Gene MLCKa (Sea Urchin)
MLCKa
Sequence
Protein domains of MLCKa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| I-set | MLCKa.AA | I-set | 275-365 | 38 | 1.2e-29 | 103.11 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 275-365 Range on HMM: 1-92/92 Sequence Identity: 38% (35 aa) PVFRQKFRHCEVIVGSVACFECRVDGHPSPDIIWYRNGKRVQE-SERSRIMKGGEDVHSLVIKEVTKDDQGTYMCEARSPAGKARCSARLVV |.| || . || .|. | |||.|.|.| |.. |...|. ... |.| .. | . ..| |..|..|| |.| | |. ..|.| |.|.| | PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | MLCKa.AA | IGc2 | 287-355 | 31 | 2e-14 | 55.17 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 287-355 Range on HMM: 1-56/56 Sequence Identity: 31% (22 aa) IVGSVACFECRVDGHPSPDIIWYRNGKRVQESERSRIMKGGEDVHSLVIKEVTKDDQGTYMCEARSPAG . | . ..|...| | |.| ||. |.... . .| ||.||..| |.| |.||.|.| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | MLCKa.AA | IG | 281-366 | 21 | 2.9e-13 | 51.33 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 281-366 Range on HMM: 1-58/58 Sequence Identity: 21% (20 aa) FRHCEVIVGSVACFECRVDGHPSPDIIWYRNGKRVQESERSRIMKGGEDVHSLVIKEVTKDDQ---GTYMCEARSPAGKARC--SARLVVQ . .| .|. . ..| | | || |.| .|...|. ||| |.|. .|.. . ...| || PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| I-set | MLCKa.AA | I-set | 825-914 | 38 | 8.6e-32 | 110.4 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 825-914 Range on HMM: 1-92/92 Sequence Identity: 38% (35 aa) PSFVKKPQKLSASEGESATLSCMVEGEPKPEVTWSFRGKPLVD-EGRVEIYQEK-GTYYLEIFDLVGRDAGLYTCRIVNSAGRSSALVELVV |.|..||. . ..|||.|...| |.|.|.|.|.| |.|| . |. . ... ||| |.| . .|.| |||. .||.| ... .|| | PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | MLCKa.AA | IGc2 | 837-904 | 32 | 6.3e-17 | 63.47 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 837-904 Range on HMM: 1-56/56 Sequence Identity: 32% (22 aa) SEGESATLSCMVEGEPKPEVTWSFRGKPLVDEGRVEIYQEKGTYYLEIFDLVGRDAGLYTCRIVNSAG ||.|.|| | ..| | |...| . |.|| . .|.| . |.|.|||. |..| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | MLCKa.AA | IG | 831-915 | 20 | 3.2e-14 | 54.48 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 831-915 Range on HMM: 1-58/58 Sequence Identity: 20% (18 aa) PQKLSASEGESATLSCMVEGEPKPEVTWSFRGKPLVDEGRVEIYQEKGTYYLEIFDLVGRDA---GLYTCRIVNSAGRSSA--LVELVVN |. ....|||..||.| |. ...|. |.| .. |. | |.|. .| .. ..| | PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGv | MLCKa.AA | IGv | 841-899 | 25 | 0.000297 | 13.56 | SMART | 1-76 (76) | Show / Hide |
Range on Protein: 841-899 Range on HMM: 1-76/76 Sequence Identity: 25% (20 aa) SATLSCMVEGEPKPEVTWSFR-------GKPLV-----DEGRVEIYQ------EKGTYYLEIFDLVGRDAGLYTCRI |.|||| . | ...| ||.| ||... |.. ||.. .| | | |.| . SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR |
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| V-set | MLCKa.AA | V-set | 388-914 | 4 | 0.426215 | 5.61 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 388-914
Range on HMM: 1-128/128
Sequence Identity: 4% (24 aa)
ESPSRQ-NSTGRKFWQFSSSKNKDQRGDKLATSSKSSTPAAAASKQSFFSLDRKGSSRTESERSEPRREQRATRTSTASSPRSQSGSSKSAVDKLKERAE
|. | ...| |
QSQVTQHPPRGC-PW-------------------------------------------------------------------------------------
AFTKQYERKKEERQSLSDREPRRSTNISNYLQRYTRSASAERSSSFSIGSTSSPSRRGSSASTSDEPDLAPYSRPRLATYATMIRSTQSIGALSAKFEAG
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KANGTDTRKGNSSTLPRKDLKYNANLDAKKALFSSTSNGTTNSSPVKSKTREPVSVLSRAAVTSPPSTSSLRSKFESKSNGDKDAPFTRTTPVRQSTGRL
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SYLDKMETKERDSSPSSSSSSSFSRSSAARHSTIGVMKSPSTGNKQDTRNGVNTKRQEPARPVSTFISPSKSSSVSSPISSTNQKTFVSRYETVINSDSE
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SSICSTTSSSTSEKKSRSTPSSSISSRYEMRSPVVEKPPSFVKKPQKLSASEGESATLSCMVEGEP----KP-EVTWSF-RGK-----------------
....||.|.||.| . . . ..|.. .
