Gene SRPK (Sea Urchin)

SRPK

Species: Sea Urchin
Alias: SPU_002645, SRPK, Spk152
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
SRPK.AA Protein None 911 None Fasta, JSON
SRPK.kin_dom Protein Kinase Domain None 161 None Fasta, JSON

Protein domain

Protein domains of SRPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SRPK.AA SRPK 364-909 30 1.3e-188 491.37 In-house 194-554 (554) Show / Hide 
Range on Protein: 364-909
Range on HMM: 194-554/554
Sequence Identity: 30% (171 aa)

STAPL--ERKPQEKMSKNKKRKMKKKQKKQLALLEKQQQQLQEIDQEKTRTISETSQPDADRDGEDNVATDAVPQNQSNNGNQSLSPSEDKMAEVLEEAE
.|||     ..|.|||||||.|||||||.|  ..|| |||.|.  .....                          . ||.... .. ..|  .  |. .
QTAPQHQTQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDN-------------------------EDNNQEDNDNEQDNKNNQNQENNM

EEEDGAVSRMKATKS--PERTSEISSPEEEQPGVVVGENATNGNEGAGCHGDEAEDADVFEDAPERIPSPVNEKGDGPGRKEVEKEQELCNGYVEENGDG
| |.   .  .  |.  ... ...  .|.|...|.   |                                                             
ENEQEEKENTNKQKKNQKKKEQHKDKKEQECQNVQKQNND------------------------------------------------------------

DVDLPLKPKLHPDVKENGLDSASSTPTPTKESLKNAANKEKSENKASDPNENTISENSTESKDKETLNNGAKENGNHKTLDNKPSDNVQENKN-----IE
                                                                        .|.. .. |  ... . .. |     ..
------------------------------------------------------------------------PNFESQN-DSQMEQETNSCNNQEHKQEK

LNSLGADSMLNGGVSPEEDVQTKDAQKEDTTSDDNRRKEIDLKWEELEKFESKNSGGEDGKEGSGSAATSPADSNKDGESVEGATSPERKD---ELPIKL
.    ... .  .  ...  ..|. ......|.| . .                                      .| .      |.  |    . ||.
TMQCQDSTKQQNKQ-DQQKEGQKQSEESECESEDMQEQ--------------------------------------AGKFLVWWKNPRNADLDHKIKIKI

ADLGNACWTHHHFTEDIQTRQYRALEVLIGAGYDTAADIWSTACMAFELACGDYLFEPHSGENYSRDEDHIAHIIELVGHIPKHVALSGKYSRDFFNKKG
||||||||.||||||||||||||..||.|||||.| ||||||||||||||.|||||||||||.||||.|||||||||.|.||.|.||||||||.||||||
ADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKG

ELRNISKLKPWSLYHVLTEKYEWPKEDAEEFASFLYPMLEFDPTKRATAKESLSHPWL
|||.|.|||||.|..||.|||||..|.|..|..||.|||...|.||||||| | ||||
ELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase SRPK.AA SRPK 283-361 56 8.6e-76 193.86 In-house 1-100 (554) Show / Hide 
Range on Protein: 283-361
Range on HMM: 1-100/554
Sequence Identity: 56% (57 aa)

YHVVRKLGWGHFSTVWLAWDLTGRRYVALKVVKSAEHYTETALDEIKLLKCVRNSDPN---------------------DIQRERVVQLVDDFKVTGVNG
|||.|||||||||||||.||. . ||||.|.||||.||||||.||||||.|||..|||                     | .|..|||| |.||..|.||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG
Kinase SRPK.AA CMGC 369-909 8 1.2e-61 200.98 In-house 232-513 (513) Show / Hide 
Range on Protein: 369-909
Range on HMM: 232-513/513
Sequence Identity: 8% (53 aa)

ERKPQEKMSKNKKRKMKKKQKKQLALLEKQQQQLQEIDQEKTRTISETSQPDADRDGEDNVATDAVPQNQSNNGNQSLSPSEDKMAEVLEEAEEEEDGAV
|                                                                                                   
E---------------------------------------------------------------------------------------------------

SRMKATKSPERTSEISSPEEEQPGVVVGENATNGNEGAGCHGDEAEDADVFEDAPERIPSPVNEKGDGPGRKEVEKEQELCNGYVEENGDGDVDLPLKPK
                                                                                                    
----------------------------------------------------------------------------------------------------

LHPDVKENGLDSASSTPTPTKESLKNAANKEKSENKASDPNENTISENSTESKDKETLNNGAKENGNHKTLDNKPSDNVQENKNIELNSLGADSMLNGGV
                                                                                                    
----------------------------------------------------------------------------------------------------

SPEEDVQTKDAQKEDTTSDDNRRKEIDLKWEELEKFESKNSGGEDGKEGSGSAATSPADSNKDGESVEGATSPERKDELPIKLADLGNACWTHHH-----
                                                                       .|. ..   .|..| |.|.|.|.|     
-------------------------------------------------------------------D-W-NPC-QKNGRLKICDFGLARWYHPHSDHHF

-------------------FTEDIQTRQYRALEVLIGAG----------YDTAADIWSTACMAFELACG--------DYLFEPHSGE-----NYSRDEDH
                   .|....|| ||| |.|.|..          |.|. |.|| .|. .|.  |        ..|| .||..     |.... |.
QQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQ

IAHIIELVGHIPKHVALSGK-------YSRDFFNKKGELRNISKLK-------------------------PWSLYHVLTEKYEWPKE------------
...|... | .. ... .||       ......|... .... ..|                         ||  .. ..... | ..            
LFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFN

--------------------DAEEFASFLYPMLEFDPTKRATAKESLSHPWL
                    . ...  .|  ||..||.|| ||.. |.||..
WIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase SRPK.AA CLK 579-909 14 5.1e-28 80.51 In-house 149-350 (350) Show / Hide 
Range on Protein: 579-909
Range on HMM: 149-350/350
Sequence Identity: 14% (51 aa)

DS-----ASSTPTPTKESLKNAANKEKSENKASDPNENTISENSTESKDKETLNNGAKENGNHKTLDNKPSDNVQENKNIELNSLGADSMLNGGVSPEED
||     . .... .| ...                                                                                
DSRFTHFDCTFKYNHKKKIN--------------------------------------------------------------------------------

VQTKDAQKEDTTSDDNRRKEIDLKWEELEKFESKNSGGEDGKEGSGSAATSPADSNKDGESVEGATSPERKD-ELPIKLADLGNAC---WTHHHFTEDIQ
                                                            | .    ...   .. |.. | |.|      | | .. ..
----------------------------------------------------------KKS-NNCVCHYWHVKNTHICVIDFGSATKIRFDHEHHSTIVS

TRQYRALEVLIGAGYDTAADIWSTACMAFELACGDYLFEPHSGENYSRDEDHIAHIIELVG-HIPKHVALSG---KYSRDFFNKKGEL---RNISKLKPW
||.||| ||  | |. .  |.|| .|  |||  |. ||  |.        .| | . .. |  ||.. . .    | .. .|.. ...    | .  .  
TRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHD------NREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGRYVM

SLYHVLTEKYEWPKEDAEEFASFLYPMLEFDPTKRATAKESLSHPWL
.  . | .  .  .......   .  |||.||.|| |.|. |.||. 
ENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase SRPK.AA DYRK 749-909 28 4.1e-26 93.07 In-house 146-320 (320) Show / Hide 
Range on Protein: 749-909
Range on HMM: 146-320/320
Sequence Identity: 28% (52 aa)

IKLADLGNACWTHHHFTEDIQTRQYRALEVLIGAGYDTAADIWSTACMAFELACGDYLFEPHSGENYSRDEDHIAHIIELVGHIPKHVALSG--KYSRDF
||..| | .|  |....  || | ||| ||..|  |..| |.||  |   ||  |  ||   .|||.    | .| |.|. | .||..  .|  .. . |
IKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKGRCRRKHKF

FNK------------KG------ELRNISKLKPWSLYHVLTE--KYEWPKEDAEEFASFLYPMLEFDPTKRATAKESLSHPWL
|..            .       ..... ...  . .   ..  ...    | ..|  |.  .|..||.|| |... | |||.
FDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase SRPK.AA CMGC 283-362 22 4.2e-23 71.96 In-house 1-115 (513) Show / Hide 
Range on Protein: 283-362
Range on HMM: 1-115/513
Sequence Identity: 22% (26 aa)

YHVVRKLGWGHFSTVWLAWD--------------LTGRRYVALKVVKSAEHYTE-------------TALDEIKLLKCVR----------NSDPNDIQRE
|....|.|.|....|. ..|                . ..||.| .|... |.|             .||.|||.||...          . ||.. ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

RVVQLVDDFKVTGVNGS
 .|.| | |.  . .|.
NIVKLYDIFYHKNSDGN
Kinase SRPK.AA CLK 283-355 35 7.6e-18 49.41 In-house 1-76 (350) Show / Hide 
Range on Protein: 283-355
Range on HMM: 1-76/350
Sequence Identity: 35% (27 aa)

YHVVRKLGWGHFSTVWLAWDLTG-RRYVALKVVKSAEHYTETALDEIK-LLKCVRNS-DPNDIQRERVVQLVDDFK
| .| .|| | |..|   ||     .|||||.....| |.| |  ||.  .| . .  ||| . .| .... | |.
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFD
Kinase SRPK.AA DYRK1 749-850 36 1.1e-15 51.1 In-house 145-240 (321) Show / Hide 
Range on Protein: 749-850
Range on HMM: 145-240/321
Sequence Identity: 36% (37 aa)

IKLADLGNACWTHHHFTEDIQTRQYRALEVLIGAGYDTAADIWSTACMAFELACGDYLFEPHSGENYSRDEDHIAHIIELVGHIPKHVALSGKYSRDFFN
||. | | .| . .   . || | ||. |||.|  ||.| |.||  |.  |.  |. ||   || |   . | . .|.| .|  |||.  ..  .. .|.
IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SGSN---EVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE

KK
|.
KD
Kinase SRPK.AA DYRK2 749-851 33 6.3e-15 44.65 In-house 143-245 (318) Show / Hide 
Range on Protein: 749-851
Range on HMM: 143-245/318
Sequence Identity: 33% (37 aa)

IKLADLGNACWTHH-HFTEDIQTRQYRALEVLIGAGYDTAADIWSTACMAFELACGDYLFEPHSGENYSRDEDHIAHIIELVGHIPKHVALSG------K
||..| |  |  |  ..  .||.| ||| || .|  |..| |.||  | . ||  |  ||    |||.    | .| ..|. | .|  . ..       .
IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLG-MPPKKFFDTWFYIHCF

YSRDFFNKKG
. . |||...
RRKYFFNSHC
Kinase SRPK.AA DyrkP 749-850 33 6.6e-15 44.86 In-house 147-242 (323) Show / Hide 
Range on Protein: 749-850
Range on HMM: 147-242/323
Sequence Identity: 33% (34 aa)

IKLADLGNACWTHHHFTEDIQTRQYRALEVLIGAGYDTAADIWSTACMAFELACGDYLFEPHSGENYSRDEDHIAHIIELVGHIPKHVALSGKYSRDFFN
.|. | | .|. | |    .| | ||| ||.||  ||   |.||  |.  ||  |  ||              .| .| ..| .|  .   |.  . || 
VKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGL------LARVIGIIGPFPEWMMQEGRLVQNFFT

KK
.|
RK
Kinase SRPK.AA DYRK 283-341 30 1.6e-13 47.17 In-house 1-59 (320) Show / Hide 
Range on Protein: 283-341
Range on HMM: 1-59/320
Sequence Identity: 30% (18 aa)

YHVVRKLGWGHFSTVWLAWDLTGRRYVALKVVKSAEHYTETALDEIKLLKCVRNSDPND
| ..  .| | |. |  .||  .  .||.|.... . .  .|..|||.|.. .. ||.|
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDD
Kinase SRPK.AA S_TKc 283-909 8 3.8e-13 15.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 283-909
Range on HMM: 1-231/231
Sequence Identity: 8% (57 aa)

YHVVRKLGWGHFSTVWLAWDLTGRRYVALKVVKSAEHYTETALDEIKLLKCVRNSDPNDIQRERVVQLVDDFKVTG--------VNG---SLSTAPLERK
|...||.| | |..|.....    |.||.|..|      |... ||..||          . . .|.| | |   .        ..|   .| .   .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

PQEK---MSKNKKRKM----------------------------------------KKKQKKQLALLEKQQQQLQEIDQEKTRTISETSQPDADRDGEDN
.. .   ..    |..                                        ..                                          
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-----------------------------------------

VATDAVPQNQSNNGNQSLSPSEDKMAEVLEEAEEEEDGAVSRMKATKSPERTSEISSPEEEQPGVVVGENATNGNEGAGCHGDEAEDADVFEDAPERIPS
                                                                                                    
----------------------------------------------------------------------------------------------------

PVNEKGDGPGRKEVEKEQELCNGYVEENGDGDVDLPLKPKLHPDVKENGLDSASSTPTPTKESLKNAANKEKSENKASDPNENTISENSTESKDKETLNN
                                                                                                    
----------------------------------------------------------------------------------------------------

GAKENGNHKTLDNKPSDNVQENKNIELNSLGADSMLNGGVSPEEDVQTKDAQKEDTTSDDNRRKEIDLKWEELEKFESKNSGGEDGKEGSGSAATSPADS
                                                                                                    
----------------------------------------------------------------------------------------------------

NKDGESVEGATSPERKDELPIKLADLGNACWTHHHFTEDIQTRQYRALEVLIGAGYDT-AADIWSTACMAFELACGDYLFEPHSGENYSRDEDHIAHIIE
                                    |  . |. |.| |||   ||.. ..|.||  |. .|..||  .|.         ... . ..| 
------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG

LVGHIPKHVALSGKYSRDFFNKKGELRNISKLKPWSLYHVLTEKYEWPKEDAEEFASFLYPMLEFDPTKRATAKESLS-------HPWL
                                                    .|. .|.  .|..||.|| || | |        |||.
---------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SRPK.AA Pkinase 748-814 26 5.3e-10 36.44 Pfam 150-222 (293) Show / Hide 
Range on Protein: 748-814
Range on HMM: 150-222/293
Sequence Identity: 26% (20 aa)

PIKLADLGNAC---WTHHHFTEDIQ-TRQYRALEVLI-GAGYDTAADIWSTACMAFELACGDYLFEPH----SGEN
..|..| | |.   . . . . ..  |. |.| ||.  | .|....|.||  |. .|..||  .|  |    .  .
CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HD
Kinase SRPK.AA CAMKL 283-340 22 4.8e-09 24.85 In-house 1-76 (297) Show / Hide 
Range on Protein: 283-340
Range on HMM: 1-76/297
Sequence Identity: 22% (17 aa)

YHVVRKLGWGHFSTVWLAWD-LTGRRYVALKVVKSAEHYTETALD----------------EIKLLKCVRNS-DPN
| ... || |.|..| ||.. .| .. || |...      ..  .                ||...| ....  ||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPN
Kinase SRPK.AA Pkinase 871-909 27 7.6e-09 32.35 Pfam 236-293 (293) Show / Hide 
Range on Protein: 871-909
Range on HMM: 236-293/293
Sequence Identity: 27% (16 aa)

KYEWPKEDA-------------------EEFASFLYPMLEFDPTKRATAKESLSHPWL
...||...                    ||. .|.. .|..||.|| ||.. | |||.
HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SRPK.AA PRP4 769-807 43 1.6e-08 27.38 In-house 167-205 (320) Show / Hide 
Range on Protein: 769-807
Range on HMM: 167-205/320
Sequence Identity: 43% (17 aa)

QTRQYRALEVLIGAGYDTAADIWSTACMAFELACGDYLF
. | ||| |..||  || . |.||..|  .||. |  .|
VSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMF
Kinase SRPK.AA DyrkP 882-909 50 2e-08 23.15 In-house 296-323 (323) Show / Hide 
Range on Protein: 882-909
Range on HMM: 296-323/323
Sequence Identity: 50% (14 aa)

FASFLYPMLEFDPTKRATAKESLSHPWL
|  |   .|  | |.| |||| |.|||.
FIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase SRPK.AA DYRK1 283-341 30 5.9e-08 23.51 In-house 1-59 (321) Show / Hide 
Range on Protein: 283-341
Range on HMM: 1-59/321
Sequence Identity: 30% (18 aa)

YHVVRKLGWGHFSTVWLAWDLTGRRYVALKVVKSAEHYTETALDEIKLLKCVRNSDPND
| .   .| | |  |  |.|   . |||.|..|    . . |. ||.||  . . |...
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEM
Kinase SRPK.AA DYRK2 880-909 40 9.8e-08 20.88 In-house 289-318 (318) Show / Hide 
Range on Protein: 880-909
Range on HMM: 289-318/318
Sequence Identity: 40% (12 aa)

EEFASFLYPMLEFDPTKRATAKESLSHPWL
| |. |.   .| ||..| |... | |||.
ENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase SRPK.AA MAPK 889-909 57 1.3e-07 22.14 In-house 308-328 (328) Show / Hide 
Range on Protein: 889-909
Range on HMM: 308-328/328
Sequence Identity: 57% (12 aa)

MLEFDPTKRATAKESLSHPWL
||.||| || |..| |.|| .
MLVFDPDKRITVEEALQHPYF
Kinase SRPK.AA CAMKL 889-909 42 2.1e-07 19.51 In-house 277-297 (297) Show / Hide 
Range on Protein: 889-909
Range on HMM: 277-297/297
Sequence Identity: 42% (9 aa)

MLEFDPTKRATAKESLSHPWL
||. .|.||.|... ..|||.
MLQVNPEKRPTIHQIMNHPWM
Kinase SRPK.AA DYRK2 283-340 25 3.9e-07 18.89 In-house 1-58 (318) Show / Hide 
Range on Protein: 283-340
Range on HMM: 1-58/318
Sequence Identity: 25% (15 aa)

YHVVRKLGWGHFSTVWLAWDLTGRRYVALKVVKSAEHYTETALDEIKLLKCVRNSDPN
| ..  .| | |  |  . |   . .||.|..     . ..|. ||. |.  |  |..
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKD
Kinase SRPK.AA MAPK 404-792 4 2e-06 17.75 In-house 173-219 (328) Show / Hide 
Range on Protein: 404-792
Range on HMM: 173-219/328
Sequence Identity: 4% (16 aa)

EIDQEKTRTISETSQPDADRDGEDNVATDAVPQNQSNNGNQSLSPSEDKMAEVLEEAEEEEDGAVSRMKATKSPERTSEISSPEEEQPGVVVGENATNGN
.. |.... ..   |                                                                                     
HHHQQDDP-HC-F-Q-------------------------------------------------------------------------------------

EGAGCHGDEAEDADVFEDAPERIPSPVNEKGDGPGRKEVEKEQELCNGYVEENGDGDVDLPLKPKLHPDVKENGLDSASSTPTPTKESLKNAANKEKSEN
                                                                                                    
----------------------------------------------------------------------------------------------------

KASDPNENTISENSTESKDKETLNNGAKENGNHKTLDNKPSDNVQENKNIELNSLGADSMLNGGVSPEEDVQTKDAQKEDTTSDDNRRKEIDLKWEELEK
                                                                                                    
----------------------------------------------------------------------------------------------------

FESKNSGGEDGKEGSGSAATSPADSNKDGESVEGATSPERKDELPIKLADLGNACWTHHHFTEDIQTRQYRALEVLIG---AGYDTAADIWS
                                                           | || . || ||| |.. .    .|..| |.||
---------------------------------------------------------KMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWS
Kinase SRPK.AA PRP4 283-355 28 7e-06 17.72 In-house 1-74 (320) Show / Hide 
Range on Protein: 283-355
Range on HMM: 1-74/320
Sequence Identity: 28% (22 aa)

YHVVRKLGWGHFSTVWLAWDLTGRR-YVALKVVKSAEHYTETALDEIKLLKCVRNS--DPNDIQRERVVQLVDDFK
| |. . | | ||.|  . |.|  .  || |.. . |    | | |.  |.   .   |.||  .  .|.. . |.
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKND--KFHCVRMFRHFN
Kinase SRPK.AA Pkinase 283-335 27 8e-06 21.64 Pfam 1-58 (293) Show / Hide 
Range on Protein: 283-335
Range on HMM: 1-58/293
Sequence Identity: 27% (16 aa)

YHVVRKLGWGHFSTVWLAWDLTGRRYVALKVVKSAEHYTETALD------EIKLLKCVR
||..||.| | |..|... .   .. ||.|..|   |  .  .       ||...| ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN
Kinase SRPK.AA DyrkP 283-332 28 1.9e-05 13.17 In-house 1-50 (323) Show / Hide 
Range on Protein: 283-332
Range on HMM: 1-50/323
Sequence Identity: 28% (14 aa)

YHVVRKLGWGHFSTVWLAWDLTGRRYVALKVVKSAEHYTETALDEIKLLK
| ..  ||   ||      |.   . . .|..     | . ..||||||.
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLR
Kinase SRPK.AA PRP4 885-909 44 7.2e-05 13.86 In-house 296-320 (320) Show / Hide 
Range on Protein: 885-909
Range on HMM: 296-320/320
Sequence Identity: 44% (11 aa)

FLYPMLEFDPTKRATAKESLSHPWL
.|  .|  || || |  | | || .
LLDKCLMLDPKKRITCNEALKHPFI
Kinase SRPK.AA DYRK1 877-909 33 0.000185 11.02 In-house 289-321 (321) Show / Hide 
Range on Protein: 877-909
Range on HMM: 289-321/321
Sequence Identity: 33% (11 aa)

EDAEEFASFLYPMLEFDPTKRATAKESLSHPWL
||   |   .  ||..|| .| |  . | |...
EDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase SRPK.AA MAPK 283-336 23 0.004158 6.33 In-house 1-63 (328) Show / Hide 
Range on Protein: 283-336
Range on HMM: 1-63/328
Sequence Identity: 23% (15 aa)

YHVVRKLGWGHFSTVWLAWDL-TGRR-----YVALKVVK---SAEHYTETALDEIKLLKCVRN
|  ....| | . .|. | |  |...     .||.| .    . ....  .. |||||.. ..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHH