Gene DYRK4 (Sea Urchin)

DYRK4

Species: Sea Urchin
Alias: SPU_022035, DYRK4, Spk139
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
DYRK4.AA Protein None 542 None Fasta, JSON
DYRK4.kin_dom Protein Kinase Domain None 223 None Fasta, JSON

Protein domain

Protein domains of DYRK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRK4.AA DYRK2 200-440 68 8.60000000001e-191 626.08 In-house 1-247 (318) Show / Hide 
Range on Protein: 200-440
Range on HMM: 1-247/318
Sequence Identity: 68% (169 aa)

YEILEVIGKGSFGQVVKAFDHKLGEMIAIKIIRNKKRFHHQALIEVKILDALRRKDRDNSHNVVHMREYFYYRNHLCITFELLGMNLYELIKKNNFQGFS
|||||||||||||||||..|||.....|||.||||||||.||..|..||...||.|.||..|.|||..|||.|||.|||||||.|||||.||||.|||||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

VALIRRFAFSLLQCLRMLHKERIIHCDLKPENILLRQKGQSTIKVIDFGSSCYEHQ-RVYTYIQSRFYRSPEVILGLPYGLPIDMWSFGCILAELYTGYP
..|.||||.|.|||||.|||..|||||||||||||.|...|.||||||||||.||| |.||||||||||.||||||..|| .|||||||||.||||||||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPGENEVEQLACIMEIFGLPPPHIIEEA-----QRRRLFFEDSSAP
|||||||..|.||.||..|.||..... .      ||..||..   .
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFE
Kinase DYRK4.AA DYRK 200-468 60 9.90000000001e-174 583.46 In-house 1-267 (320) Show / Hide 
Range on Protein: 200-468
Range on HMM: 1-267/320
Sequence Identity: 60% (165 aa)

YEILEVIGKGSFGQVVKAFDHKLGEMIAIKIIRNKKRFHHQALIEVKILDALRRKDRDNSHNVVHMREYFYYRNHLCITFELLGMNLYELIKKNNFQGF-
|||||.|||||||||||..||| .||.|||||||.||||.||.||.|||. |...|.|.....||| .|||.||||||.|||| |||||..|.|.|||| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SVALIRRFAFSLLQCLRMLHKE-RIIHCDLKPENILLRQK-GQSTIKVIDFGSSCYEHQRVYTYIQSRFYRSPEVILGLPYGLPIDMWSFGCILAELYTG
|. |.|.||...|.||..|||. .|||||||||||.|.|. ..||||||||||||.||||.||||||||||.||||||.||. .|||||.|||||||.||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

YPLFPGENEVEQLACIMEIFGLPPPHIIEEA--QRRRLFFEDSSAPDVSKKNGLRISREKSNLNAKSDFVMPPI
.||||||||..|||||||..|.||...|...  .|.. ||..       ..     ...|.| . . ... ...
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC-------FMYCECDEWTKQNKITDHYMTPKCH
Kinase DYRK4.AA CMGC 200-441 24 2e-111 367.55 In-house 1-401 (513) Show / Hide 
Range on Protein: 200-441
Range on HMM: 1-401/513
Sequence Identity: 24% (99 aa)

YEILEVIGKGSFGQVVKAFD--------------HKLGEMIAIKIIRNKKRFHHQAL-------------IEVKILDALR-RKDRDN----------SHN
|||...||.|..|.|.|..|              |. .|..|||.|.|.. ...||.              |.|||  |. ..|  |           ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-VVHMREYFYYRN-----------------HLCITFELLGMNLYELIKKNN--------------------------FQGFSVALIRRFAFSLLQCLR--
 .|.....||..|                 ||.. ||.....||..||.|.                           . |.. .|| ... .|..|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

MLHKER--IIHCDLKPENILLRQKGQS------------------TIKVIDFGSSCYEHQR------------------------VYTYIQSRFYRSPEV
 .|. .  |||.||||||||. .....                  ..|..|||.....|..                         ..|...|.||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGLP----------YGLPIDMWSFGCILAELYTG--------YPLFPGENE-----------VEQLACIMEIFGLPPPHIIEE-------AQRRRLFFE
.|| .          |. ||||||.|||.||.|||        .|||||..|           ..||..|....| |. ..|.        ... . ...
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

DSSAPD
 .. |.
MIKLPW
Kinase DYRK4.AA DYRK1 200-435 53 2.1e-110 373.07 In-house 1-238 (321) Show / Hide 
Range on Protein: 200-435
Range on HMM: 1-238/321
Sequence Identity: 53% (128 aa)

YEILEVIGKGSFGQVVKAFDHKLGEMIAIKIIRNKKRFHHQALIEVKILDALRRKDRDNSHNVVHMREYFYYRNHLCITFELLGMNLYELIKKNNFQGFS
|||   ||||||||||||.||.  |..|||||.||| |  ||.||...|. . ..|...  ..||... | .|||||. ||||  |||.|..  .|.| |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

VALIRRFAFSLLQCLRMLHKE--RIIHCDLKPENILLRQKGQSTIKVIDFGSSCYEHQRVYTYIQSRFYRSPEVILGLPYGLPIDMWSFGCILAELYTGY
. |.|.||  ... |  .      |||||||||||||.    | ||.|||||||   ||.| ||||||||||||.||..| . ||||| |||| |. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFPGENEVEQLACIMEIFGLPPPHIIEEAQRRRLFFE
||| | |||.|.  |.|. |.|| |.|..| . . .||
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE
Kinase DYRK4.AA YAK 200-434 44 1.2e-97 330.7 In-house 1-239 (347) Show / Hide 
Range on Protein: 200-434
Range on HMM: 1-239/347
Sequence Identity: 44% (106 aa)

YEILEVIGKGSFGQVVKAFDHKLGEMIAIKIIRNKKRFHHQALIEVKILDALRRKDRDNSHN----VVHMREYFYYRNHLCITFELLGMNLYELIKKNNF
| .| . |.| ||||||       |..|.|.| |.  .  ||  |..||  |  .   |  |    .. |  .| ..||.|. ||.| .||||..| |.|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

QGFSVALIRRFAFSLLQCLRMLHKERIIHCDLKPENILLRQKGQSTIKVIDFGSSCYEHQRVYTYIQSRFYRSPEVILGLPYGLPIDMWSFGCILAELYT
 |||. ||| .  . |  .  |   .|||||||||||.|..  .  ||.|||||||.| . ||||||.|.|||||.|.. .|   ||||| |||.|||. 
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GYPLFPGENEVEQLACIMEIFGLPPPHIIEEAQRRRLFF
| |.|||  | .|.  | .. | ||  .|.  . .  .|
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase DYRK4.AA HIPK 200-435 42 3.1e-78 245.9 In-house 1-238 (329) Show / Hide 
Range on Protein: 200-435
Range on HMM: 1-238/329
Sequence Identity: 42% (102 aa)

YEILEVIGKGSFGQVVKAFDHKLGEMIAIKIIRNKKRFHHQALIEVKILDALRRKDRDNSHNVVHMREYFYYRNHLCITFELLGMNLYELIKKNNFQGFS
||.||..|.| ||||||.  .  .||.||||..|   .  |  |||.||  |. .. |.  ..| . |.|  .|| |. ||.|  |||.  |.|.|    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

VALIRRFAFSLLQCLRMLHKERIIHCDLKPENILLRQKGQS--TIKVIDFGSSCYEHQRVY-TYIQSRFYRSPEVILGLPYGLPIDMWSFGCILAELYTG
.  ||   .  |  |  | .  .|| |||||||.|  . .    .|||||||  .  . |  ||.|||.|| ||.|||||.   .|||| ||..|||. |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

YPLFPGENEVEQLACIMEIFGLPPPHIIEEAQRRRLFFE
 ||.|| .| .|   | .  .|| .|....| .   ||.
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFD
Kinase DYRK4.AA S_TKc 200-489 26 3.4e-69 237.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 200-489
Range on HMM: 1-231/231
Sequence Identity: 26% (82 aa)

