Gene JNK (Sea Urchin)

JNK

Species: Sea Urchin
Alias: JNK, SPU_028478, Spk144
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: JNK

Sequence

Name Sequence Type Origin Length Description Download
JNK.AA Protein None 509 None Fasta, JSON
JNK.kin_dom Protein Kinase Domain None 299 None Fasta, JSON

Protein domain

Protein domains of JNK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase JNK.AA JNK 56-354 62 1.1e-236 792.57 In-house 1-309 (309) Show / Hide 
Range on Protein: 56-354
Range on HMM: 1-309/309
Sequence Identity: 62% (194 aa)

YKNLKSVGSGAQGLVVAAYDVLTNQSVAIKKLSRP--FQNVTHAKRAYREYILMKLCNHKNIIGLLNVFTPQRTFDDFADIYLVMELMDASLVQVVQ---
|.|||..|.||||.|..|.|..|||.|||||..||  |||..|.||||||.|.||..||||||...|.||||.|...|.|.|.|||.||..|.||..   
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

MDLDHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKILDFGLARTASTSFMMTPYVVTRYYRAPEVILGMG--YKENVDIWSIGCIFGEM
|.|||||.|||.|||.||||||||.||||||||||||||..||.|||.|||.|||....||||||||||||||||||.||.  |||||||||.|||..||
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

IRGQVMFPGSDHIDQWNKIADLLGTPTDIFLSRLQPMVKQYVENR---TKCPGYSFEMLFPDELFYQAESSTEKTKLCVAQARNLLSKMLIVDPEQRISV
||..|.|||.|||||||||...||||...|....||.|..|||||   .....|.|...|||.||.....|..|..|....||.||..||...|..||||
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQPHVRNYVENRNMDPYYQPYNFHEHFPDTLFPDVMQSEPKDHLTCHMARDLLFRMLVINPDDRISV

DEALQHPYI
|.|||||||
DDALQHPYI
Kinase JNK.AA MAPK 56-354 44 2.2e-180 605.57 In-house 1-328 (328) Show / Hide 
Range on Protein: 56-354
Range on HMM: 1-328/328
Sequence Identity: 44% (150 aa)

YKNLKSVGSGAQGLVVAAYDVLTNQS------VAIKKLSRPFQNVTHAKRAYREYILMKLC-NHKNIIGLLNVFTP-----QRTFDDFADIYLVMELMDA
|..|| .|.||.|.|..|.|..|||       |||||.||||||.||.||.||| .|.. . .|.|||.||..|||     |.. ..| |||.|||||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

SLVQVVQ-MD-LDHERISYLLYQMLCG--IKHLHSAGIIHRDLKPSNIVVKTDCSLKILDFGLARTASTS---------------FMMTPYVVTRYYRAP
 | |. . .. |....|.|..||.|.|  .|..|||..||||||||||.| ..| |||.||||||.. ..               ..||.||.||.||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVILG---MGYKENVDIWSIGCIFGEMIR-GQVMFPGSDHIDQWNKIADLLGTPTDIFLSRLQ-P-MVKQYVENR---TKCPGYSFEMLFPDELFYQAES
|..|.   |.|...||.||.||||.||.. ....|||.|.|||||.| ..||||.. |..... . ....|....   .|.|....| .||...|     
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF-----

STEKTKLCVAQARNLLSKMLIVDPEQRISVDEALQHPYI
      ..  ||..||.|||  ||..||.|.|||||||.
------NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase JNK.AA CMGC 56-354 25 6.5e-128 422.77 In-house 1-513 (513) Show / Hide 
Range on Protein: 56-354
Range on HMM: 1-513/513
Sequence Identity: 25% (132 aa)

YKNLKSVGSGAQGLVVAAYDVLTNQS--------------VAIKKLSRPFQNVTHAK----------RAYREYILMKLCN-----------------HKN
|...| .|.|. | |. ..| .|||               |||||...|| . ..||          ||.||  ..|  |                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIGLLNVFTPQ---RTFDD--------FADIYLVMELMDASLVQVVQM-----------DLDHER------------ISYLL------YQMLCGIK--HL
|..|...|..    .. ..        | ..|||.|.|| .| |. ..            |..              | |..      ||.|.|.|  ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAG--IIHRDLKPSNIVVKTDCSL--------------------KILDFGLARTAST----------------------SFMMTPYVVTRYYRAPEVIL
||..  ||||||||.|| .  .| |                    || ||||||  ..                      . ..|.|||||.|||||..|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

G----------MGYKENVDIWSIGCIFGEMIRG--------QVMFP-----------GSDHIDQWNKIADLLGTP----------------TDIFLSRLQ
|          |.| . .|.||.||||.||..|        . .||           |..||||..|| ..||||                .... ....
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

---------------------PMVKQYVEN---RTKCPGYSFEMLFPDELFYQAESSTE----------------------KTKLCVAQARNLLSKMLIV
                     . ...|...     ..|. ... |||.  . .  .  .                      | |.|  ||..||.|||. 
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DPEQRISVDEALQHPYI
||..||....||||||.
DPDKRITAEQALQHPYF
Kinase JNK.AA p38 56-306 49 5.9e-119 401.5 In-house 1-256 (289) Show / Hide 
Range on Protein: 56-306
Range on HMM: 1-256/289
Sequence Identity: 49% (128 aa)

YKNLKSVGSGAQGLVVAAYDVLTNQS---VAIKKLSRPFQNVTHAKRAYREYILMKLCNHKNIIGLLNVFTP-QRTFDDFADIYLVMELMDASLVQVVQM
|.||. ||||| | | .|.|. |.|    ||||||.|||| . ||||.|||  | |. .| |.|.||.||||  .  .|| |.|.|...|.|.| ... .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

D-LDHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKILDFGLARTASTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSIGCIFGEMI
  |  ..| .|.||.| | |  ||||||||||||||| |  || |.||||||||  ..   || ||.|| |||||..|  | | . |||||.|||  |.|
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR--HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELI

RGQVMFPGSDHIDQWNKIADLLGTPTDIFLSRLQPMV-KQYVENRTKCPGYSFEMLFP
 |.. |||.||||| ..|  ..|||.. |....|    . |...... |   |. .|.
TGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFM
Kinase JNK.AA ERK 56-354 39 8.10000000001e-107 361.17 In-house 1-307 (307) Show / Hide 
Range on Protein: 56-354
Range on HMM: 1-307/307
Sequence Identity: 39% (127 aa)

YKNLKSVGSGAQGLVVAAYDVL-----TNQSVAIKKLSRPFQNVTHAKRAYREYILMKLCN-HKNIIGLLNVFTP-QRTFDDFADIYLVMELMDASLVQV
|. .| .| || |.|..| | .     |.| ||||| ...| .   .||..||  |..... |.|||.|.... | ...  .. |||.| |||.  | |.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE--QYNDIYCVEELMETDLHQI

VQMD--LDHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKILDFGLAR----TASTSF-----MMTPYVVTRYYRAPEVILGM-GYKENV
 . .  |  . . |..||.|||.|..|||..|||||||||| |  .| ||| ||||||    ... .      .|| ||.||.|||||..|    | . .
INSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAM

DIWSIGCIFGEMIRGQVMFPGSDHIDQWNKIADLLGTP-TDIFLSRL-QPMVKQYVENRTK--CPGYSFEMLFPD-ELFYQAESSTEKTKLCVAQARNLL
||||.|||| ||.... .||| |...| | | ...||| ..  |..   . ...|. |  .  .|. ..| .||.                |  || .||
DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNAN--------------CNPQAIDLL

SKMLIVDPEQRISVDEALQHPYI
.|||  ||..||.|.|.|.||| 
EKMLVFDPDKRITVEECLEHPYF
Kinase JNK.AA S_TKc 56-354 27 3.5e-85 290.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 56-354
Range on HMM: 1-231/231
Sequence Identity: 27% (86 aa)

YKNLKSVGSGAQGLVVAAYDVLTNQSVAIKKLSRPFQNVTHAKRAYREYILMKLCNHKNIIGLLNVFTPQRTFDDFADIYLVMELMDA---SLVQVVQMD
|. |. .|.|| | |  .... |.. ||||...         ....||  ..|  .|.||. |. ||          ..|.|||..|    .| .. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

--------LDHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKILDFGLARTASTSFMMTPYVVTRYYRAPEVILGMGYKE-NVDIWSIGC
        ..  .. ...||..|.....|| |||||||||.|| . .   .|| ||||||        | ...|..|.||||.   ||    .|.||.||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

IFGEMIRGQVMFPGSDHIDQWNKIADLLGTPTDIFLSRLQPMVKQYVENRTKCPGYSFEMLFPDELFYQAESSTEKTKLCVAQARNLLSKMLIVDPEQRI
|. ||. |.  ||      | ... ...|                                                     .|.....|.| .|||.|.
ILYEMLCGYPPFP------QMQMMFKKIG---------------------------------------------------SPEAKDFIRKCLQKDPEKRP

SVDEALQ-------HPYI
.. ||||       ||..
TA-EALQDEWDIKCHPWF
Kinase JNK.AA ERK7 56-354 37 2.2e-77 263.42 In-house 1-292 (292) Show / Hide 
Range on Protein: 56-354
Range on HMM: 1-292/292
Sequence Identity: 37% (118 aa)

YKNLKSVGSGAQGLVVAAYDVLTNQSVAIKKLSRPFQNVTHAKRAYREYILMKLCN-HKNIIGLLNVFTPQRTFDDFADIYLVMELMDASLVQVVQ--MD
|. .| .| || |.|  |||  | | ||.||    |.| | | | .|| ....  . | ||| |.||.      |   ||||| | |.. |  |..    
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI----RADNDRDIYLVFEFMETDLHAVIRKGNI

LDHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKILDFGLARTASTSF-------MMTPYVVTRYYRAPEVILG-MGYKENVDIWSIGCI
|      | .||.|  ||..||. .|||||||||| . ..| .|. ||||||. .          |.| || || |||||. ||   |   || ||||||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

FGEMIRGQVMFPGSDHIDQWNKIADLLGTPTDIFLSRLQPMVKQYV-ENRTKCPGYSFEMLFPDELFYQAESSTEKTKLCVAQARNLLSKMLIVDPEQRI
 |||.||. ||||.  ..| .|| .... ||   .  ... .   . |.  . . .... ..|.               |  .| .|| ..|.  |..|.
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQ---------------CCDDAIDLLKRLLVFNPKKRL

SVDEALQHPYI
....||||||.
TAEQALQHPYV
Kinase JNK.AA ERK5 56-274 43 7.7e-75 254.94 In-house 1-228 (295) Show / Hide 
Range on Protein: 56-274
Range on HMM: 1-228/295
Sequence Identity: 43% (99 aa)

YKNLKSVGSGAQGLVVAAYDVLTNQSVAIKKLSRPFQNVTHAKRAYREYILMKLCNHKNIIGLLNVFTPQRTFDDFADIYLVMELMDASLVQVVQMD--L
|| .  .| || | | .|   .. | |||||.   |  || ||| .||  ...   | ||| . ..  |.  . .. |.| |..||.. | |..  .  .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

DHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKILDFGLARTAST------SFMMTPYVVTRYYRAPEVILGM-GYKENVDIWSIGCIFG
  | | | |||.| |.| .||| .|||||||||..|   | ||| |||.||  .|       . || || ||.|||||... .  |   .|.||.|||||
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMIRGQVMFPGSDHIDQWNKIADLLGTP
|||  . ||||   |.| . | . ||.|
EMIARRQMFPGKNYIHQLQLIMMVLGMP
Kinase JNK.AA Pkinase 56-354 27 1.9e-72 251.78 Pfam 1-293 (293) Show / Hide 
Range on Protein: 56-354
Range on HMM: 1-293/293
Sequence Identity: 27% (88 aa)

YKNLKSVGSGAQGLVVAAYDVLTNQSVAIKKLSRPFQNVTHAKRAYR--EYILMKLCNHKNIIGLLNVFTPQRTFDDFADIYLVMELMDA-----SLVQV
|. .. .|||. | |  .... |.. ||.|..... ..    ... |  |  .|| .||.||. |. .|.         .||.|||...      .|  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

VQ-------MDLDHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSL----KILDFGLAR---TASTSFMMTPYVVTRYYRAPEVIL-GMGYK
..       . .. . .   .||.|.|....|| |||||||||.|| .. .. .    || |||||.   . . |  || ...|..|.|||||. | .| 
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYG

ENVDIWSIGCIFGEMIRGQVMFPGS----DHIDQWNKIADLLGTPTDIFLSRLQPMVKQYVENRTKCPGYSFEMLFPDELFYQAESSTEKTKLCVAQARN
  ||.||.|||. ||. |.  |||.    . .||  .|.  .|.|..   . . ..   .  .. . .                .  ... ..    .. 
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------------F-HWTF-HNWSEECKD

LLSKMLIVDPEQRISVDEALQHPYI
.....| .||..|.. ...||||..
FIKWCLCKDPKKRPTAEQILQHPWF
Kinase JNK.AA ERK1 56-274 44 3.4e-66 226.21 In-house 1-223 (289) Show / Hide 
Range on Protein: 56-274
Range on HMM: 1-223/289
Sequence Identity: 44% (99 aa)

YKNLKSVGSGAQGLVVAAYDVLTNQSVAIKKLSRPFQNVTHAKRAYREYILMKLCNHKNIIGLLNVFTPQRTFDDFADIYLVMELMDASLVQVVQM-DLD
| ||. .| || |.|..||| ...| |||||.| ||   |. .|  ||  ...  .| |||.. ..     | . . |.|.| .||.  | ....   | 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKTQHLS

HERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKILDFGLARTASTSF----MMTPYVVTRYYRAPEVIL-GMGYKENVDIWSIGCIFGEMI
 . | | |||.| |.| .||| ..||||||||... | | ||| |||||| |         .| || ||.|||||..|   ||   .||||.|||  ||.
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

RGQVMFPGSDHIDQWNKIADLLGTP
    .|||   .|| |.|  .|| |
SNRPIFPGKHYLDQLNHILGVLGSP
Kinase JNK.AA CDK 56-276 34 8.4e-64 202.94 In-house 1-246 (284) Show / Hide 
Range on Protein: 56-276
Range on HMM: 1-246/284
Sequence Identity: 34% (88 aa)

YKNLKSVGSGAQGLVVAAYDVLTN-----QSVAIKKLSRPFQ----NVTHAKR-AYREYILMKLCNHKNIIGLLNVFTPQ---RTFDDF--ADIYLVMEL
|. |. .| |. | |  | | .|.     | ||.||.    .      .     | ||  |.| . |.||. |. |..     |.. |.    .|.|.| 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MDASLVQVVQMDLDHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCS-----LKILDFGLARTAS-------TSFMMTPYVVTRYYRAPEVIL
||  | ..         |  ...|.| |. ..|| .|.||||||.|| .  . .     ||| ||||||  .        .  .|. |||. |||||. |
MDHDLKKYMD-------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLL

-GMGYK--ENVDIWSIGCIFGEMIR---GQVMFPGSDHIDQWNKIADLLGTPTD
    |     .|.||.||||.||..   .. .|||.  |||  || ...||||.
GSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTE
Kinase JNK.AA MAPK-Unclassified 56-204 43 2.6e-53 183.43 In-house 1-157 (575) Show / Hide 
Range on Protein: 56-204
Range on HMM: 1-157/575
Sequence Identity: 43% (69 aa)

YKNLKSVGSGAQGLVVAAYDVLT-NQSVAIKKLSRPFQNVTHAKRAYREYILMKLCNHKNIIGLLNVFTPQRTFD-DFADIYLVMELMDA---SLVQVVQ
|   | .|||| | |. | |  . || |||||. . |.|.| .||. ||  .    || ||| . ..|..      .| |||.||..|      | |. .
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

MDL---DHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKILDFGLAR
 ..    |. | |..|| | |.| ||||.||||||||||. .  |||..| |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase JNK.AA MAPK-Unclassified 205-354 29 5.5e-35 122.56 In-house 398-575 (575) Show / Hide 
Range on Protein: 205-354
Range on HMM: 398-575/575
Sequence Identity: 29% (54 aa)

TASTSFMMTPYVVTRYYRAPEVILGMG-YKENVDIWSIGCIFGEMIRG-----------QVMFPGSD--------------------HIDQWNKIADLLG
.....  || |||||.||||| .| |. |   ||||||||||.||.             . .|||.|                    |.|| . | | ||
DCHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLG

TPTDIFLSRLQ-PMVKQYVENRTKCPGYSFEMLFPDELFYQAESSTEKTKLCVAQARNLLSKMLIVDPEQRISVDEALQHPYI
.|    ... . . ...|..   . . . |     ..|.. . .  ..      .......|||  .|  ||. |.||.|||.
MPPEEDCNFITCDSARKYIQSFKCKTPVHF-----TDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase JNK.AA CDK 294-354 32 1.2e-13 39.9 In-house 253-284 (284) Show / Hide 
Range on Protein: 294-354
Range on HMM: 253-284/284
Sequence Identity: 32% (20 aa)

TKCPGYSFEMLFPDELFYQAESSTEKTKLCVAQARNLLSKMLIVDPEQRISVDEALQHPYI
|| |.|                             .||.|||  ||..||| ..|||||| 
TKLPDY-----------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase JNK.AA p38 326-354 58 6.5e-13 40.2 In-house 261-289 (289) Show / Hide 
Range on Protein: 326-354
Range on HMM: 261-289/289
Sequence Identity: 58% (17 aa)

QARNLLSKMLIVDPEQRISVDEALQHPYI
|| .|| |||. ||..||.. ||.||||.
QAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase JNK.AA TyrKc 56-354 21 2.2e-11 -38.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 56-354
Range on HMM: 1-280/280
Sequence Identity: 21% (70 aa)

YKNLKSVGSGAQGLVVAAYDVLTNQSVAIKKLSRPFQNVTHAKRAYREYILMKLC--NHKNIIGLLNVFTPQ--RTFDDF---ADIYLVMELMDA-SLVQ
 . .|  |.|| | |. .      . ||.|.|          .  .||  .|.    .|.||. |. | | |  .    |     ...|||.|.  .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKD

VV-QMD--LDHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKILDFGLARTASTS---------FMM-----TPYVVTRYYRAPEVILGM
        | ..   .  .|  ||  .||| ..|||||   |. |. .   || ||||.|               ..     . ...     |||.|   
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

GYKENVDIWSIGCIFGEMI-RGQVMFPG-----SDHIDQWNKIADL--LGTPTDIFLSRLQPMVKQYVENRTKCPGYSFEMLFPDELFYQAESSTEKTKL
 . .  |.|| |    |.  .||   ||      . ..  ... .   .  | ..      ||                              .      
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-----PMS-----------------------------F----VC

CVAQARNLLSKMLIVDPEQRISVDEALQHPYI
| .   .. ..    |||.| .  |   | ..
CPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase JNK.AA ERK5 326-354 51 2.1e-09 30.47 In-house 267-295 (295) Show / Hide 
Range on Protein: 326-354
Range on HMM: 267-295/295
Sequence Identity: 51% (15 aa)

QARNLLSKMLIVDPEQRISVDEALQHPYI
|| .||..||. .| .||.| .|||||..
QALDLLARMLRFEPSERITVNKALQHPFL
Kinase JNK.AA ERK1 325-354 53 2.5e-08 27.35 In-house 260-289 (289) Show / Hide 
Range on Protein: 325-354
Range on HMM: 260-289/289
Sequence Identity: 53% (16 aa)

AQARNLLSKMLIVDPEQRISVDEALQHPYI
..|  || |||   |..|| |.||| |||.
SKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase JNK.AA Pkinase_Tyr 56-205 29 1e-06 23.18 Pfam 1-160 (270) Show / Hide 
Range on Protein: 56-205
Range on HMM: 1-160/270
Sequence Identity: 29% (49 aa)

YKNLKSVGSGAQGLVVAAYDV----LTNQSVAIKKLSRPFQNVTHA----KRAYREYILMKLC-NHKNIIGLLNVFT-PQR-TFDDFADIYLVMELMDA-
 . .|  |.|| | |. ..       |.. ||.|.| ..  . .|     .   ||  .||   .|.||. |. | |  ..        ||.|||.|   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHG

SLVQVVQMD------LDHERISYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKILDFGLART
.|    .        |.....    .|  .|  .|.| ..|||||   |. |. .   || ||||||.
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD