Gene CDK7 (Sea Urchin)

CDK7

Species: Sea Urchin
Alias: Spk134, SPU_027370, CDK7
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK7

Sequence

Name Sequence Type Origin Length Description Download
CDK7.AA Protein None 947 None Fasta, JSON
CDK7.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of CDK7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ASC CDK7.AA ASC 24-530 16 9.9e-69 239.45 Pfam 3-336 (494) Show / Hide 
Range on Protein: 24-530
Range on HMM: 3-336/494
Sequence Identity: 16% (93 aa)

ETSSAHGLPNIHRSSK-SITKLFWLLLFLTGIGVITWQVIALFKTYFAYEYTVSLEIKFNR--SQEFPAITICNMNPVMKSK--LEKAD-------DSFR
.... ||.. | .|.  .. ...||..||  ..   ||.  |.  .. |  ..|...|..   .  |||.|||||||. .||  ... |       .  .
SNTTIHGMRYIFCSKRHWWERFWWLCVFLCSWYMCIWQIYNLWQKWQSYPVITSIDEKYFPVWNIPFPAVTICNMNPYRYSKFNITSVDQQWWHYGMINY

ELFDTNFQPPGPMDMVDQVVQGVGQVGGVFSSGVGSFMGSGGNSGGGVEANNAKTTQRPGSSTAGGRRATDGNVEVAGSVEPPNGPSGPLSSQALCSRHQ
|.....     .|.  .                                                                                   
EMDWFFQATYSFMNYDY-----------------------------------------------------------------------------------

ASGQPPNLREIQQRYGVRNLRGGSMDLYKKGEMSANRGPTQKSMTSKKGVRTLCSPSLYLPLTLSHYVGFRSDLFRGRPSFGCSRANTSITPTRPTRPIT
                                                                                                    
----------------------------------------------------------------------------------------------------

DRAKTYITRPSRESVGFEIGLKAVETWQDRQKGDFFRKQSNDYLK------------------QQRLMVKLANKTIEERKSLGHSLDDMLLDCSWRGFPC
                                            .                     .|  ..|   | .  .||...||...|.|.| ||
-------------------------------------------CFEYGFCDMYDAVDQICEWYNFNYMEFMNNMP-E-KW-MGHPCEDMFKSCRWNGEPC

-SPANFTNIFDPQFGNCYIFNSGLD----------------------GD--TLTTNRPGPNYGLSMELFVQ-QDEYM--EDQT-EV---AGFRVIIHHPS
 .. .|. . .. .|||| ||||                        |.   ....|||..||||. |..| ||||.     | |.   |||.|.||.| 
DCCCDFFHFHHTEYGNCYTFNSGQTEQMYRDNLHRYWNLEEGYKPNQGNWYPWRSSRPGMGYGLSLMLDIQYQDEYYYCC-TTDEQSFEAGFKVMIHDPD

NMPFPSDDGIFVSPGMVTAIGVRVVTAIGVRVVEIE-----RLPEPYGLCKEDTKENIEDNIYYQNYNMSYSIQ
  ||... |. |.||.        .| |.|. ....     |||.|.. | .. ...  .|.|| ..| .||..
EYPFMDQQGFRVPPGF--------ETFISVKPQMTTTSPLRRLPPPWRQCYFNDERV--NNLYYFYFNKIYSQS
Kinase CDK7.AA CDK7 573-834 66 2.2e-255 689.33 In-house 1-288 (288) Show / Hide 
Range on Protein: 573-834
Range on HMM: 1-288/288
Sequence Identity: 66% (191 aa)

YEYIRQDPAYTFATVYKALDLQHDGKIVAVKKIK-LGHRSEAQDGINRTALREIKLLQEIKHENVIG-----------------------VIIKDSSVVL
||.|.......|||||||.|.|.. .|||.|||| |||||||.|||||||.||||.|||..|.||||                       |.|||.|..|
YEKIKHIGEGQFATVYKACDHQTG-QIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIIL

TPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGVLKIGDFGLAKFYGSPNRIYTHQVVTRWYRCPELLFGARIYGTGVDMWAMGCILAELLLR
||.|||||.||.|.||||.|.|||||||.||||||..|||.|||.|||||.|||||||||||||||||||.||||||||.||||||||..|||.|||.||
TPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLR

VPFLPGESDLDQLSRIFQTMGTPSEEEWPNMSALADYIEFKKFPG---TPLRDIFTAGTDDLLTLLKGLLLMDPCRRCKATEALKMPYF
||.|||.||.|||.|||||.|||.|||||||....|||.||.|||   ||||.||||..||||.|..|...|.||.|...|..||||||
VPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK7.AA CDK 573-834 37 5.2e-133 427.96 In-house 1-284 (284) Show / Hide 
Range on Protein: 573-834
Range on HMM: 1-284/284
Sequence Identity: 37% (118 aa)

YEYIRQDPAYTFATVYKALDLQHD----GKIVAVKKIKLGH--RSEAQDGINRTALREIKLLQEIKHENVIG----VIIKDSS-----------------
|| . .    |...|||| |.| .    |.||| |||.. .  |.|. .|.. ||.|||.||.|. |.|..     .. |...                 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

------VVLTPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGV-----LKIGDFGLAKFYGS------PNRIYTHQVVTRWYRCPELLFGARI
       ..    || |... ||||.|.| |||.|||.||.|.|...||.     |||.|||||. .|.      ||| |||.|||.||| ||||.|...
MDHDLKKYMD---IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKH

YG--TGVDMWAMGCILAELLL---RVPFLPGESDLDQLSRIFQTMGTPSEEEWPNMSALADYIEFKKFPGTPLRDIFTAGTDDLLTLLKGLLLMDPCRRC
|.  |..|||. |||.||...   | |..||.|..||| .||...|||.|. ||... | ||                        || ..| .||..|.
YSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------DLLNKMLCYDPKKRI

KATEALKMPYF
.|..||..|||
SAEQALQHPYF
Kinase CDK7.AA CMGC 573-834 23 7.6e-110 362.29 In-house 1-513 (513) Show / Hide 
Range on Protein: 573-834
Range on HMM: 1-513/513
Sequence Identity: 23% (123 aa)

YEYIRQDPAYTFATVYKALDLQHD-------------GKIVAVKKIKLGHRSE-------AQDGINRTALREIKLLQEIK-----------------HEN
|| |..    |...|||. | . .             ..|||.||||. .  |       . ||....||||||.|....                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VI---------------------------GV-------------IIKDSS--------VVLTPSH------------IKAYT------MMALRGLE--YL
..                            .             .||. .        . |.. |            || ..       . ||||.  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HANW--ILHRDMKPNNLLLDEN--------------------GVLKIGDFGLAKFYGSP---------------------NRIYTHQVVTRWYRCPELLF
| .|  |.|||.|| |.|...|                    |.|||.|||||..|...                     || |||.||||||| ||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GARIY---------GTGVDMWAMGCILAELLLR--------VPFLPGESD-----------LDQLSRIFQTMGTPS---------------EEEWPNMSA
|.. |         .|..|||. |||.||....         |. ||.|.           .||| .||...|||.               |||||||. 
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LADYIE---------------------------FKKFPGTPLRDIFTA-----------------------------------GTDDLLTLLKGLLLMDP
| .|.                            |...|. |....|                                      ..... |||..| .||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

CRRCKATEALKMPYF
 .| .| .||..|||
DKRITAEQALQHPYF
Kinase CDK7.AA CDC2 647-834 40 4.6e-83 255.05 In-house 99-301 (301) Show / Hide 
Range on Protein: 647-834
Range on HMM: 99-301/301
Sequence Identity: 40% (83 aa)

VLTPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGVLKIGDFGLAKFYGSPNRIYT--HQVVTRWYRCPELLFGARIYGTGVDMWAMGCILAE
...|. .| |..  |.|....|.. |.||| || |.|.|..|..||.|||||.  | | | ||  | |||.||| ||.|.|.. | |.||||. |||.||
HMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAE

L---LLRVPFLPGESDLDQLSRIFQTMGTPSEEEWPNMSALADYIE-FKKFPGTPLRDIFTA---------GTDDLLTLLKGLLLMDPCRRCKATEALKM
.     . |. .|.|  ||| .||...|||.|..||... | || . | ... . |..|.            ... . ||. .|  || .| .| |||. 
MFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

PYF
|||
PYF
Kinase CDK7.AA CDK5 661-834 43 2.3e-76 240.71 In-house 108-287 (287) Show / Hide 
Range on Protein: 661-834
Range on HMM: 108-287/287
Sequence Identity: 43% (78 aa)

LRGLEYLHANWILHRDMKPNNLLLDENGVLKIGDFGLAKFYGSPNRIYTHQVVTRWYRCPELLFGARIYGTGVDMWAMGCILAELL-LRVPFLPGESDLD
|.||.. |.. .||||.|| |||   || || .|||||  .| | | |.| ||| ||| |  |.|.. | | .||| .|||.||.     |  || .. |
LKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVED

QLSRIFQTMGTPSEEEWPNMSALADYI----EFKKFPGTP-LRDIFTAGTDDLLTLLKGLLLMDPCRRCKATEALKMPYF
|| |||. ||||.|..|| .. | ||     .. ..|... .  |       .. ||...| ..|  |  | .||. |||
QLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK7.AA PITSLRE 649-834 45 1.2e-73 250.97 In-house 104-295 (295) Show / Hide 
Range on Protein: 649-834
Range on HMM: 104-295/295
Sequence Identity: 45% (87 aa)

TPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGVLKIGDFGLAKFYGSPNRIYTHQVVTRWYRCPELLFGARIYGTGVDMWAMGCILAELLLR
.|. ||  .   ||| |..| |||.||| |  |||.  .|.|||.|||||  |||| . ||  ||| ||| |||| |...| | ||||  |||.||... 
KPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITM

VPFLPGESDLDQLSRIFQTMGTPSEEEWPNMSAL--ADYIE-FKKFPGTPLRDIFT---AGTDDLLTLLKGLLLMDPCRRCKATEALKMPYF
 | ..|.|..||. .||. ||||.|  ||  . |  . ... |.. |   || .|      .|  . || ..|  .| .|  |..||| |.|
KPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK7.AA CCRK 640-834 46 3.8e-67 229.39 In-house 88-285 (285) Show / Hide 
Range on Protein: 640-834
Range on HMM: 88-285/285
Sequence Identity: 46% (92 aa)

IIKDSSVVLTPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGVLKIGDFGLAK-FYGSPNRIYTHQVVTRWYRCPELLFGARIYGTGVDMWAM
.....   |..  .|.| .| |.|. . |.| |.|||.|| |||. | | ||| |||||. |     | ||||| ||||| ||||.||| |  |||.||.
VVRHAQRPLAEAQVKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADFGLARVFSNDEGRQYTHQVATRWYRAPELLYGARQYDQGVDLWAV

GCILAELLLRVPFLPGESDLDQLSRIFQTMGTPSEEEWPNMSALADY--IEFKKFPGTPLRDIFTAGTDDLLTLLKGLLLMDPCRRCKATEALKMPYF
|||. |||   |  ||| |..||  .   .|||..  ||.|  | ||  | ||  |  || ..      . | |||  |.  |  |  | .||  .||
GCIMGELLNNSPIFPGENDIEQLCCVLRILGTPTPKVWPEMKDLPDYNKISFKEQPPMPLEQVVPDASPQALDLLKQFLVYPPRQRIAASQALLHQYF
Kinase CDK7.AA CDK-Unclassified 661-834 36 2.8e-64 210.32 In-house 131-324 (324) Show / Hide 
Range on Protein: 661-834
Range on HMM: 131-324/324
Sequence Identity: 36% (72 aa)

LRGLEYLHANWILHRDMKPNNLLLDENG-----VLKIGDFGLAKFYG------------SPNRIYTHQVVTRWYRCPELLFGARIYGTGVDMWAMGCILA
| |. ||| | | ||| || |.... |.     .|||.|||.| ||              |.. |. ||.||||| |||||| . |.||||.|. |||.|
LEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVSTRWYRAPELLFGSKCYDTGVDIWSFGCIYA

ELLLRVPFLPGESDLDQLSRIFQTMGTPSEEEWPNMSALADY--IEFKKFPGTP---LRDIFTAGTDDLLTLLKGLLLMDPCRRCKATEALKMPYF
|.. ..| ..| ....|.. ||...|||.|. ||... . ||  | ||  ..     .   ..  ..  . .. ...  .|  | |. |.|. |.|
EWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASE--NNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase CDK7.AA CDK10 649-834 43 3.9e-61 209.43 In-house 98-285 (285) Show / Hide 
Range on Protein: 649-834
Range on HMM: 98-285/285
Sequence Identity: 43% (82 aa)

TPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGVLKIGDFGLAKFYGSPNRIYTHQVVTRWYRCPELLFGARIYGTGVDMWAMGCILAELLLR
| ...|  ..  |||| ||| |...|||.|  |||. ..| .|. |||||. || | .  | ..|| ||| ||||.|.|   | .||||.||||.|||. 
TETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVH

VPFLPGESDLDQLSRIFQTMGTPSEEEWPNMSALADYIEF--KKFPGTPLRDIFTAGTDDLLTLLKGLLLMDPCRRCKATEALKMPYF
 | .|| |.. |.  | . .|||||. ||  | |    .|  || |   |.  |.   .  . ||. |.. .| .|  | |.|.  ||
KPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK7.AA MAPK 661-834 36 4.6e-58 199.22 In-house 125-328 (328) Show / Hide 
Range on Protein: 661-834
Range on HMM: 125-328/328
Sequence Identity: 36% (74 aa)

LRG--LEYLHANWILHRDMKPNNLLLDENGVLKIGDFGLAKFYGS-PNRIY-------------THQVVTRWYRCPELLFG--ARIYGTGVDMWAMGCIL
|||  | |.|   ..||| || |.|..||. |||.|||||    .  . ..             |  |.||||| ||....  .. | ..||||. |||.
LRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIF

AELLL-RVPFLPGESDLDQLSRIFQTMGTPSEEEWPNMS---ALADYIE----FKKFPGTPLRDIFTA----GTDDLLTLLKGLLLMDPCRRCKATEALK
||.|  | |..||.. .||. .|....|||||| . ...   . ..||.    ..| |. |....|       ... . ||. .| .|| .|  . ||| 
AEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQ

MPYF
 |||
HPYF
Kinase CDK7.AA S_TKc 573-834 26 3.7e-57 197.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 573-834
Range on HMM: 1-231/231
Sequence Identity: 26% (79 aa)

YEYIRQDPAYTFATVYKALDLQHDGKIVAVKKIKLGHRSEAQDGINRTALREIKLLQEIKHENVI-------------------G-------VIIKDSS-
|| .|.    .|..|||. .   .|.|||.|.||            ....|||..|.. .|.|..                   |       .| |  . 
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRH

---VVLTPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGVLKIGDFGLAKFYGSPNRIYTHQVVTRWYRCPELLFGARIYGT-GVDMWAMGCI
   ..... |.. |.   ...|||.| ..|.||| || |.||||  ..||.|||||...       |....|.||. ||.|     ||.  .|.|. |||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

LAELLLRVPFLPGESDLDQLSRIFQTMGTPSEEEWPNMSALADYIEFKKFPGTPLRDIFTAGTDDLLTLLKGLLLMDPCRRCKATEALK-------MPYF
|.|.| . |  |      |. ..|. .|                                  ..... .....| .|| .|  | |||.       .|.|
LYEMLCGYPPFP------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDK7.AA Pkinase 641-834 33 3.5e-56 197.77 Pfam 95-293 (293) Show / Hide 
Range on Protein: 641-834
Range on HMM: 95-293/293
Sequence Identity: 33% (70 aa)

IK-DSSVVL--TPSHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGVL----KIGDFGLAKFY-GSPNRIYTHQVVTRWYRCPELLFGARIYGTG
|. ... ..  .. ..| |    ||||||.|...|.|||.|| |.|.|.||..    ||.||||||..   .|. .|. ..|.||. ||.. |.. ||. 
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

VDMWAMGCILAELLLRVPFLPGE----SDLDQLSRIFQTMGTPSEEEWPNMSALADYIEFKKFPGTPLRDIFTAGTDDLLTLLKGLLLMDPCRRCKATEA
||||..||||.|.|.. |  ||.    . .||. .|...||.| ...||. .   ..  |.  . ....   .. ..... ..|..| .|| .|. |...
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

LKMPYF
|. |.|
LQHPWF
Kinase CDK7.AA CDC2 583-637 44 1.1e-15 44.17 In-house 11-64 (301) Show / Hide 
Range on Protein: 583-637
Range on HMM: 11-64/301
Sequence Identity: 44% (25 aa)

TFATVYKALDLQHDGKIVAVKKIKLGHRSEAQDGINRTALREIKLLQEIK-HENVI
|.  |||. |.| .  |||.|||.| . .|   |.  ||.||| .|.|.| |.|..
TYGVVYKCKDMQTNQ-IVALKKIRLEQEDEGD-GVPSTAIREISCLKELKDHPNIV
Kinase CDK7.AA CDK5 573-637 40 1.8e-13 38.47 In-house 1-61 (287) Show / Hide 
Range on Protein: 573-637
Range on HMM: 1-61/287
Sequence Identity: 40% (26 aa)

YEYIRQDPAYTFATVYKALDLQHDGKIVAVKKIKLGHRSEAQDGINRTALREIKLLQEIKHENVI
|| .      |..|||||.. .  . ||| |...|    |   |.  ||.||| ||.|.||.|..
YEKMEKIGEGTYGTVYKARN-KETHEIVALKRVRLDSEDE---GVPSTAIREICLLKELKHKNIV
Kinase CDK7.AA TyrKc 584-834 18 5.7e-10 -61.43 SMART 12-280 (280) Show / Hide 
Range on Protein: 584-834
Range on HMM: 12-280/280
Sequence Identity: 18% (57 aa)

FATVYKALDLQHDGKIVAVKKIKLGHRSEAQDGINRTALREIKLLQEI--KHENVI---GVIIKD----------------------------SSVVLTP
| .|||.         ||||..| ..         .  .||.... ..  .|.|..   ||....                            .   |..
FGEVYKGTWK----IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

SHIKAYTMMALRGLEYLHANWILHRDMKPNNLLLDENGVLKIGDFGLAKFYGSP------NRIYT------HQ--VVTRWYRCPELLFGARIYGTGVDMW
..   .   . .| |||| . . |||    | |..||.. ||.||||... ..          |.          .  ||.  || .   ... |  | |
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFTTKSDVW

AMGCILAELLLRVPFLPGE--------SDLDQLSRIFQTMGTPSEEEWPNMSALADYIEFKKFPGTPLRDIFTAGTDDLLTLLKGLLLMDPCRRCKATEA
. |  . |.. .    . .        ... .. .    |  | . . | ||                   |   .|.. .. |     ||  |.  .| 
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI

LKMPYF
    .|
--HECF
Kinase CDK7.AA MAPK 584-640 30 1.7e-09 28.81 In-house 12-71 (328) Show / Hide 
Range on Protein: 584-640
Range on HMM: 12-71/328
Sequence Identity: 30% (20 aa)

FATVYKALDLQ-----HDGKIVAVKKIK--LGHRSEAQDGINRTALREIKLLQEI-KHENVIGVI
. .| .| |        .||.||.|||     .   ..      ..||||||... .|||.|...
YGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK-----RTYREIKLLRHFHHHENIIKLL
Kinase CDK7.AA PITSLRE 583-639 37 2.1e-09 30.61 In-house 11-66 (295) Show / Hide 
Range on Protein: 583-639
Range on HMM: 11-66/295
Sequence Identity: 37% (22 aa)

TFATVYKALDLQHDGKIVAVKKIKLGHRSEAQDGINRTALREIK-LLQEIKHENVIGV
|.  ||.| | . |  ||| |..|.. . |  .|.  |.||||. .| ...|.|.. |
TYGVVYRAKDKRTD-EIVALKRLKMERQKE-KEGFPITSLREINMILMALQHPNIVNV
Kinase CDK7.AA CDK10 573-637 35 6.9e-09 26.78 In-house 1-61 (285) Show / Hide 
Range on Protein: 573-637
Range on HMM: 1-61/285
Sequence Identity: 35% (23 aa)

YEYIRQDPAYTFATVYKALDLQHDGKIVAVKKIKLGHRSEAQDGINRTALREIKLLQEIKHENVI
.| .      |.  ||.| | . |  |||.||...    . .||.   .||||.|| ...|||..
FEKLNRVGEGTYGIVYRARDMRSD-EIVALKKVRM---DKEKDGLPISGLREIMLLIQCRHENIV
Kinase CDK7.AA CDK-Unclassified 573-637 30 5.3e-08 22.28 In-house 1-71 (324) Show / Hide 
Range on Protein: 573-637
Range on HMM: 1-71/324
Sequence Identity: 30% (23 aa)

YEYIRQDPAYTFATVYKALDLQHDGKIVAVKKIKLGHRSEAQD----------GINRTALREIKLLQEIKHENVI
|. ..     ||. |.||.|.|   |.|| ||| .   .   .           .  |..|||..||  .|.|.|
YRMQCKYGEGTFGCVCKAIDFQTQ-KHVAIKKIMV---NNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNII
Kinase CDK7.AA Pkinase 583-640 34 2.5e-07 27.01 Pfam 11-66 (293) Show / Hide 
Range on Protein: 583-640
Range on HMM: 11-66/293
Sequence Identity: 34% (20 aa)

TFATVYKALDLQHDGKIVAVKKIKLGHRSEAQDGINRTALREIKLLQEIKHENVIGVI
.|..|||. . . .|||||||.||. |... .| ..| . .||.......|.|..  .
SFGCVYKCHH-KGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLY
Kinase CDK7.AA CCRK 597-631 57 4e-06 16.81 In-house 24-55 (285) Show / Hide 
Range on Protein: 597-631
Range on HMM: 24-55/285
Sequence Identity: 57% (20 aa)

GKIVAVKKIKLGHRSEAQDGINRTALREIKLLQEI
| |||.||. |      .|||  .|||||| ||||
GEIVALKKVAL---RRLDDGIPNQALREIKALQEI
Kinase CDK7.AA Pkinase_Tyr 662-699 50 2.3e-05 18.77 Pfam 122-159 (270) Show / Hide 
Range on Protein: 662-699
Range on HMM: 122-159/270
Sequence Identity: 50% (19 aa)

RGLEYLHANWILHRDMKPNNLLLDENGVLKIGDFGLAK
.|.|||... . |||    | |..||.| ||.|||||.
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
ASC CDK7.AA ASC 556-587 34 0.000114 16.49 Pfam 437-468 (494) Show / Hide 
Range on Protein: 556-587
Range on HMM: 437-468/494
Sequence Identity: 34% (11 aa)

WTRSNMAKLEIYFDEFNYEYIRQDPAYTFATV
. |.| |...||. | ||| .....||.....
YYRENIAMVHIYYEELNYETYKRSEAYGWTDL