Gene CDKL1 (Sea Urchin)

CDKL1

Species: Sea Urchin
Alias: Spk132, SPU_010799, CDKL1
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
CDKL1.AA Protein None 361 None Fasta, JSON
CDKL1.kin_dom Protein Kinase Domain None 284 None Fasta, JSON

Protein domain

Protein domains of CDKL1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKL1.AA CDKL 4-287 66 9.69999999999e-222 742.94 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-286/286
Sequence Identity: 66% (189 aa)

YERLGKIGEGSYGVVFKCRHKDTGTIVAIKRFVESEDDPLIKKIALREIRMLKQLKHENLVNLKEVFRRKKKLHLVFEYCDYTVLNTLEANVNGVPEGQG
||.|||.||||||||.|||.|.||.|||||.|.||||||..||||.|||.|||||||||.|||.||||||.||||||||||.|||..|| ..|||.|.. 
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

MNIVYQTLEAVNFCHQHNCIHRDVKPENILIT-KDGRIKLCDFGFARILTGPDDEYTDYVATRWYRAPELLVGDMVYGPPVDVWAIGCVTAELIAGEALW
.....|.|.|.||||.|||||||.|||||||| |.|..|||||||||.|..|.. |||||||||||||||||||. ||.|||.||||||.||.| |..||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PGRSDVDQLYLIKQTLGDLIDRHSKIFSTNHFFKGMSIPEPERRIPLKDKVRNLN-STALTFLEACLQMDPADRLSCQELMEMPFF
||.||.||||.|...||.||.||..|||.|.||.||..||.|.. ||.....|.. ..||.|...||.|||..|..|..||..|.|
PGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase CDKL1.AA CMGC 4-287 23 8.8e-125 412.28 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-513/513
Sequence Identity: 23% (120 aa)

YERLGKIGEGSYGVVFKCRH--------------KDTGTIVAIKRFVESEDDPLIKK----------IALREIRMLKQLK-----------------HEN
|| ..|||||.||||.|||.              ..|. |||||.. . . ..  .|          .|||||..||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNLKEVFRRKK-----------------KLHLVFEYCDYTVLNTLEANVN--------GVPEGQ------------GMNIV------YQTLEAVN--FC
.|.|...|..|.                 .|.|||||.|.. .. .. | .        . .| .              ...      || |....  .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HQHN--CIHRDVKPENILITKD--------------------GRIKLCDFGFARILTGPDDE---------------------YTDYVATRWYRAPELLV
|.|.   |||| |||||||...                    ||.|.||||.||..  ..|.                     ||.||.||||||||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GD---------MVYGPPVDVWAIGCVTAELIAG--------EALWPGRSD-----------VDQLYLIKQTLGDLI---------------DR-------
|.         | |..|.|.|..||. ||.. |        . |.||.|.           .|||..| ..||                  ..       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------HSKIFSTNHFFKGMSIPEPERR--IPLKDKVRN--------------------------------LNSTALTFLEACLQMDP
                  | ..|  |..... . |.. ..   .|. . .|                                ... |. .|. .||.||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

ADRLSCQELMEMPFF
..|..... ...|.|
DKRITAEQALQHPYF
Kinase CDKL1.AA Pkinase 4-287 30 1.1e-108 372.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-293/293
Sequence Identity: 30% (94 aa)

YERLGKIGEGSYGVVFKCRHKDTGTIVAIKRFVESEDDPLIKKIALR--EIRMLKQLKHENLVNLKEVFRRKKKLHLVFEYCDYT----VLN----TLEA
|....|||.||.|.|.||.||.|| |||.|..  .....  .....|  ||...| |.|.| | |...|..|.....|.|||. .     |     |   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

NVNGV--PEGQGMNIVYQTLEAVNFCHQHNCIHRDVKPENILITKDGRI----KLCDFGFARIL-TGPDDEYTDYVATRWYRAPELLVGDMVYGPPVDVW
. ...  .| .  ...||.|.....||....||||.||||||| ..| |    |.||||.|. . . ..  .|... |.||.|||.. |.  |||.||.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

AIGCVTAELIAGEALWPGR----SDVDQLYLIKQTLGDLIDRHSKIFSTNHFFKGMSIPEPERRIPLKDKVRNLNSTALTFLEACLQMDPADRLSCQELM
..||. .|.. |. ..||.    . .||...|....|  .....   ...  |.  .. . .  . .. .  |...... |.. ||..||..|.......
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQIL

EMPFF
. |.|
QHPWF
Kinase CDKL1.AA S_TKc 4-287 31 9.9e-99 335.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-231/231
Sequence Identity: 31% (95 aa)

YERLGKIGEGSYGVVFKCRHKDTGTIVAIKRFVESEDDPLIKKIALREIRMLKQLKHENLVNLKEVFRRKKKLHLVFEYCDY---TVLNTLEANVNG---
|| | |||.|..|.|.|||||.|| |||||.           . ..|||..||. .|.|.|.|..||.  ..|..|.||||    ...  .. .  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VPEGQGMNIVYQTLEAVNFCHQHNCIHRDVKPENILITKDGRIKLCDFGFARILTGPDDEYTDYVATRWYRAPELLVGDMVYGP-PVDVWAIGCVTAE
   || .   ..||...|...||.|. ||||.||||||...  .||.||||.||.|       | .. |.||.|||.|     ||. ..|.|..||. .|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LIAGEALWPGRSDVDQLYLIKQTLGDLIDRHSKIFSTNHFFKGMSIPEPERRIPLKDKVRNLNSTALTFLEACLQMDPADRLSCQELME-------MPFF
...|. ..|      |.... . .|                                      . |. |.. |||.||..|... |...       .|.|
MLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDKL1.AA CDK 4-219 37 8.2e-96 307.02 In-house 1-242 (284) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-242/284
Sequence Identity: 37% (94 aa)

YERLGKIGEGSYGVVFKCRHKDTG-----TIVAIKRF-VESE----DDPLIKKIALREIRMLKQLKHENLVNLKEVFRRK-----------KKLHLVFEY
||.| |||||.||||.|.|.|.||      |||.|.. .|.|    ..  .   |.||| .||.| |.| |.|..|.  |           .|| .||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CDYTVLNTLEANVNGVPEGQGMNIVYQTLEAVNFCHQHNCIHRDVKPENILITKDGR-----IKLCDFGFARILTG------PDDEYTDYVATRWYRAPE
.|.     ..            .. .| |.....||... .||| || ||||...|      .|. |||.||.         |  .||  | |.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLVGDMVYG--PPVDVWAIGCVTAELIA---GEALWPGRSDVDQLYLIKQTLG
|| |.  |.  .|.|.|..||. ||..    ...| ||.|. ||| .| ...|
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICG
Kinase CDKL1.AA CDC2 4-219 43 1.4e-88 272.32 In-house 1-226 (301) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-226/301
Sequence Identity: 43% (99 aa)

YERLGKIGEGSYGVVFKCRHKDTGTIVAIKRF-VESEDDP-LIKKIALREIRMLKQLK-HENLVNLKEVFRRKKKLHLVFEYCDYTVLNTLE-ANV--NG
|... |||||.||||.||....|..|||.|.. .|.||.   .   |.|||  || || |.|.| |..|.   .|| .||||.|.   . ..  ..    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

VPEGQGMNIVYQTLEAVNFCHQHNCIHRDVKPENILITKDGRIKLCDFGFARILTGPDDEYT--DYVATRWYRAPELLVGDMVYGPPVDVWAIGCVTAEL
.|.    .. || |..|.||||.  .||| || |||| |.|.||. ||| ||  . | ..||    | |.||||||.| |.  |  |||.|.|||. ||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---IAGEALWPGRSDVDQLYLIKQTLG
   .  ..| .| |  |||. | ..||
FMDVTKKPLFHGDSEIDQLFKIFRILG
Kinase CDKL1.AA CDK5 4-287 36 3.9e-82 259.25 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-287/287
Sequence Identity: 36% (105 aa)

YERLGKIGEGSYGVVFKCRHKDTGTIVAIKRFVESEDDPLIKKIALREIRMLKQLKHENLVNLKEVFRRKKKLHLVFEYCDYTVLNTLEANVNGVPEGQG
||.. ||||| ||.|.| | |.|. |||.||    ..|  .   |.||| .|| |||.| | |  |    ||| ||||.||      ..    ..     
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

MNIVYQTLEAVNFCHQHNCIHRDVKPENILITKDGRIKLCDFGFARILTGPDDEYTDYVATRWYRAPELLVGDMVYGPPVDVWAIGCVTAELI-AGEALW
  . || |  . |||.|.  ||| || | || | |  || ||| ||    |   |.  | | |||.|  | |  .|  ..|.| .||. ||.. ||  | 
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGRSDVDQLYLIKQTLGDLIDRHSKIFSTNHFFK--GMSIPEPERRIPLKDKVRNLNSTALTFLEACLQMDPADRLSCQELMEMPFF
|| .. ||| .| . .|     .    .    .|      |  . . ...  |..|... . .|.  ||..|. |.| .. .. |.|
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDKL1.AA RCK 4-219 38 2e-80 254.88 In-house 1-231 (298) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-231/298
Sequence Identity: 38% (90 aa)

YERLGKIGEGSYGVVFKCRHKDTGTIVAIKRFVESEDDPLIKKIALREIRMLKQLK-HENLVNLKEVFRRKK--KLHLVFEYCDYTVLNTLEA---NVNG
|  . ..|.|.||.|.| . |.|| |||||.    .   .   . ||||. |. |. |.|...||||.| ..   |..||||.|  .   ..        
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKY

VPEGQ--GMNIVYQTLEAVNFCHQHNCIHRDVKPENILITK---------DGRIKLCDFGFARILTGPDDE-YTDYVATRWYRAPELLVGDMVYGPPVDV
.|| |   .||.||.| . ...| |.  |||.|||||..|.         ...||..||| .|     .   ||||| ||||||||.|  .  |  |.|.
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIR--SKPPYTDYVSTRWYRAPECLLRCTYYNSPMDI

WAIGCVTAELIAGEALWPGRSDVDQLYLIKQTLG
||.||. .||    .|.|| | .||.. | . .|
WAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMG
Kinase CDKL1.AA CDK-Unclassified 4-220 30 7e-65 212.33 In-house 1-257 (324) Show / Hide 
Range on Protein: 4-220
Range on HMM: 1-257/324
Sequence Identity: 30% (78 aa)

YERLGKIGEGSYGVVFKCRHKDTGTIVAIKR-FVESEDD---------PLIKKIALREIRMLKQLKHENLVNLKEVFRRKKKLH-------------LVF
|. . |.||| .| |.| .. .|  .||||. .|  . .          ..| ...|||  |....|.|.  . ...    ..              .| 
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

EYCDYTVLNTLEANVNGVPEGQGMNIVYQTLEAVNFCHQHNCIHRDVKPENILITKDG-----RIKLCDFGFARILT------------GPDDEYTDYVA
|| .||  | |. |..     |  |   | ||  .. |    .|||.||.||.||  .      .|. ||| |.               .|...|.  |.
EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVS

TRWYRAPELLVGDMVYGPPVDVWAIGCVTAELIAGEALWPGRSDVDQLYLIKQTLGD
|||||||||| |.  |.. ||.|..||. ||.. |  . .||....|.  | ..||.
TRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGT
Kinase CDKL1.AA MAK 4-219 34 1.1e-61 194.91 In-house 1-265 (352) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-265/352
Sequence Identity: 34% (92 aa)

YERLGKIGEGSYGVVFKCRH------------------------------KDTGTIVAIKRFVESEDDPLIKKIALREIRMLKQLK-HENLVNLKEVFR-
|  . ..| |.|| | . .                               .||| .|||||      . .   . |||.  || |. | |.| ||||.| 
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYS-WEECMNLREVKSLKKLNAHPNIVKLKEVIRD

-RKKKLHLVFEYCDYTVLNTLEANVN-GVPEGQGMNIVYQTLEAVNFCHQHNCIHRDVKPENILITKD-----------------GRIKLCDFGFARILT
    .|..||||        .        ||    ||.|| | .  | |.|.  ||| |||||...                    .||. ||| || . 
SENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIR

GPDDEYTDYVATRWYRAPELLVGDMVYGPPVDVWAIGCVTAELIAGEALWPGRSDVDQLYLIKQTLG
     ||||| |||||||| |    .|. |.|.||.||. |||    .| || | .||.. | | ||
S-KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLG
Kinase CDKL1.AA CDK7 105-219 47 2.7e-54 142.79 In-house 106-220 (288) Show / Hide 
Range on Protein: 105-219
Range on HMM: 106-220/288
Sequence Identity: 47% (55 aa)

NIVYQTLEAVNFCHQHNCIHRDVKPENILITKDGRIKLCDFGFARILTGPDDEYTDYVATRWYRAPELLVGDMVYGPPVDVWAIGCVTAELIAGEALWPG
..  .||  . .||..   ||| || | |. ..|..|. ||| ||    |   ||  | |||||||||| |   ||. ||.|..||. |||.      ||
AYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPG

RSDVDQLYLIKQTLG
 ||.|||  | ||||
DSDIDQLTRIFQTLG
Kinase CDKL1.AA MAPK 106-287 31 1.1e-44 152.3 In-house 120-328 (328) Show / Hide 
Range on Protein: 106-287
Range on HMM: 120-328/328
Sequence Identity: 31% (66 aa)

IVYQTLEA--VNFCHQHNCIHRDVKPENILITKDGRIKLCDFGFARILTG-PDDEY-------------TDYVATRWYRAPELLVGD--MVYGPPVDVWA
..|| | .  . . |  | |||| ||.|||.....  |.|||| ||..     ...             |.|||||||||||.. .   | |   ||.|.
FMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWS

IGCVTAELIA-GEALWPGRSDVDQLYLIKQTLG----DLIDRHSKIFS--TNHFFKGMSIPEPERRIPLKDKVRN----LNSTALTFLEACLQMDPADRL
.||  ||..  .  | ||.. .||. || ..||    ..| . ..  |    ......  . .  ..|...   |     |. |. .||  |..|| .|.
VGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICM--SEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRI

SCQELMEMPFF
. .| .. |.|
TVEEALQHPYF
Kinase CDKL1.AA CDK7 4-84 37 1.4e-28 72.9 In-house 1-85 (288) Show / Hide 
Range on Protein: 4-84
Range on HMM: 1-85/288
Sequence Identity: 37% (32 aa)

YERLGKIGEGSYGVVFKCRHKDTGTIVAIKRFV----ESEDDPLIKKIALREIRMLKQLKHENLVNLKEVFRRKKKLHLVFEYCD
|| . .|||| ...|.| . . || |||||.       || .  |   |.||| .|. ..|.| ..|  .|  |  . |||.. |
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMD
Kinase CDKL1.AA MAPK 4-84 28 1.2e-22 75.01 In-house 1-99 (328) Show / Hide 
Range on Protein: 4-84
Range on HMM: 1-99/328
Sequence Identity: 28% (28 aa)

YERLGKIGEGSYGVVFKCRHKD------TGTIVAIKRFVESEDDPLIKKIALREIRMLKQL-KHENLVNLKEVFRRK-----------KKLHLVFEYCD
|. | .||.|.||||.....|       .|..||||...   ..|.  | ..|||..|. . .||| ..|...|. .           . . .|.|...
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELME
Kinase CDKL1.AA Pkinase_Tyr 4-159 28 3.2e-21 72.51 Pfam 1-169 (270) Show / Hide 
Range on Protein: 4-159
Range on HMM: 1-169/270
Sequence Identity: 28% (48 aa)

