Gene GSK3 (Sea Urchin)

GSK3

Species: Sea Urchin
Alias: Spk142, SPU_009263, GSK3
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
GSK3.AA Protein None 427 None Fasta, JSON
GSK3.kin_dom Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of GSK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GSK3.AA GSK 73-357 59 2.2e-231 714.88 In-house 1-328 (328) Show / Hide 
Range on Protein: 73-357
Range on HMM: 1-328/328
Sequence Identity: 59% (196 aa)

YTDTRVIGNGSFGVVYQARMV----DSSDL----VAIKKVLQDKRFK-NRELQIMRRL---DHHNIVKLKYFFYSSGEKKDE--VFLN-LVLEYVPETVY
|....|||.||||||||| |     ....     ||||||.||||.| |||||||..|   || |||.||||||...|||||  |..| ||.||.|.|.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

RVARHYSKAKQTIANLYVKLYMYQLFRSLAYIHSMGICHRDIKPQNLLLNPETAVLKLCDFGSAKVLVR--GEPNVSYICSRYYRAPELIFGATDYTCDI
.|.|||.|.||.......||||||.||.|||.||.|||||||||||.|..|.|.|||.||||||| |..  .|||.||||||||||||||||.|.||| |
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI

DVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSRDQIKEMNPNYTEFKFP-----QIKPHPWNK-------------------VFRA-RTPAD-
||||.|||.||.|.|||.|||||.|||||||||.||||...||..|||.|.|||||     |||||||.|                   .|.. .|... 
DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQD

AIQLCSRLLEYTPKSRIKPLEACAHQFF
.|.|.|..|.|.||.|..|||||||.||
WIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase GSK3.AA CMGC 73-357 21 8.3e-126 415.71 In-house 1-513 (513) Show / Hide 
Range on Protein: 73-357
Range on HMM: 1-513/513
Sequence Identity: 21% (112 aa)

YTDTRVIGNGSFGVVYQARM--------------VDSSDLVAIKKVLQDKRFKN----------------RELQIMRRL-----------------DHHN
|.  ..|| |..||||..|                ..  .|||||. ... ...                ||..|...|                 .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLKYFFYSSGEKKDE-----------VFLNLVLEYVPETVYRVARHYSK------------------------AKQTIANLYVKLYMYQLFRSLA--Y
||||...||.......|           . |.|| ||.. . |.. .....                         .. . . ... ||||..|.|.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHSMG--ICHRDIKPQNLLLNPETAV-------------------LKLCDFGSAK-VLVR---------------------GEPNVSYICSRYYRAPELI
.||..  |.|||.||.|.|.|... .                   ||.||||.|. . ..                     ..|. .|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGA---------TDYTCDIDVWSAGCVLAELLLG--------QPIFPGDSG-----------VDQLVEIIKVLGTPS---------------RDQIKEMN
.|.         ..||. ||.||.||..||...|        .|.|||.|.           .||| .|.||||||.                ... .|.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

PNYTEFK---------------------------FPQIKPHPWNKVFRA----------------------------------RTPADAIQLCSRLLEYT
.... .|                           ||...|.||...|                                    . . .|| | ...|.| 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PKSRIKPLEACAHQFF
|. ||.. .|..| .|
PDKRITAEQALQHPYF
Kinase GSK3.AA Pkinase 73-357 29 1.8e-94 324.98 Pfam 1-293 (293) Show / Hide 
Range on Protein: 73-357
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

YTDTRVIGNGSFGVVYQARMVDSSDLVAIKKVLQDKRFKNR--------ELQIMRRLDHHNIVKLKYFFYSSGEKKDEVFLNLVLEYVPETVYRVARHY-
|.  |.|| ||||.||... ......||.|..  ... ..         |.|||.||.| |||.|...|..      .  . .|.||.. ..| |.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLY-VMDLFD

---SKAKQTI--ANLYVKLYMYQLFRSLAYIHSMGICHRDIKPQNLLLNPETAV---LKLCDFGSAKV--LVRGEPNVSYICSRYYRAPELIFGATDYTC
    ... ..      .| ||||..| |.|.|||||.|||.||.|.|.. .  .   .|.||||.||.  . ... . .. ....|.|||.| |...|. 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

DIDVWSAGCVLAELLLGQPIFPGD----SGVDQLVEIIKVLGTPSRDQIKEMNPNYTEFKFPQIKPHPWNKVFRARTPADAIQLCSRLLEYTPKSRIKPL
 .|.||.||.|.|.|.|.|.|||.    . .||.. | ...|.| . .. . ......| |.. . |. ...|  ... .........|.. ||.|. . 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

EACAHQFF
... | .|
QILQHPWF
Kinase GSK3.AA S_TKc 73-357 27 3.1e-87 297.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 73-357
Range on HMM: 1-231/231
Sequence Identity: 27% (82 aa)

YTDTRVIGNGSFGVVYQARMVDSSDLVAIKKVLQDKRFKNRELQIMRRLDHHNIVKLKYFFYSSGEKKDEVFLNLVLEYVPE---TVYRVARHYSKAK--
|.  |.|| |.||.||..| ...  .||||..    .   ||.||... .| |||||...|..        .| .|.||..    ..... ... . .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QTIANLYVKLYMYQLFRSLAYIHSMGICHRDIKPQNLLLNPETAVLKLCDFGSAKVLVRGEPNVSYICSRYYRAPELIFGATDYTC-DIDVWSAGCVLAE
. .    .. ||||... |.|.||.||.|||.||.|.||.    ..|.||||.|..|       ... ...|.|||..     |..  .|.|| ||.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLLGQPIFPGDSGVDQLVEIIKVLGTPSRDQIKEMNPNYTEFKFPQIKPHPWNKVFRARTPADAIQLCSRLLEYTPKSRIKPLEACA-------HQFF
.| |.| ||      |. ...|..|                                   . .|... ...|.. |. |.   || .       |..|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GSK3.AA RCK 73-357 29 2.2e-79 251.5 In-house 1-298 (298) Show / Hide 
Range on Protein: 73-357
Range on HMM: 1-298/298
Sequence Identity: 29% (91 aa)

YTDTRVIGNGSFGVVYQARMVDSSDLVAIKKVLQDKRFKN-------RELQIMRRLD-HHNIVKLKYFFYSSGEKKDEVFLNLVLEYVPETVYRVARHYS
|. .. .| |..|.|  |. ... ..|||||    ..|..       ||.. .|.|  | ||.|||  ..     .|.  | .|.||. . .|   ... 
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIR----DNDTYQLYFVFEYMDMNLYQMMKDFK

KAKQT-IANLY--VKLYMYQLFRSLAYIHSMGICHRDIKPQNLLLNPE--------TAVLKLCDFGSAKVLVRGEPNVSYICSRYYRAPELIFGATDYTC
. ... .      .| .|||.. .||..|. |. |||.|| |......        . ..|..|||...      |.  |. .|.|||||..  .| |. 
E-RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNS

DIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSRDQIKEMN--PNYTEFKFPQIKPHPWNKVFRARTPADAIQLCSRLLEYTPKSRIKPLEA
 .|.|. ||. .||   .| ||| | .||. .|.||.|||. .   .     . ..|.||| |. | ....    . |.|.|.  .| . |. || . .|
PMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQQA

CAHQFF
. |..|
LQHPYF
Kinase GSK3.AA CDK 73-357 30 2.5e-76 243.65 In-house 1-284 (284) Show / Hide 
Range on Protein: 73-357
Range on HMM: 1-284/284
Sequence Identity: 30% (98 aa)

YTDTRVIGNGSFGVVYQARMVDSS-----DLVAIKKVL--------QDKRFKN---RELQIMRRLDHHNIVKLKYFFYSS---GEKKDEVF---LNLVLE
|     || |..|||| ||  ..      ..||.||.          .  |     ||  ... | |.|||||.  ....    . ||  .   | .| |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDK-HENKLYMVFE

