Gene DYRK1 (Sea Urchin)

DYRK1

Species: Sea Urchin
Alias: DYRK1, Spk140, SPU_019900
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK1

Sequence

Name Sequence Type Origin Length Description Download
DYRK1.AA Protein None 792 None Fasta, JSON
DYRK1.kin_dom Protein Kinase Domain None 319 None Fasta, JSON

Protein domain

Protein domains of DYRK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRK1.AA DYRK1 171-489 86 4e-243 813.97 In-house 1-321 (321) Show / Hide 
Range on Protein: 171-489
Range on HMM: 1-321/321
Sequence Identity: 86% (277 aa)

YEIDSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQIEVRLLELMNKHDADSKYYIVKLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVS
|||||||||||||||.||||||||||||||||||||||.||||||.||||||||||...|||||.|||||||||||||||||||||||||||||.|||||
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGISYDMAIDMWSLGCILVEMHTGE
|||||||||||||||||..||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFSGSNELDQMNKIIEVLGMPPNHIIEQAPKAHKYFIK-TEKTWVLKRSRDGKK-YKSPRTRKLQDILGVELGGPGGRRAGEPGHTVSDPHKFKDPILR
||||||||.||||||.|||||||.|.|.||||||||| | ...||..|..||.|| ||.|.||||..||||| |||||||.|||||.|.|..||||.|.|
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIKR

MLEYDPASRIKPYYALQHSFF
||.|||..||.||||||||||
MLQYDPKQRITPYYALQHSFF
Kinase DYRK1.AA DYRK 171-489 53 3.4e-198 664.73 In-house 1-320 (320) Show / Hide 
Range on Protein: 171-489
Range on HMM: 1-320/320
Sequence Identity: 53% (174 aa)

YEIDSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQIEVRLLELMNKHDADSKYYIVKLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGV-
|||.. |||||||||.|..||. .|.||||||.|.|.|..|||||...||..|..| | ||..|.....|..|||||.||||||.|||..|.|..|.|. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNP-KRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGISYDMAIDMWSLGCILVEMHT
||||.||||||..|.|.||...| ||||||||||||.|..| ..|.||.|||||||. .||||.||||||||.|||.||. |..|||||||||||.|..|
SLNLVRKFAQQILTCLKFLHKNE-NIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFT

GEPLFSGSNELDQMNKIIEVLGMPPNHIIEQA--PKAHKYFIKTEKTWVLKRSRDG-KK-YKSPRTRKLQDILGVELGGPGGRRAGEPGHTVSDPHKFKD
|.|||.|.|| ||...|.|||||||...|...  ...||.| .  ...  ...... .| .. . |.|.. ... . ..|.||| ..|.|.  | |.|||
GWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC--FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKD

PILRMLEYDPASRIKPYYALQHSFF
 |...|..||..||.|..||||..|
FIKKCLQWDPHKRITPSQALQHPWF
Kinase DYRK1.AA DYRK2 171-489 43 1.8e-140 459.72 In-house 1-318 (318) Show / Hide 
Range on Protein: 171-489
Range on HMM: 1-318/318
Sequence Identity: 43% (148 aa)

YEIDSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQIEVRLLELMNKHDADSKYYIVKLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVS
|||.. |||||||||.|.|||  ...||||.| ||| |.|||..|.| |. . ..| |. . .|...  |.||||.|..||||| |||..... .| | |
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLGISYDMAIDMWSLGCILVEMHTG
|.| |.||... ..| ||   . ||||||||||||||  . || ||.|||||||   | ||| ||||||||.||| ||. |.|||||||.|||..|. ||
LQLVRRFAHSILQCLRFLH--KNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

EPLFSGSNELDQMNKIIEVLGMPPNHIIEQA----PKAHKYFIKT-------------EKTWVLKRSRDGKKYKSPRTRKLQDILGVELGGPGGRRAGEP
 ||| |.|| ||.  ..||||||| ......     .  |||..              ...    ... ..| . | .......|               
YPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVL---------------

GHTVSDPHKFKDPILRMLEYDPASRIKPYYALQHSFF
  . ..   | | |.| .| ||..|..|  ||.| ..
--KGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase DYRK1.AA CMGC 171-489 21 9.3e-120 395.46 In-house 1-513 (513) Show / Hide 
Range on Protein: 171-489
Range on HMM: 1-513/513
Sequence Identity: 21% (114 aa)

YEIDSLIGKGSFGQVAKAYD--------------HQEQEYVAIKIIKNKKPFLNQAQ-------------IEVRLLELMN-KHDADS-----------KY
|||.. ||.|..|.| |..|              |. .|.||||.|||.. . .||.              |...|. .| .||.             . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

