Gene Pim (Sea Urchin)
Pim
Sequence
Protein domains of Pim.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | Pim.AA | PIM | 41-154 | 61 | 1.6e-83 | 283.77 | In-house | 1-119 (260) | Show / Hide |
Range on Protein: 41-154 Range on HMM: 1-119/260 Sequence Identity: 61% (73 aa) YSIGSLIGSGGFGTVYAGSRISDN-LPVAIKLVNKEKVNDWVQLN-GREVPLEVSLLKRVSSI---HGCISMLDYFEQPDSFVIVMERPDPAKDLFDFIT |..|...|.|||||||||.||.|| .|||||.|.||.|.||..|. |..||.||..|...||| ||.|..||.||.||.|.||||||.|..||||||| YQVGPELGRGGFGTVYAGHRICDNQQPVAIKHVEKERVKDWGMLCDGQQVPMEVCMLWKCSSIGGHHGVIRLLDWFERPDGFMIVMERPYPCQDLFDFIT EQGPLPEELCRRFFKQMWK |||||.|..||.||.|.|. EQGPLNEDMCRFFFWQVWA |
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Kinase | Pim.AA | PIM | 155-258 | 62 | 1.5e-78 | 267.3 | In-house | 153-260 (260) | Show / Hide |
Range on Protein: 155-258 Range on HMM: 153-260/260 Sequence Identity: 62% (68 aa) LQAAAMRLDTVYKDFDGTRVYSPPEWITSHRYHGRSATIWSLGILLFDMACGDIPFEKDDEICR----AELYFRDGLSHSLKNLIQSMLQVKPQHRLKIE ..|.||..||||.||||||||.|||||..||||||.||.||||.||.||.|||||||.|.|||| .||.||...||....||...|..||.||...| FGAGAMLHDTVYTDFDGTRVYCPPEWIRHHRYHGREATVWSLGVLLYDMVCGDIPFENDQEICRAHLLGELHFRQHVSHECCQLIRWCLTFKPSHRCSLE DILDHPWM .||.|||| QILNHPWM |
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Kinase | Pim.AA | CAMK | 163-258 | 24 | 1.8e-34 | 107.98 | In-house | 273-425 (425) | Show / Hide |
Range on Protein: 163-258 Range on HMM: 273-425/425 Sequence Identity: 24% (38 aa) DTVYKDFDGTRVYSP-PEWITS-------------HRYHGRSATIWSLGILLFDMACGDIPFEKDD-------------------EICRAELYFRDG--- . .|.| || | . ||.. . ..|.|... .||.|..|. | || ||. |. |.... .| . GQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFS ---------------------LSHSLKNLIQSMLQVKPQHRLKIEDILDHPWM .| . |.||..|||| |..|..||..|.|||| PISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | Pim.AA | S_TKc | 41-258 | 23 | 1.1e-30 | 109.12 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 41-258 Range on HMM: 1-231/231 Sequence Identity: 23% (62 aa) YSIGSLIGSGGFGTVYAGSRISDNLPVAIKLVNKEKVNDWVQLNGREVPLEVSLLKRVSSIHGCISMLDYFEQPDSFVIVMERPDP-AKDLFDFITEQGP | |. .||.|.||.|| . .... |||| .. . . |...||. . ..|.|. |.. .||| | . ||||.| ..|. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR ------LPEELCRRFFKQM------------------------------------WKLQAAAMRLDTVYKDFDGTRVYSPPEWITSHRYHGR-SATIWSL .|| .|....|. .| . | ||. | .|| . .|. .. .||. HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-----------TTFCGTPWYMAPEVL----GYGKCKCDWWSC GILLFDMACGDIPFEKDDEICRAELYFRDGLSHSLKNLIQSMLQVKPQHRLKIEDILD-------HPWM |..|. |.|| ||. .... . | |...|..|. .||. |..|. . ..| |||. GCILYEMLCGYPPFP-----QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | Pim.AA | CAMKL | 171-258 | 32 | 1.1e-27 | 85.27 | In-house | 195-297 (297) | Show / Hide |