YEILEVIGKGSFGQVVKAFDHKLGEMIAIKIIRNKKRFHHQALIEVKILDALRRKDRDNSHNVVHMREYFYYRNHLCITFELLGM---NLYELIKKNNFQ
||||..||||.||.| |. ..| |.  |||||.       ... |..||         .  |.|.. ..|.  .||.. .|...    .|...|||.. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----FSVALIRRFAFSLLQCLRMLHKERIIHCDLKPENILLRQKGQSTIKVIDFGSSCYEHQRVYTYIQSRFYRSPEVILGLPYGL-PIDMWSFGCILA
|    |.   .|...  ... |  .|. .|||.||||||||| .    .||..|||...      .|.. ...|..|||.   .||  ..|.||.||||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELYTGYPLFPGENEVEQLACIMEIFGLPPPHIIEEAQRRRLFFEDSSAPDVSKKNGLRISREKSNLNAKSDFVMPPIHLGINAD----LTAEKPVN----
|...|||.||      |.. .... |                                           ...    |    . |    .|| .  .    
EMLCGYPPFP------QMQMMFKKIG------------------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWD

-KVKPLL
 |  | .
IKCHPWF
Kinase DYRK4.AA Pkinase 200-463 28 8.1e-61 213.16 Pfam 1-266 (293) Show / Hide 
Range on Protein: 200-463
Range on HMM: 1-266/293
Sequence Identity: 28% (81 aa)

YEILEVIGKGSFGQVVKAFDHKLGEMIAIKIIRNKKRFH--HQALI---EVKILDALRRKDRDNSHNVVHMREYFYYRNHLCITFELLGM-----NLYEL
|.|...||.||||.| |. ... |.. |.|||. ... .  .|...   |..|.  |.      . |.| ....|....|... .|....      |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IK---KNNFQGFSVALIRRFAFSLLQCLRMLHKERIIHCDLKPENILLRQKGQS--TIKVIDFGSSC---YEHQRVYTYIQSRFYRSPEVIL-GLPYGLP
|.   ...|  ||   .....  .|. |  .|...|||.||||||||. ..|.   ..|..|||...   | ... .|.  ...|..||||. | .|| .
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPK

IDMWSFGCILAELYTGYPLFPGE----NEVEQLACIMEIFGLPPPHIIEEAQRRRLFFEDSSAPDVSKKNGLRISREKSNLNAKSDF
.||||.||||.|...|.|.|||.    | ..|...| .| | |..  ...  ....|| ..  .         . ...   |. ...
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------F-HWTF-HNWSEEC
Kinase DYRK4.AA DyrkP 200-434 40 1.4e-60 197.98 In-house 1-239 (323) Show / Hide 
Range on Protein: 200-434
Range on HMM: 1-239/323
Sequence Identity: 40% (96 aa)

YEILEVIGKGSFGQVVKAFDHKLGEMIAIKIIRNKKRFHHQALIEVKILDALRRKDRDNSHNVVHMREYFYYRNHLCITFELLGMNLYELIKKN----NF
| |.| .|   | . ..  | . . |. .||| | | .  |.. |.|.|  .         ||... .||| . || |  |||  ||||  | |      
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

QGFSVALIRRFAFSLLQCLRMLHKERIIHCDLKPENILLRQKGQSTIKVIDFGSSCYEHQRVYTYIQSRFYRSPEVILGLPYGLPIDMWSFGCILAELYT
. | |  . .    .|  |  .|  |.|||||||||||.. . .  .|.|||||||. |  .  |.||| || ||||.|  |   ||||| |||||||.|
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GYPLFPGENEVEQLACIMEIFGLPPPHIIEEAQRRRLFF
|  ||  .|    || .. | |  |  ...|    . ||
GNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFF
Kinase DYRK4.AA PRP4 200-402 41 1.1e-57 197.98 In-house 1-207 (320) Show / Hide 
Range on Protein: 200-402
Range on HMM: 1-207/320
Sequence Identity: 41% (86 aa)

YEILEVIGKGSFGQVVKAFDHKLGE-MIAIKIIRNKKRFHHQALIEVKILDALRRK--DRDNSHNVVHMREYFYYRNHLCITFELLGMNLYELIKKN-NF
|..   .|.| |. |... |   |  |.|||||||.   |   | |. ||  |  .  |..    .| | . |..|.|.|. || . ||| |..||    
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

