Gene p38 (Sea Urchin)

p38

Species: Sea Urchin
Alias: SPU_010118, SPU_011286, p38, Spk147
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
p38.AA Protein None 360 None Fasta, JSON
p38.kin_dom Protein Kinase Domain None 286 None Fasta, JSON

Protein domain

Protein domains of p38.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase p38.AA p38 27-312 73 8.10000000001e-230 769.77 In-house 1-289 (289) Show / Hide 
Range on Protein: 27-312
Range on HMM: 1-289/289
Sequence Identity: 73% (213 aa)

YVRLEPVGSGAYGQVCSTEAEDTRQKGLRVAIKKLSRPFQTVIHAKRTYRELRLLKHMRHENVISLLDCFTP---DRVNFSDVYMVTHLMGADLNNIIKC
|..|.|||||||||||..|...|.||...||||||.||||..||||||||||||||||||||||.|||.|||   .. .|.|||||||.||||||||.||
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QKLSDDHVQFLIYQVLRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARSTDDEMTGYVATRWYRAPEIMLNWMHYTEKVDIWSVGCIMAELLTQ
|.|||||.|||.||.|||||||||||.|||||||||||||||||||||||||||..||||||||||||||||||||||||||..|||||||||||||.|.
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITG

KTLFPGCDHIDQLNKIIAITGKPDETFLQKIASESAKTYLMSMAAYPKRDFSTIFLGASRKAVDLLEKMLQLDEDRRLSAEQALQHPYL
.|||||.||||||..|....|.|||.|.|||.||.|..|..|....|.|||...| ||...|.|||||||.||.|.|..||.|.||||.
RTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase p38.AA MAPK 27-312 54 1.4e-199 669.36 In-house 1-328 (328) Show / Hide 
Range on Protein: 27-312
Range on HMM: 1-328/328
Sequence Identity: 54% (180 aa)

YVRLEPVGSGAYGQVCSTEAEDTRQK---GLRVAIKKLSRPFQTVIHAKRTYRELRLLKHM-RHENVISLLDCFTP-------DRVNFSDVYMVTHLMGA
|. |.|.|.||||.|||     |.||   | .|||||.|||||...|.||||||..||.|. .|||.|.|||.|||       .. .| |.|.|..||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLNNIIKCQK-LSDDHVQFLIYQVLRG--LKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARSTDDE-----------------MTGYVATRWYRAP
||..|||.|. |||||.|...||.|||  |||||||.|||||||||||.|||.|.|.|.|||||||.|.|                 ||.||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--WMHYTEKVDIWSVGCIMAELLT-QKTLFPGCDHIDQLNKIIAITGKPDETFLQKIA-SESAKTYLMSM---AAYPKRDFSTIFLG----ASRK
|||||  |||||..||.||||||.||.|| .|.|||| |.|||.|.|....|.|.| |.|.|  ||.|..|. |.     |||......| .    |...
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AVDLLEKMLQLDEDRRLSAEQALQHPYL
|.|||||||..| |.|...|.||||||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase p38.AA ERK 27-312 49 9.40000000001e-152 510.44 In-house 1-307 (307) Show / Hide 
Range on Protein: 27-312
Range on HMM: 1-307/307
Sequence Identity: 49% (153 aa)

YVRLEPVGSGAYGQVCSTEAEDTR----QKGLRVAIKKLSRPFQTVIHAKRTYRELRLLKHMR-HENVISLLDCFTPD-RVNFSDVYMVTHLMGADLNNI
|  ....| |||| |||  | |.     ..| .||||| ...| . | .|||.||..||.| . |||.|.|.| . |. . .. |.|.|. ||  ||  |
YQIIKQIGHGAYGVVCS--AIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQI

IKCQ-KLSDDHVQFLIYQVLRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLAR----STDDE-------MTGYVATRWYRAPEIMLNWMHYTEKV
|. |  |||||.|...|| |.||||||||.||||||||||| ||..| | | ||||||    | ..        ||.||||||||||||||.|  ||...
INSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAM

DIWSVGCIMAELLTQKTLFPGCDHIDQLNKIIAITGKP-DETFLQKIASESAKTYLMSMAA--YPKRDFSTIFLGAS--RKAVDLLEKMLQLDEDRRLSA
||||.|||.||.|  |.|||| |...|.| |..|.|.| .|  ||.|.|| |. |. ..    .|......||  |.   .|.|||||||. |.| |...
DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITV

EQALQHPYL
|..|.|||.
EECLEHPYF
Kinase p38.AA CMGC 27-312 27 8.49999999999e-141 465.88 In-house 1-513 (513) Show / Hide 
Range on Protein: 27-312
Range on HMM: 1-513/513
Sequence Identity: 27% (141 aa)

YVRLEPVGSGAYGQVCSTEAEDTRQK-----------GLRVAIKKLSRPFQTVIHAK----------RTYRELRLLKHMR-----------------HEN
|  ....|.|.||.|..    .| ||           . .|||||...||   ..||          |..||...|||..                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VISLLDCFTPDRVN-------------FSDVYMVTHLMGADLNNIIKCQK----------LSDDH------------VQFLI------YQVLRGLK--YI
...|.|.|...  .             | ..|.|. .|. || ..|| ..          ||. |            .....      ||.|||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAG--VIHRDLKPSNIAVNEDCEL--------------------RILDFGLARSTDDE------------------------MTGYVATRWYRAPEIML
||..  .|||||||.|| .|..|||                    .| ||||||.....                        .| ||.|||||||||.|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

NW---------MHYTEKVDIWSVGCIMAELLTQ--------KTLFP-----------GCDHIDQLNKIIAITGKP----------------DETFLQKIA
.|         ||||...|.||||||.||..|         |.|||           | .|||||.||. . |.|                .|.. ..| 
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------SESAKTYLMS---MAAYPKRDFSTIFLG-----------------------------------ASRKAVDLLEKMLQLDE
                    ||.|..|. |      .|..... .| .                                   .. .|.|||.||||.| 
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DRRLSAEQALQHPYL
|.|..|||||||||.
DKRITAEQALQHPYF
Kinase p38.AA JNK 27-312 43 2.4e-116 392.85 In-house 1-309 (309) Show / Hide 
Range on Protein: 27-312
Range on HMM: 1-309/309
Sequence Identity: 43% (137 aa)

YVRLEPVGSGAYGQVCSTEAEDTRQKGLRVAIKKLSRP--FQTVIHAKRTYRELRLLKHMRHENVISLLDCFTPDRV--NFSDVYMVTHLMGADLNNIIK
|. | ..|.|| | ||.  | |.   . ||||||..||  || . |.|| |||. ..|.  |.|.|... ||||..    | |||.|  .| . | ..| 
YQNLKFIGQGAQGIVCM--AFDQ-VTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIH

C--QKLSDDHVQFLIYQVLRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARSTDDE--MTGYVATRWYRAPEIMLNWM-HYTEKVDIWSVGCIM
    .|  . . .|.||...| |. ||.|.|||||||||| ||.|| | |.|||.||  |    || || ||.|||||. .  |  |.|.||||||||||
STFMELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIM

AELLTQKTLFPGCDHIDQLNKIIAITGKPDETFLQKIASESAKTYLMSM---AAYPKRDFS-----TIFLG---ASRK-------AVDLLEKMLQLDEDR
||... . |||| ||||| ||||   | ||  |...   .....|. .      |. . |.     |.|..   . .|       | ||| .||  . |.
AEMIRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQ-PHVRNYVENRNMDPYYQPYNFHEHFPDTLFPDVMQSEPKDHLTCHMARDLLFRMLVINPDD

RLSAEQALQHPYL
|.| ..||||||.
RISVDDALQHPYI
Kinase p38.AA ERK1 27-312 50 1.5e-112 380.22 In-house 1-289 (289) Show / Hide 
Range on Protein: 27-312
Range on HMM: 1-289/289
Sequence Identity: 50% (147 aa)

YVRLEPVGSGAYGQVCSTEAEDTRQKGLRVAIKKLSRPFQTVIHAKRTYRELRLLKHMRHENVISLLDCFTPDRVN-FSDVYMVTHLMGADLNNIIKCQK
|..|. .| |||| |||  | ||..|  ||||||.| ||    . .|| ||...|.  .|||.| . |    | .. . |||.|  ||  ||  ..| |.
YTNLQYIGEGAYGMVCS--AYDTVHKQ-RVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQH

LSDDHVQFLIYQVLRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARSTDDE------MTGYVATRWYRAPEIMLNWMHYTEKVDIWSVGCIMAE
|| ||. . .||.|||||||||| |.||||||||. .|  |.|.| |||||| .| |      .| |||||||||||||||   ||  .||||||||.||
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE

LLTQKTLFPGCDHIDQLNKIIAITGKPDETFLQKIASESAKTYLMSMAAYPKRDFSTIFLGASRKAVDLLEKMLQLDEDRRLSAEQALQHPYL
.|  . .|||   .||||.|... | | .  |. |  | |. ||.|.   ||  .  .| .|  ||.|||.|||    ..|.  |.|| ||||
MLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase p38.AA ERK5 27-312 44 1.3e-109 370.44 In-house 1-295 (295) Show / Hide 
Range on Protein: 27-312
Range on HMM: 1-295/295
Sequence Identity: 44% (132 aa)

YVRLEPVGSGAYGQVCSTEAEDTRQKGLRVAIKKLSRPFQTVIHAKRTYRELRLLKHMRHENVISLLDCFTPDR--VNFSDVYMVTHLMGADLNNIIKC-
|  .| .| |||| |||      |. | .|||||.   |  |  ||||.|||..|.| ||.|.| . |   |      . |||.|  || .||  ||   
YKIIEKIGNGAYGVVCSARR---RKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSN

QKLSDDHVQFLIYQVLRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLAR-----STDDE---MTGYVATRWYRAPEIMLNWMHYTEKVDIWSVGC
| .. .|. . .||.||||||.||| ||||||||||. ||| |||.| |||.||     |.|..   || |||||||||||.|.    ||  .|.|||||
QPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGC

IMAELLTQKTLFPGCDHIDQLNKIIAITGKPDETFLQKIASESAKTYLMS-MAAYPKRDFSTIFLGASRKAVDLLEKMLQLDEDRRLSAEQALQHPYL
|. |... . .|||   |.||. |. . | |    .| ....  . |. . ..    .|..... .| |.|.||| .||  .   |... .|||||.|
IFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase p38.AA ERK7 27-312 41 1.2e-102 347.28 In-house 1-292 (292) Show / Hide 
Range on Protein: 27-312
Range on HMM: 1-292/292
Sequence Identity: 41% (122 aa)

YVRLEPVGSGAYGQVCSTEAEDTRQKGLRVAIKKLSRPFQTVIHAKRTYRELRLLKHMR-HENVISLLDCFTPDRVNFSDVYMVTHLMGADLNNIIK-CQ
|  .. .| |||| |    | | | |   ||.||    |.  . | ||.||  .|. .. |.|.|.|.. .  |  |  |.|.|   | .||...|.  .
YEIRKRLGKGAYGIVW--KAYDKRTKQV-VALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRAD--NDRDIYLVFEFMETDLHAVIRKGN

KLSDDHVQFLIYQVLRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARS-TDDE--------MTGYVATRWYRAPEIMLNWMHYTEKVDIWSVGC
 | | |.|. .||.|| .||.||. ||||||||||| .. .| ... ||||||| .. |        .| ||||||||||||.|   .||  || ||.||
ILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGC

IMAELLTQKTLFPGCDHIDQLNKIIAITGKPDETFLQKIASESAKTYLMSMAAYPKRDFSTIFLGASRKAVDLLEKMLQLDEDRRLSAEQALQHPYL
|..|.|..| .|||   ..|..||. ...|| .  .. | |. | . | .|   ... .. .. ...  |.||| ..|..  ..||.||||||||| 
ILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase p38.AA nmo 31-312 45 7.1e-100 307.85 In-house 5-292 (292) Show / Hide 
Range on Protein: 31-312
Range on HMM: 5-292/292
Sequence Identity: 45% (132 aa)

EPVGSGAYGQVCSTEAEDTRQKGLRVAIKKLSRPFQTVIHAKRTYRELRLLKHMRHENVISLLDCFTPDRV-NFSDVYMVTHLMGADLNNII-KCQKLSD
 |.| ||.| | |    | |. | |||.||.   || .. .|| .|||..|   .|.||.|.||.  |  .  | ..|.|| || .||  ||   |.|| 
RPIGYGAFGVVWS--VTDPRD-GKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

DHVQFLIYQVLRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARSTDDE----MTGYVATRWYRAPEIMLNWMHYTEKVDIWSVGCIMAELLTQK
|||.  .||.||||||.|||...|||.|| |. || .| |.| ||||||  . .    ||  | | .||||||..   |||. ||||||||| ||||  .
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRR

TLFPGCDHIDQLNKIIAITGKPDETFLQKIASESAKTYLMSMAAYPKRDFSTIFLGAS-----RKAVDLLEKMLQLDEDRRLSAEQALQHPYL
 ||     |.||. |. . | |    . | | | ||. .. |.  |  ... ..  .|       ||.|| .||  | |.|.|...||.||||
ILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHMLRMPHKP-PCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase p38.AA S_TKc 27-312 29 5.6e-88 299.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-312
Range on HMM: 1-231/231
Sequence Identity: 29% (89 aa)

YVRLEPVGSGAYGQVCSTEAEDTRQKGLRVAIKKLSRPFQTVIHAKRTYRELRLLKHMRHENVISLLDCFTPDRVNFSDVYMVTHLMGA---DLNNIIKC
|  |...|.||.|.|.     .    | .||||...         ....||...||. .|.|.. |.|.|       ...|||. ...    ||  .|| 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKK

QK-------LSDDHVQFLIYQVLRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARSTDDEMTGYVATRWYRAPEIMLNWMHYTE-KVDIWSVGC
..       ..  |..|..||....|.|.|| |.|||||||.|| ..|  .. | ||||||      | .. |.||.|||..    .|.  |.|.||.||
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

IMAELLTQKTLFPGCDHIDQLNKIIAITGKPDETFLQKIASESAKTYLMSMAAYPKRDFSTIFLGASRKAVDLLEKMLQLDEDRRLSAEQALQ-------
|..|.|. ...||      |..... . |                                     |. | |...|.|| | ..|..| .|||       
ILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

HPYL
||..
HPWF
Kinase p38.AA Pkinase 27-312 30 2.3e-87 301.33 Pfam 1-293 (293) Show / Hide 
Range on Protein: 27-312
Range on HMM: 1-293/293
Sequence Identity: 30% (94 aa)

YVRLEPVGSGAYGQVCSTEAEDTRQKGLRVAIKKLSRPFQTVIHAKRTYR--ELRLLKHMRHENVISLLDCFTPDRVNFSDVYMVTHLMGA-----DLNN
|......|||..|.|.     .|..   .||.|..... .     ..  |  |....|...|.|.. |.|.|.      ...|||. ...      ||  
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFD

IIK---CQKL--SDDHVQFLIYQVLRGLKYIHSAGVIHRDLKPSNIAVNEDCEL----RILDFGLAR---STDDEMTGYVATRWYRAPEIMLNWMHYTEK
.|.     ..  |.....| .||.||||.|.|| |.|||||||.|| .......    .| |||||.      ..||... |.||.|||. .   .|. |
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPK

VDIWSVGCIMAELLTQKTLFPGC----DHIDQLNKIIAITGKPDETFLQKIASESAKTYLMSMAAYPKRDFSTIFLGASRKAVDLLEKMLQLDEDRRLSA
||.||.|||..|.|. ...|||.    . .||. .|  | |.| .   ..  |.|  . ..       . ..|    .|. . |.....|..|  .|..|
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

EQALQHPYL
||.||||..
EQILQHPWF
Kinase p38.AA MAPK-Unclassified 27-182 44 2.9e-67 229.77 In-house 1-162 (575) Show / Hide 
Range on Protein: 27-182
Range on HMM: 1-162/575
Sequence Identity: 44% (73 aa)

YVRLEPVGSGAYGQVCSTEAEDTRQKGLRVAIKKLSRPFQTVIHAKRTYRELRLLKHMRHENVISLLDCFTP-DRVN--FSDVYMVTHLMGA---DLNNI
|   . .|||||||||  .| |.. ..  |||||. . |.... .||. ||.|.| .. |.|.| . | |.. .  |  | |.| |. .|     ||  |
YEYQKNIGSGAYGQVC--RAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQI

IKCQK--LSDDHVQFLIYQVLRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARSTDDE
||     ... |.| ..|| ||||||.|||..|||||||||. .|.|| .|| |||..||  |.
IKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIEDN
Kinase p38.AA MAPK-Unclassified 183-312 34 2.8e-45 156.77 In-house 405-575 (575) Show / Hide 
Range on Protein: 183-312
Range on HMM: 405-575/575
Sequence Identity: 34% (59 aa)

MTGYVATRWYRAPEIMLNWMHYTEKVDIWSVGCIMAELLT-----------QKTLFPGCD--------------------HIDQLNKIIAITGKPDETFL
||.||.|||||||||||    |. .|||||.||| ||..            .. |||| |                    |.||.. |.   | |.|  .
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

QKIASESAKTYLMSMAAYPKRDFS-TIFLGAS---------RKAVDLLEKMLQLDEDRRLSAEQALQHPYL
. | . ||. |. | .  .  .|.  .|  |.           . |.. |||| .  .| .|.|||.||| 
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase p38.AA TyrKc 27-312 20 1.2e-15 30.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-312
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

YVRLEPVGSGAYGQVCSTEAEDTRQKGLRVAIKKLSRPFQTVIHAKRTYRELRLLKHM--RHENVISLLDCFTPDRVNF---SDVYMVTHLMGA-DLNNI
 . ..  |.||.|.|.  ..       . ||.|.|          .  .||.|....   .|.|.. |. . | .  ||     ...|. .|   ||.. 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKCQK--LSDDHVQFLIYQVLRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARSTDDE--------MT-------GY--VATRWYRAPEIMLNW
..  .  |. ..     .|. .|  |.|| ..|||||   |. |.|.   .| ||||.|  .|.        .        |   .  ||. ||| . | 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NY

MHYTEKVDIWSVGCIMAELLTQ-KTLFPG-----CDHIDQLNKIIAI--TGKPDE----TFLQKIASESAKTYLMSMAAYPKRDFSTIFLGASRKAVDLL
  .|.| |.|| |  | |..|  ..  ||     .. .. .... .     .|..                                 | ... .  .. 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------FVCCPDEMYQIM

EKMLQLDEDRRLSAEQALQHPYL
..  . | . | . ..   | ..
KQCWHEDPEDRPTFSEI--HECF
Kinase p38.AA Pkinase_Tyr 27-93 22 1.2e-07 26.58 Pfam 1-70 (270) Show / Hide 
Range on Protein: 27-93
Range on HMM: 1-70/270
Sequence Identity: 22% (16 aa)

YVRLEPVGSGAYGQVCSTEAE-DTRQKGLRVAIKKLSRPFQTVIH--AKRTYRELRLLKHM-RHENVISLL
 . ..  |.||.|.|.  ..  |  .... ||.|.| ..  .  .   .   ||....|.. .|.|...|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase p38.AA Pkinase_Tyr 136-222 35 1.5e-05 19.43 Pfam 118-209 (270) Show / Hide 
Range on Protein: 136-222
Range on HMM: 118-209/270
Sequence Identity: 35% (34 aa)

YQVLRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARST-DDEMTGYVAT-------RWYRAPEIMLNWMHYTEKVDIWSVGCIMAELLT
.|. .|. | .| . |||||   |. |.|.   .| ||||||   .|.   |...       .|. ||| . .   .|.| |.|| |  | |..|
WQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIFT