Gene Pftaire (Sea Urchin)

Pftaire

Species: Sea Urchin
Alias: Pftaire, Spk120, SPU_003654
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: PFTAIRE

Sequence

Name Sequence Type Origin Length Description Download
Pftaire.AA Protein None 376 None Fasta, JSON
Pftaire.kin_dom Protein Kinase Domain None 287 None Fasta, JSON

Protein domain

Protein domains of Pftaire.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Pftaire.AA PFTAIRE 57-343 77 4e-237 794.03 In-house 1-287 (287) Show / Hide 
Range on Protein: 57-343
Range on HMM: 1-287/287
Sequence Identity: 77% (221 aa)

YKKICPLGEGSYAKVYKAVSCINQQVVALKEIRLQQDEGTPFTAIREASLLKDLKHANIVCLHDIIHTKTTLSFVFEYVHTDLSTYLERHPGGLNPNNVR
|.|...|||||||.|||..||||||.||||||||||.|||||||||||||||.||||||||||||||||.||.||||||||||..|...||||..|||||
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

LFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGELKLADFGLARAKSIPSRTYSHEVVTLWYRPPDVLMGSTDYSTQLDIWGVGCIFLEMMWGQPAFPG
||||||.||||.||.|..|||||||||||||..|||||||||||||||.||.|||||||||||||||||.|||.|||.||.|||||||.|||||||||||
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPG

LKDATDQLEKIFKVLGTPTEQTWHGVSRLPNYGKVAAAGRFHKPKLLCEILPSILLIPGAESLMTDMLQLEPRKRISTVQAMTCQYF
.||.||||||||||||||||.||.||..||||......|||.||| ||...|.|..||.||.||..|||.|||.|.|...||...||
MKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase Pftaire.AA CDK 57-343 43 2.4e-163 526.63 In-house 1-284 (284) Show / Hide 
Range on Protein: 57-343
Range on HMM: 1-284/284
Sequence Identity: 43% (141 aa)

YKKICPLGEGSYAKVYKAVSCINQ-----QVVALKEIRLQQ------DEGTPFTAIREASLLKDLKHANIVCLHDIIHTK-----------TTLSFVFEY
|.|.. .|||.|..|||| . ...     |.||||.||...      .|| |.||||| ||||.| |.|||.|||..|||           ..|..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VHTDLSTYLERHPGGLNPNNVRLFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGE-----LKLADFGLARAKSI------PSRTYSHEVVTLWYRPPD
...||..|..          .. ...||.|||..||...|.||||||||.||.. ||     ||.||||||||..|      |.|||.|||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLMGSTDYS--TQLDIWGVGCIFLEMM---WGQPAFPGLKDATDQLEKIFKVLGTPTEQTWHGVSRLPNYGKVAAAGRFHKPKLLCEILPSILLIPGAES
.|.||..||  |. |.|.||||| ||.   ...| |||  . .|||.|||...|||||..| ||. ||.|                              
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE-IDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------------D

LMTDMLQLEPRKRISTVQAMTCQYF
|.  ||...| ||||  ||. ..||
LLNKMLCYDPKKRISAEQALQHPYF
Kinase Pftaire.AA PCTAIRE 57-343 57 3.4e-156 525.19 In-house 1-291 (291) Show / Hide 
Range on Protein: 57-343
Range on HMM: 1-291/291
Sequence Identity: 57% (170 aa)

YKKICPLGEGSYAKVYKAVSCINQQVVALKEIRLQQDEGTPFTAIREASLLKDLKHANIVCLHDIIHTKTTLSFVFEYVHTDLSTYLERHPGGLNPNNVR
|.|.  ||||.|| |||  |     .||||||||. .|| |.|||||.|||||||||||| |||||||   | .||||   ||. |..    ..| .||.
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

LFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGELKLADFGLARAKSIPSRTYSHEVVTLWYRPPDVLMGSTDYSTQLDIWGVGCIFLEMMWGQPAFPG
|||||| ||| .||.||||||||||||||| | |||||||||||||||.|..||||||||||||||||||||||||||.|.||||||| ||  |.| |||
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

LK-----DATDQLEKIFKVLGTPTEQTWHGVSRLPNYGKVAAAGRFHKPKLLCEILPSIL--LIPGAESLMTDMLQLEPRKRISTVQAMTCQYF
 .        |||. ||..||||.|.|| ||. .... .    .   ... |    | .   |  ... |.|..||.|...|.|  .||   ||
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPR--YREQPLINHAPRLDKILKQCQD-LLTMLLQYESKNRVSAEKAMKHPYF
Kinase Pftaire.AA CDK5 57-343 50 6.2e-146 464.39 In-house 1-287 (287) Show / Hide 
Range on Protein: 57-343
Range on HMM: 1-287/287
Sequence Identity: 50% (147 aa)

YKKICPLGEGSYAKVYKAVSCINQQVVALKEIRLQQD-EGTPFTAIREASLLKDLKHANIVCLHDIIHTKTTLSFVFEYVHTDLSTYLERHPGGLNPNNV
|.|.  .||| |. ||||     . .||||..|| .. ||.| ||||| .||| ||| ||| |||.||.   |  |||..  ||  |..   |..... .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RLFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGELKLADFGLARAKSIPSRTYSHEVVTLWYRPPDVLMGSTDYSTQLDIWGVGCIFLEMM-WGQPAF
. |..|| .||.|||....||||||||||||.  |||||||||||||  || |.|||||||||||||||||||  |||  |.| .|||| ||.  |.| |
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGLKDATDQLEKIFKVLGTPTEQTWHGVSRLPNYGKVAAAGRFHKPKL-LCEILPSILLIPGAESLMTDMLQLEPRKRISTVQAMTCQYF
||  | .||| .|||..|||.| .| ... ||.|   . .   . ..  . .| |. |   | . |.  |||..| .|||  .|.  .||
PG-NDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMD-LLQKMLQCNPNQRISAKAALHHPYF
Kinase Pftaire.AA CDC2 57-343 48 3.7e-135 418.07 In-house 1-301 (301) Show / Hide 
Range on Protein: 57-343
Range on HMM: 1-301/301
Sequence Identity: 48% (147 aa)

YKKICPLGEGSYAKVYKAVSCINQQVVALKEIRLQ-QDEG--TPFTAIREASLLKDLK-HANIVCLHDIIHTKTTLSFVFEYVHTDLSTYLE-RHPG--G
|.||  .|||.| .|||.     .|.|||| |||  .|||   | ||||| |.||.|| | |||.|||.||    |  ||||.. ||  |..   |    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LNPNNVRLFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGELKLADFGLARAKSIPSRTYS--HEVVTLWYRPPDVLMGSTDYSTQLDIWGVGCIFLEM
. |..|. ...|...|..||| |.|.||||||||.||...|..|.|||||||| .||.|||   |||||||||.| .|.|. .|||  |.| .|||| ||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---MWGQPAFPGLKDATDQLEKIFKVLGTPTEQTWHGVSRLPNYGKVAAAGRFHKPKLLCEILPS-------ILLIPGAESLMTDMLQLEPRKRISTVQA
   .   | |.| .   ||| |||..||||.|||| ||. || |   .  .|... .|  .|.|.       . | | . .|   |||..| ||||  .|
FMDVTKKPLFHG-DSEIDQLFKIFRILGTPNEQTWPGVTQLPDY--KNTFPRWKPQDLS-KICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEA

MTCQYF
.   ||
LQHPYF
Kinase Pftaire.AA CMGC 57-343 24 1e-121 402.01 In-house 1-513 (513) Show / Hide 
Range on Protein: 57-343
Range on HMM: 1-513/513
Sequence Identity: 24% (127 aa)

YKKICPLGEGSYAKVYKAVS--------------CINQQVVALKEIRLQ----------QDEGTPFTAIREASLLKDLK-----------------HANI
|..| ..|||.|..|||..               . ....||.| |...            .| |..|.|| ..|| |.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VCLHDIIHTKT-----------------TLSFVFEYVHTDLSTYLERHPG--------GLNPNN------------VRLFL------FQLIRGLS--FCH
|.|.||...|                   | .||||. .||  |......        .|..              .. |.      .|..|||   .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KRK--ILHRDLKPQNLLISEAGEL--------------------KLADFGLARAKSIP---------------------SRTYSHEVVTLWYRPPDVLMG
...  |.||||||.|.||.. .||                    |..||||||. ...                     .|.|.|.|||.|||.| .|.|
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

STDYS---------TQLDIWGVGCIFLEMMWG--------QPAFPGLKDA----------TDQLEKIFKVLGTPT---------------EQTWHGVSRL
...|.         |. |.|.||||| ||. |        .| |||  .            |||.||||||||||               |..| ... |
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PNYGK--------------VAAAGRFH-----KPKLLCEILPSILLI-------------------------------------PGAESLMTDMLQLEPR
|.| |                 | ..      .|.  .  . ..                                        | |  |.  |||..| 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRISTVQAMTCQYF
|||.  ||.   ||
KRITAEQALQHPYF
Kinase Pftaire.AA CDK7 57-288 43 2.6e-106 284.16 In-house 1-236 (288) Show / Hide 
Range on Protein: 57-288
Range on HMM: 1-236/288
Sequence Identity: 43% (102 aa)

YKKICPLGEGSYAKVYKAVSCINQQVVALKEIR-----LQQDEGTPFTAIREASLLKDLKHANIVCLHDIIHTKTTLSFVFEYVHTDLSTYLERHPGGLN
|.||  .||| .| ||||      |.|| |.|.      . . |  .|||||  .|. ..| |.. | ||.  |. .. ||..  .||    .     | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PNNVRLFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGELKLADFGLARAKSIPSRTYSHEVVTLWYRPPDVLMGSTDYSTQLDIWGVGCIFLEMMWGQ
| ..  .  .. .|| .||.  |||||||| |||..| |.||.|||||||.   | | |.| ||| ||| |  | |   | |  |.| ||||| | |   
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PAFPGLKDATDQLEKIFKVLGTPTEQTWHGVSRLPNY
| .||  |  |||..||. ||||||..| ... ...|
PYLPGDSDI-DQLTRIFQTLGTPTEEEWPNMCCMMDY
Kinase Pftaire.AA S_TKc 57-343 26 3.8e-84 286.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 57-343
Range on HMM: 1-231/231
Sequence Identity: 26% (81 aa)

YKKICPLGEGSYAKVYKAVSCINQQVVALKEIRLQQDEGTPFTAIREASLLKDLKHANIVCLHDIIHTKTTLSFVFEYVHT---DLSTYLERHPGG----
|... ..|.|...||||..    ...||.|.|.         ...|| ..||  .| ||| |.|.... . | .|.||. .   || .|.......    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LNPNNVRLFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGELKLADFGLARAKSIPSRTYSHEVVTLWYRPPDVLMGSTDYST-QLDIWGVGCIFLEM
 ...  .| .. |....| .||...|.||||||.|.|..|  ..|..||||||         .. ..|.||..| ||     |..   |.| .|||. ||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

MWGQPAFPGLKDATDQLEKIFKVLGTPTEQTWHGVSRLPNYGKVAAAGRFHKPKLLCEILPSILLIPGAESLMTDMLQLEPRKRISTVQAMT-------C
. |.| ||       |....||..|                                         | | ...  .|| .|.||..  .|..        
LCGYPPFP-------QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

QYF
..|
PWF
Kinase Pftaire.AA CRK7 57-343 31 2.1e-79 270.11 In-house 1-343 (343) Show / Hide 
Range on Protein: 57-343
Range on HMM: 1-343/343
Sequence Identity: 31% (109 aa)

YKKICPLGEGSYAKVYKAVSCINQQVVALKEIRLQQD----EGTPFTAIREASLLKDLKHANIVCLHDIIHTK----------TTLSFVFEYVHTDLSTY
|..|   ||| | .||||.   . . |||| .|.. .    || | |||||  .|. |.|.||| |..|.  |           .   ||||.  ||.  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LERH-PGGLNPNNVRLFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGELKLADFGLARAKSIPS--RTYSHEVVTLWYRPPDVLMGSTDY--------
||       ...... |. ||  |.  |||...||||.|  |.|.   ||.|.|||||||     .  | |   |.|||||||  | | . |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STQLDIWGVGCIFLEMMWGQPAFPGLKDATDQLEKIFKVLGTPTEQTWHGVSRLPNYGKVAAAGRFHKPK
                               .. |.|..|||. | . ..| |.|     .|||||.|. |.|. . |  | .|| .       | .. .
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEM-AQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPK-RQYNRR

LLCEIL---PSILLIPGAESLMTDMLQLEPRKRISTVQAMTCQYF
|. |      . .. . .  |.  || | | ||..  ..  ...|
LREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase Pftaire.AA PITSLRE 57-343 35 1.4e-75 257.42 In-house 1-295 (295) Show / Hide 
Range on Protein: 57-343
Range on HMM: 1-295/295
Sequence Identity: 35% (106 aa)

YKKICPLGEGSYAKVYKAVSCINQQVVALKEIRLQ--QD-EGTPFTAIREAS-LLKDLKHANIVCLHDII--HTKTTLSFVFEYVHTDLSTYLERHP---
....   .|| |  ||.|.      .|||| . .   .. || | |..|| . .|. |.| ||| .  |.   ...    |.|||  ||   .| .    
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

GGLNPNNVRLFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGELKLADFGLARAKSIPSRTYSHEVVTLWYRPPDVLMGSTDYSTQLDIWGVGCIFLEM
    |  .  .. || || .. |. .|.|||||  |||.| .| ||..||||||    | . |.  ||||||| | .| |.  ||| .|.| ||||| |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

MWGQPAFPGLKDATDQLEKIFKVLGTPTEQTWHGVSRLPNYGKVAAAGRFHKPKLLCEILP-SILLIPGAESLMTDMLQLEPRKRISTVQAMTCQYF
. ..| |.| |  .||...||| .|||||. | |.. ||.  ..    . ...  | .. |   ..   . .|.  || . | .||.  .|.   .|
ITMKPLFQG-KSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNN-FPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase Pftaire.AA Pkinase 57-343 27 3.7e-74 257.46 Pfam 1-293 (293) Show / Hide 
Range on Protein: 57-343
Range on HMM: 1-293/293
Sequence Identity: 27% (84 aa)

YKKICPLGEGSYAKVYKAVSCINQQVVALKEIRLQQDEGTPF-TAIR--EASLLKDLKHANIVCLHDIIHTKTTLSFVFEYVHT-----DLSTYLE-RHP
|... ..|.||...|||..   ....||.|.|... ..     |..|  |....| |.| ||| |.|. ..|. . .|.||.       ||..|.. .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGL--NPNNVRLFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGEL----KLADFGLARAK-SIPSRTYSHEVVTLWYRPPDVLMGSTDYSTQLDIWGV
|..   .. .. .. |..||| .||...|.||||||.|.||.. |..    |..|||||. .   ... ... ..|.||..| |..|...|..  |.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIFLEMMWGQPAFPGL---KDATDQLEKIFKVLGTPTEQTWHGVSRLP----NYGKVAAAGRFHKPKLLCEILPSILLIPGAESLMTDMLQLEPRKRIS
|||. ||. |.| |||    ..  ||...|....|.|..  |   .. .    .. . .            . .  ... . . ......|.. | ||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H----------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPT

TVQAMTCQYF
  |..   .|
AEQILQHPWF
Kinase Pftaire.AA CDK4 57-279 42 3e-72 246.36 In-house 1-233 (290) Show / Hide 
Range on Protein: 57-279
Range on HMM: 1-233/290
Sequence Identity: 42% (102 aa)

YKKICPLGEGSYAKVYKAVSCINQQVVALKEIRLQQDEG---TPFTAIREASLLKDLK---HANIVCLHDIIHT------KTTLSFVFEYVHTDLSTYLE
|...  .||| | .||.| . .. . |||| .| .  |     |   ||| |... |.   |.||| | |. |.      .. .  ||| .  ||.|||.
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

RHPG-GLNPNNVRLFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGELKLADFGLARAKSIPSRTYSHE------VVTLWYRPPDVLMGSTDYSTQLDI
. |  |. |  ..   .||.||. | |   | ||||||||.|..  |..||||||||       |.|| .      ||||||| | ||  |. | |  |.
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLA-------RIYSFQMALTPVVVTLWYRAPEVLLQSY-YNTPVDM

WGVGCIFLEMMWGQPAFPGLKDATDQLEKIFKVLGTPTEQTW
| ||||| ||   .| |.|  .. |||.|||.| |.|.|. |
WSVGCIFAEMYCRRPLFCGQSEK-DQLHKIFDVMGLPPEDDW
Kinase Pftaire.AA Pkinase_Tyr 57-202 28 3.4e-15 52.08 Pfam 1-160 (270) Show / Hide 
Range on Protein: 57-202
Range on HMM: 1-160/270
Sequence Identity: 28% (47 aa)

YKKICPLGEGSYAKVYKAVSCI-----NQQVVALKEIRLQQDEGTPFTA------IREASLLKDL-KHANIVCLHDIIH-TKTT--LSFVFEYVHT-DLS
 ...  ||||.. .|||.. .      ... || | ..    ||.   .      .|||...| | .| |||.|. ..   .    .  |.||.   || 
ITFGKKLGEGAFGEVYKGT-WKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

TYLERH---PGGLNPNNVRLFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGELKLADFGLARA
.|| .|   .. |..     . .|  .|... . ... ||||   | |..| .  | .||||||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase Pftaire.AA TyrKc 57-343 19 2.1e-11 -38.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 57-343
Range on HMM: 1-280/280
Sequence Identity: 19% (63 aa)

YKKICPLGEGSYAKVYKAVSCINQQVVALKEIRLQQDEGTPFTAIREASLLKDL--KHANIVCLHDIIHTK-------TTLSFVFEYV-HTDLSTYLERH
 ...  |||| . .|||..     . || | ..           .|||.... |  .| |||.|. .. ..         |  |.||. | ||  || .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

PGGLNPNNVRLFLFQLIRGLSFCHKRKILHRDLKPQNLLISEAGELKLADFGLARAKSIP------SRTYS-----HEV--VTLWYRPPDVLMGSTDYST
 . |..     | .|  .| .. |.... ||||   | |..| .  | .||||.|.          . .|.     ..   . .   .| ... .. ..|
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-FTT

QLDIWGVGCIFLEMM-WGQPAFPG-------LKDATDQLEKIFKVLGTPT----EQTWHGVSRLPNYGKVAAAGRFHKPKLLCEILPSILLIPGAESLMT
. |.|  |    |..  ||.  ||        ...  .... .     |                                      .    .   ..|.
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------FVCCPDEMYQIMK

DMLQLEPRKRISTVQAMTCQYF
.  . .| .| .  .   ...|
QCWHEDPEDRPTFSEI--HECF
Kinase Pftaire.AA CDK7 319-343 36 9e-08 16.32 In-house 264-288 (288) Show / Hide 
Range on Protein: 319-343
Range on HMM: 264-288/288
Sequence Identity: 36% (9 aa)

LMTDMLQLEPRKRISTVQAMTCQYF
||  |. ..| ||.. .|.    ||
LMCGMWTMNPCKRWTCTQCLKMPYF
Kinase Pftaire.AA CDK4 316-343 32 0.00173 7.59 In-house 263-290 (290) Show / Hide 
Range on Protein: 316-343
Range on HMM: 263-290/290
Sequence Identity: 32% (9 aa)

AESLMTDMLQLEPRKRISTVQAMTCQYF
.  |.  ||  .. ||.|  |.    ||
GDDLLQKMLCYNHHKRMSAYQCLQHPYF