Gene CDK8 (Sea Urchin)

CDK8

Species: Sea Urchin
Alias: CDK8, Spk133, SPU_001690
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK8

Sequence

Name Sequence Type Origin Length Description Download
CDK8.AA Protein None 681 None Fasta, JSON
CDK8.kin_dom Protein Kinase Domain None 451 None Fasta, JSON

Protein domain

Protein domains of CDK8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK8.AA CDK8 26-263 75 4.2e-217 688.1 In-house 1-256 (329) Show / Hide 
Range on Protein: 26-263
Range on HMM: 1-256/329
Sequence Identity: 75% (194 aa)

K-VGRGTYGHVYKATTKKE---PKKEYALKQI----------EGTGISMSACREVALLRELRHPNVICLRRVFLSHSDRKVYLLCDFSEHDLWHIIKYHR
| .|||||||||||..||.   |.|||||||.          ||||||||||||.||.|||.|||||||.||||.|.|..|..|.|..|||||||||.||
KYIGRGTYGHVYKAKRKKQKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWMLFDYAEHDLWHIIKFHR

ANKASKKGPTSVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSE--RGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGAR
.|||..|.||.||  ||||...||||||||||||||||||||||||.|||.|.|  .|.||||||||||.|..|||||.|||||||||||||||||||||
HNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGAR

HYTKAIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPQ
||||||||||||||||||.||||||||..|  ||||.||||||||||||.||||||
HYTKAIDIWAIGCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFPQ
Kinase CDK8.AA CDK8 264-476 77 5e-195 617.64 In-house 112-329 (329) Show / Hide 
Range on Protein: 264-476
Range on HMM: 112-329/329
Sequence Identity: 77% (170 aa)

VPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSE--RGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAI
||  ||||...||||||||||||||||||||||||.|||.|.|  .|.||||||||||.|..|||||.||||||||||||||||||||||||||||||||
VPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGARHYTKAIDIWAI

GCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIKKMPEHGNLMKDFRR-SNYASCCLPKYMEKHKVPKDSKAFQLLSKLLT
|||||||.||||||||..|  ||||.||||||||||||.||||||.|.|.|||||||| .||||||| ..|..|.|..||||||...||.|..||.|.||
GCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFPQDKMWPDIKKMPEHQRLMKDFRRMQTYPNCSLHWYMEKHKIKRDSHAYHLLYKMLT

MDPTKRMTSEQAMEDQYF
||||||.|.|||||..||
MDPTKRITCEQAMEHPYF
Kinase CDK8.AA CDK 22-262 36 1.4e-125 403.81 In-house 1-244 (284) Show / Hide 
Range on Protein: 22-262
Range on HMM: 1-244/284
Sequence Identity: 36% (101 aa)

FEGCK-VGRGTYGHVYKATTKK----EPKKEYALKQI---------EGTGISMSACREVALLRELRHPNVICLRRVFLSHS---------DRKVYLLCDF
.| .. .|.||||.||||  |.    .... .|||.|         |..|....|.||..||.|| |||...|. |.....         ..|.|.  ..
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

SEHDLWHIIKYHRANKASKKGPTSVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSE-RGRVKIADMGFARLFNSPLK---PLADLDPVV
 .|||.....                   .|....|.|.|.||.||||..||||||.|||..  |.. .||.||||.|.||.|..|..   |.  ....|
MDHDLKKYMD-------------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEV

VTFWYRAPELLLGARHYT--KAIDIWAIGCIFAELLT---SEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFP
|| ||||||||||..||.   .||.|..||||||..|    .|.|....|         .|||..||...| |
VTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE---------IDQLFKIFRICGTP
Kinase CDK8.AA CDK 269-476 38 1.9e-107 344.85 In-house 110-284 (284) Show / Hide 
Range on Protein: 269-476
Range on HMM: 110-284/284
Sequence Identity: 38% (84 aa)

VKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSE-RGRVKIADMGFARLFNSPLK---PLADLDPVVVTFWYRAPELLLGARHYT--KAIDIWAIG
.|....|.|.|.||.||||..||||||.|||..  |.. .||.||||.|.||.|..|..   |.  ....||| ||||||||||..||.   .||.|..|
IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVG

CIFAELLT---SEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIKKMPEHGNLMKDFRRSNYASCCLPKYMEKHKVPKDSKAFQLLSKLLTM
|||||..|    .|.|....|         .|||..||...| | |..| ...|.|..                                 .||.|.|..
CIFAEMFTDVTRKPLFPGDSE---------IDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------------DLLNKMLCY

DPTKRMTSEQAMEDQYF
||.||...|||....||
DPKKRISAEQALQHPYF
Kinase CDK8.AA CMGC 22-262 26 8.9e-98 321.89 In-house 1-373 (513) Show / Hide 
Range on Protein: 22-262
Range on HMM: 1-373/513
Sequence Identity: 26% (99 aa)

FEGCK-VGRGTYGHVYKATTK-------------KEPKKEYALKQIE-------------GTGISMSACREVALLRELR-----------------HPNV
.|  | .|.|||| |||.. |             .| ....|.| |              ..|....|.||. .|..|.                 |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

ICLRRVFLSHS---------------DRKVYLLCDFSEHDLWHIIKYHRANKASKKGPTSVPPV-----------MVKSLL------YQILDGIH--YLH
..|. .| ..                ....||  .. .|||...|| .. ..  |..    . .           ..|...      |||| |..  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SNW--VLHRDLKPANILVMGEGSE----------------RGRVKIADMGFARLFNSPLKP------------------LADLDPVVVTFWYRAPELLLG
|.|  ..||||||.|||.  ..                  .||.||.| |.|| .... ..                  .  . . ||| ||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

ARHYT---------KAIDIWAIGCIFAELLTS--------EPIFHCRQE----DIKTSNPYHHDQLDRIFNVMGFP
..|||         ..||.|..||||||..|         .|.|. . |    | | .   | |||..||.|.| |
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDD-K-NGKSHIDQLFKIFKVLGTP
Kinase CDK8.AA CMGC 265-476 26 2.6e-89 293.56 In-house 172-513 (513) Show / Hide 
Range on Protein: 265-476
Range on HMM: 172-513/513
Sequence Identity: 26% (91 aa)

PPVMVKSLL------YQILDGIH--YLHSNW--VLHRDLKPANILVMGEGSE----------------RGRVKIADMGFARLFNSPLKP-----------
|| ..|...      |||| |..  |.||.|  ..||||||.|||.  ..                  .||.||.| |.|| .... ..           
PPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKN

-------LADLDPVVVTFWYRAPELLLGARHYT---------KAIDIWAIGCIFAELLTS--------EPIFHCRQE----DIKTSNPYHHDQLDRIFNV
       .  . . ||| ||||||.|||..|||         ..||.|..||||||..|         .|.|. . |    | | .   | |||..||.|
VNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDD-K-NGKSHIDQLFKIFKV

MGFPQ---------------EKDWEDIKKMPEHGN-------------LMKDFRRSNYASCCLPKYMEKHKVP---------------------------
.| |                |..| ...|.|.. .             .... |.     . .|..  |.  .                           
LGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFK

------------KDSKAFQLLSKLLTMDPTKRMTSEQAMEDQYF
             |..|. ||.|.|..||.||.| |||..  ||
SHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase CDK8.AA CDK7 26-262 38 8.1e-79 209.42 In-house 6-222 (288) Show / Hide 
Range on Protein: 26-262
Range on HMM: 6-222/288
Sequence Identity: 38% (94 aa)

KVGRGTYGHVYKATTKKEPKKEYALKQIE--------GTGISMSACREVALLRELRHPNVICLRRVFLSHSDRKVYLLCDFSEHDLWHIIKYHRANKASK
..| |... ||||. ..   .  | | |           || ..| ||. .|.|..|.||| |. .|   |   ..|  || . || ..||         
HIGEGQFATVYKACDHQTG-QIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSN--IQLVFDFMDWDLEVVIKDKSI-----

KGPTSVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDI
       |  .|.   ..| |. |.| ||.||||||| | |.    .| |..|||| | || . || . .    . ||| |||||||| |||||. ..|.
----ILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLM----NENGQLKIADFGLARFYGSPNRIYT---HQVVTRWYRAPELLFGARHYGTGVDM

WAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFP
|..|||||||.   |..   . ||        ||| |||. .| |
WSVGCIFAELMLRVPYLPG-DSDI--------DQLTRIFQTLGTP
Kinase CDK8.AA CDC2 26-235 39 2e-76 234.24 In-house 6-210 (301) Show / Hide 
Range on Protein: 26-235
Range on HMM: 6-210/301
Sequence Identity: 39% (89 aa)

KVGRGTYGHVYKATTKKEPKKEYALKQI------EGTGISMSACREVALLRELR-HPNVICLRRVFLSHSDRKVYLLCDFSEHDLWHIIK-YHRANKASK
|.| ||||.|||.  ..  .   |||.|      || |.  .| ||  .| ||. |||...|. |. .   .|.|.  .. ..||    . .   |    
KIGEGTYGVVYKCKDMQTNQ-IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN----

KGPTSVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPV--VVTFWYRAPELLLGARHYTKAI
   ...||  |||..||||.|.|..|.. ..|||||| |||.    .. |..||||.| || |. |....    .   ||| ||||||.|||...|. ..
---KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILI----DKKGNIKIADFGLARAFGIPIRTYT---TEHEVVTLWYRAPEILLGCKRYSTPV

DIWAIGCIFAEL---LTSEPIFH
|.|.|||||||.    | .|.||
DMWSIGCIFAEMFMDVTKKPLFH
Kinase CDK8.AA CDC2 263-476 37 8.1e-75 229.23 In-house 99-301 (301) Show / Hide 
Range on Protein: 263-476
Range on HMM: 99-301/301
Sequence Identity: 37% (83 aa)

QVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPV--VVTFWYRAPELLLGARHYTKAIDIWA
..||  |||..||||.|.|..|.. ..|||||| |||.    .. |..||||.| || |. |....    .   ||| ||||||.|||...|. ..|.|.
HMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILI----DKKGNIKIADFGLARAFGIPIRTYT---TEHEVVTLWYRAPEILLGCKRYSTPVDMWS

IGCIFAEL---LTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIKKMPEHGNLMKDFRRSNYASCCLPKYMEKHKVPKDSKAFQLLSKLL
|||||||.    | .|.||   | |        ||| .|| ..| | |..|......|.  |    .....  . |  .. .|.    | ....||...|
IGCIFAEMFMDVTKKPLFHGDSE-I--------DQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQML

TMDPTKRMTSEQAMEDQYF
  || || ....|..  ||
QYDPQKRISAKEALQHPYF
Kinase CDK8.AA PITSLRE 269-476 38 1.2e-66 227.79 In-house 108-295 (295) Show / Hide 
Range on Protein: 269-476
Range on HMM: 108-295/295
Sequence Identity: 38% (80 aa)

VKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAEL
.|.|. | | |....|.||..||||| .|.|     |  |  ||.| | || . ||.||.    |.||| ||||||||||.. |. ..|.| .||||||.
IKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLY----SHKGILKICDFGLAREYGSPIKPYT---PCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

LTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIKKMPEHGNLMKDFR-RSNYASCCLPKYMEKHKVPKDSKAFQLLSKLLTMDPTKRMTS
.| .|.|  . |          ||...||. || | || | .....|    ..| .   ..|  . | |     .   |  .| || ..|| .|..|.| 
ITMKPLFQGKSE---------IDQINCIFKEMGTPTEKIWPGWTELP----HWKMMNNFPHYPYNNLRKRFPAENHISD-TGFDLLNQMLTYNPKNRITA

EQAMEDQYF
..|. . .|
SDALKHPWF
Kinase CDK8.AA CDK7 269-416 44 2.3e-63 167.44 In-house 104-235 (288) Show / Hide 
Range on Protein: 269-416
Range on HMM: 104-235/288
Sequence Identity: 44% (66 aa)

VKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAEL
.|.   ..| |. |.| ||.||||||| | |.    .| |..|||| | || . || . .    . ||| |||||||| |||||. ..|.|..|||||||
IKAYMMMTLQGLEYCHRNWILHRDLKPNNLLM----NENGQLKIADFGLARFYGSPNRIYT---HQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAEL

LTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIKKMPE
.   |..   . ||        ||| |||. .| | |..| .. .|..
MLRVPYLPG-DSDI--------DQLTRIFQTLGTPTEEEWPNMCCMMD
Kinase CDK8.AA CDK5 26-264 37 2.6e-63 198.69 In-house 6-221 (287) Show / Hide 
Range on Protein: 26-264
Range on HMM: 6-221/287
Sequence Identity: 37% (92 aa)

KVGRGTYGHVYKATTKKEPKKEYALKQI----EGTGISMSACREVALLRELRHPNVICLRRVFLSHSDRKVYLLCDFSEHDLWHIIKYHRANKASKKGPT
|.| |||| ||||   || .  .|||..    |  |.  .| ||..||.||.|.|.. |  |   ||..|  |   |   ||   .              
KIGEGTYGTVYKA-RNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVI--HSEKKLTLVFEFCDQDLKKYMDSCNG---------

SVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIG
 . . ..||..|| | |. . |.. |||||||| | |.    . .|  | || | || |  | .        ||| |||.|  |.|..||.  ||.| .|
EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLI----NKNGELKLADFGLARAFGIPVRCYSH---EVVTLWYRPPDVLMGSKHYSTSIDMWSCG

CIFAELL-TSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQV
|||||.  .  | |   ...         ||| ||| .|| | .
CIFAEMANAGRPLFPGNDVE---------DQLKRIFKIMGTPCE
Kinase CDK8.AA PITSLRE 26-262 36 1e-59 204.69 In-house 6-226 (295) Show / Hide 
Range on Protein: 26-262
Range on HMM: 6-226/295
Sequence Identity: 36% (89 aa)

KVGRGTYGHVYKATTKKEPKKEYALKQIEGT------GISMSACREVA-LLRELRHPNVICLRRVFLSHSDRKVYLLCDFSEHDLWHIIKYHR-ANKASK
... |||| ||.|  |.      ||| .         |.   . ||.  .|..|.|||.. .... .     |.|.  .. ||||  ..  ..  |.  |
RIHEGTYGVVYRAKDKRT-DEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRNQPFK

KGPTSVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDI
 |        .|.|. | | |....|.||..||||| .|.|     |  |  ||.| | || . ||.||.    |.||| ||||||||||.. |. ..|.
PG-------EIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLY----SHKGILKICDFGLAREYGSPIKPYT---PCVVTLWYRAPELLLGCKKYSTPVDM

WAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFP
| .||||||..| .|.|  . |          ||...||. || |
WSVGCIFAEFITMKPLFQGKSE---------IDQINCIFKEMGTP
Kinase CDK8.AA Pkinase 26-251 29 1.4e-59 209.03 Pfam 6-229 (293) Show / Hide 
Range on Protein: 26-251
Range on HMM: 6-229/293
Sequence Identity: 29% (70 aa)

KVGRGTYGHVYKATTKKEPKKEYALKQIEGTGISMSACR------EVALLRELRHPNVICLRRVFLSHSDRKVYLLCDFSEH-----DLWHIIKYHRANK
|.|.|..| |||.. |...| ..|.|.|.  ..... ..      |......|.|||.. |...| .  ....|.  .. |.     ||...|.      
KIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-----

ASKKGPTSVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKA
 ...|. . ..  .|. .|||| |. |.||....||||||.|||.  .|    .|||.| |.|..|.  . .   .. ...| ||.|||...|...|...
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDIWAIGCIFAELLTSEPIFH--CRQEDIKTSNPYHHDQ
.|.|..|||..|.|. .|.|   | ..|   .  . ...
VDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICR
Kinase CDK8.AA CRK7 269-476 29 5e-58 198.64 In-house 114-343 (343) Show / Hide 
Range on Protein: 269-476
Range on HMM: 114-343/343
Sequence Identity: 29% (74 aa)

VKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHY----------------
.|... |.|.|. |.| . .||||.| .|||.      .| ||||| | |||.||  |  ...   |.| |||.||||||. .|                
CKCFMKQLLEGMDYCHKKNFLHRDIKCSNILM----NNQGEVKIADFGLARLYNSEEK-RRPYTNRVITLWYRPPELLLGEERYTEQHILKELIRNIKSI

----------------------TKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIKKMPEHGNLMKDFRRSNYA
                      ...||.|  |||..||.| .|||  ..|          .||. |. ..| |    | .. |.|    ..    . .| 
QLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNE---------MAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKP---KRQYN

SCCLPKYMEKHK-VPKDSKAFQLLSKLLTMDPTKRMTSEQAMEDQYF
.  .    .. | |  ......|| |.|..||.||.| |.. . ..|
RRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK8.AA CDK5 268-476 35 8.6e-57 177.75 In-house 99-287 (287) Show / Hide 
Range on Protein: 268-476
Range on HMM: 99-287/287
Sequence Identity: 35% (75 aa)

MVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAE
..||..|| | |. . |.. |||||||| | |.    . .|  | || | || |  | .        ||| |||.|  |.|..||.  ||.| .||||||
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLI----NKNGELKLADFGLARAFGIPVRCYSH---EVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAE

LL-TSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIKKMPEHGNLMKDFRRSNYASCCLPKYMEKHKVPKDSKAFQLLSKLLTMDPTKRMT
.  .  | |   ...         ||| ||| .|| | |  |  | |.|.   .....   . |   . .   |     |.|   ||.|.| ..| .|..
MANAGRPLFPGNDVE---------DQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYP-AHQSWQQIVPK----LDEKGMDLLQKMLQCNPNQRIS

SEQAMEDQYF
 ..|.. .||
AKAALHHPYF
S_TKc CDK8.AA S_TKc 21-252 25 4.2e-53 183.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-252
Range on HMM: 1-231/231
Sequence Identity: 25% (68 aa)

DFEGCKVGRGTYGHVYKATTKKEPKKEYALKQIEGTGISMSACREVALLRELRHPNVICLRRVFLSHSDRKVYLLCDFSEH---DLWHIIKYHRANKASK
   . |.|.|..| |||.. ||  ....|.|.|       ...||...|.. .|||.. |  || .    ..|.  .. ..   || ..|| .. ..   
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL--

KGPTSVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK-AID
  .   |. ......|||.... |.||....||||||.|||.        ..||.| |.||..          . ...| ||.|||.|    .|.| ..|
--RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCD

IWAIGCIFAELLTSEPIFHCRQEDIK------------------TSNPY--------H-------HDQL
.|..|||..|.|. .| |.   .. .                  . .|         .       |  .
WWSCGCILYEMLCGYPPFP---QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase CDK8.AA MAPK 269-476 33 6.3e-50 170.79 In-house 117-328 (328) Show / Hide 
Range on Protein: 269-476
Range on HMM: 117-328/328
Sequence Identity: 33% (78 aa)

VKSLLYQILDG--IHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNS-PLKPLA----------DLDPVVVTFWYRAPELLLG--ARHYT
.....|||| |  . |.||  |.||||||.||||     | . .||.|.| || . .   ..            .. . |.| ||||||..|.  ..|||
IQYFMYQILRGLKLKYIHSANVIHRDLKPSNILV----NENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYT

KAIDIWAIGCIFAELLT-SEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIKKMPEHG-NLMKDF----RRSNYAS-CCLPKYMEKHKVPKD
||.|.|..||||||.||   |.|             . ||. .|..|.| | | ... |.. .||  |. . .    ..  .     .|...      ..
KAVDMWSVGCIFAEMLTDRKPLFP---------GKDYIDQWNLIMEVLGTPSEEFIQCICM-SEHARNYIQSLGNLPKYPKKPWEKMFPNANF----NAN

SKAFQLLSKLLTMDPTKRMTSEQAMEDQYF
..|  ||.|.|..|| || | |.|..  ||
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDK8.AA MAPK 64-262 33 2.7e-49 168.55 In-house 53-254 (328) Show / Hide 
Range on Protein: 64-262
Range on HMM: 53-254/328
Sequence Identity: 33% (75 aa)

REVALLREL-RHPNVICLRRVFLSH-----SD----RKVYLLCDFSEHDLWHIIKYHRANKASKKGPTSVPPVMVKSLLYQILDG--IHYLHSNWVLHRD
||. |||.. .|.|.|.|. .|  .     ..    . .|.  .. |.|| .|||  .                .....|||| |  . |.||  |.|||
REIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ----------PLSDDHIQYFMYQILRGLKLKYIHSANVIHRD

LKPANILVMGEGSERGRVKIADMGFARLFNS-PLKPLA----------DLDPVVVTFWYRAPELLLG--ARHYTKAIDIWAIGCIFAELLT-SEPIFHCR
|||.||||     | . .||.|.| || . .   ..            .. . |.| ||||||..|.  ..|||||.|.|..||||||.||   |.|   
LKPSNILV----NENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFP--

QEDIKTSNPYHHDQLDRIFNVMGFP
          . ||. .|..|.| |
-------GKDYIDQWNLIMEVLGTP
Kinase CDK8.AA CDK4 23-262 37 3.2e-49 166.94 In-house 3-228 (290) Show / Hide 
Range on Protein: 23-262
Range on HMM: 3-228/290
Sequence Identity: 37% (94 aa)

EGCKVGRGTYGHVYKATTKKEPKKEYALKQI------EGTGISMSACREVALLRELR---HPNVICLRRVF-LSHSDR---KVYLLCDFSEHDLWHIIKY
.   .| | || ||.|   ..  . .||||.      || |. ||  ||....| |    |||.. |  |.  .  ||   |. .     . ||   .  
CVAEIGEGAYGTVYRARDLHTG-HFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYL--

HRANKASKKGPTSVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGAR
    |. . |   .||  .| .  |.| |. .|||. . |||||| ||||    .  |.||.|| | || . .  .    | ||||| |||||| || . 
---DKCPPPG---MPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILV----TSDGHVKLADFGLARIYSFQMA----LTPVVVTLWYRAPEVLL-QS

HYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFP
 |   .|.|..||||||.    | |    |          |||..|| ||| |
YYNTPVDMWSVGCIFAEMYCRRPLFCGQSE---------KDQLHKIFDVMGLP
Kinase CDK8.AA Pkinase 269-476 28 8.4e-49 173.24 Pfam 110-293 (293) Show / Hide 
Range on Protein: 269-476
Range on HMM: 110-293/293
Sequence Identity: 28% (62 aa)

VKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAEL
.|. .|||| |. |.||....||||||.|||.  .|    .|||.| |.|..|.  . .   .. ...| ||.|||...|...|....|.|..|||..|.
CKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM

LTSEPIFH--CRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIKKMP-------EHGNLMKDFRRSNYASCCLPKYMEKHKVPKDSKAFQLLSKLLTM
|. .|.|   | ..      .  |||. .|...|| | . ||.    ..       .                   .  ..  .  .. . ......|..
LCGRPPFPGHC-WH------DN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWH-------------------F-HWTF-HNWSEECKDFIKWCLCK

DPTKRMTSEQAMEDQYF
||.|| | ||.... .|
DPKKRPTAEQILQHPWF
Kinase CDK8.AA CRK7 128-262 32 9.3e-43 145.17 In-house 114-272 (343) Show / Hide 
Range on Protein: 128-262
Range on HMM: 114-272/343
Sequence Identity: 32% (57 aa)

VKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHY----------------
.|... |.|.|. |.| . .||||.| .|||.      .| ||||| | |||.||  |  ...   |.| |||.||||||. .|                
CKCFMKQLLEGMDYCHKKNFLHRDIKCSNILM----NNQGEVKIADFGLARLYNSEEK-RRPYTNRVITLWYRPPELLLGEERYTEQHILKELIRNIKSI

----------------------TKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFP
                      ...||.|  |||..||.| .|||  ..|          .||. |. ..| |
QLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNE---------MAQLEKIYKICGSP
Kinase CDK8.AA CDK4 264-408 44 3.2e-42 142.56 In-house 107-233 (290) Show / Hide 
Range on Protein: 264-408
Range on HMM: 107-233/290
Sequence Identity: 44% (65 aa)

VPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGC
.||  .| .  |.| |. .|||. . |||||| ||||    .  |.||.|| | || . .  .    | ||||| |||||| || .  |   .|.|..||
MPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILV----TSDGHVKLADFGLARIYSFQMA----LTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGC

IFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDW
||||.    | |    |          |||..|| ||| | |.||
IFAEMYCRRPLFCGQSE---------KDQLHKIFDVMGLPPEDDW
Kinase CDK8.AA S_TKc 256-476 16 5.7e-25 90.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 256-476
Range on HMM: 1-231/231
Sequence Identity: 16% (53 aa)

FNVMGF---------------------------------------------------------------PQ--------------------VPPVMVKSL
. ..                                                                 ..                     |. .....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

LYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTK-AIDIWAIGCIFAELLTS
.|||.... |.||....||||||.|||.        ..||.| |.||..          . ...| ||.|||.|    .|.| ..|.|..|||..|.|. 
MYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCG

EPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIKKMPEHGNLMKDFRRSNYASCCLPKYMEKHKVPKDSKAFQLLSKLLTMDPTKRMTSEQAM
.| |.               |....|...|                                            .. | ....|.|..||.||.|  .|.
YPPFP---------------QMQMMFKKIG--------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

E-------DQYF
.       ...|
QDEWDIKCHPWF
Kinase CDK8.AA CDK7 449-476 35 1.5e-11 26.55 In-house 261-288 (288) Show / Hide 
Range on Protein: 449-476
Range on HMM: 261-288/288
Sequence Identity: 35% (10 aa)

AFQLLSKLLTMDPTKRMTSEQAMEDQYF
.  |.....||.| ||.|  |. .  ||
LLDLMCGMWTMNPCKRWTCTQCLKMPYF
TyrKc CDK8.AA TyrKc 21-287 20 2.2e-11 -38.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 21-287
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

DFEGCKVGRGTYGHVYKATTKKEPKKEYALKQIEGTGISMSACREVALLREL--RHPNVICLRRVFLSH-----SDRKVYLLCDFSEH-DLWHIIKYHRA
   | | |.| .| |||.| |     . | | .      .  .||  ....|  .|||...|  | ...     ..  ....  . .| || . ...|| 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

NKASKKGPTSVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSP--------LKPLA---DLDPVVVTFWYRA
.         ...    |  .|| .|  ||||. . ||||   |.||  ..    .|||.| | .|   .          .  .   . . ..   |. |
K---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-A

PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQ--------VPPVMVKSLLYQILDG-------IHYLHSN
|| .   . .| . |.|. |    |..|     .  ..  . ||   . .... .  .  |          |. | . .  |  .           .|. 
PECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHEC

W
.
F
Kinase CDK8.AA CRK7 26-103 27 2.7e-09 27.98 In-house 6-97 (343) Show / Hide 
Range on Protein: 26-103
Range on HMM: 6-97/343
Sequence Identity: 27% (26 aa)

KVGRGTYGHVYKATTKKEPKKEYALKQIEGTGI-------SMSACREVALLRELRHPNVICLRRVFLSH-------SDR-KVYLLCDFSEHDL
 .| |||| ||||  |.  ..  ||| ..  .           | ||. .||.| |.|.. |. . ..        ...  .|.  .   |||
QIGEGTYGQVYKAKNKHT-GEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDL
Kinase CDK8.AA CDK4 446-476 32 3e-06 17.22 In-house 260-290 (290) Show / Hide 
Range on Protein: 446-476
Range on HMM: 260-290/290
Sequence Identity: 32% (10 aa)

DSKAFQLLSKLLTMDPTKRMTSEQAMEDQYF
.  . .|| | |. .. |||. .|. .  ||
CKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Pkinase_Tyr CDK8.AA Pkinase_Tyr 20-173 28 9.3e-05 16.73 Pfam 1-154 (270) Show / Hide 
Range on Protein: 20-173
Range on HMM: 1-154/270
Sequence Identity: 28% (47 aa)

FDFEGCKVGRGTYGHVYKATTK---KEPKKEYALKQI-EGTGIS----MSACREVALLREL-RHPNVICLRRVFLSHSDR-KVYLLCDFSEH-DLWHIIK
  |   | |.| .|.|||.| |   ...| . | | . ||.  .     .  ||......| .|||...|  | .....  ..|.   . .| || .  .
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

YHRANKASKKGPTSVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIAD
 ||       .. .... .  .  .|| .|  ||.|.   ||||   |.||     | . |||.|
KHR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT----ENNVVKICD
Kinase CDK8.AA Pkinase_Tyr 274-314 43 1.624582 2.37 Pfam 118-154 (270) Show / Hide 
Range on Protein: 274-314
Range on HMM: 118-154/270
Sequence Identity: 43% (18 aa)

YQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIAD
.|| .|  ||.|.   ||||   |.||     | . |||.|
WQIAKGMEYLESKNCIHRDLAARNCLVT----ENNVVKICD