ERK7

Species: Sea Urchin
Alias: SPU_006869, Spk145, ERK7
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK7

Sequence

Name Sequence Type Origin Length Description Download
ERK7.AA Protein None 291 None Fasta, JSON
ERK7.kin_dom Protein Kinase Domain None 85 None Fasta, JSON

Protein domain

Protein domains of ERK7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ERK7.AA ERK7 1-235 66 1.5e-155 523.06 In-house 57-292 (292) Show / Hide
Range on Protein: 1-235
Range on HMM: 57-292/292
Sequence Identity: 66% (158 aa)

DHKNIVKLLNVMRAENDKDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSITQIDAV
.| ||..|.||.||.||.|||||||.|.|||||||.|| |||||||.||||||..|. |||||||||||.||||||||.||.|||.||||||||.|....
CHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEY

LSEDNPALTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGSSTFNQLERIMAIIDPPTKKDIEAIQSDYXXX---XXXXRHRQSIE
 .|.||.|||||||||||||||||.|.||||||||||.|||.||.|.|||||||.||.||.|.|. .|  ||..|||||.|.|          ..|....
-DEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLD

EVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV
...| ... |||||...|| |||.|||||.|||.||||
QMMP-QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV

Kinase ERK7.AA MAPK 1-235 43 6.4e-126 424.62 In-house 63-328 (328) Show / Hide
Range on Protein: 1-235
Range on HMM: 63-328/328
Sequence Identity: 43% (116 aa)

DHKNIVKLLNVMRAE-----ND----KDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINA--TMYMHSGNVIHRDQKPSNILLDTECFVKVADFG
.|.||.|||.....|     |.    .|||.|.|.|.||||..|| . .| |.|..|.|||....    |.||.|||||| ||||||....| .|..|||
HHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFG

LARSITQI-DAVLSEDNP------ALTEYVATRWYRAPEILLA--SKRYTKGVDMWSVGCIIGELLK-GKPMFPGSSTFNQLERIMAIIDPPTKKDIEAI
||||| .      ..|.|       .||||||||||||||.|   ...|||.||||||||| .|.|. .||.|||... .|...||...  |.. .|. |
LARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCI

Q-S----DYXXXX--XXXRHRQSIEEVLPX---GAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV
. |    .|         . ... |...|    .|  .||||. |.|.|.||||.|...||.|||.
CMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF

Kinase ERK7.AA CMGC 1-235 24 2.4e-103 340.54 In-house 96-513 (513) Show / Hide
Range on Protein: 1-235
Range on HMM: 96-513/513
Sequence Identity: 24% (103 aa)

DHKNIVKLLNVMRAEN---------------DKDIYLVFEYMDTDLHAVIKKGG---------ILKDIH------------KRYIM------YQLINATM
.|.|||||... . .|               ....||||||||.||. .||.            |.. |            ..|.|      ||....  
HHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLK

--YMHSGN--VIHRDQKPSNILLDTECFV--------------------KVADFGLARSITQIDAVLSEDNP--------------ALTEYVATRWYRAP
  |.|| .  .|||| ||.|||.. .| .                    |..||||||.. . . .  ...|              ..|.||.|||||||
LKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAP

EILLASKRYT---------KGVDMWSVGCIIGELLKG--------KPMFP-----------GSSTFNQLERIMAIIDPPT---------------KKDIE
|||| .|.||         ...||||||||..|.. |        ||.||           |.|. .||..|. .. .||               .... 
EILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWP

AIQSDYXXXX---------------------------XXXRHRQSIEEVLPX----------------------------------GAPADAIDLVRKLL
 . . .                                  ......... |                                    .. .||||. |.|
NMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKML

HFNPDKRLTAKQALSHPYV
...||||.||.|||.||| 
QYDPDKRITAEQALQHPYF

Kinase ERK7.AA CDK 2-235 35 5.9e-79 252.21 In-house 66-284 (284) Show / Hide
Range on Protein: 2-235
Range on HMM: 66-284/284
Sequence Identity: 35% (92 aa)

HKNIVKLLNVMRAEN---------DKDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECF-----VKVAD
|.|||||. |   .|         .. .|.||||||.||  ...          . .|.||...  |.|| ...||| ||.|||..         .|.||
HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIAD

FGLARSITQ--IDAVLSED-NPALTEYVATRWYRAPEILLASKRYT--KGVDMWSVGCIIGELLK---GKPMFPGSSTFNQLERIMAIIDPPTKKDIEAI
|||||           | . | ..|  | |.||||||.|| ||.|.   ..||||||||..|..    .||.|||.|  .||..|  |.  || ..   .
FGLARAFGIPHQ---MS-EPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGV

QS--DYXXXXXXXRHRQSIEEVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV
 .  ||                          ||  |.| ..|.||..|.|||.||| 
TKLPDY--------------------------DLLNKMLCYDPKKRISAEQALQHPYF

Kinase ERK7.AA ERK 2-182 46 9.6e-79 267.92 In-house 63-248 (307) Show / Hide
Range on Protein: 2-182
Range on HMM: 63-248/307
Sequence Identity: 46% (86 aa)

HKNIVKLLNVMRAE---NDKDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSIT-QI
|.||..|...|. .   . .|||.|.|.|.|||| .|.    | | |  | |||....  |.|| |||||| ||||||.   |  |..|||||| .   .
HENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASY

DAVLSEDNPALTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGSSTFNQLERIMAIIDPP-TKKDIEAIQSD
.   .. .. .||||||||||||||.|  . ||| .|.||.|||. |.|..||.||| .. .|..|| .||  | .. |.. |.|.
QENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSE

Kinase ERK7.AA p38 1-235 39 2.2e-71 243.23 In-house 59-289 (289) Show / Hide
Range on Protein: 1-235
Range on HMM: 59-289/289
Sequence Identity: 39% (95 aa)

DHKNIVKLLNVMRA-----ENDKDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSIT
.| |...||.|        .. .|.|.| . |..||. ..|    | | | ... ||.. .  | || ..|||| ||||| .  .| ... ||||||   
RHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKCQR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR---

QIDAVLSEDNPALTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGSSTFNQLERIMAIIDPPTKKDIEAIQSDYXX---XXXXXRH
       .    .|.||||||||||||.|   .||. ||.||||||. ||. |.. |||.   .||.|||...  |..  .. |||.           . 
-------HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMP

RQSIEEVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV
|.  ..|.. ||   ||||  |.|.  ||||.||..|..||| 
RRDFHHVFM-GANPQAIDLLEKMLELDPDKRITAEEAMQHPYF

Kinase ERK7.AA Pkinase 1-235 30 2.8e-71 247.92 Pfam 58-293 (293) Show / Hide
Range on Protein: 1-235
Range on HMM: 58-293/293
Sequence Identity: 30% (78 aa)

DHKNIVKLLNVMRAENDKDIYLVFEYMDT-----DLHAVIK--KGGIL--KDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFV----KVAD
.|.|||.|. ...   ...||.|.||..      ||...|.  ..| .   . . . .|||.. .  |.|| ..|||| ||.|||.| .. .    |..|
NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICD

FGLARSITQIDAVLSEDNPALTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGS----STFNQLERIMAIIDPPTKKDIEAIQSDY
||||. .          |. .| .. |.||.|||... .. |.. |||||.|||. |.| |.| |||.    .  .|...|  | .||.. |..   | .
FGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSIS

XXXXXXXRHRQSIEEVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV
             ....   .. ...|.....|...| ||.||.|.| ||..
YFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase ERK7.AA RCK 2-235 35 5.8e-71 224.32 In-house 57-298 (298) Show / Hide
Range on Protein: 2-235
Range on HMM: 57-298/298
Sequence Identity: 35% (90 aa)

HKNIVKLLNVMRAENDKDIYLVFEYMDTDLHAVIKK---GGI-LKDIH--KRYIMYQLINATMYMHSGNVIHRDQKPSNILLDT---------ECFVKVA
|.||.||. | | ...   |.||||||..|   .|    ..  |  .    . ||||.. .  .||. .  ||| || ||..              .|.|
HPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIA

DFGLARSITQIDAVLSEDNPALTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGSSTFNQLERIMAIIDPPTKKD-IEAI-QSDYX
||||.|.|        ...|  |.|| ||||||||.|| .  |.. .|.|.||||. ||   .|.|||||   |.  |  ..  |.|||  ... ..   
DFGLCREI--------RSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQM

XXXXXXRHRQSIEEVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV
       . .......|  .. |.|.|..|.|  .|.|| ||.||| ||| 
NFNFPQCKGMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQQALQHPYF

Kinase ERK7.AA ERK1 2-235 42 4.6e-67 229.11 In-house 56-289 (289) Show / Hide
Range on Protein: 2-235
Range on HMM: 56-289/289
Sequence Identity: 42% (101 aa)

HKNIVKLLNVMRA---ENDKDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSITQID
| ||... ...||   |. .|.|.| . |.|||  ..|   .  | |  | .||..    |.|| ||.||| ||||.|| | | .|. |||||| |.  .
HENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSND-HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPE

AVLSEDNPALTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGSSTFNQLERIMAIIDPPTKKDIEAIQSDYXXXXXX---XRHRQS
    .    |||||||||||||||.| || ||| .|.||||||. |.|  .|.|||     ||  |....  | ..|.. |  .           . ...
H---DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVP

IEEVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALSHPYV
 ... | .| . |.||. |.| |||.||.|  .|| |||.
WARLFP-KADSKALDLLDKMLTFNPHKRITVEEALAHPYL

Kinase ERK7.AA ERK5 18-235 40 1.8e-64 220.52 In-house 77-295 (295) Show / Hide
Range on Protein: 18-235
Range on HMM: 77-295/295
Sequence Identity: 40% (90 aa)

KDIYLVFEYMDTDLHAVIKKGGILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSITQIDAVLSEDNPALTEYVATRWY
||.| ||. |. ||| .|     .   | || .||..    |||| .||||| ||||.|    | .|. |||.|| .. . .   .    .|||||||||
KDVYVVFDLMESDLHQIIHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSP--DKHQMFMTEYVATRWY

RAPEILLASKRYTKGVDMWSVGCIIGELLKGKPMFPGSSTFNQLERIMAIIDPPTKKDIEAIQSDYXXXXXXX----RHRQSIEEVLPXGAPADAIDLVR
||||....|. ||. .|.||||||.||..  . ||||    .||. || ..  |  . |.|. .|            |  . .|.| | .|   |.||. 
RAPELMFSSHDYTQAIDVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYP-KADRQALDLLA

KLLHFNPDKRLTAKQALSHPYV
..| | | .|.|. .|| ||..
RMLRFEPSERITVNKALQHPFL

Kinase ERK7.AA S_TKc 1-235 29 1.1e-43 152.33 SMART 19-231 (231) Show / Hide
Range on Protein: 1-235
Range on HMM: 19-231/231
Sequence Identity: 29% (83 aa)

DHKN---------------------------IVKLLNVMRAENDKDIYLVFEYMDT---DLHAVIKKGGI------LKDIHKRYIMYQLINATMYMHSGN
 ||.                           ||||. |..    ...|.|.||.|.   ||. .||| |       .   | |..|||...|  |.|| .
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG

VIHRDQKPSNILLDTECFVKVADFGLARSITQIDAVLSEDNPALTEYVATRWYRAPEILLASKRYTK-GVDMWSVGCIIGELLKGKPMFPGSSTFNQLER
.|||| ||.|||||.   .|..|||||| .              | .. |.||.|||.|     |.|  .|.||.|||. |.| |.| ||      |...
IIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQM

IMAIIDPPTKKDIEAIQSDYXXXXXXXRHRQSIEEVLPXGAPADAIDLVRKLLHFNPDKRLTAKQALS-------HPYV
.. .|                                    . .|.|..||.|...|.||.|| .||        ||..
MFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase ERK7.AA MAPK-Unclassified 108-235 30 1.1e-34 121.52 In-house 405-575 (575) Show / Hide
Range on Protein: 108-235
Range on HMM: 405-575/575
Sequence Identity: 30% (52 aa)

LTEYVATRWYRAPEILLASKRYTKGVDMWSVGCIIGELLKG-----------KPMFPGSS--------------------TFNQLERIMAIIDPPTKKDI
.|.||.|||||||||.| .. |.. ||.||.||| .|..             .|.|||..                       |.  |      | . |.
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

EAIQSDYXXXXXXXRHRQSIEEVL---PXGAP---------ADAIDLVRKLLHFNPDKRLTAKQALSHPYV
  |..|          .    ..    .  ||          ..||.| |.| ||| || || |||.|||.
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF

Kinase ERK7.AA MAPK-Unclassified 2-94 37 3.2e-31 109.9 In-house 58-159 (575) Show / Hide
Range on Protein: 2-94
Range on HMM: 58-159/575
Sequence Identity: 37% (38 aa)

HKNIVKLLNVMRAENDKD-----IYLVFEYMDT---DLHAVIKKGG-ILKDIHKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLAR
| ||... .. ... ..      ||.| .|| |   ||| .||     . ..| .|..||. .   |.|| ..|||| ||||.|..  | |...|||..|
HPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR

SI
||
SI

Kinase ERK7.AA ERK 204-235 50 4.1e-15 52.87 In-house 274-307 (307) Show / Hide
Range on Protein: 204-235
Range on HMM: 274-307/307
Sequence Identity: 50% (17 aa)

AP--ADAIDLVRKLLHFNPDKRLTAKQALSHPYV
|.   .|||| .|.|.|.||||.|....|.||| 
ANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF

Kinase ERK7.AA TyrKc 1-183 16 3.5e-07 -106.58 SMART 1-280 (280) Show / Hide
Range on Protein: 1-183
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

D-------------------------------------------------HKNIVKLLNVMRAE-----NDKDIYLVFEYMDT-DLHAVIKKGGI-LKDI
                                                  |.|||.|. | . .      .. ...|.|||.  ||.  ..| .  |.  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

HKRYIMYQLINATMYMHSGNVIHRDQKPSNILLDTECFVKVADFGLARSITQI---DAVLSEDNPA----LTEY-VATRWYRAPEILLASKRYTKGVDMW
.. ....|  .   | || |.||||    |.|.. .  ||..||||.| |.       . ..   .     . . .  ||. ||| .   ...|   | |
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFTTKSDVW

SVGCII------GELLKGKP---MFPGSSTFNQLERIMAIIDPPT---------------------KK------DIEAIQSDY
| |  .      |.     .   | . .  ...... .    ||                      .         ..| .. 
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase ERK7.AA Pkinase_Tyr 74-94 52 7.1e-05 17.14 Pfam 141-161 (270) Show / Hide
Range on Protein: 74-94
Range on HMM: 141-161/270
Sequence Identity: 52% (11 aa)

NILLDTECFVKVADFGLARSI
|.|.. . .||..|||||| |
NCLVTENNVVKICDFGLARDI

Kinase ERK7.AA Pkinase_Tyr 1-69 32 0.008422 10.11 Pfam 62-136 (270) Show / Hide
Range on Protein: 1-69
Range on HMM: 62-136/270
Sequence Identity: 32% (24 aa)

DHKNIVKLLNVMRAENDK-DIYLVFEYMDT-DLHAVIKK----GGILKDIHKRYIMYQLINATMYMHSGNVIHRD
.|.|||.|. |   . .   ||.|.|||   ||.   .|    .. |.  ..  . .|  ..  | .| | ||||
HHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRD