PKD

Species: Sea Urchin
Alias: SPU_017816, Spk078, PKD
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: PKD

Sequence

Name Sequence Type Origin Length Description Download
PKD.AA Protein None 992 None Fasta, JSON
PKD.kin_dom Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of PKD.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PKD_Nterm_DUF PKD.AA PKD_Nterm_DUF 20-107 37 8e-30 97.13 In-house 1-87 (87) Show / Hide
Range on Protein: 20-107
Range on HMM: 1-87/87
Sequence Identity: 37% (33 aa)

VSFAVQIGFVRENFQIPPEGGDPSIPLIKEIVTSMVRQRFPEHDFYG-VYDKLLLFKHNPGTSYSLTPVTSVSDVTEGALIEAVLSDQW
..| .|.||.||  ... ||.  .... ||.. . . | .|...... .|||..||.|.....  | ..||.|||||| ||| |||.  
CHFHFQCGFHRE--MVCVEGHELTLTALKELACQFIEQKYPDCGCCNRLYDKIYLFRHDYNSPNILQMITSASDVTEGCLIEIVLSACP

C1_1 PKD.AA C1_1 171-223 41 1e-14 57.7 Pfam 1-55 (55) Show / Hide
Range on Protein: 171-223
Range on HMM: 1-55/55
Sequence Identity: 41% (23 aa)

HTLYVH-SYKSPTFCDFCGQMLFG-LVRQGLKCDGCGGNYHKRCAFKIPNDCTLS
|   .| ..|.||||. ||....| | .||.||. |. |.|.||. | |. | ..
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN

C1 PKD.AA C1 171-220 27 1.1e-13 52.7 SMART 1-61 (61) Show / Hide
Range on Protein: 171-220
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HTLYVHSYKSPTFCDFCGQMLFGLVRQ-----GLKCDGCGGNYHKRCAFKIPN-------DC
|. . ... .||.|. |..|..|. .|     |..|  |. ..||.|. |.|.       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC

C1_3 PKD.AA C1_3 182-213 25 5.7e-05 14.15 Pfam 1-30 (30) Show / Hide
Range on Protein: 182-213
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TFCDFCGQMLFGLVRQGLKCDGCGGNYHKRCA
 .|. ||  . .  . . .|  |  . |..||
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA

C1 PKD.AA C1 304-353 35 2e-19 71.76 SMART 1-61 (61) Show / Hide
Range on Protein: 304-353
Range on HMM: 1-61/61
Sequence Identity: 35% (22 aa)

HTFVVHNYTKPTICQYCKRLLVGLFRQ-----GLQCKDCKFNCHKRCADKVPK-------DC
|... ... ||| |..|. .. |.|.|     |..| .||..|||.|.||||.       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC

C1_1 PKD.AA C1_1 304-356 41 3e-18 70.66 Pfam 1-55 (55) Show / Hide
Range on Protein: 304-356
Range on HMM: 1-55/55
Sequence Identity: 41% (23 aa)

HTFVVH-NYTKPTICQYCKRLLVG-LFRQGLQCKDCKFNCHKRCADKVPKDCLGE
| .|.| |. .|| | .|. .. | |..||..| .|..|||.||. |||. | . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN

C1_3 PKD.AA C1_3 315-346 25 0.004445 9.33 Pfam 1-30 (30) Show / Hide
Range on Protein: 315-346
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TICQYCKRLLVGLFRQGLQCKDCKFNCHKRCA
  |. |.. . .  . .  |  | |. |..||
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA

PH PKD.AA PH 432-530 22 8.9e-09 34.29 Pfam 1-72 (92) Show / Hide
Range on Protein: 432-530
Range on HMM: 1-72/92
Sequence Identity: 22% (22 aa)

VLKEGWMVHYTDKDSMRKRHYWRIDTKAITLYQSESSTRYYKEIPLSEILSVRMVKPSQDGSGSGSSSSGMGISGLVGGDGFNSTHCFEIQTAKT-NYYV
| ||||.  .. | . .|...  . .. . .|....  |. . ||||.. .|. |...                        .  |||.| |     ||.
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN------------------------KRPHCFQIRT-DRRTYYF





PH PKD.AA PH 432-591 12 2.4e-08 34.98 SMART 1-82 (82) Show / Hide
Range on Protein: 432-591
Range on HMM: 1-82/82
Sequence Identity: 12% (21 aa)

VLKEGWMVHYTDKDSMRKRHYWRIDTKAITLYQSESSTRYYKEIPLSEILSVRMVKPSQDGSGSGSSSSGMGISGLVGGDGFNSTHCFEIQTAKTNYYVG
|.||||. ...     .|... ..... ...|...   .. ..||||.. .||. .                              |||| . .      
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P------------------------------CFEIHH-DR-----

ERASLGDSSSEKGSGGSTTSSSKLPVPSSSSVDEEPEQSWVGAD---VARDWEQKIRQALMPV
                                       .. ..    ...| | |..|. . 
-------------------------------------TYYFQCESEEEMQEWMQAIQKAIHNN

Kinase PKD.AA PKD 664-920 81 2.6e-228 764.76 In-house 1-260 (260) Show / Hide
Range on Protein: 664-920
Range on HMM: 1-260/260
Sequence Identity: 81% (213 aa)

IFPDEILGSGQFGIVYGGVHRTSGRQVAIKVIDKFRFPTKQ--ETQLKNEVAILHKVRHPGVVNLEQMFETPERVFVVMEKLKGDMLEMILSSVHGRLFE
|||||.||||||||||||.||..||.||.|||||.||||||  |.|..||||||..|.|||||.||.|.|||.|.||||||..||||||||||..|||.|
IFPDEVLGSGQFGIVYGGIHRHTGRHVAVKVIDKLRFPTKQSGEEQMRNEVAILQQVCHPGVVCLECMCETPDRIFVVMEKMHGDMLEMILSSEKGRLNE

RVTRFLISQILIALKYLHSKSIVHCDLKPENVLLSSD-GDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSG
|||.|||.|||.||||||...|||||||||||||||. .||||||||||||||||||||||||||||||||||||||.|||||||||||||||.||||||
RVTKFLITQILCALKYLHHQNIVHCDLKPENVLLSSMGSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSG

TFPFNEDEEITDQIHNAAFMFPPNPWNEISEGAIDLIRNLLQVKIRKRYTADKSLAHPWL
||||||||.|.|||.|||||.|||||.||||.|||||.||||||.|||||.||.|.||||
TFPFNEDEDINDQIQNAAFMYPPNPWKEISENAIDLINNLLQVKMRKRYTVDKCLSHPWL

Kinase PKD.AA CAMK 669-920 24 1.8e-110 357.32 In-house 1-425 (425) Show / Hide
Range on Protein: 669-920
Range on HMM: 1-425/425
Sequence Identity: 24% (105 aa)

ILGSGQFGIVYGGVHR-TSG-----------RQVAIKVIDKFRFP--------------------------TKQETQLKNEVAILHK-------VRHPGV
.||.|.||.|. ..|. | |           ..||||.||| . .                           | . ....|..|. |       ..|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLEQMFE------------TPER--------VFVVM---EKLKG-----DMLEMILSSVH-------------GRLFERVTRFLISQILIALKYLHSKS
..| ...|            | ..        .. ||   |   |     |....| .  .             ||. || .|... ||. |..|.||. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHCDLKPENVLLSSDGDFP--------------QVKLCDFGFARIIGE------------------------KSFRRSVVGTPAYLA-PEVLRS-----
|||.||||||.||....|                ..|..|||||... .                            . ..|||.| | ||||..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KGYNRSLDMWSVGVIVYVSLSGTFPFNED---------------EEITDQIHNAAFMFPPNP------------WNEISEG--------AI
         ..|... ||||.||| |. |.|..||..|               .|.  .| .. . ||| .            |..||.         ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLIRNLLQVKIRKRYTADKSLAHPWL
||||..|||   ||.|..  |.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase PKD.AA RAD53 667-920 34 3e-99 296.31 In-house 4-305 (305) Show / Hide
Range on Protein: 667-920
Range on HMM: 4-305/305
Sequence Identity: 34% (105 aa)

DEILGSGQFGIVYGGVHRTSGRQVAIKVIDK---F---RFPTKQETQLKNEVAILHKVRHPGVVNLEQMFETP-ERVFVVMEKLKG-DMLEMILSSV-HG
...|||| ||.|. .. .. ...|||| |||   |   .  .| . |. ||| || |. || .....  |.|| . .. |.|.  | . .. |   | ..
SKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKI---VSNK

R----LFERVTRFLISQILIALKYLHSKSIVHCDLKPENVLLSSDGDFP---------------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRS
|    . |   ...  |.. |.||||.. |.| ||||||.|......                 ..|. ||| ....||.|| .   |||.|.||||..|
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITS

K---------------GYNRSLDMWSVGVIVYVSLSGTFPFNED-------EEITDQIHN-AAFMFPPNPWNEISEGAIDLIRNLLQVKIRKRYTADKSL
|               ||... |.|| |.|.|..|.|. || .|         . .|| | . . ||.  | .||| | |||...|.|   ||||.|. |
KGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEAL

AHPWL
 |||.
NHPWM

Kinase PKD.AA S_TKc 664-920 33 2.7e-92 313.82 SMART 1-231 (231) Show / Hide
Range on Protein: 664-920
Range on HMM: 1-231/231
Sequence Identity: 33% (92 aa)

IFPDEILGSGQFGIVYGGVHRTSGRQVAIKVIDKFRFPTKQETQLKNEVAILHKVRHPGVVNLEQMFETPERVFVVMEKLKG---DMLEMILSSVHGR--
    ...|.| || || ..|. .||.||||.|.          ....|..||.| .|| .|.|  .|.. .....||| . |   |....| .  ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LFERVTRFLISQILIALKYLHSKSIVHCDLKPENVLLSSDGDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNR-SLDMWSVGVIVY
  . | ..||.. ||. ||.|.||. |.|.||||||.||..     ..|.||||.||..      ....||| |.|||||   ||.. . |.||.|.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

VSLSGTFPFNEDEEITDQIHNAAFMFPPNPWNEISEGAIDLIRNLLQVKIRKRYTADKSLA-------HPWL
  |.|  ||    ..   ...             |. |.|.||..||.  .||.|| . |.       |||.
EMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase PKD.AA AGC 664-920 23 1e-85 220.83 In-house 1-395 (395) Show / Hide
Range on Protein: 664-920
Range on HMM: 1-395/395
Sequence Identity: 23% (93 aa)

IFPDEILGSGQFGIVYGGVHR------TSGRQVAIKVIDKFR--FPTK--QETQLKNE------------VAILHKVR----------HPGVVN-LEQMF
     ..| | || ||   ..      ..|.. |.||..| .    .|  .. . ..|              || |..          || .|. |   |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETPER--VFVVME----KLK-----GD-MLEMILSSV--HGRLFERVTRFLISQ-------ILIALKYLHS-KSIVHCD-LKPENVLLSSDGDFPQVKLC
.....  .. |||     ..     |. .| ..|  .   ||. | ..|| ...       |. || |||| . |.| | |||||.|| .||    .||.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDG---HIKLT

DFGFARIIG---------------------------------------------------EKSFRRSVVG--TPAYLAPEVLRSKGYNRSLDMWS--VGV
|||.. ..                                                    ..    . .|  || |.|||.|    |... | ||  .|.
DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGC

IVYVSLSGTFPFNEDE------------EITDQIH------NAAFMFPPN------PWNEISEGAIDLIRNLLQVKIRKRYT----------ADKSLAHP
. |  |.|  ||. |.            |. ..|       |    ||..      .. ..|. | |||. ||..  .|| .          |.   .||
LMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHP

WL
| 
WF

Kinase PKD.AA Pkinase 664-920 32 1.3e-83 288.87 Pfam 1-293 (293) Show / Hide
Range on Protein: 664-920
Range on HMM: 1-293/293
Sequence Identity: 32% (95 aa)

IFPDEILGSGQFGIVYGGVHRTSGRQVAIKVIDKFRFPTKQETQLKN--EVAILHKVRHPGVVNLEQMFETPERVFVVMEKLKGD----MLEMILS-SVH
.   ...||| || || ..|. .|..||.|.|.| .   ... .. .  |..|.....|| .| |  .||.. .. .||| . |.     |  ..| . |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRL--FERVTRFLISQILIALKYLHSKSIVHCDLKPENVLLSSDGDF-PQVKLCDFGFARI--IGEKSFRRSVVGTPAYLAPEVLR-SKGYNRSLDMWSV
|..   |.. .| . ||| .|.|.||..|.|.||||||.|....|.  . ||.||||.|.   .  .|   ...||| |.||||.| ...| .. ||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVIVYVSLSGTFPFNED--------EEITDQIHNAAFMFPPNPWNEIS-----------------EGAIDLIRNLLQVKIRKRYTADKSLAHPWL
|.|.|  |.| .|| ..         .. ..|  . ..|.   |..||                 | ..|.|...|...  ||.||.  | |||.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase PKD.AA CAMKL 662-920 31 3.3e-80 255.63 In-house 1-297 (297) Show / Hide
Range on Protein: 662-920
Range on HMM: 1-297/297
Sequence Identity: 31% (95 aa)

YQIFPDEILGSGQFGIVYGGVH-RTSGRQVAIKVIDKFRFPTKQETQ-------------LKNEVAILHKVR---HPGVVNLEQMFETPER------VFV
|.|   . || | || |  ..| || |..||||.|||..   .. ..             .. |..|. ...   || .. | ...||||       .. 
YRI--GKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

VMEKLKGD---MLEMILSSVH--GRLFERVTRFLISQILIALKYLHSKSIVHCDLKPENVLLSSDGDFPQVKLCDFGFARIIGE-----KSFRRSVVGTP
|||   |    ....| .  |  ||. |. .|..  ||. |..|.||. ||| |.||||.||...|.  ..|..||||. .. .       . .   |.|
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

AYLAPEVLRS--KGYN-RSLDMWSVGVIVYVSLSGTFPFNEDEE------ITDQIHNAAFM-FPPNPWNEISEGAIDLIRNLLQVKIRKRYTADKSLAHP
.| |||.. .  | |. .  |.|| ||| |. . |..||..|         .   ..     . |..|...|  ..|||| .|||.  ||.|..  . ||
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCGYYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP

WL
|.
WM

Kinase PKD.AA DCAMKL 662-920 37 9.4e-72 222.34 In-house 1-279 (279) Show / Hide
Range on Protein: 662-920
Range on HMM: 1-279/279
Sequence Identity: 37% (107 aa)

YQIFPDEILGSGQFGIVYGGVHRTSG-RQVAIKV-----------------IDKFRFPTKQETQLKNEVAILHKVRHPGVVNLEQMFETPERVFVVMEKL
|||    | | | | .|.  .||. | .. | |.                 ||| .   | |    |||.|. |..|| .. |   ..|..  . |||  
YQIG--RIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKRKCKGK-EHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYV

K-GDMLEMILSSVHGRLFERVTRFLISQILIALKYLHSKSIVHCDLKPENVLLSS--DGDFPQVKLCDFGFARIIGE---KSFRRSVVGTPAYLAPEVLR
. ||  . | ...  .  ||  . .. ..  ||||||...||| |.|||| |.    || .  .|||||| | .. .     ..  | ||| | |||.|.
QGGDLFDAITENT--KFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEK-SLKLCDFGLACHVNGDFGPLYT--VCGTPTYVAPEILM

SKGYNRSLDMWSVGVIVYVSLSGTFPF----NEDEEITDQIHNAAFMFPPNPWNEISEGAIDLIRNLLQVKIRKRYTADKSLAHPWL
 .||    |.|..||| |. | |  ||    |. ||  |||  ..| ||   | .|| .| |||...|||   |||||   ..||| 
ETGYGCKVDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQHPWV

Kinase PKD.AA CAMK1 767-920 39 1.8e-71 207.0 In-house 113-276 (276) Show / Hide
Range on Protein: 767-920
Range on HMM: 113-276/276
Sequence Identity: 39% (65 aa)

LISQILIALKYLHSKSIVHCDLKPENVLLSSDGDFPQVK--LCDFGFARIIGEKS-FRRSVVGTPAYLAPEVLRS---KGYNRSLDMWSVGVIVYVSLSG
.. ||| |..|.||| |||.|||||| |...  .  ..|  ..||| ..|..... .   ..||| | |||||     |.|  . ||||.||| |. | |
IMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCG

TFPFNEDE-E--ITDQIHNAAFMFPPNPWNEISEG-AIDLIRNLLQVKIRKRYTADKSLAHPWL
  ||...  .  ....| .. . || . |..||.. | |.|...| |   ||||....|.|||.
YPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI

Kinase PKD.AA MARK 670-920 32 5.4e-68 221.4 In-house 7-262 (262) Show / Hide
Range on Protein: 670-920
Range on HMM: 7-262/262
Sequence Identity: 32% (85 aa)

LGSGQFGIVYGGVHRTSGRQVAIKVIDKFRFPT-KQETQLKNEVAILHKVRHPGVVNLEQMFE--TPER-VFVVMEKLKGDMLEMILSSV-HGRLFERVT
.| | .. |. ..|. .||.||||...||.    ..   .. |..|. |. || .. | ...|  |... ....||   |  |   . .. .||| |. .
IGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEA

RFLISQILIALKYLHSKSIVHCDLKPENVLLSSDG--DFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYN-RSLDMWSVGVIVYVSLSGT
| . .||. |..|.|||.|||.|.||||.|. ..|  .   .|..||||...| . .   .  |||.| |||.. .| |. .  |.|| ||. |. ..|.
RRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHN---IKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGY

FPFN--E--DEEITDQIHNAAFMFPPNPWNEISEGAIDLIRNLLQVKIRKRYTADKSLAHPWL
|||      ..|.  .| .  . .|..    .| .. .||. ||.|   .| |..  . |||.
FPFDGDTQDYKELYKKILRGKYDIPCH----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase PKD.AA CAMK-Unique 668-920 24 6.9e-67 219.77 In-house 5-363 (363) Show / Hide
Range on Protein: 668-920
Range on HMM: 5-363/363
Sequence Identity: 24% (88 aa)

EILGSGQFGIVYGGVHRTSGRQVAIKVIDKFRFP-TKQETQ-----------------LKNEVAILHKVRHPGVVNLEQM----FETPE-----------
.|.|.| ||.|| .  |. |   |.|.. | .    || .|                 ||.|..|. .| ||  . |..     |....           
RIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTP

----RVFVVMEKL-KGDMLEMILS------------------SVHGRLFE--RVTRFLISQILIALKYLHSKSIVHCDLKPENVLLSSDGD---------
    . . ||| . .||... |..                   . |.. |  . |.|.. ..| |..|.||..||| |||.||..... ..         
RALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFP

----FPQVKLCDFGFARIIGEKSFRR---SVVGTPAYLAP--------------EVLRSKGYNRSL----DMWSVGVIVYVSLSGTFPFNE--DE-----
    .  .|||||| .. . ..  .    ...||| |.||              ||.   .| . .    | || ||| |  |.|  ||..  ..     
YDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYEN

---EITDQIHNAAF-MFPPNPWNE---ISEGAIDLIRNLLQVKIRKRYTADKSLAHPWL
   || . |  . .  |.   |.    ||..|.|.. ....|.  .| .|   | |.|.
HDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI

Kinase PKD.AA Ciliate-E2 668-920 22 8.2e-65 221.4 In-house 5-365 (365) Show / Hide
Range on Protein: 668-920
Range on HMM: 5-365/365
Sequence Identity: 22% (85 aa)

EILGSGQFGIVYGGVHRTSGR------------------QVAIKVIDKFRFPTKQETQLKNEVAILHKVR----------------HPGVVNLEQMFE--
...|.|.||.|| . ..  ..                  .|.|| . . ..  .|  |.|.|  |. ...                || ....   |.  
KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK

TPERVFVVMEKLKG-DMLEMILSS-----------------VHGRLFERVTR-------FLISQILIALKYLHSKS-IVHCDLKPENVLLSSDGDFPQVK
. . .. ||| ..| |... | ..                   ..... ...       | | .|. ||.|||||  |.| |.||||.|.        .|
DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IK

LCDFGFARIIGEKSFRRS--------------------------------VVGTPAYLAPEVLRSKG---------YNRSLDMWSVGVIVYVSLSGTFPF
..|||..... ... .|.                                ..||| |.|||.|..|.         |. . |.||.||| |  |.| .||
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

NEDEEITDQIHNAAFMFPPN--------------PWNEISEGAIDLIRN----LLQVKIRKRYT-ADKSLAHPWL
       .||..  . ||..               |...|. ..|||..    .||..  ||.| ... | |||.
------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase PKD.AA CAMK1 662-741 31 2.1e-24 67.8 In-house 1-88 (276) Show / Hide
Range on Protein: 662-741
Range on HMM: 1-88/276
Sequence Identity: 31% (28 aa)

YQIFPDEILGSGQFGIVYGGVHRTS---GRQVAIKVID-KFRFPTKQE---TQLKNEVAILHKV---RHPGVVNLEQMFETPERVFVVME
|...  ...|.| |..|| ..|. .   |.|.|||.|| |    .| .   ..|.||..|..||    || .....  .|... .  |||
YEFG--KEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVME

Kinase PKD.AA TyrKc 664-920 21 5.8e-14 3.1 SMART 1-280 (280) Show / Hide
Range on Protein: 664-920
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

IFPDEILGSGQFGIVYGGVHRTSGRQVAIKVIDKFRFPTKQETQLKNEVAILHKV--RHPGVVNLEQMFETP-------ERVFVVMEKLKGDMLEMILSS
|  ...||.|.||.|| |. .   .|||.|.. .       .  . .|  |..|.  .|| .|.|     ..       | ...|||  ..  |   | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

VHGRLFERVTRFLISQILIALKYLHSKSIVHCDLKPENVLLSSDGDFPQVKLCDFGFARIIGEK--------SFRRSV-VGTP-----AYLAPEVLRSKG
 ...|  .       ||     ||||| ..| ||   |.|.....   .|| .||| .| |...          | .   |.        .|||... . 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YNRSLDMWSVGVIVY--VSLSGTFPFN------EDEEITDQIHNAAFMFPPNP-----WNEISEGAIDLIRNLLQVKIRKRYTADKSLAHPWL
..   | || ||  .   .. .. . .      ...|.  .. .   | .|         . ..   ....   . .  .| |      |  .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase PKD.AA Pkinase_Tyr 667-726 28 2.1e-07 25.72 Pfam 4-69 (270) Show / Hide
Range on Protein: 667-726
Range on HMM: 4-69/270
Sequence Identity: 28% (19 aa)

DEILGSGQFGIVYGGVHR----TSGRQVAIKVIDKFRFPTKQ--ETQLKNEVAILHKV-RHPGVVNL
.. ||.|.|| || |. .      . .||.|.. |     .|     . .|..|...  .|| .|.|
GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL

Kinase PKD.AA Pkinase_Tyr 774-815 42 0.00027 15.17 Pfam 123-161 (270) Show / Hide
Range on Protein: 774-815
Range on HMM: 123-161/270
Sequence Identity: 42% (18 aa)

ALKYLHSKSIVHCDLKPENVLLSSDGDFPQVKLCDFGFARII
.. ||.|| ..| ||   |.|...  .. .|| |||| || |
GMEYLESKNCIHRDLAARNCLVTE--NN-VVKICDFGLARDI