YVPETVYRVARHYSKAKQTIANLYVKLYMYQLFRSLAYIHSMGICHRDIKPQNLLLNPETA----VLKLCDFGSAKVLV-------RGEPNVSYICSRYY
|..   . . .             .| ||.|| | |.|.|| .| |||.||||.|.|        .||. ||| |.             .  . .  . |
YMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPELIFGATDYT--CDIDVWSAGCVLAELLL---GQPIFPGDSGVDQLVEIIKVLGTPSRDQ---IKEMNPNYTEFKFPQIKPHPWNKVFRARTPADAI
||||| .|...|.  . ||.||.||..||...   ..|.|||||  |||  |....|||. |.   .... |.|                          
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKL-PDY--------------------------

QLCSRLLEYTPKSRIKPLEACAHQFF
.| ...| | || ||.  .|  |..|
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase GSK3.AA CDC2 73-357 29 7.5e-71 216.82 In-house 1-301 (301) Show / Hide 
Range on Protein: 73-357
Range on HMM: 1-301/301
Sequence Identity: 29% (93 aa)

YTDTRVIGNGSFGVVYQARMVDSSDLVAIKKVLQDKRFKN--------RELQIMRRLD-HHNIVKLKYFFYSSGEKKDEVFLNLVLEYVPETVYRVARHY
|.  . || |..||||... ... ..||.||.  .             ||. ..  |. | |||||.  ...         | .| ||.     .  . .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-------NKLYMVFEYLDMDLKKYMDMS

SKAKQTIANLYVKLYMYQLFRSLAYIHSMGICHRDIKPQNLLLNPETAVLKLCDFGSAKVLVRGEPNVSYICS-----RYYRAPELIFGATDYTCDIDVW
 . .. .   .|| ||||. . ... |...| |||.||||.|.. .....|. ||| |.    | |   |        . |||||. .|. .|.. .|.|
IPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMW

SAGCVLAEL---LLGQPIFPGDSGVDQLVEIIKVLGTPSRDQIKEMNPNYTEFK--FPQIKPHPWNKVFRA--------RTPADAIQLCSRLLEYTPKSR
| ||..||.       |.|.|||  |||  | ..||||. .   ..  .....|  ||. ||    |..           .. ..|.| ...| | |  |
SIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVT-QLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKR

IKPLEACAHQFF
|.  || .| .|
ISAKEALQHPYF
Kinase GSK3.AA CDK7 175-357 38 3.2e-61 161.6 In-house 104-288 (288) Show / Hide 
Range on Protein: 175-357
Range on HMM: 104-288/288
Sequence Identity: 38% (73 aa)

VKLYMYQLFRSLAYIHSMGICHRDIKPQNLLLNPETAVLKLCDFGSAKVLVRGEPNVSY---ICSRYYRAPELIFGATDYTCDIDVWSAGCVLAELLLGQ
.| || .. . | | |   | |||.|| |||.|..  .||. ||| |.    | ||  |   .  |.|||||| |||  |.  .|.|| ||..|||.|  
IKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNEN-GQLKIADFGLARFY--GSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PIFPGDSGVDQLVEIIKVLGTPSRDQIKEMN--PNYTEFK-FPQIKPHPWNKVFRARTPADAIQLCSRLLEYTPKSRIKPLEACAHQFF
|..|||| .|||. | . ||||.  .  .|   ..| .|| ||     | ...| |  . |.. | ....   |  |..  ..  . .|
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTA-ASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase GSK3.AA CDKL 73-357 34 1.3e-60 206.0 In-house 1-286 (286) Show / Hide 
Range on Protein: 73-357
Range on HMM: 1-286/286
Sequence Identity: 34% (102 aa)

YTDTRVIGNGSFGVVYQARMVDSSDLVAIKKVLQ---DKRFK---NRELQIMRRLDHHNIVKLKYFFYSSGEKKDEVFLNLVLEYVPETVYRVARHYSKA
|    ..| || |||.  |  ..  .||||| .    |.  |    ||. . . | | ||| |.  |     .| . .  || ||.  ||  .  .    
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVF----RRKRKLH--LVFEYCDHTVLHELEE---Y

KQTIANLYVKLYMYQLFRSLAYIHSMGICHRDIKPQNLLLNPETAVLKLCDFGSAKVLV-RGEPNVSYICSRYYRAPELIFGATDYTCDIDVWSAGCVLA
 . .    |. ||.|. ..... |.. . |||||| |.|..|   ..|||||| |. |   ||    |   | ||||||  | |.|   .|.|..|||.|
PNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMA

ELLLGQPIFPGDSGVDQLVEIIKVLG--TPSRDQIKEMNPNYTEFKFPQIK-PHPWNKVFRARTPADAIQLCSRLLEYTPKSRIKPLEACAHQFF
|.. |||..||.| .|||  |.|.||  .|   .|  .|| .   |||.|. . |  | ...   . |. .   .|.  |  |.   ..  | .|
EMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase GSK3.AA CDK-Unclassified 73-357 28 8.9e-60 195.27 In-house 1-324 (324) Show / Hide 
Range on Protein: 73-357
Range on HMM: 1-324/324
Sequence Identity: 28% (95 aa)

YTDTRVIGNGSFGVVYQARMVDSSDLVAIKKVLQDK-------------RFK---NRELQIMRRLDHHNIVKLKYFFYSSGEKK---DEVFLN----LVL
|   ...| | || |. |.  . .  |||||.                 ..|   .||. ..... |.|| |.   .|.    .       |.    .|.
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

EYVPETVYRVARHYSKAKQTIANLY---VKLYMYQLFRSLAYIHSMGICHRDIKPQNLLLNPET----AVLKLCDFGSAKVLV----------RGEPNVS
||.| | | .       .    ||    .. .| |.. ..||.|. .| ||||||||...   .     .||. |||.|                .|. .
EYMPYTWYNQ------LHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQ

Y---ICSRYYRAPELIFGATDYTCDIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSRDQ---IKEMNPNYTEFKFPQIKPHPWNKVFRART
|   .  | |||||| ||   |. ..|.||.||..||.. | |||.| . ..|.  |.|.||||. |.   .  | | |    |..  .  |   |   .
YSTQVSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYM-PDYCKIFFKYKQKFHWWNRFPKCK

PADAIQLCSRLLEYTPKSRIKPLEACAHQFF
 |  . . . .. | |. | |  |.  |  |
HASENNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase GSK3.AA MAPK 179-357 35 1.1e-53 184.03 In-house 121-328 (328) Show / Hide 
Range on Protein: 179-357
Range on HMM: 121-328/328
Sequence Identity: 35% (75 aa)

MYQLFRS--LAYIHSMGICHRDIKPQNLLLNPETAVLKLCDFGSAKVLVRGEPNV-------------------SYICSRYYRAPELIFG--ATDYTCDI
|||. |   | ||||... |||.|| |.|.| |   ||.||||    | |.. .                     |.  |.|||||....  ...||  .
MYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFG----LARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAV

DVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPSRDQIKEMN-P----NYTE-FK-FPQIKPHPWNKVFRA---RTPADAIQLCSRLLEYTPKS
|.||.|| .||.|  ..|.|||.. .||.  |..||||||.. |. .  .    || . .. .|. ...|| |.|     ..  .|| | ...|.  |. 
DMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDK

RIKPLEACAHQFF
||   || .| .|
RITVEEALQHPYF
Kinase GSK3.AA ERK 179-357 34 5.3e-50 172.43 In-house 114-307 (307) Show / Hide 
Range on Protein: 179-357
Range on HMM: 114-307/307
Sequence Identity: 34% (67 aa)

MYQLFRSLAYIHSMGICHRDIKPQNLLLNPETAVLKLCDFGSAKVLVRGEPNV---------SYICSRYYRAPELIFGATDYTCDIDVWSAGCVLAELLL
|||. . | |||| .. |||.|| |.|.| .  .|| |||| | ..  .  .           |. .|.|||||..  ...||. .|.||.|| .||.| 
MYQILCGLKYIHSANVIHRDLKPSNILVN-SNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLG

GQPIFPGDSGVDQLVEIIKVLGTP-SRDQIKEM-NPNYTEF--KFPQ--IKPHPWNKVFRARTP--ADAIQLCSRLLEYTPKSRIKPLEACAHQFF
..|.||| . |.|. .|....||| | .....  ..|. ..  ..|   ..| || ..|  ...   .|| | ...|.  |. ||   |. .| .|
RKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIF-PNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase GSK3.AA TyrKc 73-357 21 3.5e-13 -9.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 73-357
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

YTDTRVIGNGSFGVVYQARMVDSSDLVAIKKVLQDKRFKN---RELQIMRRL--DHHNIVKLKYFFYSSGEKKDEVF-----LNLVLEYVPETVYRVARH
 |  ...|.| ||.||....      ||.|..  |.  .    ||..||..|  .| |||.|     ..|..    |     | .|.||.|    .   .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKDYLR

YSKAKQTIANLYVKLYMYQLFRSLAYIHSMGICHRDIKPQNLLLNPETAVLKLCDFGSAKVLVRG----EPNVSYI-----CSR-----YYRAPELIFGA
... |  . .     ...|  .  .|.||... |||.   | |.. .  . | .||| .. .  .    |    |      ...        ||| |   
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

TDYTCDI--DVWSAGCVLAELL-LGQPIFPG---DSGVDQLVEIIKVLGTPSRDQIKEM----NPNYTEFKFPQIKPHPWNKVFRARTPADAIQLCSRLL
 .... .  |||| | .. |.. .||.  ||      .    |.|. . .  |  . .                         |  . |..  |. ..  
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------F-VCCPDEMYQIMKQCW

EYTPKSRIKPLEACAHQFF
.. |..|    |   |..|
HEDPEDRPTFSEI--HECF
Kinase GSK3.AA Pkinase_Tyr 73-129 28 3.6e-11 38.44 Pfam 1-69 (270) Show / Hide 
Range on Protein: 73-129
Range on HMM: 1-69/270
Sequence Identity: 28% (20 aa)

YTDTRVIGNGSFGVVYQARMV----DSSDLVAIKKVLQDKRFKN-------RELQIMRRL-DHHNIVKL
 |  ...| |.||.||....     .    ||.|.. ..   ..       ||..||. | .|.|||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase GSK3.AA MAPK 73-130 30 1.1e-10 32.9 In-house 1-71 (328) Show / Hide 
Range on Protein: 73-130
Range on HMM: 1-71/328
Sequence Identity: 30% (22 aa)

YTDTRVIGNGSFGVVYQARMVD------SSDLVAIKKV---LQDKRFKN---RELQIMRRL-DHHNIVKLK
|.. . || |..|||  |. .       . . |||||.    |.. .     ||. ..|.. .| ||.||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLL
Kinase GSK3.AA CDK7 73-104 40 6.6e-10 22.12 In-house 1-32 (288) Show / Hide 
Range on Protein: 73-104
Range on HMM: 1-32/288
Sequence Identity: 40% (13 aa)

YTDTRVIGNGSFGVVYQARMVDSSDLVAIKKV
|.  . || | |..|| |.   .   |||||.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKI
Kinase GSK3.AA ERK 73-130 28 6e-07 22.12 In-house 1-70 (307) Show / Hide 
Range on Protein: 73-130
Range on HMM: 1-70/307
Sequence Identity: 28% (20 aa)

YTDTRVIGNGSFGVVYQARMVD-----SSDLVAIKKV---LQDKRFKN---RELQIMRRLD-HHNIVKLK
| ..  || |..|||  |.        ... |||||.     .... .   ||. ..| .. | ||..|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLF