------------TPVTTPELLTPVGSAEFMA-PEIVEAFIY---
.||||||||||. . .. |. |||.|||. . ..... || ... . |..|. |.|| ||...
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM
----DLQATVYDKRCDLWSLGVILYILLCGHPPFVGSCG-EDCGWDRGEACQDCEELLLHCIQSGEYDFHGAE------------WEHISAG--------
| . . |.. || ||.||||||.|||.||| |.|. |.|. | . .... |.. |..|.||| . | .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D-E-WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE
AKDLISHLLVRDAKQRYTAGMVLNHPWV
.||||...|..| ..|.|. .|||||.
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | Mnk.AA | CAMK1 | 134-422 | 34 | 5.6e-108 | 314.97 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 134-422 Range on HMM: 1-276/276 Sequence Identity: 34% (105 aa) YDLTGELLGSGSYASVRTCRQISS---GKEYAVKMME-KR--PGNSR---TKIFREVETLYHCQ--GHNNILQLIEYFEDDDRFYLIFEKMYGGALLQHI | . |. .|.|. . |. | .... ||.||.|... |. .... ... .|.| . . | || ...|..|.|. |||. | . || |. | YEF-GKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI EQRGTFTEQEASQVIRDIASALSFLHNKGIAHRDLKPENILCESMYSISPIK--ICDFGLGSGIHLSSQYNTPVTTPELLTPVGSAEFMAPEIVEAFIYD ..| .||..|. ... |.||. ..| |||.||||||||.|..... |.|| |.|||| . . . |..|. ...|||..| VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN--------LMKTACGTPGYVAPEVLECKK-- LQATVYDKRCDLWSLGVILYILLCGHPPFVGSCGEDCGWDRGEACQDCEELLLHCIQSGEYDFHGAEWEHISAG-AKDLISHLLVRDAKQRYTAGMVLNH .. ||| ||.|| |||.||||||.||| .. . .. |. .| ..||.|. .| .|| . |||.|.|.|. | |.|||. .||| --DKPYDKACDMWSIGVITYILLCGYPPFYDENV--------------DNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNH PWV ||. PWI |
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| Kinase | Mnk.AA | S_TKc | 135-422 | 29 | 3e-89 | 303.74 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 135-422 Range on HMM: 1-231/231 Sequence Identity: 29% (91 aa) DLTGELLGSGSYASVRTCRQISSGKEYAVKMMEKRPGNSRTKIFREVETLYHCQGHNNILQLIEYFEDDDRFYLIFEKMYG--GALLQHIEQRGT----- ....|.|....|. || ...|...|.|.. .| ||.. | . .| || .|...|.| |..|...| . | | |...|..||. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -FTEQEASQVIRDIASALSFLHNKGIAHRDLKPENILCESMYSISPIKICDFGLGSGIHLSSQYNTPVTTPELLTPVGSAEFMAPEIVEAFIYDLQATVY |.| .| ... |..|| ..|..|| ||||||||||. . |||||||| . | .|. ..||||.. | PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------------TTFCGTPWYMAPEVL----------GY DK-RCDLWSLGVILYILLCGHPPFVGSCGEDCGWDRGEACQDCEELLLHCIQSGEYDFHGAEWEHISAGAKDLISHLLVRDAKQRYTAGMVLN------- .| .|| ||.|.|||..||| ||| ...... | | |||.|...|..| ..|.|| .|. GKCKCDWWSCGCILYEMLCGYPPFP-----------------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC HPWV |||. HPWF |
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| Kinase | Mnk.AA | RSK | 137-422 | 31 | 5.5e-79 | 268.73 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 137-422 Range on HMM: 1-278/278 Sequence Identity: 31% (96 aa) TGEL--LGSGSYASVRTCRQISSGKEYAVKMMEKRPGNSRTK----IFREVETLYHCQGHNNILQLIEYFEDDDRFYLIFEKMYGGALLQHIEQRGT--- .| .| |.. .| |.. .|..||.| .|. | | ..|.. | .||.| .| .| . |.... .||| | . || |. |...... LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC FTEQEASQVIRDIASALSFLHNKGIAHRDLKPENILCESMYSISPIKICDFGLGSGIHLSSQYNTPVTTPELLTPVGSAEFMAPEIVE-AFIYDLQATVY |.| ||..... |..|...|| .|| |||||||||| ... . ||..|||. . .. . . . |.....|.||||.. | . | . FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGF-------CKQFRCDHNQWTMTFCYTIEYMAPEMLKRA---N-QQGGH DKRCDLWSLGVILYILLCGHPPFVGSCGEDCGWDRGEACQDCEELLLHCIQSGEYDFHGAEWEHISAGAKDLISHLLVRDAKQRYT-----AGMVLNHPW || ||.|||||..| .| |.||| | ..| . . .. ||.|.... . .|. .|. |||||...| || ..|.. | ...||| DKACDWWSLGVLMYEMLTGCPPFQG--PND----------NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPW V F |
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| Kinase | Mnk.AA | Pkinase | 136-422 | 30 | 1.4e-74 | 258.88 | Pfam | 2-293 (293) | Show / Hide |
Range on Protein: 136-422 Range on HMM: 2-293/293 Sequence Identity: 30% (98 aa) LTGELLGSGSYASVRTCRQISSGKEYAVKMMEKRPGNSRTK---IFR--EVETLYHCQGHNNILQLIEYFEDDDRFYLIFEKMYGG----ALLQHIE--Q .|. .||||...|. |. ...||..||| ..|| ... | .| |.. . .. .| ||..|...|||.|. |...| . || | .|. . HIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR RGTF--TEQEASQVIRDIASALSFLHNKGIAHRDLKPENILCESMYSI-SPIKICDFGLGSGIHLSSQYNTPVTTPELLTPVGSAEFMAPEIVEAFIYDL .|.| .|.|. ... |...| ..|..|| ||||||||||. . . | ...||||||| . . . |..|. ..||||. . HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPWYMAPEV-------I Q-ATVYDKRCDLWSLGVILYILLCGHPPFVGSCGEDCGWDRGEACQDCEELLLHCIQSGEYDFHGAEWEHIS-----------------AGAKDLISHLL . .. |....| ||.|.|||..|||.||| |.| . . .. . .. | .....|. .| || .||.|. .| RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQ-------MICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL VRDAKQRYTAGMVLNHPWV .| |.|.|| .|.|||. CKDPKKRPTAEQILQHPWF |
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| Kinase | Mnk.AA | Ciliate-E2 | 135-422 | 25 | 2.6e-69 | 236.59 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 135-422
Range on HMM: 1-365/365
Sequence Identity: 25% (101 aa)
DLTGELLGSGSYASVRTCRQISSG-----------------------KEYAVKMMEKRPGNSRTK---IFREVE----------TLYHCQGHNNILQLIE
...|.|...||. |.... . |.||.|.|.|. .. . |.||.. | . . |.||....|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMYE
YFE--DDDRFYLIFEKMYGGALLQHIEQR-----------GTFTEQEASQVIRDIAS---------------ALSFLHNKG-IAHRDLKPENILCESMYS
.|. ||. .||..| || |...|... . |||.|...... |.. || .||.|. | |||.||||||
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----
ISPIKICDFGLGSGIHLSSQYNTPVTTPELLTPVG------------------------SAEFMAPEIVEAFIYD--LQATVYDKRCDLWSLGVILYILL
|||.|||| .. ..|..| .... . ....|||||.. || . . ||. ||.||||||||..|
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML
CGHPPFVGSCGEDCGWDRGEACQDCEELLLHCIQSGEYDFHGAE--------------WEHISAGAKDLISH----LLVRDAKQRYT-AGMVLNHPWV
.| ||| . |. ...|| .| |...| .||||. .|..| ..|.| . .|||||
FGKPPF-----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | Mnk.AA | CAMK-Unique | 137-422 | 25 | 3.6e-68 | 224.09 | In-house | 3-363 (363) | Show / Hide |
Range on Protein: 137-422
Range on HMM: 3-363/363
Sequence Identity: 25% (95 aa)
TGELLGSGSYASVRTCRQISSGKEYAVKMMEK-RPGNSRTKI------------------FREVETLYHCQGHNNILQLIEY----FEDDD---------
.....|.|.. |. | .. ||..|.|| .| ..||.. |. ... . . ..|.||..| .. |.|..
MHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIK
------RFYLIFEKMYGGALLQHIEQ--------------------RGTFTE--QEASQVIRDIASALSFLHNKGIAHRDLKPENILCESM---------
..|.. | || |.. | . .| |.| ....... ..||....|...| |||||.|||. .
TPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRD
----YSISPIKICDFGLGSGIHLSSQYNTPVTTPE-LLTPVGSAEFMAPEIVEAFIYD-------LQATVYDKRC----DLWSLGVILYILLCGHPPFVG
| . ||.|||| |. .||. . .. . | .|. ..|||||| | . . || | |.||||||.|..||| ||| .
FPYDWSNWHIKLCDFG------LCCHYNH-NKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDC
SCGEDCGWDRGEACQDCEELLLHCIQSGEY-DFHGAEWEH---ISAGAKDLISHLLVRDAKQRYTAGMVLNHPWV
.| .. |. . .. || .|.| .| |. || .|||.. ....| ..| .| | |.|.
ECEDR---DY----ENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
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| Kinase | Mnk.AA | MSK | 136-349 | 34 | 1.2e-59 | 200.3 | In-house | 1-210 (277) | Show / Hide |
Range on Protein: 136-349 Range on HMM: 1-210/277 Sequence Identity: 34% (77 aa) LTGE-LLGSGSYASVRTCRQISSGKEYAVKMME------KRPGNSRTKIFREVETLYHCQGHNNILQLIEYFEDDDRFYLIFEKMYGGALLQHIEQRGTF | .| |.. .| |.. ..||.||.| || . |. .|. .| .||.| || .| . | |. .||. | || |. || .|. | LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQ--TERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHF TEQEASQVIRDIASALSFLHNKGIAHRDLKPENILCESMYSISPIKICDFGLGSGIHLSSQYNTPVTTPELLTPVGSAEFMAPEIVE-AFIYDLQATVYD .|.|.....| . .|....| ||| |||||||||| .. . ..|. |||. . .... . . .| .. ..||||... . . | . || DESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGF-------ARLFPQDEEWRMKSPCFTLHYMAPEMLRRG---YAQDGGYD KRCDLWSLGVILYILLCGHPPF . ||.|||||||| .| |. || EACDWWSLGVILYTMLTGQVPF |
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| Kinase | Mnk.AA | RSK | 134-280 | 32 | 1.2e-38 | 134.66 | In-house | 1-151 (271) | Show / Hide |
Range on Protein: 134-280 Range on HMM: 1-151/271 Sequence Identity: 32% (50 aa) YDLTGELLGSGSYA---SVRTCRQISSGKEYAVKMMEKRPGNSR-TKIFREVETLYHCQGHNNILQLIEYFEDDDRFYLIFEKMYGGALLQHIEQRGTFT |.| | .| ||. .. |. ....||.| .| . . |.. . | .| .| . |.| |.| . | || |. .. . |. YELH-ECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS EQEASQVIRDIASALSFLHNKGIAHRDLKPENILCESM-YSISPIKICDFGL |.|.. . . ||.|. .|| .||.|||||||||| .. .. . |||||||. EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGF |
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| Kinase | Mnk.AA | CDPK | 136-280 | 32 | 1e-37 | 113.42 | In-house | 2-156 (271) | Show / Hide |
Range on Protein: 136-280 Range on HMM: 2-156/271 Sequence Identity: 32% (52 aa) LTGELLGSGSYASVRTCRQI-SSGKEY-AVKMMEKR-PGNSR--TKIFREVE---TLYHCQGHNNILQLIEYFEDDDRFYLIFE--KMYGGALLQHIEQR .. ||.|.. .|| . . ... | |.|. .|. .. . |.|.| .| | ||... |...|.. .|...| .|| |.. | .. KIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQL----DHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEK GTFTEQEASQVIRDIASALSFLHNKGIAHRDLKPENILCESMYSIS----PIKICDFGL | |||.||....| | ||.. |...| |||||||||| .| . | .||. |.|. GHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGT |
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| Kinase | Mnk.AA | RSK | 299-422 | 28 | 2.9e-25 | 87.2 | In-house | 162-271 (271) | Show / Hide |
Range on Protein: 299-422 Range on HMM: 162-271/271 Sequence Identity: 28% (37 aa) LLTPVGSAEFMAPEIVEAFIYDLQATVYDKRCDLWSLGVILYILLCGHPPFVGSCGEDCGWDRGEACQDCEELLLHCIQSGEYDFHGAEWEHISAGAKDL |.|. ..|..||||. | .|. || ||.||..|. | |..||. . .. ..... |..| ... . |. ||. |||| LMTFCYTANYMAPEV-------LKRQGHDQACDWWSFGVLMYEMLTGCTPFQ-----------NKPRDTPMNIIQR-IKLGMFSMTHGNWDFISDEAKDL ISHLLVRDAKQRYTA-----GMVLNHPWV ....| || .|..| ...|||. LRMMLHRDPHNRLGAGPNGVEQIKQHPWF |
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| Kinase | Mnk.AA | CDPK | 376-422 | 48 | 2.8e-23 | 68.44 | In-house | 225-271 (271) | Show / Hide |
Range on Protein: 376-422 Range on HMM: 225-271/271 Sequence Identity: 48% (23 aa) IQSGEYDFHGAEWEHISAGAKDLISHLLVRDAKQRYTAGMVLNHPWV .. |.|.| | ||.||| |||||. .|..| |.|..| ..|.|||. VKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | Mnk.AA | CDPK | 326-351 | 73 | 1.6e-17 | 50.52 | In-house | 190-215 (271) | Show / Hide |
Range on Protein: 326-351 Range on HMM: 190-215/271 Sequence Identity: 73% (19 aa) YDKRCDLWSLGVILYILLCGHPPFVG |.. ||.||.|||||||||| ||| | YNEKCDIWSCGVILYILLCGYPPFYG |
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| Kinase | Mnk.AA | TyrKc | 135-422 | 18 | 8e-11 | -47.65 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 135-422
Range on HMM: 1-280/280
Sequence Identity: 18% (59 aa)
DLTGELLGSGSYASVRTCRQISSGKEYAVKMMEKRPGNSRTKIFREVETLYHC-QGHNNILQLIEYFEDD-------DRFYLIFEKMYGGALLQHI-EQR
|. ||.| . |. .. . . ||||. . | . || . . . | ||..|. . .. . ....| | .|.|.... . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR
GTFTEQEASQVIRDIASALSFLHNKGIAHRDLKPENILCESMYSISPIKICDFGLGSGIHLS------SQYNTPVT--TPELLTPVGSAEFMAPEIVEAF
.... .. . .||. ..|| |.. |||| |.| . . .||.|||| |. ..| .. . . |. ||||
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI---RWMAPECI---
IYDLQATVYDKRCDLWSLGVILY-ILLCGHPPFVG---SCGEDCGWDRGEACQDCEELLLHCIQSGEYDFHGAEWE-----HISAGAKDLISHLLVRDAK
. .. | || || .. |. | .| | .. ... .......|.. .. . . .. .... .|..
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQE----------VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE
QRYTAGMVLNHPWV
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DRPTFSEI--HECF
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| Kinase | Mnk.AA | MSK | 376-422 | 40 | 1.4e-10 | 31.94 | In-house | 231-277 (277) | Show / Hide |
Range on Protein: 376-422 Range on HMM: 231-277/277 Sequence Identity: 40% (19 aa) IQSGEYDFHGAEWEHISAGAKDLISHLLVRDAKQRYTAGMVLNHPWV |. || | | .|. .|. |||||. || .| | | ... . | | ICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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| Kinase | Mnk.AA | Pkinase_Tyr | 138-257 | 23 | 5.5e-10 | 34.45 | Pfam | 4-137 (270) | Show / Hide |
Range on Protein: 138-257 Range on HMM: 4-137/270 Sequence Identity: 23% (32 aa) GELLGSGSYASVRTCRQI----SSGKEYAVKMMEKRPGNS---RTKIFREVETLYHCQGHNNILQLIEYFE-DDDR--FYLIFEKMYGGALLQHIEQ--- |. ||.|.. .|. .. . . . ||||. . | . .||.... . | ||..|. ... |...| | .| || . . GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRE -RGTFTEQEASQVIRDIASALSFLHNKGIAHRDL .. .| .. | ..||.....|..|.. |||| DKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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