----------------------------------------------WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYN
------PLVDEGRVEIYQEKG--TYYLEIFDLVGRDAGLYTCRIVNS-AGRSSALVELVV
. . |||.... . ...| | .| | | |.| . |. . . ..|.|
FGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
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| I-set | MLCKa.AA | I-set | 922-1013 | 40 | 1.7e-27 | 95.82 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 922-1013 Range on HMM: 1-92/92 Sequence Identity: 40% (38 aa) PFFLQKLSDCEVHEAGANGRLQCKLEGAPVPETSWLKEGKPLEE-SDRVHFIQSANGIHAIIIDDVTEDDDSIYTCIAKNKHGQVSSSAELIV | |.||..| || | | |..|. .| | |. ||.| |.|| . |||... .. .|.. .|..|. || .|||.|.|. |.....|||.| PKFTQKPKDVEVQE-GETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | MLCKa.AA | IGc2 | 935-1003 | 30 | 2.8e-10 | 41.39 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 935-1003 Range on HMM: 1-56/56 Sequence Identity: 30% (21 aa) EAGANGRLQCKLEGAPVPETSWLKEGKPLEESDRVHFIQSANGIHAIIIDDVTEDDDSIYTCIAKNKHG . | . .|.|. .|.|.|. .|.| |.||. . | .||..|. .|||.| |..| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | MLCKa.AA | IG | 928-1014 | 19 | 2.6e-09 | 38.2 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 928-1014 Range on HMM: 1-58/58 Sequence Identity: 19% (18 aa) LSDCEVHEAGANGRLQCKLEGAPVPETSWLKEGKPLEESDRVHFIQSANGIHAIIIDDVTEDDD---SIYTCIAKNKHGQVSS--SAELIVE . .| | | . .|.| . . .|. ..| .|...| .|.| |. |||..| ...|.|. PP-VTVKE-GETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| V-set | MLCKa.AA | V-set | 922-1013 | 11 | 0.002042 | 13.61 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 922-1013 Range on HMM: 1-128/128 Sequence Identity: 11% (15 aa) PFFLQK-LSD----CEVHEAGANGRLQCKLE-GA----PVPETSWLKEGKPL-------------------------EESDRVHFIQSAN-GIHAIIIDD ..... . . . |.. .|.|.. . .. .| . |. . ..||.| .. . . . | . QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN VTEDDDSIYTCIAKNK-HGQVSSSAELIV ....| .|.| ..| ... .. .|.| LQPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| I-set | MLCKa.AA | I-set | 1064-1153 | 35 | 1.1e-26 | 93.02 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1064-1153 Range on HMM: 1-92/92 Sequence Identity: 35% (33 aa) PQFLARPSSVTADQAKSARFSCSVSGFPLPVVTWAKDEKILRD-EGRFEIYDEG-QEFIMEVFELEPEDEGLYTVTAENPAGKAATGAQLTI |.|. .|..|.. ..|||.| |.| | |.|.| ||.. || . |. . .| .. .. . .|.||| ||..|.|..|.| . |.||. PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | MLCKa.AA | IG | 1070-1154 | 18 | 6.6e-10 | 40.16 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1070-1154 Range on HMM: 1-58/58 Sequence Identity: 18% (17 aa) PSSVTADQAKSARFSCSVSGFPLPVVTWAKDEKILRDEGRFEIYDEGQEFIMEVFELEPEDE---GLYTVTAENPAGKAAT--GAQLTIN |. ||. .....| || ..| ... ...|||. | |. .|. .|.. |..||. PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | MLCKa.AA | IGc2 | 1076-1143 | 26 | 2.1e-05 | 25.21 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1076-1143 Range on HMM: 1-56/56 Sequence Identity: 26% (18 aa) DQAKSARFSCSVSGFPLPVVTWAKDEKILRDEGRFEIYDEGQEFIMEVFELEPEDEGLYTVTAENPAG . |... | ..|.| | ..| | .. | . .. . .|||.|.|| .|.||.| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | MLCKa.AA | V-set | 1063-1153 | 16 | 0.000125 | 17.79 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 1063-1153 Range on HMM: 1-128/128 Sequence Identity: 16% (21 aa) APQFLA-RPS----SVTADQAKSARFSCSVS-GF----PLPVVTWAKDEKIL-------------------------RDEGRFEIYDEGQ--EFIMEVFE . | . |. .||. . .|....|..| . . ..| .. . | ||.... .. | . QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN LEPEDEGLYTVTAENP-AGKAATGAQLTI |.|.|.| |. . |. . .| .||. LQPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| IGv | MLCKa.AA | IGv | 1080-1136 | 24 | 0.004468 | 1.76 | SMART | 1-76 (76) | Show / Hide |
Range on Protein: 1080-1136 Range on HMM: 1-76/76 Sequence Identity: 24% (19 aa) SARFSCSVSGFPLPVVTWAKD-------EKILR-----DEGRFEIYDEG------QEFIMEVFELEPEDEGLYT--V |.. ||..||| . ...| . | | |||.. | .. |.|||.| |. . SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR |
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| I-set | MLCKa.AA | I-set | 1216-1305 | 34 | 4.4e-28 | 97.81 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1216-1305 Range on HMM: 1-92/92 Sequence Identity: 34% (32 aa) PEFLALPTQRTITEPNSAKFNCRVVGDPKPTVTWSRNGVVLSD-SGRYELYEEK-DEFVLEIFDTTTDDSGVYVCTATNLAGQKAAETMLTV |.|. |. ...| .|.|.|.| |||.|.|.| ..| |. | |. ... .. |.| . . ||.|.| |.||| .|. .. ||| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | MLCKa.AA | IGc2 | 1228-1295 | 29 | 4.1e-12 | 47.5 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1228-1295 Range on HMM: 1-56/56 Sequence Identity: 29% (20 aa) TEPNSAKFNCRVVGDPKPTVTWSRNGVVLSDSGRYELYEEKDEFVLEIFDTTTDDSGVYVCTATNLAG | .|. ..|.. |.| |...| . | |. .. |.| . | .|||.|.|.|.| .| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | MLCKa.AA | IG | 1222-1306 | 23 | 9.1e-12 | 46.33 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1222-1306 Range on HMM: 1-58/58 Sequence Identity: 23% (21 aa) PTQRTITEPNSAKFNCRVVGDPKPTVTWSRNGVVLSDSGRYELYEEKDEFVLEIFDTTTDDS---GVYVCTATNLAGQKAA--ETMLTVE | | | .....| | ...|. |.| . . .|| |.|.|.|| .||. . .| |||. PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| V-set | MLCKa.AA | V-set | 1232-1305 | 18 | 4e-06 | 22.84 | Pfam | 23-128 (128) | Show / Hide |
Range on Protein: 1232-1305 Range on HMM: 23-128/128 Sequence Identity: 18% (20 aa) SAKFNCRVVGDP----KP-TVTWSR-NGV-------------VLSD----------SGRYELYEEKD--EFVLEIFDTTTDDSGVYVCTATNL-AGQKAA |....| . |. . ...|.| . .. .||.... . | | | . . .|||.| | ..| .. . SVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGH ETMLTV .|.||| GTRLTV |
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| IGv | MLCKa.AA | IGv | 1232-1290 | 22 | 0.000334 | 13.05 | SMART | 1-76 (76) | Show / Hide |
Range on Protein: 1232-1290 Range on HMM: 1-76/76 Sequence Identity: 22% (17 aa) SAKFNCRVVGDPKPTVTWSRN-------GVVL-----SDSGRYELYE------EKDEFVLEIFDTTTDDSGVYVCTA |.. |.. |. ...| | |. | | .||... | | |.. . . .|.|.| | SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR |
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| I-set | MLCKa.AA | I-set | 1415-1504 | 34 | 5.4e-34 | 117.86 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1415-1504 Range on HMM: 1-92/92 Sequence Identity: 34% (32 aa) PEFLQKLKDIQAIDGSPLSLPVRIKGSPAPDVQWFFNKEQIKE-DNDFKFVVDG-DRLSLVIAEVYPDDAGIYTCKIFNSAGSAECACKVFV |.|.||.||... |. . . ....|.| |.|.|| . ..... .. .... || .. .| | .| |||.|.|||. ||.|.||| ... | PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| I-set | MLCKa.AA | I-set | 1315-1405 | 31 | 4.9e-21 | 73.91 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1315-1405 Range on HMM: 1-92/92 Sequence Identity: 31% (29 aa) PEFIEKMSGTAVRDADKAKFTCKLRGIPSPSVHWYYRNQEIVGSDEVYELYHEG-EIASLCLPEVLPEDEGEYSCTIKNDMGETSCSAFLKV |.|. | . |. . |.|.|. .| | |.| |.. .|.. ... . .| ...| .| |.|||.|.|. .| || .|.|.|.| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | MLCKa.AA | IGc2 | 1427-1494 | 25 | 3.9e-11 | 44.23 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1427-1494 Range on HMM: 1-56/56 Sequence Identity: 25% (17 aa) IDGSPLSLPVRIKGSPAPDVQWFFNKEQIKEDNDFKFVVDGDRLSLVIAEVYPDDAGIYTCKIFNSAG . | ...|. . |.|.|...|.. ... .. .| | .| |.|.|.|||. |..| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IGc2 | MLCKa.AA | IGc2 | 1327-1395 | 27 | 1.1e-09 | 39.44 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1327-1395 Range on HMM: 1-56/56 Sequence Identity: 27% (19 aa) RDADKAKFTCKLRGIPSPSVHWYYRNQEIVGSDEVYELYHEGEIASLCLPEVLPEDEGEYSCTIKNDMG . . . .||. .| | |..|||. .|.. .| . .| |||.|.|.|. | .| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | MLCKa.AA | IG | 1421-1505 | 15 | 1.8e-09 | 38.73 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1421-1505 Range on HMM: 1-58/58 Sequence Identity: 15% (14 aa) LKDIQAIDGSPLSLPVRIKGSPAPDVQWFFNKEQIKEDNDFKFVVDGDRLSLVIAEVYPDDA---GIYTCKIFNSAGSAEC--ACKVFVQ . . . |....|. .. ..|. |.| .| |.|. |.|.| .|.... .. || PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IG | MLCKa.AA | IG | 1321-1406 | 18 | 2e-09 | 38.58 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1321-1406 Range on HMM: 1-58/58 Sequence Identity: 18% (17 aa) MSGTAVRDADKAKFTCKLRGIPSPSVHWYYRNQEIVGSDEVYELYHEGEIASLCLPEVLPEDE---GEYSCTIKNDMGETSC--SAFLKVQ . . |. . ...|| ...|| | . .| |||. |.| |. . |.... .. |.|| PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGv | MLCKa.AA | IGv | 1331-1489 | 8 | 0.00032 | 13.24 | SMART | 1-76 (76) | Show / Hide |
Range on Protein: 1331-1489
Range on HMM: 1-76/76
Sequence Identity: 8% (15 aa)
KAKFTCKLRGIPSPSVHWYYRNQEIVGSDEVYELYHEGEIASLCLPEVLPEDEGEYSCTIKNDMGETSCSAFLKVQVASPKSTMPEFLQKLKDIQAIDGS
.. .||. | . .|||. . . . |....
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY---------------------------------------------------------------
PLSLPVRIKGSPAPDVQWFFNKEQIKEDNDFKFVVDGDR--------LSLVIAEVYPDDAGIYTCKI
.| . .| .|.. . |.| |.|.| .
---------------------------SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
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| V-set | MLCKa.AA | V-set | 1415-1504 | 11 | 0.008241 | 11.52 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 1415-1504 Range on HMM: 1-128/128 Sequence Identity: 11% (15 aa) PEFLQK--LK----DIQAIDGSPLSLPVRIKGSP----AP-DVQWFF-NKE-----------------------QIKEDNDFKFVVDGD--RLSLVIAEV ..... . . . | ..|| . .. .. ...|.. . . . . | .... ..|| | . QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL YPDDAGIYTCKIFNS-AGSAECACKVFV |.| |.|.| ..|. .. . .. | QPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| V-set | MLCKa.AA | V-set | 1330-1405 | 14 | 0.170761 | 6.98 | Pfam | 22-128 (128) | Show / Hide |
Range on Protein: 1330-1405 Range on HMM: 22-128/128 Sequence Identity: 14% (16 aa) DKAKFTCKLR-GI----PSPSVHWYY-RNQ-----EIV----------GSDEVYELYHEGE---------IASLCLPEVLPEDEGEYSCTIKN-DMGETS ......|... . .. ...||. ... .|. |.. .|. . . . .|| . . |.|.| | | ..| ... QSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFG CSAFLKV . | | HGTRLTV |
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| I-set | MLCKa.AA | I-set | 1514-1606 | 37 | 1.1e-30 | 106.61 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1514-1606 Range on HMM: 1-92/92 Sequence Identity: 37% (35 aa) PKFVQKPRSIHIDEGSSVTLSCKIDGEPLPTVTWIKDGRPIEA-GRRFKMESSGISGTTRSLNIPTVLATDAGSYTCVLHNQSGGDQCSVNVVV |||.|||... . ||......|...|.| |.|.| |||.|. ..|..| .| . | .| | | . |.|.|||| | .| ..|.... | PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDG--DGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | MLCKa.AA | IG | 1520-1607 | 18 | 2.9e-15 | 57.96 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1520-1607 Range on HMM: 1-58/58 Sequence Identity: 18% (17 aa) PRSIHIDEGSSVTLSCKIDGEPLPTVTWIKDGRPIEAGRRFKMESSGISGTTRSLNIPTVLATDA---GSYTCVLHNQSGGDQC--SVNVVVK |. . ||..|||.| . ...| |.| | . |. | |.|. . .| ... .... |. PP-VTVKEGETVTLTC-VS-----QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | MLCKa.AA | IGc2 | 1526-1596 | 33 | 1e-13 | 52.85 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1526-1596 Range on HMM: 1-56/56 Sequence Identity: 33% (24 aa) DEGSSVTLSCKIDGEPLPTVTWIKDGRPIEAGRRFKMESSGISGTTRSLNIPTVLATDAGSYTCVLHNQSG || |||| |. .| | |...|.| | |.. . .|.| | |.| |||. | | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | MLCKa.AA | V-set | 1514-1606 | 17 | 6e-06 | 22.46 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 1514-1606 Range on HMM: 1-128/128 Sequence Identity: 17% (23 aa) PKFVQK--PR----SIHIDEGSSVTLSCKID-----GEPLPTVTWIKDGRPI--------------EAGRRFKMESSGISGTTR----------SLNIPT . .|. || ... || ||||.|. |. ...|... .| .. . . .. .|... ||.| QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN VLATDAGSYTCVLHNQ-SGGDQCSVNVVV . | | |.|. | .. . .....| LQPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| IGv | MLCKa.AA | IGv | 1530-1591 | 25 | 0.000909 | 8.69 | SMART | 1-76 (76) | Show / Hide |
Range on Protein: 1530-1591 Range on HMM: 1-76/76 Sequence Identity: 25% (20 aa) SVTLSCKIDGEPLPTVTWIKD-------GRPIE-----AGRRFKMESSGI---SGTTRSLNIPTVLATDAGSYTCVL ||||||| | . ...|.. |.. | || . . | |... .| . . . | | |.| SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGYSYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR |
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| I-set | MLCKa.AA | I-set | 1662-1751 | 40 | 4.1e-39 | 135.26 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1662-1751 Range on HMM: 1-92/92 Sequence Identity: 40% (37 aa) PSFIKPLTDIEVVEGESVTFECHVDGIPEPIIIWTANKKEIKE-SKYFQMSYKD-TVAKLLIAEAFAEDEGDYACTATNGVGSVTCAAELTV |.|.....|.|| |||...|||.|.| |.| . |. . ..... |...||.|.. ..| | .....||| | |.||| .|...| ||||| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | MLCKa.AA | IG | 1668-1752 | 26 | 5.1e-15 | 57.14 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1668-1752 Range on HMM: 1-58/58 Sequence Identity: 26% (24 aa) LTDIEVVEGESVTFECHVDGIPEPIIIWTANKKEIKESKYFQMSYKDTVAKLLIAEAFAEDE---GDYACTATNGVGSVTC--AAELTVQ ..|.|||.||..| | | |. | | .. .||. |.| |.|| |.... ..|||| PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | MLCKa.AA | IGc2 | 1674-1741 | 30 | 1.6e-11 | 45.52 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1674-1741 Range on HMM: 1-56/56 Sequence Identity: 30% (21 aa) VEGESVTFECHVDGIPEPIIIWTANKKEIKESKYFQMSYKDTVAKLLIAEAFAEDEGDYACTATNGVG ||.|||..|...| |.| | |. ... . | | .. ||.| |.|.|.| .| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | MLCKa.AA | V-set | 1662-1685 | 30 | 0.238434 | 6.48 | Pfam | 1-30 (128) | Show / Hide |
Range on Protein: 1662-1685 Range on HMM: 1-30/128 Sequence Identity: 30% (9 aa) PSFIKP--LT----DIEVVEGESVTFECHV .|.... . ..|.||.|||..||. QSQVTQHPPRGCPWWVTVQEGQSVTLPCHY |
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| I-set | MLCKa.AA | I-set | 1889-1979 | 36 | 1.5e-33 | 116.4 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1889-1979 Range on HMM: 1-92/92 Sequence Identity: 36% (34 aa) PCFLEPLKDTAVLEESSAMLKCKVVGEPEPDIFWYKDGVELKD-DRKYKMDFPDDDVAMLIVREAGLEDAGEYTCKAVNSCGTKESTAEIIV |.|. ..|| | | ..| ..|.| |.|.|.. |.||| .|. .....|.. .|. . |..... .|.|.|||.|.|| |. |.||| .| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IGc2 | MLCKa.AA | IGc2 | 1901-1969 | 33 | 3.4e-13 | 51.08 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1901-1969 Range on HMM: 1-56/56 Sequence Identity: 33% (23 aa) LEESSAMLKCKVVGEPEPDIFWYKDGVELKDDRKYKMDFPDDDVAMLIVREAGLEDAGEYTCKAVNSCG .| |. |.|.. | |.|.| ||| | .| . | .... .||.|.|||.| |. | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | MLCKa.AA | IG | 1895-1980 | 19 | 3.2e-11 | 44.53 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1895-1980 Range on HMM: 1-58/58 Sequence Identity: 19% (18 aa) LKDTAVLEESSAMLKCKVVGEPEPDIFWYKDGVELKDDRKYKMDFPDDDVAMLIVREAGLEDA---GEYTCKAVNSCGTKES--TAEIIVE . . | | ... |.| | |.|| |.. .. .||. |.|.| | |...| .....|. PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| V-set | MLCKa.AA | V-set | 1882-1979 | 16 | 0.017407 | 10.4 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 1882-1979 Range on HMM: 1-128/128 Sequence Identity: 16% (21 aa) AAPATD-PPCFLEPLKDTAVLEESSAMLKCKVVGEP----EP-DIFWYK-DGV-------------------------ELKDDRKYKMDFPDDDVAMLIV . . | || .. | | | |. |.|.. . . .|.||. . |. . .. ...|. . | QSQVTQHPPRGC-PW-WVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTIS REAGLEDAGEYTCKAVNS-CGTKESTAEIIV . ..| | |.| . |. .. .. . .| N-LQPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| I-set | MLCKa.AA | I-set | 1983-2073 | 25 | 1.1e-16 | 59.07 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1983-2073 Range on HMM: 1-92/92 Sequence Identity: 25% (24 aa) ARIKDAPKTLQVMAGHDLSVTCNFVAIPEPDVVVWRKNRKTVQE-SDRVKIEETD-TSTTLTVTKATHDDSGRYTLQVENDLGSDDTAIYVSV .. || ..|. | .. .|. |.|. |.| |. . ... |||... ... .|||..... ||.| || ...| .|.. . . . | PKFTQKPKDVEVQEGETARFECQVTGDPPPQ-VSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | MLCKa.AA | IG | 1989-2074 | 16 | 8.2e-11 | 43.17 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 1989-2074 Range on HMM: 1-58/58 Sequence Identity: 16% (15 aa) PKTLQVMAGHDLSVTCNFVAIPEPDVVVWRKNRKTVQESDRVKIEETDTSTTLTVTKATHDDS---GRYTLQVENDLGSDDT--AIYVSVL |. . |..| ... || . . |. ||. ... .|| | |. |.. |.. ....|. PP-VTVKEGETVTLTC-VS------QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | MLCKa.AA | IGc2 | 1995-2063 | 23 | 5.8e-05 | 22.44 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 1995-2063 Range on HMM: 1-56/56 Sequence Identity: 23% (16 aa) MAGHDLSVTCNFVAIPEPDVVVWRKNRKTVQESDRVKIEETDTSTTLTVTKATHDDSGRYTLQVENDLG | ... || .. . . |.| . .. .. |||.. .| .|||.|| ...| | HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | MLCKa.AA | V-set | 1982-2073 | 13 | 0.819941 | 4.63 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 1982-2073 Range on HMM: 1-128/128 Sequence Identity: 13% (17 aa) PARIKD-APK----TLQVMAGHDLSVTCNFV---AIPEPD-VVVWRK-NRK-----------------------TVQESDRVKIEETDT--STTLTVTKA . .. |. . | | ... .| . .|.. . | . . . . ..|| . . . . .|| ... QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL THDDSGRYTLQVEN-DLGSDDTAIYVSV . .||| |. .| | . .. . . . | QPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| FN3 | MLCKa.AA | FN3 | 2077-2159 | 22 | 1.7e-16 | 62.08 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 2077-2159 Range on HMM: 1-69/69 Sequence Identity: 22% (22 aa) PDPPVGT--PIASNISRQ------SLTLSWTGSSYDGGSRITGYVVEMRTVDDEAWTKADVVSHTSHTIDNLKPE----TKYLFRVSSENE--HGIS |.|| . . ...... |.||||. |.||. .|...||| |.| |||. .|. .|.. PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR---------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| Kinase | MLCKa.AA | MLCK | 2209-2464 | 68 | 1.1e-248 | 663.93 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 2209-2464 Range on HMM: 1-257/257 Sequence Identity: 68% (176 aa) YQIKEVLGKGRFGTVHKCIEKVTGKAYAAKMIKTIKSTDKESVKNEIEIMNKLHHAKLLQCLDAFESPKQMIMVLEIVNGGELFERVIDDDFGLTESDVI |||.|.||.|.||.||.|||| |||..|||.||..|..||| |||||||||.||| .|.|| ||||....|.|..|...|||||||..|.|| |||..|| YQIHEELGRGKFGIVHRCIEKSTGKTWAAKFIKCRKPKDKENVKNEIEIMNQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVI EFMRQICAGVHHMHSTNILHLDLKPENILCIDKTGSRIKLIDFGLARDFNPAQS-TKVMFGTPEFVAPEVINYDVIGFTTDMWSVGVICYILLSGLSPFM ..|||||.||||||. ||.|||||||||.| ..|...||.||||||| ..|... .||||||||||||||.|||..|| |||||||||||.||||||||| HYMRQICEGVHHMHWQNIVHLDLKPENIMCQTRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFM GDNDAETLNNVTLAEWDFEDEAFDAISEDAKTFIEGLLIQKKEERMTAAECLQHHWL ||||.||.|||| .||||.||.||.||..|| ||. ||...||.||||.|||||.|| GDNDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL |
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| Kinase | MLCKa.AA | DAPK | 2211-2464 | 44 | 1e-130 | 362.35 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 2211-2464 Range on HMM: 1-264/264 Sequence Identity: 44% (118 aa) IKEVLGKGRFGTVHKCIEKVTGKAYAAKMIKTIKSTDK------ESVKNEIEIMNKLH-HAKLLQCLDAFESPKQMIMVLEIVNGGELFERVID--DDFG . | || |.| | ||..| ||| |||| || ... | . || | .. | .. ...| . .|..|| | ||||| . . . MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREE-C LTESDVIEFMRQICAGVHHMHSTNILHLDLKPENILCIDKTGSR--IKLIDFGLARDFNPAQSTKVMFGTPEFVAPEVINYDVIGFTTDMWSVGVICYIL |.| |...||.|| |||..|| || ||||||.||. |. . ||.|||||.| ... . ..||||.||||..||. .. |||||.||| ||. LCEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIM LSGLSPFMGDNDAETLNNVTLAEWDFEDEAFDAISEDAKTFIEGLLIQKKEERMTAAECLQHHWL ||| ||| ||. ||. |.. ||..| |. || || || || . | ||||.||||| |. LSGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI |
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| Kinase | MLCKa.AA | Trio | 2209-2464 | 37 | 2.9e-120 | 310.02 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 2209-2464 Range on HMM: 1-258/258 Sequence Identity: 37% (97 aa) YQIKEVLGKGRFGTVHKCIEKVTGKAYAAKMIKTIKSTDKESVKNEIEIMNKLHHAKLLQCLDAFESPKQMIMVLEIVNGGELFERVIDDDFGLTESDVI | ..| .| |||. |..|..| ||.. ||| | .. |||.| | |.. |.| ... .|..|.|.. | .|| .||| ... . . ..||.|. YTFQEEIGRGRFSVVRRCWHKATGRTCAAKFI-PYRMMDKEQVYHEYEMLQHLQHPCVCSLHDTYETPRHYILILELCDDGELLCCLM-RWGSYCESEVK EFMRQICAGVHHMHSTNILHLDLKPENILCIDKTG--SRIKLIDFGLARDFNPA--QSTKVMFGTPEFVAPEVINYDVIGFTTDMWSVGVICYILLSGLS .|.|. .|| |. |||||.||||.. . . .||..||| | . .|. |.|||.|||.|. . .. .|| ||.||. |..||| | TYMWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGIS PFMGDNDAETLNNVTLAEWDFEDEAFDAISEDAKTFIEGLLIQKKEERMTAAECLQHHWL || ...| ||. |. .|... | .|..|| || ..| . .| .|.|||||.|. PFYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF |
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| Kinase | MLCKa.AA | CAMK | 2214-2464 | 26 | 4.2e-116 | 375.78 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 2214-2464
Range on HMM: 1-425/425
Sequence Identity: 26% (112 aa)
VLGKGRFGTVHKCIEKVTG------------KAYAAKMIKTIKST----------------------------DKESVKNEIEIMNK-------LHHAKL
.||.|.||.|..||.| |. . .|.|.|.. | . |...|..|||||.| |.| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
LQCLDAFES-------------------PKQMIMVL---EIVNGGEL----FERVIDD--------------DFGLTESDVIEFMRQICAGVHHMHSTNI
.......|. .|.|.||. | . |||| |..... .. .||... ..|||| .||..|| ||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
LHLDLKPENILCIDKTG---------------SRIKLIDFGLARDFNP------------------------AQSTKVMFGTPEFVA-PEVINY------
|.||||||||. |. . ||.||||.|. |.| | | ..||||..| |||.|.
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM
--------DVIGFTTDMWSVGVICYILLSGLSPFMGD-------------NDAETLNNVTLAEWDFEDEAFDAIS--------------------EDAKT
. .|. .||||.|||.||.|.| .|| || || |.. ... ...||... |. || ...|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD
FIEGLLIQKKEERMTAAECLQHHWL
.| ..| |.|||...||.| |.
LIRKMLQVDPEKRMTIEQCLNHPWM
|
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| Kinase | MLCKa.AA | DAPK | 2209-2464 | 46 | 1e-114 | 332.32 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 2209-2464 Range on HMM: 1-264/264 Sequence Identity: 46% (123 aa) YQIKEVLGKGRFGTVHKCIEKVTGKAYAAKMIKTIKST------DKESVKNEIEIMNKLH-HAKLLQCLDAFESPKQMIMVLEIVNGGELFERVIDDDFG |.. | .| | | | || || ||| |||| || ..| | . |. | .. | |..| . ...|| | ||||| . . . YDMGEEIGSGQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKEC- LTESDVIEFMRQICAGVHHMHSTNILHLDLKPENILCIDKTGSR--IKLIDFGLARDFNPAQSTKVMFGTPEFVAPEVINYDVIGFTTDMWSVGVICYIL |.| .| || ||||||| .| |.||||||| |. . ||.||||||. | . | .||||||||||..|| | |||||.||| ||| LNEEEATQFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYIL LSGLSPFMGDNDAETLNNVTLAEWDFEDEAFDAISEDAKTFIEGLLIQKKEERMTAAECLQHHWL ||| |||.||. ||| |.| . .|..| | || || || ||.. . ||| .||||| | LSGASPFLGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI |
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| Kinase | MLCKa.AA | CAMK1 | 2209-2464 | 38 | 8.60000000001e-102 | 296.69 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 2209-2464 Range on HMM: 1-276/276 Sequence Identity: 38% (108 aa) YQIKEVLGKGRFGTVHKCIEKVT---GKAYAAKMI--KT-IKSTDK---ESVKNEIEIMNK---LHHAKLLQCLDAFESPKQMIMVLEIVNGGELFERVI |......|.| |..|..|..| | ||.|| |.| |. .| | |...|||||| | ..| .. . .||.. .|.| |.|||||.|.. YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV DDDFGLTESDVIEFMRQICAGVHHMHSTNILHLDLKPENILCIDK-TGSRIK--LIDFGLARDFNPAQ-STKVMFGTPEFVAPEVINY---DVIGFTTDM . .. || | . |.||. |..||| .| | ||||||.|. || .| || ..||||.. |.. | ..|||..|||||... . . . || EKGN-YTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM WSVGVICYILLSGLSPFMGDN-DAETLNNVTLAEWDFEDEAFDAISED-AKTFIEGLLIQKKEERMTAAECLQHHWL ||.||| |||| | .|| ..| |.| . .. .|..| .| ||. || || ..| ..| |...||.| |. WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | MLCKa.AA | DRAK | 2212-2464 | 40 | 5.7e-92 | 286.07 | In-house | 2-259 (259) | Show / Hide |
Range on Protein: 2212-2464 Range on HMM: 2-259/259 Sequence Identity: 40% (106 aa) KEVLGKGRFGTVHKCIEKVTGKAYAAKMIKTIK---STDKESVKNEIEIMNKLHHAKLLQCLDA-FESPKQMIMVLEIVNGGELFE-RVIDDDFGLTESD .|.|.| | |||.| ||. .||| .| . . ..| .. || .. . . | . .| ||.||| |||.|. | | . ...| | AKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRME-ILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKD VIEFMRQICAGVHHMHSTNILHLDLKPENI-LCIDKTGSRIKLIDFGLARDFNPAQSTKVMFGTPEFVAPEVINYDVIGFTTDMWSVGVICYILLSGLSP |. |||| ||| .|. || |||||| || | . . ||..|||..| . . . |||..||||. ||| | |||||.||. |..|...|| VQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISP FMGDNDAETLNNVTLAEWDFEDEAFDAISEDAKTFIEGLLIQKKEERMTAAECLQHHWL |.|| || |. |. .| |. .|. | || |. | |.|||| |||.| || FVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL |
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| Kinase | MLCKa.AA | S_TKc | 2209-2464 | 33 | 5.8e-91 | 309.43 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 2209-2464 Range on HMM: 1-231/231 Sequence Identity: 33% (91 aa) YQIKEVLGKGRFGTVHKCIEKVTGKAYAAKMIKTIKSTDKESVKNEIEIMNKLHHAKLLQCLDAFESPKQMIMVLEIVNG--GELFERVIDDDFG----- |.| ...||| ||.|.||..| ||. .| |.|| |....||.|. | || . ...|.|.. . . ||.| ..| |.||.. . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP LTESDVIEFMRQICAGVHHMHSTNILHLDLKPENILCIDKTGSRIKLIDFGLARDFNPAQSTKVMFGTPEFVAPEVINYDVIGF-TTDMWSVGVICYILL ..| .. .|.||| .. ..|| .|.| ||||||||. . .||..|||||| . . . |||...||||. |. |.||.|.| |..| FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML SGLSPFMGDNDAETLNNVTLAEWDFEDEAFDAISEDAKTFIEGLLIQKKEERMTAAECLQ-------HHWL .| || ......... |..|| ||...| |.|.|| |.|| | |. CGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | MLCKa.AA | Pkinase | 2209-2464 | 31 | 5.6e-84 | 290.1 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 2209-2464 Range on HMM: 1-293/293 Sequence Identity: 31% (93 aa) YQIKEVLGKGRFGTVHKCIEKVTGKAYAAKMIKTIKSTDKESVKN----EIEIMNKLHHAKLLQCLDAFESPKQMIMVLEIVNGG----ELFERVI-DDD |.|....|.| ||.| ||..| ||| .| | || . ... . . ||.||..|.| ....|.||... . ||.| ..|| .||... ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH FGL--TESDVIEFMRQICAGVHHMHSTNILHLDLKPENILCIDKTGSR---IKLIDFGLARD--FNPAQSTKVMFGTPEFVAPEVIN-YDVIGFTTDMWS .. .| ... .|.||. |. ..|| .|.| ||||||||. ..| .|..|||||. . . ... |||...|||||. . .| |||| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS VGVICYILLSGLSPFMGD------NDAETLNNVTLAEWDFEDEAFDAIS-----------------EDAKTFIEGLLIQKKEERMTAAECLQHHWL .|.|.|..|.| || |. .. . .... ....|. . . || |..| ||...| .. ..| ||...||| |. CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | MLCKa.AA | Ciliate-E2a | 2209-2464 | 33 | 2.3e-79 | 233.29 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 2209-2464 Range on HMM: 1-275/275 Sequence Identity: 33% (93 aa) YQIKEVLGKGRFGTVHKCIEKVTGKAYAAKMIKTIKSTDKE----SVKNEIEIMNKLHHAKLLQCLDAFESPKQMIMVLEIVNGGELFERVIDDD-FGLT | .. ..||| || | . | ||| .|.| .. | ... ...||| || .| | ... . .|. .. .|.| ..||||... . .. | YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE ESDVIEFMRQIC-AGVHHMHSTNILHLDLKPENILCI--DKTG---SRIKLIDFGLARDFNPAQS--TKVMFGTPEFVAPEVINYDVI------GFTTDM . .. ..|.|. |.|.||. ||.| |||||||| .|.. | ||.||||||..... . ... ||| .|||||.|. . . || IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM WSVGVICYILLSGLSPFMGDNDAETLNNVTLAEWDFEDEA-FDAISEDAKTFIEGLLIQKKEERMTAAECLQHHWL ||.||| ||||.| .|| | . .|.| .. . ||.. . .| ..| .. ..| ..| ||...|.|.| WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | MLCKa.AA | Ciliate-E2 | 2209-2464 | 21 | 1.7e-70 | 240.5 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 2209-2464 Range on HMM: 1-365/365 Sequence Identity: 21% (82 aa) YQIKEVLGKGRFGTVHKCIEKVTGKAYAAKM--------------------IKTIKSTDKESVKNEIEIMNKLH----------------HAKLLQCLDA | . ...|.| ||.| || . ..| .| |. .|..| ..|..|.|| ||.... | .... .. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--SPKQMIMVLEIVNGGELFERVIDDDF----------GLTESDVIEFMRQICA---------------GVHHMHSTN-ILHLDLKPENILCIDKTGS |. . . . .|.| ..||.||.. .. . .|| ....|.||. .....|| | |.| |.|||||| FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ RIKLIDFGLARDFNPA----------------QSTKVMFG----------------TPEFVAPEVINYDV---------IGFTTDMWSVGVICYILLSGL ||.|||||...... . |....| ||...|||..|. .. |.||.||| |..|.| -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK SPFMGDNDAETLNNVTLAEWDFEDE--------------AFDAISEDAKTFIEG----LLIQKKEERMT-AAECLQHHWL || ... ..|| . .. .|...| .| .| . |.|.| . ..|.|.|. PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | MLCKa.AA | CDPK | 2282-2464 | 39 | 3.8e-62 | 189.48 | In-house | 79-271 (271) | Show / Hide |
Range on Protein: 2282-2464 Range on HMM: 79-271/271 Sequence Identity: 39% (78 aa) VLE--IVNGGELFERVIDDDFGLTESDVIEFMRQICAGVHHMHSTNILHLDLKPENIL-CIDKTGS----RIKLIDFGLARDFNPA-----QSTKVMFGT |.| .. |||||...|. .|| . . |||| | ..|| || | |||||||| ...|..| ||.||.|....|... . . ..|| VMETEYCTGGELFDYIIEKGH-FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGT PEFVAPEVIN--YDVIGFTTDMWSVGVICYILLSGLSPFMGDNDAETLNNVTLAEWDFEDEAFDAISEDAKTFIEGLLIQKKEERMTAAECLQHHWL | .||||.. |. | || ||| ||||.| || |.|| |....| . .||.. .| ||..|| |. .| . ||.|...||| | PYYIAPEVLQKKYNE---KCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | MLCKa.AA | CDPK | 2209-2263 | 45 | 1.3e-14 | 41.47 | In-house | 37-96 (271) | Show / Hide |
Range on Protein: 2209-2263 Range on HMM: 37-96/271 Sequence Identity: 45% (27 aa) YQIKEVLGKGRFGTVHKCIEK-VTGKAY-AAKMIKTIKSTDKE---SVKNEIEIMNKLHH |.||.||||| ||.| |...| |. | |.|. . ||| ...|||||. .| | YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDH |
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| Kinase | MLCKa.AA | TyrKc | 2209-2464 | 23 | 1.6e-14 | 11.96 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 2209-2464 Range on HMM: 1-280/280 Sequence Identity: 23% (68 aa) YQIKEVLGKGRFGTVHKCIEKVTGKAYAAKMIKTIKSTDKESVKNEIEIMNKL--HHAKLLQCLDAFESP-------KQMIMVLEIVNGGELFERVIDDD . ...|| | ||.|.|.. | | ||.| . .| .|..|| || || ..... . .. ... .|.| . .| | .. . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR FGLTESDVIEFMRQICAGVHHMHSTNILHLDLKPENILCIDKTGSRIKLIDFGLARDFNPA-------QSTKVMF--GTPEFV-----APEVINYDVIGF |. .| ..|. ||..| . || |. | || |.| ... . ..| ||||.|| . ... |. . |||.||| . . PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL-VGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT TTDMWSVGVICY-ILLSGLSPFMG-----DNDAETLNNVTLAEWDFEDEAFDA--------ISEDAKTFIEGLLIQKKEERMTAAECLQHHWL .| || || .. |. | .| | ...| ...| . . . ... . .. . |.| | .|. |. . KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY---RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | MLCKa.AA | Pkinase_Tyr | 2209-2331 | 27 | 5.2e-12 | 41.3 | Pfam | 1-137 (270) | Show / Hide |
Range on Protein: 2209-2331
Range on HMM: 1-137/270
Sequence Identity: 27% (37 aa)
YQIKEVLGKGRFGTVHKCIEK----VTGKAYAAKMIKTIKSTD---KESVKNEIEIMNKL-HHAKLLQCLDAFE---SPKQMIMVLEIVNGGELFERVID
.. ..||.| ||.|.|.. | |. | ||.| . . .|. .|..|| .| || ...... . |.|...|.| . .| | . .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK
D---DFGLTESDVIEFMRQICAGVHHMHSTNILHLDL
. || .| ... .||..| . .| |. | ||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
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| RVT_1 | MLCKa.AA | RVT_1 | 3119-3218 | 27 | 2.9e-17 | 64.04 | Pfam | 1-94 (223) | Show / Hide |
Range on Protein: 3119-3218 Range on HMM: 1-94/223 Sequence Identity: 27% (29 aa) IFKKGDKKKTGNYRP--VSLTSSLSKLMETIVRDEIVKYMNENSLFTEEQYGFRRSRSCATQLLNVSETWTKEL--DNKGS-IDCIYLDYSKAFDSVPHA | ||.. ..|..|| .|. . . |... |... . . ...| . |.||| ||| ..| .. . ||. .| || .|.||..||. IPKKDK--RMGKWRPCHISICNCDYKILNKIMKKRLEPHY--EPIFHYPQHGFRPGRSCHDAL-------VIHCLNKWKGCYWWFIKLDIKKCFDQIPHH RLLKK |... PLIRP |
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