YERLGKIGEGSYGVVFKCRHK----DTGTIVAIKRFVESEDDPL--IKKIALREIRMLKQL-KHENLVNLKEVFR-RKKK--LHLVFEYCDY-TVLNTLE
 . . |.|||..|.|.|.. |    .|.. ||.|   |. ...   ...  .||....||| .|.|.|.|  |   ...   . .|.||. .   |. | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF-MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AN---VNGVPEGQGMNIVYQTLEAVNFCHQHNCIHRDVKPENILITKDGRIKLCDFGFARILTGPDDEY-T
..    . ..  .  .. .|  .. .. ...||||||.   |.|.|... .| |||| || .  .||.| .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYR
Kinase CDKL1.AA TyrKc 4-287 21 1.8e-15 27.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

YERLGKIGEGSYGVVFKCRHKDTGTIVAIKRFVESEDDPLIKKIALREIRMLKQL--KHENLVNLKEVFRRK-------KKLHLVFEYCDY-TVLNTLEA
 . . |.||| .|.|.|.. |   . ||.|   |.     .. . .||.|....|  .|.|.|.|  | . .       . | .|.||...   .. | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NVNGVPEGQGMNIVYQTLEAVNFCHQHNCIHRDVKPENILITKDGRIKLCDFGFARILTGP------DDEYT------DY--VATRWYRAPELLVGDMVY
. . ..  .  .. .|  .  .. |..||||||    |.|.......| .||| .| ..        .| |.          .  ||. ||| .  . ..
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

GPPVDVWAIGCVTAELIA-GEALWPG-----RSDVDQLYLIKQTLGDLIDRH----SKIFSTNHFFKGMSIPEPERRIPLKDKVRNLNSTALTFLEACLQ
 .  |||. | .  |.   |.  .||      |. . . ..||     .  .    |                          |.          . | .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F---VCCPDEMYQ-IMKQCWH

MDPADRLSCQELMEMPFF
 ||.|| . .|.    .|
EDPEDRPTFSEI--HECF
Kinase CDKL1.AA CDK 263-287 32 5.8e-08 21.38 In-house 260-284 (284) Show / Hide 
Range on Protein: 263-287
Range on HMM: 260-284/284
Sequence Identity: 32% (8 aa)

FLEACLQMDPADRLSCQELMEMPFF
.|. .|..||. |.|... ...|.|
LLNKMLCYDPKKRISAEQALQHPYF
Kinase CDKL1.AA CDK7 260-287 28 4.2e-07 14.49 In-house 261-288 (288) Show / Hide 
Range on Protein: 260-287
Range on HMM: 261-288/288
Sequence Identity: 28% (8 aa)

ALTFLEACLQMDPADRLSCQELMEMPFF
.|....  . |.|  |..| .  .||.|
LLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDKL1.AA MAK 247-287 30 9.7e-07 17.0 In-house 311-352 (352) Show / Hide 
Range on Protein: 247-287
Range on HMM: 311-352/352
Sequence Identity: 30% (13 aa)

IPLKDKVRNLNS-TALTFLEACLQMDPADRLSCQELMEMPFF
.|||  . | ..  |.  .. .|| ||  |   |.....|.|
MPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase CDKL1.AA RCK 247-287 31 2.4e-05 12.59 In-house 258-298 (298) Show / Hide 
Range on Protein: 247-287
Range on HMM: 258-298/298
Sequence Identity: 31% (13 aa)

IPLKDKVRNLNSTALTFLEACLQMDPADRLSCQELMEMPFF
.|||  . |... ..  .| .|| ||  | . |.. ..|.|
MPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase CDKL1.AA CDC2 245-287 25 4.4e-05 10.99 In-house 250-301 (301) Show / Hide 
Range on Protein: 245-287
Range on HMM: 250-301/301
Sequence Identity: 25% (13 aa)

RRIPLKDKVRN---------LNSTALTFLEACLQMDPADRLSCQELMEMPFF
... |.. . |         |. ...  |.  || ||..|.| .| .. |.|
KPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase CDKL1.AA CDK-Unclassified 271-287 35 0.043677 2.5 In-house 308-324 (324) Show / Hide 
Range on Protein: 271-287
Range on HMM: 308-324/324
Sequence Identity: 35% (6 aa)

DPADRLSCQELMEMPFF
.|  |..|.|.   | |
QPYNRWKCMEILQHPWF