YIVKLKRHFMFRN-----------------HLCLVFELLSYNLYDLLRNTN--------------------------FRGVSLNLTRKFAQQMCTALL--
.||||. .|...|                 ||.||||.. ..||....|..                           .  .. . | ...|....|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

FLATPELNIIHCDLKPENILLCNPKRS------------------AIKIIDFGSSCQLGQR------------------------IYQYIQSRFYRSPEV
..    .||||.||||||||... ...                   .||.|||........                        ...|...|.||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

LLGIS----------YDMAIDMWSLGCILVEMHTG--------EPLFSGSNE-----------LDQMNKIIEVLGMPPNHIIEQ-------APKAHKYFI
||| .          |. .|||||.|||. || ||        .||| |..|           .||..||..|||.|. ..|..       ...  ... 
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

KTE---------------------------------KTWVLKRSRDGKKYKSPR---------TRKLQDILGVELGGPGGRRAGEPGHTVS---------
...                                 . |. ...   .. ..|.          .  . |.  |             ...          
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVF-NW-IY--E-------------EKFKSHKFNHQFK

---DPHKFKDPILRMLEYDPASRIKPYYALQHSFF
   ..... | . .||.|||. ||..  |||| .|
RKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase DYRK1.AA YAK 171-407 44 3.4e-104 352.45 In-house 1-239 (347) Show / Hide 
Range on Protein: 171-407
Range on HMM: 1-239/347
Sequence Identity: 44% (107 aa)

YEIDSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQIEVRLLELMN-KHDADSKY---YIVKLKRHFMFRNHLCLVFELLSYNLYDLLRNTNF
| .    |.| ||||.|       | .|.|.|||.  .. ||  |...|.. | .|| . |     |...   | ..||.|||||.|| |||..| ...|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

RGVSLNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGISYDMAIDMWSLGCILVEM
.| | .| | .  |   ..  |.  . .|||||||||||.||.| . .|||||||||||  . .| |||.|.|||||..... |  .|||||||||..| 
CGFSFQLIRQWTKQILDGMCVLE--NKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL

HTGEPLFSGSNELDQMNKIIEVLGMPPNHIIEQAPKAHKYF
  | |.| |  | .|.  ||..|| ||. .|.|     |||
FLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase DYRK1.AA S_TKc 171-489 26 2.3e-83 284.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 171-489
Range on HMM: 1-231/231
Sequence Identity: 26% (90 aa)

YEIDSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQIEVRLLELMNKHDADSKYYIVKLKRHFMFRNHLCLVFELLSY---NLYDLLRNTNFR
|||  .||||.||.| |....  ...|||||||      .... |...|.           .||||. .|   .||..|.|...    .|.|.... . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----VSLNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGISYDM-AIDMWSLGCI
|     .   .|....|.| || ..   ...|||.|||||||||..     |||.|||...||    . .. ...|..||||   .|.  ..|.||.|||
GLRFPFPE-HARFYMYQICCALEYCH--SHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LVEMHTGEPLFSGSNELDQMNKIIEVLGMPPNHIIEQAPKAHKYFIKTEKTWVLKRSRDGKKYKSPRTRKLQDILGVELGGPGGRRAGEPGHTVSDPHKF
| || .|.|.|.      ||.......|                                                                    .. .
LYEMLCGYPPFP------QMQMMFKKIG--------------------------------------------------------------------SPEA

KDPILRMLEYDPASRIKPYYALQ-------HSFF
|| | ..|..||. |.    |||       | .|
KDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DYRK1.AA HIPK 171-407 42 3.9e-75 235.96 In-house 1-237 (329) Show / Hide 
Range on Protein: 171-407
Range on HMM: 1-237/329
Sequence Identity: 42% (101 aa)

YEIDSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQIEVRLLELMNKHDADSKYYIVKLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVS
||.  ..|.| ||||.|.  .  .| |||||.||   .  | ||||..|. . . .||  | .|.    |  .|| |||||.|  |||| ... .|    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNPKRSA--IKIIDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLGISYDMAIDMWSLGCILVEMH
|.  |   ||  |||. |   || .|| |||||||.|  |.|    .|.|||||   . . . . |.|||.|| ||..||. .  ..|||||||.. | .
LKHIRPILQQVLTALMKLK--ELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELF

TGEPLFSGSNELDQMNKIIEVLGMPPNHIIEQAPKAHKYF
 | ||. |..| ||   |..  . |  |....| |.|..|
LGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFF
Kinase DYRK1.AA PRP4 171-376 38 3.6e-57 196.24 In-house 1-208 (320) Show / Hide 
Range on Protein: 171-376
Range on HMM: 1-208/320
Sequence Identity: 38% (82 aa)

