Gene CDC2 (Sea Urchin)

CDC2

Species: Sea Urchin
Alias: SPU_002210, CDC2, Spk135, SpCDK1
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
CDC2.AA Protein None 301 None Fasta, JSON
CDC2.kin_dom Protein Kinase Domain None 283 None Fasta, JSON

Protein domain

Protein domains of CDC2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDC2.AA CDC2 4-286 65 2.9e-233 725.12 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-301/301
Sequence Identity: 65% (198 aa)

FMKIEKLGEGTYGVVYKGKHKRTGKIVALKKIRLESEEEG--VPSTAIREISLLKELY-HPNIVMLEDVLMEPNRLYLVFEYLTMDLKKYME-SLKG-KQ
..||||.||||||||||.|...|..||||||||||.|.||  ||||||||||.||||  |||||.|.||... |.||.||||| |||||||. |..  |.
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

MDPALVKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGTIKLADFGLARAFGIPVRVYT--HEVVTLWYRAPEVLLGSTRYACPIDMWSLGCIFAEM
|.|.|||||..|...|. |||.|||.||||||||.|||..|.||.||||||||||||.|.||  ||||||||||||.|||. || .|.||||.|||||||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---VTKRPLFHGDSEIDQLFRIFRTLGTPTDDIWPGVTQLQDYKSTFPMWTKPNIKGAVKG---------MDEGGLDLLEQMLIYDPAKRITAKASMRHP
   |||.|||||||||||||.|||.||||....|||||||.|||.|||.|.. ...  ..          .|. |.|||.|||.|||.|||.||. ..||
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHP

YF
||
YF
Kinase CDC2.AA CDK 4-286 54 1.9e-192 621.22 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-284/284
Sequence Identity: 54% (174 aa)

FMKIEKLGEGTYGVVYKGKHKRTG-----KIVALKKIRLES-----EEEGVPSTAIREISLLKELYHPNIVMLEDVLMEP-----------NRLYLVFEY
. |.||.||||||||||...|.||     .||||||||.|.     |.||.|.|||||||||||| ||||| | || .             |.||.||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LTMDLKKYMESLKGKQMDPALVKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGT-----IKLADFGLARAFGI------PVRVYTHEVVTLWYRAP
. .||||||.           .|.|..|. .|. .|||..|.||||||||.||.|||.     .|.|||||||||||      |.|.|||||||||||||
MDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

EVLLGSTRYA--CPIDMWSLGCIFAEMVT---KRPLFHGDSEIDQLFRIFRTLGTPTDDIWPGVTQLQDYKSTFPMWTKPNIKGAVKGMDEGGLDLLEQM
|.||||..|   .||||||.|||||||.|   ..|||.|||||||||.|||..||||.|.|||||.|.||                        |||..|
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKM

LIYDPAKRITAKASMRHPYF
| |||.|||.|.. . ||||
LCYDPKKRISAEQALQHPYF
Kinase CDC2.AA CDK5 4-286 58 1.8e-181 578.64 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 58% (169 aa)

FMKIEKLGEGTYGVVYKGKHKRTGKIVALKKIRLESEEEGVPSTAIREISLLKELYHPNIVMLEDVLMEPNRLYLVFEYLTMDLKKYMESLKGKQMDPAL
. |.||.||||||.|||.. | |. |||||..||.|| |||||||||||.||||| |.||| | ||.   ..| ||||..  ||||||.|..| .||...
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG-EMDMHI

VKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGTIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSTRYACPIDMWSLGCIFAEMV-TKRPL
.||.. |.  |. |||....||||||||||||  ||. |||||||||||||||| |.|||||||||.| ||.||  |  .||||| |||||||. . |||
IKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPL

FHGDSEIDQLFRIFRTLGTPTDDIWPGVTQLQDYK---STFPMWTKPN-IKGAVKGMDEGGLDLLEQMLIYDPAKRITAKASMRHPYF
| | .. |||.|||. .|||. | ||..|.| |||     .||.      .  |...|| |.|||..||...|..||.||| ..||||
FPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDC2.AA CMGC 4-286 28 5.69999999999e-155 513.32 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-513/513
Sequence Identity: 28% (149 aa)

FMKIEKLGEGTYGVVYKGKHKRTG--------------KIVALKKIRLES---------EEEGVPSTAIREISLLKEL-----------------YHPNI
. .|.|.||||||||||...|||.              .|||.|||...          |..|.|..|.|||..||.|                  |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VMLEDVLMEPN-----------------RLYLVFEYLTMDLKKYMESLK-------GKQMDPAL------------VKSYL------HQMVDGIL--FCH
| | |... .|                  |||||||. .||..|... .       .. ...              .|...      .|.  |.   .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SRR--ILHRDLKPQNLLIDNN--------------------GTIKLADFGLARAFGIP---------------------VRVYTHEVVTLWYRAPEVLLG
|..  |.||||||.|.||..|                    |..|..||||||.....                     .| |||.|||.||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

STRYA---------CPIDMWSLGCIFAEMVTK--------RPLFHGDSE-----------IDQLFRIFRTLGTPT---------------DDIWPGVTQL
...|          .||||||.|||||||.|.        .|||.|.||           |||||.||..|||||               ...||....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

QDY---------------KST-----------FPMWTKPNIKGAVKG-----------------------------------MDEGGLDLLEQMLIYDPA
..|               .|            ||.| ....|  ...                                   .|. ..|||..||.|||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRITAKASMRHPYF
|||||.  ..||||
KRITAEQALQHPYF
Kinase CDC2.AA CDK7 4-286 44 8.8e-144 386.0 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-288/288
Sequence Identity: 44% (128 aa)

FMKIEKLGEGTYGVVYKGKHKRTGKIVALKKIR-LESEEE---GVPSTAIREISLLKELYHPNIVMLEDVLMEPNRLYLVFEYLTMDLKKYMESLKGKQM
. ||...|||....|||.  . ||.||| |||. | . .|   |.  |||||| .|.|. |.|.. | |..|    ..|||...  ||    .  |   .
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKD-KSIIL

DPALVKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGTIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSTRYACPIDMWSLGCIFAEMVTK
 || .|.|  ..  |. .||   |||||||| |||.. || .|.|||||||..| | |.||| ||| |||||| | |   |   .|||| ||||||    
TPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLR

RPLFHGDSEIDQLFRIFRTLGTPTDDIWPGVTQLQDYKS--TFPMWTKPNIKGAVKGMDEGGLDLLEQMLIYDPAKRITAKASMRHPYF
 | . |||.|||| |||.||||||.  ||......||     ||  ..   .       .  |||.. |.  .| ||.|.  .  .|||
VPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDC2.AA PCTAIRE 4-286 51 1.8e-128 433.09 In-house 1-291 (291) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-291/291
Sequence Identity: 51% (150 aa)

FMKIEKLGEGTYGVVYKGKHKRTGKIVALKKIRLESEEEGVPSTAIREISLLKELYHPNIVMLEDVLMEPNRLYLVFEYLTMDLKKYMESLKGKQMDPAL
..|..|||||||  |||.. | |. .|||| ||||  ||| | |||||.||||.| | ||| | |..     | |||||. ||||.||.   |  |.   
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDC-GNIMNMHN

VKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGTIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSTRYACPIDMWSLGCIFAEMVTKRPLF
|| .| |.  |  .|| |.|||||||||||||.  |  ||||||||||  .| ..| ||||||||| |.||.||| |  .||||  ||||.|| | ||||
VKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLF

HGDS------EIDQLFRIFRTLGTPTDDIWPGVTQLQDYKS-TFPMWTKPNIKGAVKGMD---EGGLDLLEQMLIYDPAKRITAKASMRHPYF
 |          |||  ||| ||||..  ||||. ......  || . .  .      .|   . . |||...| | . .|. | . |.||||
PGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase CDC2.AA PITSLRE 4-286 46 3e-126 425.73 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-295/295
Sequence Identity: 46% (138 aa)

FMKIEKLGEGTYGVVYKGKHKRTGKIVALKKIRLE--SEEEGVPSTAIREIS-LLKELYHPNIVMLEDVLM--EPNRLYLVFEYLTMDLKKYMESLK--G
| .. . .||||||||..| |||. |||||.. .|   | || | |..|||. .|..| ||||| .  ..|    .  |.|.||.  |||  ||  |   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

KQMDPALVKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGTIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSTRYACPIDMWSLGCIFAEM
..  |  .|. . |   |. . |.  |.|||||  |||. ..|  |..|||||| .| |.. ||  ||||||||||.|||.  |  |.|||| ||||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

VTKRPLFHGDSEIDQLFRIFRTLGTPTDDIWPGVTQLQDYKS-T-FPMWTKPNIKGAVK---GMDEGGLDLLEQMLIYDPAKRITAKASMRHPYF
.|..||| |.|||||. .||  .||||  ||||.| |   |  . ||     | .  ..      . |.||| ||| |.|..|||| . . ||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDC2.AA PFTAIRE 4-286 49 3.2e-124 418.99 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 49% (144 aa)

FMKIEKLGEGTYGVVYKGKHKRTGKIVALKKIRLESEEEGVPSTAIREISLLKELYHPNIVMLEDVLMEPNRLYLVFEYLTMDLKKYMESLKGKQMDPAL
. |.||||||.|  ||||. . ....|||| |||. .|||.| ||||| ||||.| | |||.| |.      | .||||.  ||..||..  |  |.|  
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQ-QEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPG-GMHPNN

VKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGTIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSTRYACPIDMWSLGCIFAEMVTKRPLF
|. .| |.. |  .|| ||.|||||||||||| . |  ||||||||||  .| . | ||||||||| | |||||| |   .|||  |||| ||.. .|.|
VRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAF

HGD-SEIDQLFRIFRTLGTPTDDIWPGVTQLQDYK-STFP--MWTKPNIKGAVKGMD--EGGLDLLEQMLIYDPAKRITAKASMRHPYF
 |     ||| .||..|||||.| ||||..|  ||   |.  . .  . . ..  ..   .. ||. .|| . | .|. |.. | ||||
PGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDC2.AA Pkinase 4-286 36 2e-109 374.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-293/293
Sequence Identity: 36% (110 aa)

FMKIEKLGEGTYGVVYKGKHKRTGKIVALKKIRLESEEEGVPSTAIR--EISLLKELYHPNIVMLEDVLMEPNRLYLVFEYLTMDLKKYMESL------K
. ...|.|.|..|.|||..|| ||||||.|.|....|..... |..|  ||...|.| ||||| | |. ......|.|.||. ..|.  |.        .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

GKQM--DPALVKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGTI----KLADFGLARAF-GIPVRVYTHEVVTLWYRAPEVLLGSTRYACPIDMWS
.. .  ..  .|.|. |.. |. .|||..|.||||||.|.||||||.|    |..|||||. |   . . .|. ..|.||.||||..|.. |  ..||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCIFAEMVTKRPLFHGD----SEIDQLFRIFRTLGTPTDDIWPGVTQLQDYKSTFPMWTKPNIKGAVKGMDEGGLDLLEQMLIYDPAKRITAKASMRHP
.|||..||...||.| |.    . .||...|.|..|.|..  ||      ... ... | ..  .   . ..| ..|... .| .||.||.||.  . ||
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase CDC2.AA S_TKc 4-286 31 2.9e-107 363.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-231/231
Sequence Identity: 31% (94 aa)

FMKIEKLGEGTYGVVYKGKHKRTGKIVALKKIRLESEEEGVPSTAIREISLLKELYHPNIVMLEDVLMEPNRLYLVFEYLTM---DLKKYMESLKG----
. ...|.|.|..|.|||..||.||.|||.|.|.          ...|||..||.  ||||| | ||  . ..||.|.||.     ||..|... ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

KQMDPALVKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGTIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSTRYAC-PIDMWSLGCIFAE
.....  ...|..|..... .|||..|.||||||.|.|.|.  .||..|||||| .       |. ..|.||.|||||     | . ..|.||.|||..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MVTKRPLFHGDSEIDQLFRIFRTLGTPTDDIWPGVTQLQDYKSTFPMWTKPNIKGAVKGMDEGGLDLLEQMLIYDPAKRITAKASMR-------HPYF
|.. .|.|.      |....|. .|                                   .. ..|.....| .||.||.||   ..       ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDC2.AA CRK7 4-286 36 4.7e-107 361.97 In-house 1-343 (343) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-343/343
Sequence Identity: 36% (124 aa)

FMKIEKLGEGTYGVVYKGKHKRTGKIVALKKIRLESE---EEGVPSTAIREISLLKELYHPNIVMLEDVLME--------PNR--LYLVFEYLTMDLKKY
. .|.  |||||| ||| | |.||..|||||.|.. |   .|| | |||||| .|..| |.||| | ..  .          .   |.||||   ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

MESLKGKQMDPALVKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGTIKLADFGLARAFGIPV--RVYTHEVVTLWYRAPEVLLGSTRY--------
.||   ..  .  .|... |. .|.  || . .||||.|  |.|..|.| .|.||||||| .      | ||  |.|||||.|| ||| .||        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------ACPIDMWSLGCIFAEMVTKRPLFHGDSEIDQLFRIFRTLGTPTDDIWPGVTQLQDYKSTFPMWT--KPNI
                                 ||||| |||..|  ||.|.| |  |..||  |..  |.|. . || |..|. .. |. .    .  .
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWN-TMKPKRQYNRRL

KGAVK------GMDEGGLDLLEQMLIYDPAKRITAKASMRHPYF
   .        |..  |||| .|| .|| ||.||.   .|..|
REEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDC2.AA CDK4 4-286 45 1.4e-106 360.38 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-290/290
Sequence Identity: 45% (134 aa)

FMKIEKLGEGTYGVVYKGKHKRTGKIVALKKIRLESEEE--GVPSTAIREISLLKELY---HPNIVMLEDV--LMEPNR----LYLVFEYLTMDLKKYME
. ..  .||| || ||.     ||..||||..|  ..||  |.|   |||||... |    ||||| | ||   |.. |    . .|||    ||. |..
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

SLKGKQMDPALVKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGTIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSTRYACPIDMWSLGCI
 .    | |  .|   ||.. |. | || || ||||||||.|.  .|..||||||||| ..      |  ||||||||||||| |. |. |.||||.|||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMAL-TPVVVTLWYRAPEVLLQSY-YNTPVDMWSVGCI

FAEMVTKRPLFHGDSEIDQLFRIFRTLGTPTDDIWPGVTQLQDYKSTFPMWTKPNIKGAVKGMDEGGLDLLEQMLIYDPAKRITAKASMRHPYF
||||   |||| | || ||| .||   |.|. | ||    |    . ||     ..|  .  |.. |.|||..|| |...||..| .   ||||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP--WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDC2.AA Pkinase_Tyr 4-151 33 5.9e-25 85.14 Pfam 1-160 (270) Show / Hide 
Range on Protein: 4-151
Range on HMM: 1-160/270
Sequence Identity: 33% (55 aa)

FMKIEKLGEGTYGVVYKGKHK----RTGKIVALKKIRLESEEEGVPSTA------IREISLLKEL-YHPNIVMLEDVLM---EPNRLYLVFEYLTM-DLK
  ...||||| .|.||||. |     |.  || |...     ||  . .      .||....|.| .||||| |  | .   |||..|.|.||    ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KYMESL--KGKQMDPALVKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGTIKLADFGLARA
.|  .    ... ..    .. .|  .|  . .|... ||||   | |...|...| .||||||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase CDC2.AA TyrKc 4-213 23 2.1e-13 -6.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-213
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FMKIEKLGEGTYGVVYKGKHKRTGKIVALKKIRLESEEEGVPSTAIREISLLKEL--YHPNIVMLEDVLMEP-------NRLYLVFEYLTM-DLKKYMES
  ...||||| .|.||||. |     || |... ..         .||......|   ||||| |  | ...         |..|.||    |||.|  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LKGKQMDPALVKSYLHQMVDGILFCHSRRILHRDLKPQNLLIDNNGTIKLADFGLARAFGIPVR--------VYT-----HEV--VTLWYRAPEVL----
 ..|   ..   |. .|  .|  . ||... ||||   | |...|.|.| .||||.|.  |           .|.     ..   . .   |||..    
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRD--IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

-------------------LGSTRYA-----------------------------------CPIDMWSL-GCIFAEMVTKRPLFHGDSEIDQLF
                   .| . |                                    || .| ..  .  .|   .|| |   ||| ..|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF---SEIHECF