Gene Pctaire (Sea Urchin)

Pctaire

Species: Sea Urchin
Alias: SPU_016385, Pctaire, Spk121
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: PCTAIRE

Sequence

Name Sequence Type Origin Length Description Download
Pctaire.AA Protein None 465 None Fasta, JSON
Pctaire.kin_dom Protein Kinase Domain None 271 None Fasta, JSON

Protein domain

Protein domains of Pctaire.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Pctaire.AA PCTAIRE 68-338 67 2.1e-218 731.85 In-house 1-291 (291) Show / Hide 
Range on Protein: 68-338
Range on HMM: 1-291/291
Sequence Identity: 67% (196 aa)

YTKLDKLGEGTYATVFKGRSRLTDNLVALKEIRLEHEEGAPCTAIREVSLLKGLKHHNIVTLHDIVHTEKALTLVFEYLEKDLKQYMDDCGSIMNMNNVK
|.|||||||||||||.|.||.|||||||||||||||||||||||||||||||.|||.||||||||.||...|||||||...||||||||||.||||.|||
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

LFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGELKLADF---------ANVFSPHLVSSLERSRNAVLPNTIF--LFCTRGVGCIFYEMSAGRPLFPG
||||||||||||||.|..||||||||||||||.||||||||         ....|...|....|........|..  .....|||||||||..|||||||
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

ST------VEDELHLIFKFLGTPDDKTWPGISANEDFVSYGFPGYPKEPVVTHAPRLD---LQCQDLLEDLLKYEGKNRVSAAKAMRHPCF
||      |.|.||.||..|||||.|||||...||.|..|.||.|...|...||||||   .||||||..||.||.||||||.|||.||.|
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase Pctaire.AA PFTAIRE 68-208 70 5.5e-103 348.44 In-house 1-141 (287) Show / Hide 
Range on Protein: 68-208
Range on HMM: 1-141/287
Sequence Identity: 70% (99 aa)

YTKLDKLGEGTYATVFKGRSRLTDNLVALKEIRLEHEEGAPCTAIREVSLLKGLKHHNIVTLHDIVHTEKALTLVFEYLEKDLKQYMDDCGSIMNMNNVK
| ||.|||||.||||.||.|...  .||||||||. |||.|.|||||.||||.||| |||.||||.||.. ||.||||...||.|||| .   |..|||.
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

LFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGELKLADF
||||||||||.|||.|.||||||||||||| ..||||||||
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADF
Kinase Pctaire.AA CDK5 68-208 63 7.8e-92 290.44 In-house 1-142 (287) Show / Hide 
Range on Protein: 68-208
Range on HMM: 1-142/287
Sequence Identity: 63% (90 aa)

YTKLDKLGEGTYATVFKGRSRLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKGLKHHNIVTLHDIVHTEKALTLVFEYLEKDLKQYMDDCGSIMNMNNV
| |..|.|||||.||.|.| . |  .||||..||. | || |.|||||..||| |||.||| |||..|.|| ||||||.. .||| |||.|.  |.|. .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KLFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGELKLADF
| |..|||.|||.||...|||||||||||||| .||||||||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADF
Kinase Pctaire.AA CDK 68-208 48 8e-90 287.55 In-house 1-157 (284) Show / Hide 
Range on Protein: 68-208
Range on HMM: 1-157/284
Sequence Identity: 48% (82 aa)

YTKLDKLGEGTYATVFKGRSRLTD-----NLVALKEIRLEH-----E-EGAPCTAIREVSLLKGLKHHNIVTLHDIVHTE-----------KALTLVFEY
| ||.|.|||||..|.|.|...|.     ..||||.||.|.     | || |.|||||.|||| | |.|||.|||..||.           . |..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LEKDLKQYMDDCGSIMNMNNVKLFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGE-----LKLADF
.. |||.|||          .| ...||||||.|||.. ..||||||||.|||..||     ||.|||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADF
Kinase Pctaire.AA CDC2 68-208 51 1e-79 244.56 In-house 1-147 (301) Show / Hide 
Range on Protein: 68-208
Range on HMM: 1-147/301
Sequence Identity: 51% (76 aa)

YTKLDKLGEGTYATVFKGRSRLTDNLVALKEIRLEHEEGA---PCTAIREVSLLKGLK-HHNIVTLHDIVHTEKALTLVFEYLEKDLKQYMD-DCG--SI
|.|. |.|||||  |.|.. . |. .|||| ||||.|.     | ||||| |.|| || | |||.|||..|  . | .|||||. |||.|||   .  . 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

MNMNNVKLFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGELKLADF
|  ..|| ...|.|.|...|| |...||||||||.||..||..|.|||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADF
Kinase Pctaire.AA CMGC 68-208 27 4.6e-67 219.1 In-house 1-248 (513) Show / Hide 
Range on Protein: 68-208
Range on HMM: 1-248/513
Sequence Identity: 27% (68 aa)

YTKLDKLGEGTYATVFKGRSRLTD--------------NLVALKEIRLE----------HEEGAPCTAIREVSLLKGLK----------------HHN-I
|....|.|||||..|.|.| ..|.              ..||.| |...          ...| |..|.||...|| |.                ||| |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTLHDIVHTEK-----------------ALTLVFEYLEKDLKQYMDDCG------SIMNM-------------NNVKLFL------FQLLRGLA--YCHK
|.|.||.....                  | |||||...||.||....         |..             .|.| |.      .|.||||.  |||.
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHS

RQ--VLHRDLKPQNLLINEKGEL--------------------KLADF
.   ..||||||.|.|||...||                    |..||
HWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF
Kinase Pctaire.AA CDK7 68-208 40 2.6e-63 167.29 In-house 1-146 (288) Show / Hide 
Range on Protein: 68-208
Range on HMM: 1-146/288
Sequence Identity: 40% (59 aa)

YTKLDKLGEGTYATVFKGRSRLTDNLVALKEIR-----LEHEEGAPCTAIREVSLLKGLKHHNIVTLHDIVHTEKALTLVFEYLEKDLKQYMDDCGSIMN
|.|....|||..|||.|..   |.  || |.|.      | . |   |||||. .|. ..| |.. | ||      . |||.... ||     |   |. 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

MNNVKLFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGELKLADF
  ..| .  ..|.|| |||.  .||||||| |||.|| |.||.|||
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADF
Kinase Pctaire.AA S_TKc 68-338 23 1.1e-59 205.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 68-338
Range on HMM: 1-231/231
Sequence Identity: 23% (71 aa)

YTKLDKLGEGTYATVFKGRSRLTDNLVALKEIRLEHEEGAPCTAIREVSLLKGLKHHNIVTLHDIVHTEKALTLVFEYLEK---DLKQYMDDCGSI----
|..|.|.|.|....|.|.| . |. .||.|.|.        ....||...||  .| |||.|.|. .. . | .|.||..    ||..|....|.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-MNMNNVKLFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGELKLADF--ANVFSPHLVSSL-----ERSRNAVLPNTIFLFCTR------GVGCIFYE
 ..   .. .. |....|.|||.....||||||.|.|..|  ..|..||  | ..  ... ..     |               ..       .|||.||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWYMAPEVL-----------GYGKCKCDWWSCGCILYE

MSAGRPLFPGSTVEDELHLIFKFLGTPDDKTWPGISANEDFVSYGFPGYPKEPVVTHAPRLDLQCQDLLEDLLKYEGKNRVSAAKAMR-------HPCF
| .|.|.||      .....|| .|                                    . .. |... .|... ..| .| .|..       || |
MLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Pctaire.AA CRK7 68-208 40 1.2e-46 158.79 In-house 1-156 (343) Show / Hide 
Range on Protein: 68-208
Range on HMM: 1-156/343
Sequence Identity: 40% (64 aa)

YTKLDKLGEGTYATVFKGRSRLTDNLVALKEIRLEHE----EGAPCTAIREVSLLKGLKHHNIVTLHDIVHTEK-----------ALTLVFEYLEKDLKQ
| ...  |||||  | | .   |  .|||| .|...|    || | |||||. .|. |.| |||.|..|| |.|           .  .||||   ||  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIV-TDKQDASEFKKHKGSFYMVFEYMDHDLMG

YMDDC-GSIMNMNNVKLFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGELKLADF
 ..       . ...| |. ||| |..||||. .||||.|  |.|.| .||.|.|||
LLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADF
Kinase Pctaire.AA Pkinase 68-208 33 8.2e-45 159.54 Pfam 1-156 (293) Show / Hide 
Range on Protein: 68-208
Range on HMM: 1-156/293
Sequence Identity: 33% (53 aa)

YTKLDKLGEGTYATVFKGRSRLTDNLVALKEIRLEHEEG-APCTAIR--EVSLLKGLKHHNIVTLHDIVHTEKALTLVFEYLEKDLKQYMDDC-------
|... |.|.|....|.|.. . |  .||.|.|...||.   . |..|  |....| |.| |||.|.|...... . .|.||.|..|.  || .       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

GSIM--NMNNVKLFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGEL----KLADF
.  .   .. .| .. |.||||.|||.. ..||||||.|.||...|..    |..||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF
Kinase Pctaire.AA PITSLRE 68-208 37 1.5e-42 147.66 In-house 1-150 (295) Show / Hide 
Range on Protein: 68-208
Range on HMM: 1-150/295
Sequence Identity: 37% (56 aa)

YTKLDKLGEGTYATVFKGRSRLTDNLVALKEIRLE---HEEGAPCTAIREVS-LLKGLKHHNIVTLHDIV--HTEKALTLVFEYLEKDLKQYMDDCG---
. .|.. .||||  |.... ..||  |||| . .|     || | |..||.. .|..|.| |||..  ||   .     .|.||.| |||  |.      
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

SIMNMNNVKLFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGELKLADF
       .| .. ||||| .. |.  ..|||||  |||.. || ||..||
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDF
Kinase Pctaire.AA CDK4 68-208 40 4.5e-40 135.07 In-house 1-154 (290) Show / Hide 
Range on Protein: 68-208
Range on HMM: 1-154/290
Sequence Identity: 40% (63 aa)

YTKLDKLGEGTYATVFKGRSRLTDNLVALKEIRLE-HEE--GAPCTAIREVSLLKGLK---HHNIVTLHDIVHT------EKALTLVFEYLEKDLKQYMD
| ..  .||| | ||.. |.  | . |||| .|    ||  | |   |||.|... |.   | ||| | |. |.      |  .|.|||  . ||..|.|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

DCGS-IMNMNNVKLFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGELKLADF
 |    |    .|   .|||||. . |   . ||||||||.|..  |..|||||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADF
Kinase Pctaire.AA CDK 239-338 34 1.3e-39 124.28 In-house 207-284 (284) Show / Hide 
Range on Protein: 239-338
Range on HMM: 207-284/284
Sequence Identity: 34% (36 aa)

GVGCIFYEMSA---GRPLFPGSTVEDELHLIFKFLGTPDDKTWPGISANEDFVSYGFPGYPKEPVVTHAPRLDLQCQDLLEDLLKYEGKNRVSAAKAMRH
.|||||.||     ..|||||..  | |..||...|||....|||..   |.                         |||. .| |. |.|.||  |. |
SVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKMLCYDPKKRISAEQALQH

PCF
| |
PYF
Kinase Pctaire.AA CDK5 240-338 43 4.7e-39 120.71 In-house 185-287 (287) Show / Hide 
Range on Protein: 240-338
Range on HMM: 185-287/287
Sequence Identity: 43% (45 aa)

VGCIFYEMS-AGRPLFPGSTVEDELHLIFKFLGTPDDKTWPGISANEDFV--SYGFPGYPKEP-VVTHAPRLDLQCQDLLEDLLKYEGKNRVSAAKAMRH
.|||| ||. ||||||||. |||.| .||| .|||   .||.|.   |.      .| || ..  . . |.|| .  |||. .|... . |.||..|..|
CGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHH

PCF
| |
PYF
Kinase Pctaire.AA PFTAIRE 239-338 40 2.1e-32 111.42 In-house 183-287 (287) Show / Hide 
Range on Protein: 239-338
Range on HMM: 183-287/287
Sequence Identity: 40% (43 aa)

GVGCIFYEMSAGRPLFPGS-TVEDELHLIFKFLGTPDDKTWPGISANEDFVSYGFP--GYPKEPVVTHAPRLD--LQCQDLLEDLLKYEGKNRVSAAKAM
|||||| || .|.|.|||  .. | | .||| |||| . ||||..    .  . |.   |  ..     ||..   .  ||. ..|..|...||||..||
GVGCIFVEMMWGQPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAM

RHPCF
 || |
QHPYF
Kinase Pctaire.AA CMGC 239-338 22 6e-31 98.21 In-house 320-513 (513) Show / Hide 
Range on Protein: 239-338
Range on HMM: 320-513/513
Sequence Identity: 22% (43 aa)

GVGCIFYEMSAG--------RPLFPGSTV-----------EDELHLIFKFLGTPD---------------DKTWPGISANEDF---------------VS
.|||||.||  |        .|||||..             | |..||| ||||.               ...||... . ..                |
SVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWS

YG----------FPGYPKEPVVTHAPR-----------------------------------LDLQCQDLLEDLLKYEGKNRVSAAKAMRHPCF
..          || .|. |     |.                                   .| |. |||. .|.|. ..| .|. |..|| |
EFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase Pctaire.AA CDC2 240-338 36 1.2e-30 91.04 In-house 192-301 (301) Show / Hide 
Range on Protein: 240-338
Range on HMM: 192-301/301
Sequence Identity: 36% (40 aa)

VGCIFYEM---SAGRPLFPGSTVEDELHLIFKFLGTPDDKTWPGISANEDFVSYGFPGYPKEPVVTHAPR---------LDLQCQDLLEDLLKYEGKNRV
.||||.||      .|||.|    |.|  ||..||||...||||.. . |. .  || ...    .. |.         || .. |||. .| |.  .|.
IGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNT-FPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRI

SAAKAMRHPCF
|| .|..|| |
SAKEALQHPYF
Kinase Pctaire.AA CDK4 240-338 39 4.1e-19 62.04 In-house 195-290 (290) Show / Hide 
Range on Protein: 240-338
Range on HMM: 195-290/290
Sequence Identity: 39% (39 aa)

VGCIFYEMSAGRPLFPGSTVEDELHLIFKFLGTPDDKTWP-GISANEDFVSYGFPGYPKEPVVTHAPRLDLQCQDLLEDLLKYEGKNRVSAAKAMRHPCF
||||| ||   ||||.|.   | || ||.  |.|  . ||  .|   |     || .   |.    | .. | .|||.  | |. . |.|| ..  || |
VGCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWD----HFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase Pctaire.AA PITSLRE 240-338 37 6.7e-18 61.89 In-house 193-295 (295) Show / Hide 
Range on Protein: 240-338
Range on HMM: 193-295/295
Sequence Identity: 37% (39 aa)

VGCIFYEMSAGRPLFPGSTVEDELHLIFKFLGTPDDKTWPGISANEDFVSYG-FPGYPKEPVVTHAP---RLDLQCQDLLEDLLKYEGKNRVSAAKAMRH
||||| |.  ..|||.|.   |... ||| .|||  | |||..    .     || ||      . |   ..  .  |||  .| |  ||| .| .|. |
VGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKH

PCF
| |
PWF
Kinase Pctaire.AA Pkinase_Tyr 68-208 28 2.1e-14 49.4 Pfam 1-155 (270) Show / Hide 
Range on Protein: 68-208
Range on HMM: 1-155/270
Sequence Identity: 28% (45 aa)

YTKLDKLGEGTYATVFKGRSR----LTDNLVALKEIRLEHEEGAPCTA------IREVSLLKGL-KHHNIVTLHDIVH-TEKA--LTLVFEYLEK-DLKQ
 |.. ||||| . .|.||. .     |.  || | ..    |||   .      .||....| | .|.||| |. ..   ..   . .|.|| .. ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YMDDC---GSIMNMNNVKLFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGELKLADF
|  .    .   .|     . .|  .|..| . ..  ||||   | |..|..  | .||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDF
Kinase Pctaire.AA CDK7 240-338 31 1.1e-13 32.43 In-house 189-288 (288) Show / Hide 
Range on Protein: 240-338
Range on HMM: 189-288/288
Sequence Identity: 31% (32 aa)

VGCIFYEMSAGRPLFPGSTVEDELHLIFKFLGTPDDKTWPGISANEDFVSY-GFPG---YPKEPVVTHAPRLDLQCQDLLEDLLKYEGKNRVSAAKAMRH
||||| |     | .||    | |  ||. |||| ...||....  |..    |||    | . . | |.   |   ||.. ..  .  .|.... .  .
VGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLL---DLMCGMWTMNPCKRWTCTQCLKM

PCF
| |
PYF
Kinase Pctaire.AA Pkinase 239-338 27 2.1e-12 44.91 Pfam 197-293 (293) Show / Hide 
Range on Protein: 239-338
Range on HMM: 197-293/293
Sequence Identity: 27% (29 aa)

GVGCIFYEMSAGRPLFPGS----TVEDELHLIFKFLGTPDDKTWPGISANEDFVSYGFPGYPKEPVVTHAPRLDLQCQDLLEDLLKYEGKNRVSAAKAMR
..|||.|||  |||.|||.    .  |....|.. .|.| .  ||  . . .|    .   . .   |  ....  |.|.....|..  | | .|. .. 
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPCF
|| |
HPWF
Kinase Pctaire.AA TyrKc 68-338 19 1.1e-10 -50.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 68-338
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

YTKLDKLGEGTYATVFKGRSRLTDNLVALKEIRLEHEEGAPCTAI-REVSLLKGL--KHHNIVTLHDIVHTE-------KALTLVFEYLEK-DLKQYMDD
 |...||||| . .|.||. .     || | .. ..       .. || .... |  .| ||| |. .. ..       . | .|.|| .. |||.|  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CGSIMNMNNVKLFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGELKLADFA---NVFSP--------HLVSSLERSRNAVLPN------TIFLF-CTR
..   .|     | .|  .| .| |.... ||||   | |..|..  | .||    .. .           ... .......||       .|.   .| 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

GV-----GCIFYEM-SAGRPLFPG-----STVEDELHLIFKF--LGTPDDKTWPGISANEDFVSYGFPGYPKEPVVTHAPRLDLQCQDLLEDLLKYEGKN
       |   .|. . | .  ||      . .. .... .   .  |..   | .|                      ..      .. ..  ... ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS---------------------FVCCPDEMYQIMKQCWHEDPED

RVSAAKAMRHPCF
| . .    | ||
RPTFSEI--HECF
Kinase Pctaire.AA CRK7 239-279 34 5.4e-07 19.95 In-house 238-278 (343) Show / Hide 
Range on Protein: 239-279
Range on HMM: 238-278/343
Sequence Identity: 34% (14 aa)

GVGCIFYEMSAGRPLFPGSTVEDELHLIFKFLGTPDDKTWP
..|||. |   ..|.|.|.   . | .|.|  |.|    ||
SCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWP
Kinase Pctaire.AA CRK7 307-338 31 0.001102 8.35 In-house 312-343 (343) Show / Hide 
Range on Protein: 307-338
Range on HMM: 312-343/343
Sequence Identity: 31% (10 aa)

LDLQCQDLLEDLLKYEGKNRVSAAKAMRHPCF
.. .| |||  .| .  | |..|  . .|. |
MPKECLDLLDKMLCLDPKKRFTAEECLQHDWF