YEIDSLIGKGSFGQVAKAYDHQEQE-YVAIKIIKNKKPFLNQAQIEVRLLELMNKH--DADSKYYIVKLKRHFMFRNHLCLVFELLSYNLYDLLRN-TNF
|.. . .|.| |. | .. |       |||||| |.         |.  |  .|    | . |. .|...||| .|.|.||||| .| || ..|      
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

RGVSLNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLG-QRIYQYIQSRFYRSPEVLLGISYDMAIDMWSLGCILVE
 | .|.  | .|||.  ||  |    .||.| |.|| |||  |  .. .|..||||  .   . |  | .|||||.||...|..|| .||||| || | |
VGLHLKAVRSYAQQLFLALKHLK--KCNILHADIKPDNILV-NESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYE

MHTGEPLFSGS
. ||  .|.|.
LYTGKIMFPGK
Kinase DYRK1.AA Pkinase 171-489 25 5.7e-57 200.37 Pfam 1-293 (293) Show / Hide 
Range on Protein: 171-489
Range on HMM: 1-293/293
Sequence Identity: 25% (89 aa)

YEIDSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQI-----EVRLLELMNKHDADSKYYIVKLKRHFMFRNHLCLVFELLSY-----NLYDL
|.| . ||.||||.| |.... ... ||.|||| ..   .. |.     |....  . .|.      ||.|.. |. ..|...|.|..        |.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPN-----IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LR---NTNFRGVSLNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNPKRSAI----KIIDFGSSCQL---GQRIYQYIQSRFYRSPEVLL-GIS
..   ...|   | .  .... |.. .| ..     .|||.||||||||.   ..  |    ||.|||...|.   ..  . .  ...|..|||.. |  
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS--MGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQY

YDMAIDMWSLGCILVEMHTGEPLFSGS----NELDQMNKIIEVLGMPPNHIIEQA---PKAHKYFIKTEKTWVLKRSRDGKKYKSPRTRKLQDILGVELG
|. ..||||.|||| || .|.|.|.|.    | .||| .| ...| |.   ...    .  .  .. . .                              
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------------------------

GPGGRRAGEPGHTVSDP---HKFKDPILRMLEYDPASRIKPYYALQHSFF
         . |..  .     .|| | ..|..||..|. .  .||| .|
---------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DYRK1.AA CDK 171-489 26 6e-54 170.9 In-house 1-284 (284) Show / Hide 
Range on Protein: 171-489
Range on HMM: 1-284/284
Sequence Identity: 26% (96 aa)

YEIDSLIGKGSFGQVAKAYDHQEQ-----EYVAIKIIK---N-----KKPFLNQAQIEVRLLELMNKHDADSKYYIVKLKRHFMFR-----------NHL
||.   || |..|.| || |.| .     ..||.| |.   .     |  |   |  |. ||  .  |.     .||||.  ..             | |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HP-----NIVKLHDVCHTKNMDRNNKDKHENKL

CLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNPK---RSAIKIIDFGSSCQLG--------QRIYQ-YI
 .||| . . |. ...            . . .|.  .| ..   . .|.| |||| |||. |     .  .|| ||| ..  |        .| |   .
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCH--SNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEV

QSRFYRSPEVLL-GISYD--MAIDMWSLGCILVEMHT---GEPLFSGSNELDQMNKIIEVLGMPPNHIIEQAPKAHKYFIKTEKTWVLKRSRDGKKYKSP
  . ||.||.||    |.   .|||||.|||..|| |   ..||| |..|.||. ||....| |   .     |   |                      
VTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------

RTRKLQDILGVELGGPGGRRAGEPGHTVSDPHKFKDPILRMLEYDPASRIKPYYALQHSFF
                                   | . .|| |||. ||.   |||| .|
-----------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase DYRK1.AA CLK 171-310 32 4.1e-46 135.81 In-house 1-150 (350) Show / Hide 
Range on Protein: 171-310
Range on HMM: 1-150/350
Sequence Identity: 32% (49 aa)

YEIDSLIGKGSFGQVAKAYDHQE-QEYVAIKIIKNKKPFLNQAQIEVR-LLELMNKH-DADSKYY--IVKLKRHFMF-RNHLCLVFELLSYNLYDLLRNT
||| .  | | || | .  ||.    |||.|||.| . .  .|..|..  ..  |.  |...||   ..|.   | .  .| |.||||.  ..||... .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------FRGVSLNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNP
|      ...  .. .|..| | |.|. ||   .. ..| |||||||.....
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH--DMKLTHTDLKPENICFVDS
Kinase DYRK1.AA GSK 171-393 33 2.5e-43 129.82 In-house 1-239 (328) Show / Hide 
Range on Protein: 171-393
Range on HMM: 1-239/328
Sequence Identity: 33% (83 aa)

YEIDSLIGKGSFGQVAKAYDH----QEQEY----VAIKIIKNKKPFLNQAQIEVRLLELMN--KHDADSKYYIVKLKRHFM-FRNH--------LCLVFE
||.. .|| |||| | .||.     ...|     |||| .  .| .   .. |.  .. .   .|       ||.|| .|  . .         .|||.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYK--CNRELQIMKMLGKLDHPN-----IVRLKYFFYMHYEKKDENHVYCNCLVME

LLSYNLYDLLR--NTNFRGVSLNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRI----YQYIQSRFYRSPEVL
 . ..||...|  ..| . ..... . .. ||. .| .|   ...| | |.||.|||. .|.    || ||||. ||  .       || ||.|| || .
YMPQTLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLH--SHGICHRDIKPQNILV-DPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELI

LGIS-YDMAIDMWSLGCILVEMHTGEPLFSGSNELDQMNKIIEVLGMPP
.|.. |. .||.||.||.. || .|.|||.| ...||   ||..|| |.
FGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPT
Kinase DYRK1.AA CLK 315-424 31 1.3e-20 57.83 In-house 186-301 (350) Show / Hide 
Range on Protein: 315-424
Range on HMM: 186-301/350
Sequence Identity: 31% (37 aa)

IKIIDFGSSC---QLGQRIYQYIQSRFYRSPEVLLGISYDMAIDMWSLGCILVEMHTGEPLFSGSNELDQMNKIIEVLGMP-PNHIIEQAP---KAHKYF
|..|||||     .     .  ...| || ||| ||  .    | || ||||.|  ||. || . .... .  . ...||| |.. |          |||
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYF

IKTEKTWVLKRSRDGKK
..    |.   ..||..
YHNRLDWDW-HNSDGRY
Kinase DYRK1.AA GSK 466-489 45 2.1e-10 27.38 In-house 305-328 (328) Show / Hide 
Range on Protein: 466-489
Range on HMM: 305-328/328
Sequence Identity: 45% (11 aa)

ILRMLEYDPASRIKPYYALQHSFF
| ..|.||| .|..|. |..| ||
ISKCLVYDPKKRLSPLEACAHPFF
Kinase DYRK1.AA CLK 460-489 53 4.9e-10 25.54 In-house 321-350 (350) Show / Hide 
Range on Protein: 460-489
Range on HMM: 321-350/350
Sequence Identity: 53% (16 aa)

HKFKDPILRMLEYDPASRIKPYYALQHSFF
... | | .||||||. ||.   |||| ||
RQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase DYRK1.AA TyrKc 171-489 17 9.7e-09 -81.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 171-489
Range on HMM: 1-280/280
Sequence Identity: 17% (62 aa)

YEIDSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQIEVRLLELM-NKHDADSKYYIVKLKRHFMFR-------NHLCLVFELLSY-NLYDLL
 . .  .| | ||.| |.      . ||.| .|. .  .     | |..     .|.      ||.|    .           |..|.|. .. .| | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-----NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RNTNFRGVSLNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQR-------IYQYI----QSR-----FYRSPEVL
|..  . ...    .|. | .    .|.  . |.|| ||   |.|. ...   .|| ||| |  ..          |       ...        .||..
RKHRPK-LCMKDLLSFCWQIACGMEYLH--SKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

LGISYDMAIDMWSLGCILVEMHT-GEPLFSG-------SNELDQMNKIIEVLGMPPN----HIIEQAPKAHKYFIKTEKTWVLKRSRDGKKYKSPRTRKL
    .  . | || |  . |. | |..  .|         |. .  |  . .  |||                                           
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------------

QDILGVELGGPGGRRAGEPGHTVSDPHKFKDPILRMLEYDPASRIKPYYALQHSFF
                      |  | .  . ...  ..||..|        |..|
--------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase DYRK1.AA PRP4 460-489 43 2e-06 19.62 In-house 291-320 (320) Show / Hide 
Range on Protein: 460-489
Range on HMM: 291-320/320
Sequence Identity: 43% (13 aa)

HKFKDPILRMLEYDPASRIKPYYALQHSFF
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HQFKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase DYRK1.AA HIPK 468-489 40 0.000157 9.64 In-house 308-329 (329) Show / Hide 
Range on Protein: 468-489
Range on HMM: 308-329/329
Sequence Identity: 40% (9 aa)

RMLEYDPASRIKPYYALQHSFF
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KMCTWDAHKRITPCEALNHPFV
Kinase DYRK1.AA YAK 469-489 42 0.010376 4.59 In-house 327-347 (347) Show / Hide 
Range on Protein: 469-489
Range on HMM: 327-347/347
Sequence Identity: 42% (9 aa)

MLEYDPASRIKPYYALQHSFF
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LLQLNPRERWKPMQAMQHPFI