QGFSVALIRRFAFSLLQCLRMLHKERIIHCDLKPENILLRQKGQSTIKVIDFGS-SCYEHQRVYTYIQSRFYRSPEVILGLPYGLPIDMWSFGCILAELY
 |...  .| .|  |.  |. | |  |.| |.|| |||     ..|.| .|||| |  . . .  | .|||||.||.|.| ||   ||||| || |.|||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNES-KNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGYPLFPG
||  .|||
TGKIMFPG
Kinase DYRK4.AA CDK 200-419 31 1.2e-57 182.94 In-house 1-244 (284) Show / Hide 
Range on Protein: 200-419
Range on HMM: 1-244/284
Sequence Identity: 31% (82 aa)

YEILEVIGKGSFGQVVKAFDHKLG-----EMIAIKIIR---N-----KKRFHHQALIEVKILDALRRKDRDNSHNVVHMREYFYYR-----------NHL
||.|| || |..|.| || |.. |     ...|.| ||   .     |  | . |. |...|  |        .|.|  .. ..             | |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-------HPNIVKLHDVCHTKNMDRNNKDKHENKL

CITFELLGMNLYELIKKNNFQGFSVALIRRFAFSLLQCLRMLHKERIIHCDLKPENILLRQKGQST---IKVIDFGSSCYEH--------QRVYT-YIQS
 . || . . |.....           |. . . ||. |  .|. .|.| |||| |||.  .|. .   .|. ||| ..  .        .|.||  .  
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVT

RFYRSPEVIL-GLPYG--LPIDMWSFGCILAELYT---GYPLFPGENEVEQLACIMEIFGLP
. ||.||. |    |.   ||||||.|||.||..|   . |||||..| .|| .| .|.| |
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTP
Kinase DYRK4.AA CLK 200-334 36 9.2e-54 159.19 In-house 1-147 (350) Show / Hide 
Range on Protein: 200-334
Range on HMM: 1-147/350
Sequence Identity: 36% (53 aa)

YEILEVIGKGSFGQVVKAFDHKLG-EMIAIKIIRNKKRFHHQALIEVK-ILDALRRK-DRDNSHN--VVHMREYFYY-RNHLCITFELLGMNLYELIKKN
|||. . | | || ||.  ||| |   .|.||||| ...  .| .|.. |. ..  | | .| .   ...|...| |  .| || |||.| ..|...|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------FQGFSVALIRRFAFSLLQCLRMLHKERIIHCDLKPENILL
|      ....  . ||..|. |.. .. ||. ...| |||||||..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase DYRK4.AA CLK 342-419 49 1.2e-33 97.72 In-house 186-266 (350) Show / Hide 
Range on Protein: 342-419
Range on HMM: 186-266/350
Sequence Identity: 49% (40 aa)

IKVIDFGSSC---YEHQRVYTYIQSRFYRSPEVILGLPYGLPIDMWSFGCILAELYTGYPLFPGENEVEQLACIMEIFGLP
|.||||||     ..|   .| ...| || |||||||..  | | ||.|||| |||||. ||.. ...| || . .| |.|
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMP
Kinase DYRK4.AA TyrKc 200-434 17 5.8e-09 -77.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 200-434
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

YEILEVIGKGSFGQVVKAFDHKLGEMIAIKIIRNKKRFHHQALI-EVKILDAL-RRKDRDNSHNVVHMREYFYYR-------NHLCITFELLGM-NLYEL
 . ....| | ||.|.|.      .. |.| ... .   ..... | .|.  |       .  |.| .  .             |.| .|.    .| . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGG-----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKKNNFQGFSVALIRRFAFSLLQCLRMLHKERIIHCDLKPENILLRQKGQSTIKVIDFGSSCYEHQR-------VYTYI----QSR-----FYRSPEVIL
..|.  . ....    |..   .  . ||. ..|| ||   |.|.  ..  |.|. ||| | . .          |       ...        .||.| 
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GLPYGLPIDMWSFGCILAELYT-GYPLFPGE----NEVEQ-LACIMEIFGLPPPHI---------------------IEEAQRR------RLFF
   .    | ||||  . |..| | .  ||.     . .. ...... . .|.|.                       |..  |      . .|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF