Gene Chk2 (Sea Urchin)

Chk2

Species: Sea Urchin
Alias: SPU_004975, Spk080, Chk2
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: RAD53

Sequence

Name Sequence Type Origin Length Description Download
Chk2.AA Protein None 466 None Fasta, JSON
Chk2.kin_dom Protein Kinase Domain None 232 None Fasta, JSON

Protein domain

Protein domains of Chk2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FHA Chk2.AA FHA 86-164 28 1.2e-17 69.79 Pfam 1-73 (73) Show / Hide 
Range on Protein: 86-164
Range on HMM: 1-73/73
Sequence Identity: 28% (24 aa)

YIFGRDPSCDVCYNGPEISKNPCYQT-LSKTHFRI-FKESNDNCNFYFIED--KSSNGTFV--NGEKIGKGKKQVLNNNDEIALS
...||||.||.  .        . ..  |. |..| .....     ..|.|   |.|||||  ||..|..|.. .|...|.| . 
WTIGRDPDCDIVLD--------NDPSFVSRHHCEIRRYDNG----RWYIRDLGCSTNGTFVTGNGQRIQPGEPHRLHHGDRIRFG
FHA Chk2.AA FHA 85-147 24 3.9e-12 47.55 SMART 1-49 (49) Show / Hide 
Range on Protein: 85-147
Range on HMM: 1-49/49
Sequence Identity: 24% (16 aa)

EYIFGRDPSCDVCYNGPEISKNPCYQTLSKTHFRIFKESNDNCNFYFIEDKS---SNGTFVNGEKI
....||.. ||.   .|           |. |..|. ...      .|.| .   .|||.|||...
TWTIGRHS-CDIQLPHPS---------ISRHHCQIR-DGD------YIIDLGEHSTNGTYVNGRRV
Kinase Chk2.AA RAD53 192-429 53 3e-187 563.37 In-house 1-275 (305) Show / Hide 
Range on Protein: 192-429
Range on HMM: 1-275/305
Sequence Identity: 53% (147 aa)

FIMSKVLGRGACGQVKLAFEKGTCRKVAVKIIEKKTFSIGGTMVRNMEKTVMEEVRILKRLHHPCIIGIEDVCDTP-EVLYIVLELVESGELFDRVVSLG
..|||.||.|..|.||||.|| ||.|||.|||.||.|.|...........||.||.|||.|.||||| |.|..||| ...|.||||...||||...|| .
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

K----FDEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMSDDKET---------------ILKVTDFGLSKFVGEQSLMKTLCGTPTYLAPEILTS
.    |||.|.|.|||||..|.||||||||.|||||||| |....|.|.               ..|.|||||||||||.|.|||.||||.|.|||..||
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITS

MGM------------GGYTKAVDCWSIGVILYICLAGYPPFSDEIKA----MNLDEQIKR-GYYSFPTKYWGSVS
.|.            .||||.|||||.|.||||||.|||||||....    |.|.||||. |.|.||..|| ..|
KGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRIS
Kinase Chk2.AA CAMK1 192-429 40 2.7e-108 315.9 In-house 1-245 (276) Show / Hide 
Range on Protein: 192-429
Range on HMM: 1-245/276
Sequence Identity: 40% (103 aa)

FIMSKVLGRGACGQVKLAFEKGT---CRKVAVKIIEKKTFSIGGTMVRNMEK-------TVMEEVRILK---RLHHPCIIGIEDVCDTPEVLYIVLELVE
..  |..|||| ..|.|. .| |    ...|.|.|.|          ..|.|        .. |. |.|   ...|| || .... .... .|.|.||| 
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK---------KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVT

SGELFDRVVSLGKFDEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMSDDKETILK--VTDFGLSKFVGEQS-LMKTLCGTPTYLAPEILTS-MGM
 ||||||.|  |.. |  |     | . | .|.|..|| ||||||||||. . | . ..|  . ||||||...... |||| |||| | |||.|.     
GGELFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK-D

GGYTKAVDCWSIGVILYICLAGYPPFSDEIKAMNLDEQIKRGYYSFPTKYWGSVS
 .| ||.|.||||||.|| | ||||| ||   ..| |.||.. | ||...|...|
KPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNIS
Kinase Chk2.AA CAMK 197-429 26 4.90000000001e-103 332.9 In-house 1-387 (425) Show / Hide 
Range on Protein: 197-429
Range on HMM: 1-387/425
Sequence Identity: 26% (103 aa)

VLGRGACGQVKLAFEK-GTC-----------RKVAVKIIEK----------------KTFSIGGTMVRN----MEKTVMEEVRILKR-------LHHPCI
.||||. |.|||...|  |.           .|||.|||.|                . .| .. . ..    ..| |. |..|.|.       |.||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IGIEDVCDTPEV-------------------LYIVL---ELVESGEL----FDRVVSL---------------GKFDEATAKFYFYQMITACKYLHDNGI
| . .| ..|..                   .|.|.   |... |||    ||..|.                |.|.|. |..|| |.. | .|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

THRDLKPENLLLMSDDKET--------------ILKVTDFGLSKFVGE------------------------QSLMKTLCGTPTYLA-PEILTSMGM---
 ||||||||.|| ......               .|..|||..... .                          .||| |||| | | ||.| . |.   
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------GGYTKAVDCWSIGVILYICLAGYPPFSDE------------IKAMNLDEQIKRGYYSFPTKY------------WGSVS
         .|....|.||.||||||.| ||||| ..                .| |.|..| |.|| .|            |...|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDIS
Kinase Chk2.AA CAMKL 192-424 36 6.8e-83 264.34 In-house 1-265 (297) Show / Hide 
Range on Protein: 192-424
Range on HMM: 1-265/297
Sequence Identity: 36% (99 aa)

FIMSKVLGRGACGQVKLAFE-KGTCRKVAVKIIEKKTFSIGGTMVRN--------MEKTVMEEVRILKRLH---HPCIIGIEDVCDTPEV------LYIV
... |.||.|..|.||||   . | .|||.|||.||  .    | .|        ..  .  |..|.|.|.   || || . .| .|||       .|.|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LELVESGE--LFDRVVSL----GKFDEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMSDDKETILKVTDFGLSKF-----VGEQSLMKTLCGTPT
.|....||  |||..|.     |...|  |..|| |.. | .|.|..|| |||.||||.|| .....  .|..|||.| .     .|.  ..|| ||.| 
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YLAPEILTSMG-MGGYT-KAVDCWSIGVILYICLAGYPPFSDEI-------KAMNLDEQIKRGYYSFPTKY
| ||||.   |    |  ..||.||.|||||  . || || |.           .| ..|..| | .|  |
YMAPEIF--QGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWY
Kinase Chk2.AA S_TKc 192-453 31 1.4e-80 274.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 192-453
Range on HMM: 1-231/231
Sequence Identity: 31% (89 aa)

FIMSKVLGRGACGQVKLAFEKGTCRKVAVKIIEKKTFSIGGTMVRNMEKTVMEEVRILKRLHHPCIIGIEDVCDTPEVLYIVLELVES--GELFDRVVSL
. . ...|.|| |.|... .|.| |.||.|||                .... |..|||. ||| |. . ||... . ||.|.|...   |.|||. .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

GK------FDEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMSDDKETILKVTDFGLSKFVGEQSLMKTLCGTPTYLAPEILTSMGMGGYTK-AVD
|.      |.| .|.||.||.. | .|.|..|| ||||||||.|| .      .|..||||....      .|.|||| |.|||.|      ||.| ..|
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL------GYGKCKCD

CWSIGVILYICLAGYPPFSDEIKAMNLDEQIKRGYYSFPTKYWGSVSAPDVFIRMVRW-----ISILKCPN-D-----AKLI
 ||.|.|||..|.|||||.      .... .|.           | .| |   .. ..     ... .. . .        .
WWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Chk2.AA AGC 192-403 27 1.5e-80 207.13 In-house 1-308 (395) Show / Hide 
Range on Protein: 192-403
Range on HMM: 1-308/395
Sequence Identity: 27% (88 aa)

FIMSKVLGRGACGQVKLAFEK------GTCRKVAVKIIEKKT-FSIGG--TMVRNMEKT-------VMEEVRILKRLH----------HPCIIG-IEDVC
| . ||.|.|. |.| |. .|      .| .  |.|...||.   |    .. ..|          | || .||....          || |.       
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DTPEV--LYIVLELVE---------SG-ELFDRVV---SLGKFDEATAKFYFYQ-------MITACKYLHD-NGITHRD-LKPENLLLMSDDKETILKVT
 ...   ||.|.|...          | ||| .       |.||| .|.||. .       .. |  |||. .|| ||| |||||.|| .|     .| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLT

DFGLSKFVG---------------------------------------------------EQSLMKTLCG--TPTYLAPEILTSMGMGGYTKAVDCWS--
||||.| .                                                    .. . .|.||  || |.|||||       |.||.| ||  
DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-------YGKACDWWSFG

IGVILYICLAGYPPFSDE
 |...|  |.|||||...
LGCLMYEMLTGYPPFYGD
Kinase Chk2.AA Pkinase 192-429 35 8.7e-73 252.92 Pfam 1-246 (293) Show / Hide 
Range on Protein: 192-429
Range on HMM: 1-246/293
Sequence Identity: 35% (91 aa)

FIMSKVLGRGACGQVKLAFEKGTCRKVAVKIIEKKTFSIGGTM-VRNMEKTVMEEVRILKRLHHPCIIGIEDVCDTPEVLYIVLELVESG----ELFDRV
.   ...|.|. |.|... .|||...||||||.|.. . .  .  |.       |..|.|||.||.|. . |.. ..  .|.|.|..| |    .|||..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

V--SLGKF--DEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLM-SDDKETILKVTDFGLSKF--VGEQSLMKTLCGTPTYLAPEILTSMGMGGYTK
   . |.|  .| ..|||.||.. . .|.|..|| ||||||||.|.   .. ....|..||||.|.     .| |.|.|||| |.|||..   |  .|..
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--GGQYYGP

AVDCWSIGVILYICLAGYPPFSDE-----IKAMNLDEQIKRGYYSFPTKYWGSVS
.|| ||.|.|||. | |.|||...     .  | . ..|... ..|.  .| |.|
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSIS
Kinase Chk2.AA DCAMKL 192-430 36 1.3e-70 218.76 In-house 1-250 (279) Show / Hide 
Range on Protein: 192-430
Range on HMM: 1-250/279
Sequence Identity: 36% (94 aa)

FIMSKVLGRGACGQVKLAFEKGTC-RKVAVKI-----------------IEKKTFSIGGTMVRNMEKTVMEEVRILKRLHHPCIIGIEDVCDTPEVLYIV
.   .. | |    |... .. |  .| | ||                 |.|.        ... |. .  ||.|.... || || . .. ||.. .|.|
YQIGRIIGDGNFAVVHECRHRETGDHKYAMKIRYQSTLQFSFPSKFFQQIDKR-------KCKGKEHMIDNEVSIMQKIKHPHIIQLYEHWDTETHYYLV

LELVESGELFDRVVSLGKFDEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMS-DDKETILKVTDFGLSKFVGE-QSLMKTLCGTPTYLAPEILTS
.|.|. | ||| ... .|| |  |    ...  | ||||. .| |||.||||||.   .|.|. ||  |||| . | .   .. | |||||| |||||  
MEYVQGGDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLYTVCGTPTYVAPEILME

MGMGGYTKAVDCWSIGVILYICLAGYPPF-SDEIKAMNLDEQIKRGYYSFPTKYWGSVSA
    ||   || |..|||||| | |.||| | .     | .||  | ..||  ||  .|.
T---GYGCKVDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISD
Kinase Chk2.AA AMPK 192-422 40 1.1e-69 206.12 In-house 1-221 (254) Show / Hide 
Range on Protein: 192-422
Range on HMM: 1-221/254
Sequence Identity: 40% (94 aa)

FIMSKVLGRGACGQVKLAFEKGTCRKVAVKIIEKKTFSIGGTMVRNMEKTVMEEVRILKRLHHPCIIGIEDVC-DTPEVLYIVLELVESGELFDRVVSLG
.|. | .|.|. | ||..  . |  |||.||..|.           | . .  |..||| . || ||   .|  .||. ...|.| |  ||||| .|. |
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKI-----KDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHG

KFDEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMSDDKETILKVTDFGLSKFVGEQSLMKTLCGTPTYLAPEILTSMGMGGYTKAVDCWSIGVIL
. .|  |. .| |.| .  |.|...| |||||||||||   |..  .|. |||||.   .  . || || | | |||. ..    |    || || ||||
RLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLL---DHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCG--PEVDIWSCGVIL

YICLAGYPPFSDEIKAMNLDEQIKRGYYSFPT
|  | || || ||  .. |   || | |. |.
YAMLCGYLPFDDENTPT-LYKKIKNGEYYIPK
Kinase Chk2.AA CAMK-Unique 192-429 24 1.4e-66 218.75 In-house 1-333 (363) Show / Hide 
Range on Protein: 192-429
Range on HMM: 1-333/363
Sequence Identity: 24% (81 aa)

FIMSKVLGRGACGQVKLAFEKGTCRKVAVKIIEKKTFSIGGTMV------------RNMEKTVMEEVRILKRLHHPCIIGIEDV----CDTPE-------
 .| ...| |. | |. .. . |  | |.|...|.| ..    .            .  .   ..|..|.|.. ||.|| ..|.      ...       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------VLYIVLELVESGELFDRVVS--------------------LGKFDE--ATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMSDDK-----
         .|||.|... |.||| ...                     |.| |  . . |.. .   | .|.|...| |||||.||... .  |     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------ETILKVTDFGLSKFVG-EQSL--MKTLCGTPTYLAP--------------EILTSMGMGGYTKAV----DCWSIGVILYICLAGYPPFSDEI
         . .|..||||.. .   ..   |.| |||| |.||              |..   .| .|   .    |.||.|||.|. | |.|||  | 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVI---NMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCEC

KA-------MNLDEQIKRGYY-SFPTKYWGS---VS
..        .. | |. | | .|..|.|..   .|
EDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYIS
Kinase Chk2.AA Ciliate-E2 192-437 23 1.1e-64 220.97 In-house 1-344 (365) Show / Hide 
Range on Protein: 192-437
Range on HMM: 1-344/365
Sequence Identity: 23% (86 aa)

FIMSKVLGRGACGQVKLAFEKGTCR------------------KVAVKIIEKKTFSIGGTMVRNMEKTVMEEVR----------ILKRLHHPCIIGIEDV
..  |..|.|. |.|...  . . .                  ||..||...|...  .    ..|. .| |..          ||..| || || . ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CD--TPEVLYIVLELVESGELFDRVVSL-----------GKFDEATAKFYFYQMIT---------------ACKYLHDNG-ITHRDLKPENLLLMSDDKE
    . . .|.|.|... |.|||.  .            ..|.|  .|....| .                | .||| .. | |||.||||.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

TILKVTDFGLSKFVGEQ--------------------------------SLMKTLCGTPTYLAPEILTSMGMGG------YTKAVDCWSIGVILYICLAG
  .|..||||||.. ..                                 . .|.|||| |.||||| . . ..      |....| ||.|||||..| |
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

YPPFSDEIKAMNLDEQIKRGYYSFP------------TKY--WGSVSAP--DVFIR----M
.|||          .||| . ..||            .|.  | ..|    | . .    |
KPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRM
Kinase Chk2.AA CDPK 271-400 43 3e-55 168.01 In-house 77-213 (271) Show / Hide 
Range on Protein: 271-400
Range on HMM: 77-213/271
Sequence Identity: 43% (61 aa)

YIVLE--LVESGELFDRVVSLGKFDEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMSDDKET----ILKVTDFGLSKFVGEQ-----SLMKTLCG
|||.|  ... |||||.... |.|.|  |  ...| . |  | |.|.|.||||||||.|. |... .    ..|| |.|.||  . .       |.. ||
YIVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCG

TPTYLAPEILTSMGMGGYTKAVDCWSIGVILYICLAGYPPF
||.|.|||.|     . | . .| ||.|||||| | |||||
TPYYIAPEVLQ----KKYNEKCDIWSCGVILYILLCGYPPF
Kinase Chk2.AA CDPK 192-258 38 9.6e-16 44.97 In-house 1-64 (271) Show / Hide 
Range on Protein: 192-258
Range on HMM: 1-64/271
Sequence Identity: 38% (27 aa)

FIMSKVLGRGACGQVKLAFEK-GT-CRKVAVKIIEKKTFSIGGTMVRNMEK--TVMEEVRILKRLHHPCII
....||||.|. |||... .| .|  ..||.|||.|.        |.. |.   . .|. ||| | ||.||
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSR-------VKDKEQQQQFFNEIEILKQLDHPNII
Kinase Chk2.AA TyrKc 192-444 22 4e-15 21.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 192-444
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

FIMSKVLGRGACGQVKLAFEKGTCRKVAVKIIEKKTFSIGGTMVRNMEKTVMEEVRILKRL--HHPCIIGIEDVCDTP-------EVLYIVLELVESGEL
  . |.||.|| |.| ..  |   ..|||| . . .           ..  |.| ||...|  |||.|. .  || ..       | |.||.|... | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

FDRVVSLGK-FDEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMSDDKETILKVTDFGLSKFVGEQ-------SLMKTL---CGTP----TYLAPE
 |.  . .. .  ..   . .|    . |||.... ||||   | |. ..    . |..|||||.....        .  ..    .|        .|||
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

ILTSMGMGG-YTKAVDCWSIGVILY-ICLAGYPPFSDE----IKAMNLDEQIKRGYYSFPTKY-----WGSVSAPDVFIR---------------MVRWI
 .    . | .| . | || || .. |.  | .| ...    ...  . |..|.||.  . ..        | .||   .               .   .
CI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEIH

SIL
...
ECF
Kinase Chk2.AA Pkinase_Tyr 192-348 28 1.5e-11 39.78 Pfam 1-161 (270) Show / Hide 
Range on Protein: 192-348
Range on HMM: 1-161/270
Sequence Identity: 28% (49 aa)

FIMSKVLGRGACGQVKLAFEK----GTCRKVAVKIIEKKTFSIGGTMVRN-MEKTVMEEVRILKRL-HHPCIIGIEDVCD-TPEV--LYIVLELVESGEL
 .. |.||.|| |.|...  |    .|. .||||.. |      |.| .. . .  |.|..|.| | ||| |.    ||    |   .|||.|... | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL

FDRVVS----LGKFDEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMSDDKETILKVTDFGLSKFV
 |   .     ....  .   . .|   .. ||..... ||||   | |. .   . . |..||||.. .
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDI