Gene CDK4 (Sea Urchin)

CDK4

Species: Sea Urchin
Alias: SPU_000151, CDK4, Spk131
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK4

Sequence

Name Sequence Type Origin Length Description Download
CDK4.AA Protein None 373 None Fasta, JSON
CDK4.kin_dom Protein Kinase Domain None 287 None Fasta, JSON

Protein domain

Protein domains of CDK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK4.AA CDK4 14-300 70 2.1e-229 768.39 In-house 1-290 (290) Show / Hide 
Range on Protein: 14-300
Range on HMM: 1-290/290
Sequence Identity: 70% (204 aa)

YVQAAEIGSGAYGIVYKARDTETGHFVALKSVRIPIGEE--GMPVSTIREISLLRHLCQLDHPNIVKLLDVCDVMDVGRSEMMLTLVFELVDQDLAQYLE
|...||||.||||.||.|||..||||||||.||||||||  |||.|||||||..|||||..|||||||.|||.|||..|.||..|.|||..|.||..||.
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

KCPPPGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSRVYSFQMALTPVVVTMWYRAPEVLLQASYATPVDMWSVGCIFA
||||||..|||||..|||||.||..|||||..|||||||||||.||...||.||||.|.|||||||||||||.||||||||||..|.|||||||||||||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQSYYNTPVDMWSVGCIFA

ELYRRRPLFRGQSDKDQLHKIFEVIGLPPEDQWP-DVALPWSSFRQTGQRSFLDLVQEICNQGLDLLERMLCFNPDHRMTAEQGLLHGFF
|.|.|||||.|||.||||||||.|.||||||.|| ||.|||..|.|...|.|.|.....|.||.|||..|||.|...||.|.|.| |..|
EMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK4.AA CDK 14-300 42 7.29999999999e-151 486.01 In-house 1-284 (284) Show / Hide 
Range on Protein: 14-300
Range on HMM: 1-284/284
Sequence Identity: 42% (137 aa)

YVQAAEIGSGAYGIVYKARDTETG-----HFVALKSVRIPI-----GEEGMPVSTIREISLLRHLCQLDHPNIVKLLDVCDVMDVGRS-----EMMLTLV
| . ..|| |.||.||||||..||     ..|||| .|.        .||.| ..|||||||..|    |||||||.|||  ..  |.     |  |..|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL----HPNIVKLHDVCHTKNMDRNNKDKHENKLYMV

FELVDQDLAQYLEKCPPPGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLKPQNILVASDKK-----LKLTDFGLSRVYS-------FQMALTPVVVTMWY
|| .|.||..|..           || .|.|||.|..|.||... ||||||||||. .. .     ||..||||.| ..        ....|..|||.||
FEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPEVLL-QASYA--TPVDMWSVGCIFAELYR---RRPLFRGQSDKDQLHKIFEVIGLPPEDQWP-DVALPWSSFRQTGQRSFLDLVQEICNQGLDLLER
||||.|| .  |   ||.|||||||||||...   |.||| |.|. |||.|||...| | ||.||  . ||.                       |||..
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------DLLNK

MLCFNPDHRMTAEQGLLHGFF
|||..|..|..||| | | .|
MLCYDPKKRISAEQALQHPYF
Kinase CDK4.AA CMGC 14-300 26 4e-130 430.18 In-house 1-513 (513) Show / Hide 
Range on Protein: 14-300
Range on HMM: 1-513/513
Sequence Identity: 26% (136 aa)

YVQAAEIGSGAYGIVYKARD--------------TETGHFVALKSVR---IPIG------EEGMPVSTIREISLLRHLCQ--------------LDHPNI
|     ||.|.||.|||.||              .||. .||.| ..    ...      ..|.| ...|||..|.|| .               .|.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLLDVCDVMDVGRSEM-----------MLTLVFELVDQDLAQYLEKCP-------PPGLSPCT------------IKFLM------HQLLSGVE--YLH
|||.|..   .  ..|             | ||||..|.||.||.....       | .||.              ||..|      .|.| |..  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SHR--VTHRDLKPQNILVASDKKL--------------------KLTDFGLSRVYSF----------------------QMALTPVVVTMWYRAPEVLLQ
||.  . ||||||.|||. ....|                    |. ||||.| |.                       ....|. |||.||||||.|| 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

AS----------YATPVDMWSVGCIFAELYRR--------RPLFRGQSD-----------KDQLHKIFEVIGLPP---------------EDQWPDVAL-
..          | ||.|||||||||||.|..        .||| |.|.            |||.|||.|.| |.               |..||..   
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

-----------------PWSS-----------FRQTGQRSFLDLVQE-----------------------------------ICNQGLDLLERMLCFNPD
                  ||.           | .   ... .|.                                     .. |..|||..||...||
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

HRMTAEQGLLHGFF
 |.|||| | | .|
KRITAEQALQHPYF
Kinase CDK4.AA CDC2 14-300 41 1.3e-120 372.58 In-house 1-301 (301) Show / Hide 
Range on Protein: 14-300
Range on HMM: 1-301/301
Sequence Identity: 41% (128 aa)

YVQAAEIGSGAYGIVYKARDTETGHFVALKSVRIPIGEEG--MPVSTIREISLLRHLCQLDHPNIVKLLDVCDVMDVGRSEMMLTLVFELVDQDLAQYLE
| .   || | ||.|||..|..|.  |||| .|.   .||   | ..|||||.|  |   |||||||| ||  ..        | .||| .|.|| .|..
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELK--DHPNIVKLHDV--IHQ-----NKLYMVFEYLDMDLKKYMD

-KCPP-PGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSRVYSFQM-ALTPV--VVTMWYRAPEVLL-QASYATPVDMWS
 . |.   ..| ..| .|.|.|.||...|..|. ||||||||||. .. ..|. ||||.|  .. . ..|.   ||| ||||||.|| .  | |||||||
MSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWS

VGCIFAEL---YRRRPLFRGQSDKDQLHKIFEVIGLPPEDQWPDVA-LP--WSSFRQTGQRSFLDLVQE---------ICNQGLDLLERMLCFNPDHRMT
.||||||.     ..||| |.|  ||| |||...| | |. ||.|  ||   ..| .  .  . ...           ....|.|||..||. .| .| .
IGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRIS

AEQGLLHGFF
|.. | | .|
AKEALQHPYF
Kinase CDK4.AA CDK5 14-300 43 8.9e-111 351.34 In-house 1-287 (287) Show / Hide 
Range on Protein: 14-300
Range on HMM: 1-287/287
Sequence Identity: 43% (130 aa)

YVQAAEIGSGAYGIVYKARDTETGHFVALKSVRIPIGEEGMPVSTIREISLLRHLCQLDHPNIVKLLDVCDVMDVGRSEMMLTLVFELVDQDLAQYLEKC
| .   || | ||.|||||. ||. .|||| ||.    ||.| . ||||.||.    | |.||| | ||        ||  |||||| .||||  |...|
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLK---ELKHKNIVRLHDVI------HSEKKLTLVFEFCDQDLKKYMDSC

PPPGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSRVYSFQM-ALTPVVVTMWYRAPEVLLQA-SYATPVDMWSVGCIFA
   .... .|| .| ||| |... |.|.| |||||||| |.    .||| |||| | .       .  |||.|||.| ||. .  | |..||||.|||||
NG-EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFA

ELY-RRRPLFRGQSDKDQLHKIFEVIGLPPEDQWPDVA-LP-WS----SFRQTGQRS-FLDLVQEICNQGLDLLERMLCFNPDHRMTAEQGLLHGFF
|.    |||| | ...||| .||...| | ||.|| .. || .      .     .  .  .|..   .|.|||..|| .||..|..|...| | .|
EMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK4.AA S_TKc 14-300 30 3.9e-98 333.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-300
Range on HMM: 1-231/231
Sequence Identity: 30% (92 aa)

YVQAAEIGSGAYGIVYKARDTETGHFVALKSVRIPIGEEGMPVSTIREISLLRHLCQLDHPNIVKLLDVCDVMDVGRSEMMLTLVFELVDQ---DLAQYL
|    .||.||.| |||.|...||. ||.| ..          ...|||..|..    .|||||||.||..          | .|.|..|.   || .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK----HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYI

EKCPPPG----LSPCTIKFLMHQLLSGVEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSRVYSFQMALTPVVVTMWYRAPEVLLQASYAT-PVDMWS
.|....|    ... ...|.|.|.....||.|||.. ||||||.|||. .   .|..||||.|..      | ...| ||.|||||   .| . ..|.||
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWS

VGCIFAELYRRRPLFRGQSDKDQLHKIFEVIGLPPEDQWPDVALPWSSFRQTGQRSFLDLVQEICNQGLDLLERMLCFNPDHRMTAEQGLL-------HG
.|||..|.. ..|.|.      |....|..||                                  ...|.....|...|..|.|| . |        | 
CGCILYEMLCGYPPFP------QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

FF
.|
WF
Kinase CDK4.AA CDK7 14-247 42 9.2e-88 233.74 In-house 1-230 (288) Show / Hide 
Range on Protein: 14-247
Range on HMM: 1-230/288
Sequence Identity: 42% (101 aa)

YVQAAEIGSGAYGIVYKARDTETGHFVALKSVR-IPIGEE---GMPVSTIREISLLRHLCQLDHPNIVKLLDVCDVMDVGRSEMMLTLVFELVDQDLAQY
|   . || | .. ||||.|..||  || | .. . . .|   |.  . |||| .|.    . |.|.. |.|.    .       . |||.. | || . 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQ---EMQHDNVIGLIDIFMHKS------NIQLVFDFMDWDL-EV

LEKCPPPGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSRVY-SFQMALTPVVVTMWYRAPEVLLQA-SYATPVDMWSVG
  |     | |  ||  | ..| |.||.| . . |||||| | |. .. .||..|||| | | |   ..|. ||| |||||| |  | .| | |||||||
VIKDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVG

CIFAELYRRRPLFRGQSDKDQLHKIFEVIGLPPEDQWPDV
||||||  | | . |.|| ||| .||. .| | | .||..
CIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNM
Kinase CDK4.AA MAPK 14-300 35 1.1e-87 297.59 In-house 1-328 (328) Show / Hide 
Range on Protein: 14-300
Range on HMM: 1-328/328
Sequence Identity: 35% (119 aa)

YVQAAEIGSGAYGIVYKARDTETGHF------VALKSVRIPIGEEGMPVSTIREISLLRHL-CQLDHPNIVKLLDVCDVM---DVGRSEMMLT--LVFEL
|.    ||.||||.| .|.|..|...      ||.| .  |   .     |.||| ||||. .   |.||.||||.       | .  | . .  .|.||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHH---HENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMEL

VDQDLAQYLEKCPPPGLSPCTIKFLMHQLLSG--VEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSRVYSFQ---------------MALTPVVVTM
 . || | ..  .   ||   |...| |.| |  . |.|| .| |||||| |||| ..  ||. ||||.|.   .               | .|. |.| 
METDLHQIIKSQQ--PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRAPEVLLQ---ASYATPVDMWSVGCIFAELYR-RRPLFRGQSDKDQLHKIFEVIGLPPEDQWPDVA---LPWSSFRQ------TGQRSFLDLVQE---
||||||..|      | . ||||||||||||... |.|||.|..  ||. .|.||.| |.|. .  .     ... ...      . .... ..      
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF

-ICNQGLDLLERMLCFNPDHRMTAEQGLLHGFF
  . | .||||.|| |.||.| |.|. | | .|
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDK4.AA PITSLRE 14-300 39 1.9e-87 296.83 In-house 1-295 (295) Show / Hide 
Range on Protein: 14-300
Range on HMM: 1-295/295
Sequence Identity: 39% (120 aa)

YVQAAEIGSGAYGIVYKARDTETGHFVALKSVRIP--IGEEGMPVSTIREISLLRHLCQLDHPNIVKLLDVCDVMDVGRSEMMLTLVFELVDQDLAQYLE
..    |. |.||.||.|.|..|.  |||| . .      || |.  .|||. .  |  | |||||... .     .|       .|.| |. ||.  .|
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMI--LMALQHPNIVNVKEIV----MGSNMDKIYMVMEYVEHDLKSLME

KCP--PPGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSRVYSFQ-MALTPVVVTMWYRAPEVLL-QASYATPVDMWSVG
.        .|  || || |||.|||..|.. . |||||  |.|      ||. |||| | |    ...||.|||.||||||.|| .  | |||||||||
NMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVG

CIFAELYRRRPLFRGQSDKDQLHKIFEVIGLPPEDQWPDVA-LPWS----SFRQTGQRSFLDLVQ---EICNQGLDLLERMLCFNPDHRMTAEQGLLHGF
|||||.   .||| |.|. ||...||   | | |  ||..  || .    .|..        ...    |  .|.||| .||..||  |.||...| |..
CIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPW

F
|
F
Kinase CDK4.AA Pkinase 14-300 31 5e-84 290.27 Pfam 1-293 (293) Show / Hide 
Range on Protein: 14-300
Range on HMM: 1-293/293
Sequence Identity: 31% (98 aa)

YVQAAEIGSGAYGIVYKARDTETGHFVALKSVRIPIGEEGMPVSTIR--EISLLRHLCQLDHPNIVKLLDVCDVMDVGRSEMMLTLVFELVDQ-----DL
|.    ||||..| |||...  ||. ||.| .. .  ....... .|  ||.....|.   |||||.|.|..      ....   .|.|...      ||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFED----KDHIY--MVMEYCEGGLYVMDL

AQYLE---KCPPPGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLKPQNILVASDKKL----KLTDFGLSRV--YSFQMALTPVVVTMWYRAPEVLL-QAS
. |..   ...   .|. ..|| | |.|.|.||.||... ||||||.|||. ..  .    |..||||...  |  .  .| ...| ||.||||.. .  
FDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

YATPVDMWSVGCIFAELYRRRPLFRGQ----SDKDQLHKIFEVIGLPPEDQWPDV-ALPWSSFRQTGQRSFLDLVQEICNQGLDLLERMLCFNPDHRMTA
| ..|||||.|||..|.. .||.|.|.    .  ||...|... | |.. .||     .... ... . .|. .. ..   ..|.....||..|  | ||
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

EQGLLHGFF
|| | | .|
EQILQHPWF
Kinase CDK4.AA CRK7 14-300 34 2.1e-79 270.09 In-house 1-343 (343) Show / Hide 
Range on Protein: 14-300
Range on HMM: 1-343/343
Sequence Identity: 34% (118 aa)

YVQAAEIGSGAYGIVYKARDTETGHFVALKSVRIPIG---EEGMPVSTIREISLLRHLCQLDHPNIVKLLD-VCDV--MDVGRSEM-MLTLVFELVDQDL
|   ..||.| || ||||....||  |||| ||       .|| |.  |||| .||   ||.|.|||.| . | |   ..  ...     .||| .| ||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILR---QLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDL

AQYLEKCPPPGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSRVYSF---QMALTPVVVTMWYRAPEVLL-QASY-----
.  ||       |.  .| .| ||| |..|.|   . |||.|  |||.    ..|..|||| | |     .  .|  |.| |||.|| ||    |     
MGLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHI

---------------------------------ATPVDMWSVGCIFAELYRRRPLFRGQSDKDQLHKIFEVIGLPPEDQWPDVA-LP-WSSFRQTG--QR
                                  . .||||.|||..||  ..|.|.|.   .|| ||... | |  . ||.|  || |  ...    .|
LKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNR

SFLDLVQE------ICNQGLDLLERMLCFNPDHRMTAEQGLLHGFF
  .  . .      .  . ||||  ||| .|. |.|||. | |..|
RLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK4.AA PFTAIRE 14-300 40 2.2e-74 253.45 In-house 1-287 (287) Show / Hide 
Range on Protein: 14-300
Range on HMM: 1-287/287
Sequence Identity: 40% (120 aa)

YVQAAEIGSGAYGIVYKARDTETGHFVALKSVRIPIGEEGMPVSTIREISLLRHLCQLDHPNIVKLLDVCDVMDVGRSEMMLTLVFELVDQDLAQYLEKC
|..    | | |  |||..   .. ||||| .|.   ||| |   ||| |||.   .| | ||| | |.         .  ||.||| |. ||.||..|.
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQ-EEGTPFTAIREASLLK---NLKHANIVCLHDII------HTKETLTFVFEYVHTDLCQYMDKH

PPPGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSRVYSF-QMALTPVVVTMWYRAPEVLLQAS-YATPVDMWSVGCIFA
 | |. |  ..  . ||| |  | |  || |||||||| |.     ||| |||| |  |         |||.||| | ||| .  | | .||| ||||| 
-PGGMHPNNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFV

ELYRRRPLFRGQ-SDKDQLHKIFEVIGLPPEDQWPDVA-LPWSSFRQTG-----QRSFLDLVQEIC--NQGLDLLERMLCFNPDHRMTAEQGLLHGFF
|.   .|.| |     ||| |||.| | | || || |  ||     . .      ..    .  |   ... ||.  ||  .|  |. |.. . | .|
EMMWGQPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDK4.AA Pkinase_Tyr 14-169 31 2.6e-13 45.68 Pfam 1-159 (270) Show / Hide 
Range on Protein: 14-169
Range on HMM: 1-159/270
Sequence Identity: 31% (53 aa)

YVQAAEIGSGAYGIVYKARDT----ETGHFVALKSVRIPIGEEGMPVST------IREISLLRHLCQLDHPNIVKLLDVCDVMDVGRSEMMLTLVFELVD
 .   ..|.||.| |||.. .    .|.  || |...     ||   .       .||......|.  .|||||.|. ||  .| |..   . .|.|.. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLG--HHPNIVRLYGVC--TDQGEPN-QIYIVMEYMP

Q-DLAQYLEKC--PPPGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSR
  ||  || |   ... |.. ..    .|  .| |||.|..  ||||   |.||..... | .||||.|
HGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase CDK4.AA TyrKc 14-300 21 3.6e-12 -26.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-300
Range on HMM: 1-280/280
Sequence Identity: 21% (71 aa)

YVQAAEIGSGAYGIVYKARDTETGHFVALKSVRIPIGEEGMPVSTIREISL-LRHLCQL--DHPNIVKLLDVCDVMDVGRSE-------MMLTLVFELVD
 .   ..|.||.|.|||.. .     || |...            ....   .| .|.|  .|||||.|. ||      ...         | .|.|...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVC------TQQGRNFMYIEPLMIVMEYMP

Q-DLAQYLEKCPPPGLSPCTIKFLMHQLLSGVEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSRVY----------SFQMA----LTPVVVTMWYRA
  || .|| |. |  |.. .    ..|  .| |||||... ||||   |.||....  | .||||||            .  ..     .  ..     |
HGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEVLLQASYATPVDMWSVGCIFAELYRR-RPLFRG-----QSDKDQLHKIFEVIGLPPEDQ----WPDVALPWSSFRQTGQRSFLDLVQEICNQGL-DLL
||..    . |  | || |    |.. .  .   |      |... .... .   .|. .                       |      .| . . .. 
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------F-----VCCPDEMYQIM

ERMLCFNPDHRMTAEQGLLHGFF
..   ..|. | | ..  .| .|
KQCWHEDPEDRPTFSE--IHECF
Kinase CDK4.AA CDK7 274-300 40 3.8e-10 22.78 In-house 262-288 (288) Show / Hide 
Range on Protein: 274-300
Range on HMM: 262-288/288
Sequence Identity: 40% (11 aa)

LDLLERMLCFNPDHRMTAEQGLLHGFF
|||...|. .||  |.|. | | . .|
LDLMCGMWTMNPCKRWTCTQCLKMPYF