Range on Protein: 171-258 Range on HMM: 195-297/297 Sequence Identity: 32% (34 aa) GTRVYSPPEWITS-HR-YHGRSATIWSLGILLFDMACGDIPFEKDD-------------EICRAELYFR--DGLSHSLKNLIQSMLQVKPQHRLKIEDIL |. | .|| . . .. |.|. . |||.|..|. | || ||. |. .| . |.. .| ....||..||||.| .| .|..|. GSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM DHPWM |||| NHPWM |
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Kinase | Pim.AA | AGC | 171-258 | 22 | 1.3e-27 | 67.13 | In-house | 267-395 (395) | Show / Hide |
Range on Protein: 171-258 Range on HMM: 267-395/395 Sequence Identity: 22% (30 aa) G--TRVYSPPEWITSHRYHGRSATIWS--LGILLFDMACGDIPFEKDD------------EICRAEL------YFR--------------DGLSHSLKNL | | | .|| . .|... .|| ||.|.. | .| || |. |. . .. . .| .|.| GPCTPEYMAPEIL-----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDL IQSMLQVKPQHRLK----------IEDILDHPWM |. .|.. | .|| .|.| .||| IKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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Kinase | Pim.AA | CAMK | 46-152 | 18 | 9.8e-27 | 82.57 | In-house | 1-188 (425) | Show / Hide |
Range on Protein: 46-152 Range on HMM: 1-188/425 Sequence Identity: 18% (34 aa) LIGSGGFGTVYAGSRISDN------------LPVAIKLVNKEKVND----------------------WVQLNGRE-VPLEVSLLKRVS------SIHGC .|.|.||.|. . ..... |||| ..|.|. | |.. . |. |. |....|... . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI ISMLDYFEQ-------------------PDSFVIVM---ERPDPA---KDLFDFITEQGP---------------LPEELCRRFFKQM |......| .. ...|| | . ||||.|.|.|. ..|. .||.|.|. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQI |
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Kinase | Pim.AA | MARK | 171-258 | 35 | 1.9e-24 | 76.95 | In-house | 167-262 (262) | Show / Hide |
Range on Protein: 171-258 Range on HMM: 167-262/262 Sequence Identity: 35% (35 aa) GTRVYSPPEWITSHRYHGRSATIWSLGILLFDMACGDIPFE--K--DDEI------CRAELYFRDGLSHSLKNLIQSMLQVKPQHRLKIEDILDHPWM || | .|| . . .| |. . |||||..|. | || ||. . |. .. . ... .|....||||..|.| | | .||.|. |||| GTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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Kinase | Pim.AA | Pkinase | 41-152 | 29 | 6.9e-24 | 85.54 | Pfam | 1-117 (293) | Show / Hide |
Range on Protein: 41-152 Range on HMM: 1-117/293 Sequence Identity: 29% (36 aa) YSIGSLIGSGGFGTVYAGSRISDNLPVAIKLVNKEKVNDWVQ-----LNGREVPLEVSLLKRVSSIHGCISMLDYFEQPDSFVIVMERPDPA---KDLFD | ||. ||||.||.|| . ..... ||.| ..|.. ..|.. | |....||... . . ..|.|| .|. .||| . |||| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL------SEIQIMKRLNHPNI-VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD FIT--EQGPL--PEELCRRFFKQM .|. ..|.. .|. |.....|. YISTWRHGCFYFSEWECKFYMYQI |
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Kinase | Pim.AA | AMPK | 175-258 | 40 | 1.8e-22 | 63.56 | In-house | 165-254 (254) | Show / Hide |
Range on Protein: 175-258 Range on HMM: 165-254/254 Sequence Identity: 40% (36 aa) YSPPEWITSHRYHGRSATIWSLGILLFDMACGDIPFEKDD------EICRAELYFRDGLSHSLKNLIQSMLQVKPQHRLKIEDILDHPWM | || |.. .| |. ||| |. |. | || ||. .. |. | | . || . |.||..|||| |. |..|.|| ||| YAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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Kinase | Pim.AA | Ciliate-E2 | 163-258 | 25 | 2e-22 | 73.81 | In-house | 241-365 (365) | Show / Hide |
Range on Protein: 163-258 Range on HMM: 241-365/365 Sequence Identity: 25% (32 aa) DTVYKDFDGTRVYSPPEWITS--------HRYHGRSATIWSLGILLFDMACGDIPFEKDDEICRAELYFR------------------DGLSHSLKNLIQ . ... . || | .|| . . . ... .. |||||..|. | .| || ..|. .. |. . .| . |.||. QNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIK S----MLQVKPQHRLK-IEDILDHPWM |||..|. |. .|.||.|||. KFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | Pim.AA | MELK | 171-258 | 36 | 1.1e-21 | 70.56 | In-house | 161-254 (254) | Show / Hide |
Range on Protein: 171-258 Range on HMM: 161-254/254 Sequence Identity: 36% (34 aa) GTRVYSPPEWITSHRYHGRSATIWSLGILLFDMACGDIPFEKDD------EICRAELYFRDGLSHSLKNLIQSMLQVKPQHRLKIEDILDHPWM | | || | .| | | .||.||||. . || .||. | | . . . || . |.|.. ||||.|..|... ..|.|||. GSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV |
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Kinase | Pim.AA | CAMKL | 41-152 | 27 | 2.3e-20 | 61.59 | In-house | 1-136 (297) | Show / Hide |
Range on Protein: 41-152 Range on HMM: 1-136/297 Sequence Identity: 27% (37 aa) YSIGSLIGSGGFGTVYAGSRISD-NLPVAIKLVN--KEKVNDWVQLNGRE--------VPLEVSLLKRVSSIHG---CISMLDYFEQPDS------FVIV | || .| |.||.| . |. . |||| .. | . ..|.. | . . |....|... | . |.... .| |. ...| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLN-IGKHPNIIKLYEVIETPEHDIETKKIYLV MERPDPAK-DLFDFITEQ----GPLPEELCRRFFKQM || . ||||.| .. |..||. .||.|.|. MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQI |
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Kinase | Pim.AA | Pkinase | 163-258 | 23 | 2.6e-20 | 72.88 | Pfam | 166-293 (293) | Show / Hide |
Range on Protein: 163-258 Range on HMM: 166-293/293 Sequence Identity: 23% (31 aa) DTVYKDFDGTRVYSPPEWITSHRYHGRSATIWSLGILLFDMACGDIPFEKD----DEICRAELYFRDGL------------------------------S .. ...| ||. | .||.| ...|.|... .||.|..|. |.|| || . . .. ....|.. | NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWS HSLKNLIQSMLQVKPQHRLKIEDILDHPWM ..| .| ..|...|. |. .|.|| |||. EECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | Pim.AA | Ciliate-E2-Unclassified | 171-258 | 24 | 1.1e-16 | 54.39 | In-house | 224-352 (352) | Show / Hide |
Range on Protein: 171-258 Range on HMM: 224-352/352 Sequence Identity: 24% (31 aa) GTRVYS----PPEWITSHRYHGR---SATIWSLGILLFDMACGDIPFE----------------------KDDEICRAELYFR--------DGLSHSLKN || | .|| . .. | .. .. |||||..|. | | ||. ..|. ...|. ...| . |. GTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKD LIQ----SMLQVKPQHRLKIEDILDHPWM .|. .||...| |. .|.|| |||. FINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | Pim.AA | PASK | 169-258 | 31 | 1.8e-16 | 47.64 | In-house | 169-260 (260) | Show / Hide |
Range on Protein: 169-258 Range on HMM: 169-260/260 Sequence Identity: 31% (29 aa) FDGTRVYSPPEWITSHRYHGRSATIWSLGILLFDMACGDIPFEKDDEICRAELYFR--DGLSHSLKNLIQSMLQVKPQHRLKIEDILDHPWM | || | || .| |. .|.||..|. . || .|. ||. | | . || |||. .|. | ...| ||. FCGTIEYCAPEVLMGNPYRGPEQEMWALGVTLYTLMFKENPFCNIEETLEAEIHFPNAEHVSEECMSLIKSMLNRCPEKRCTMHQIITDPWL |
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Kinase | Pim.AA | PASK | 41-151 | 28 | 1.7e-15 | 44.57 | In-house | 1-118 (260) | Show / Hide |
Range on Protein: 41-151 Range on HMM: 1-118/260 Sequence Identity: 28% (34 aa) YSIGSLIGSGGFGTVYAGSRISDNLPVAIKLVNKEKV--NDWVQ-LNGREVPLEVSLLKRVS--SIHGCISMLDYFEQPDSFVIVMERPDPA--KDLFDF |.. . .|.| .| |. . .... | .|.. |||| ||. ..|||. .. .. . ...|| || | . .||| ||||| YTSIQQMGEGAYGYVWMCIHNECRYIVVVKFIFKEKVCEDCWVRDRKCGCIPLEIHIMQTLNKNPHENIVKVLDFFENDDFYQLVMEKHGSGGCMDLFDF ITEQGPLPEELCRRFFKQ | . . |.| |.| IDRHPNMDEHLASYIFRQ |
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Kinase | Pim.AA | MARK | 41-152 | 26 | 7.3e-15 | 45.18 | In-house | 1-113 (262) | Show / Hide |
Range on Protein: 41-152 Range on HMM: 1-113/262 Sequence Identity: 26% (31 aa) YSIGSLIGSGGFGTVYAGSRISDNLPVAIKLVNKEKVNDWVQLNGREVPLEVSLLKRVSSIHGCISMLDYFE--QPDS-FVIVMERPDPAKDLFDFITEQ | .. || |....|. . . . |||| ..|.| || .. ..| |....|... . .|......| . ....|| . ..|.|.| .. YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWM--KNVMREIEIMKKLDHPN-IIKLFHVIEQDTEQHQIYLIMEYA-SGGELYDYIKAH --GPLPEELCRRFFKQM |.|.||..||.|.|. PNGRLHEEEARRIFRQI |
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Kinase | Pim.AA | MELK | 41-152 | 33 | 2.9e-11 | 34.43 | In-house | 1-106 (254) | Show / Hide |
Range on Protein: 41-152 Range on HMM: 1-106/254 Sequence Identity: 33% (38 aa) YSIGSLIGSGGFGTVYAGSRISDNLPVAIKLVNKEKVNDWVQLNGREVPLEVSLLKRVSSIHGCISMLDYFEQPDSFVIVMERPDPAKDLFDFITEQGPL | . ||.|||. | . | | ||||...|... . . | |. || .. | | . | | | . .||| | ..||.| .| | YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLP----RVKTEMDALKNLRHQHIC-QLYHYIETEDKIFMVMEYC-PGGEMFDYIIRQDRL PEELCRRFFKQM || | ||.|. EEEETRHFFRQI |
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Kinase | Pim.AA | Ciliate-E2-Unclassified | 41-151 | 17 | 5.1e-09 | 27.46 | In-house | 1-151 (352) | Show / Hide |
Range on Protein: 41-151 Range on HMM: 1-151/352 Sequence Identity: 17% (27 aa) YSIGSLIGSGGFGTVYAGSRISDNLPVAIKLVNKEKVNDWVQLNGR-------EVPLEVS-------------LLKRVSSIHGCISMLDYFEQPDSFVIV | |. ||.||||.|| ...... |.| .| .... | . . . . .|. ... . |...|.. . . || YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPF-IVKMFYCFQDKQNIYIV MERPDPAKDLFDFITEQGP-----------------LPEELCR-----RFFKQ || . .||...|.... ..|. .. ..|.| MEYCE-GGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQ |
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Kinase | Pim.AA | Ciliate-E2 | 41-151 | 19 | 2.8e-07 | 21.04 | In-house | 1-153 (365) | Show / Hide |
Range on Protein: 41-151 Range on HMM: 1-153/365 Sequence Identity: 19% (30 aa) YSIGSLIGSGGFGTVYAGSRISD-----------------------NLPVAIKLVNKEKVNDWVQLNG--REVP------LEVSLLKRVSSIHGCISMLD | . .||.|.||.|| ...... . .|.| ..| ... . | . ||. | ..|..... . | | . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPN-IIKMYE YFE--QPDSFVIVMERPDPAKDLFDFITEQ-----------GPLPEELCRRFFKQ .|. . ... .||| . .||||.| .. ... |. .....|| CFQEKDDNNIYLVMEYCQ-GGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQ |
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Kinase | Pim.AA | AGC | 41-77 | 22 | 4e-06 | 10.38 | In-house | 1-44 (395) | Show / Hide |
Range on Protein: 41-77 Range on HMM: 1-44/395 Sequence Identity: 22% (10 aa) YSIGSLIGSGGFGTVYAGSRI------SDNLPVAIKLVNKEK-V . . .|| |.||.|| . . . |.| ..|.. . FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKI |
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Kinase | Pim.AA | AMPK | 41-79 | 48 | 2e-05 | 12.15 | In-house | 1-39 (254) | Show / Hide |
Range on Protein: 41-79 Range on HMM: 1-39/254 Sequence Identity: 48% (19 aa) YSIGSLIGSGGFGTVYAGSRISDNLPVAIKLVNKEKVND | || || | || | | | . |||| ||.| | YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKD |
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Kinase | Pim.AA | AMPK | 129-152 | 45 | 6.2e-05 | 10.66 | In-house | 86-109 (254) | Show / Hide |
Range on Protein: 129-152 Range on HMM: 86-109/254 Sequence Identity: 45% (11 aa) DLFDFITEQGPLPEELCRRFFKQM .|||.|. | |.|. .|||.|. ELFDYIVKHGRLQEREACRFFQQI |
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Kinase | Pim.AA | TyrKc | 41-258 | 13 | 0.000231 | -152.1 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 41-258 Range on HMM: 1-280/280 Sequence Identity: 13% (40 aa) YSIGSLIGSGGFGTVYAGSRISDNLPVAIKLVNKEKVNDWVQLNGREVPLEVSLLKRV--SSIHGCISMLDYFEQP-------DSFVIVMERPDPAKDLF . | .|.| ||.|| | . ..||.| ..... .. | ...... . . . .. . |. . |||| . || ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPN-IVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLK DFITEQGP-LPEELCRRFFKQ------------------------MWKLQ---------AAAMRLD------TVYKDFD---GTR--V---YSPPEWITS |.. . .| |. . | | . . . . | . |.. |.. . .|| | DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY HRYHGRSAT-IWSLGILLFDMA-CGDIPFEK-------DDEICRA-----ELYFRDG--------LSHSLKNLIQSMLQVKPQHRLKIEDILDHPWM ... ... .|| |.... . |. | . ..|. . . . . . ..... . .| | ..| | . GKF--TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | Pim.AA | Pkinase_Tyr | 41-76 | 35 | 0.000435 | 14.47 | Pfam | 1-39 (270) | Show / Hide |
Range on Protein: 41-76 Range on HMM: 1-39/270 Sequence Identity: 35% (14 aa) YSIGSLIGSGGFGTVYAGSRI----SDNLPVAIKLVNKEK ..| .|.| ||.|| | ....|||.| . ||. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEG |