Gene BUB1 (Sea Urchin)
BUB1
Sequence
Protein domains of BUB1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Mad3_BUB1_I | BUB1.AA | Mad3_BUB1_I | 47-171 | 45 | 2.4e-58 | 201.09 | SMART | 1-133 (133) | Show / Hide |
Range on Protein: 47-171 Range on HMM: 1-133/133 Sequence Identity: 45% (61 aa) LILQRQGFETEL--RTYTGDDPLDSWIRYIQWTEQNFPQG--GKDSHLGVLMQKCLIQFKNDDLYKQDIRYVSIWLKMAQYD----SESLEIFKFMQANQ | ||| || |. . | |||||| |.|||.|||||.||| .|.|.| .|...|. |..|. ||.| ||..||.... . .|..|||..|.... LEQQRQEFEQEIQDDSYEGDDPLDVWYRYIKWTEQNYPQGQQTKQSGLQTLLERCTRYFWDDERYKNDPRYLKIWIWYMDMCYNYFDEPREIFQYMYRHG TGTKLTLFYEAWAWELEQVGNTKRADAIYKEGL ||.. ||||.|| ..|. || . ||.||. |. IGTQCALFYEEWAQWYENMGNYQKADEIYQLGI |
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| Mad3_BUB1_I | BUB1.AA | Mad3_BUB1_I | 47-171 | 42 | 1.3e-53 | 188.9 | Pfam | 1-134 (134) | Show / Hide |
Range on Protein: 47-171 Range on HMM: 1-134/134 Sequence Identity: 42% (57 aa) LILQRQGFETELRTYT---GDDPLDSWIRYIQWTEQNFPQ--GGKDSHLGVLMQKCLIQFKNDDLYKQDIRYVSIWLKMAQYDS----ESLEIFKFMQAN |. ||| || |...|. |||||. |.|||.|.|...|| |.| | | |...|. |..|. ||.| ||. |||... | . |...||..| .. LQQQRQQFEEEIQNYECEEGDDPLQPWYRYIKWMEEAYPQGGGTKQSGLPTLLERCVKYFWHDERYKNDPRYLKIWLWYMNYCNNNFDEPRDIFQYMYNQ QTGTKLTLFYEAWAWELEQVGNTKRADAIYKEGL . |||. ||||.|| ||..|. . ||.....|. GIGTKCALFYEEWAQYLESMGKWQKADEVFQLGI |
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| Kinase | BUB1.AA | BUB | 1232-1510 | 41 | 2.4e-133 | 449.32 | In-house | 1-311 (311) | Show / Hide |
Range on Protein: 1232-1510 Range on HMM: 1-311/311 Sequence Identity: 41% (131 aa) YSVMEKVGEGAFATIYLAACLDALDM----TDLDRDFRRVALKVQHPPCPWEMYVIKELHARLSRLPSQIDVRPSIMTAECAHIYQDKSCMVTEYK-SKG ... .|||..|..|.| .| | . ||.||| ||.||| | ..| || . .| . . ...|.. .|.|||||||..||. ..| FCIQKEIGEGSYAYVYKAEHSDCGDYRLFWVAPRKSAHWVACKVQKPPNPWEFYICDQMHERL-KERSETMMHCCFMHICSCHYYQDKSCMWMEYHIDYG TLLDLINKVK---AVNKKDLSEDWVLFFAIEILQTVEYMHRCKIIHGDIKPDNFLINTDNDENFTCSQEPSSL-------VKLIDFGRSIDMTLFPEGTV ||||.||..| .||.|...|.||.||....|..||..|||.|||||||||||...........|....|. .|||||||||||||||.|.. TLLDVINHMKEKAQVNNKVMHEYWVMFFCCQMLKMVEHLHRCEIIHGDIKPDNFMLMNRIHDDWDCWHKMSCGEAWKNKGLKLIDFGRSIDMTLFPDGQR FTAKCKTSG--FNCTEMQ----SDQPWTYQVDYYGIAGTVHCLMFGKYMKVF--REGGIWKMTSKVPRCAKVD--------WKGFFHTLLN----VPSCD |...|.|.. |.|.||| ...||||||||.|||.|.||..|||||.|. .|..|| ...| . | | |||..|| |.|. FKFNCETQQDPFECWEMQQSSTTNCPWTYQVDYFGIAATMHCMLFGKYMQVKQKWDGQYWKLEQNFRRYWQKDSFSELDTMWNKFFHRMLNHNGEIPDCQ PSDLPHLGDLRRQL || .. || |. --TLPMWHELRQQF |
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| Kinase | BUB1.AA | Jak | 1232-1379 | 30 | 2.1e-44 | 153.8 | In-house | 1-151 (299) | Show / Hide |
Range on Protein: 1232-1379 Range on HMM: 1-151/299 Sequence Identity: 30% (47 aa) YSVMEKVGEGAFATIYLAACLDALDMTDLDRDFRR----VALKVQHPPCPWEMYVIKELHARLSRLPSQIDVRPSIMTAECAHIYQDKSCMVTEYKSKGT . | .|||.|...|. ..... ||||.. .... |..|||||..| .....|...|......... ......|.|..||..|||.||...| LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHP---QHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGP LLDLINKVKAVNKKDLSE--DWVLFFAIEILQTVEYMHRCKIIHGDIKPDNFLI |.| .|||...|.... ||...||..|.. ..|......||||....|.|. LDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILV |
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| Kinase | BUB1.AA | Ciliate-E2 | 1318-1458 | 20 | 4.6e-21 | 69.03 | In-house | 111-294 (365) | Show / Hide |
Range on Protein: 1318-1458 Range on HMM: 111-294/365 Sequence Identity: 20% (42 aa) MVTEYKSKGTLLDLIN--KVKAVNK----KDLSEDWVLFFAIEILQ---------------TVEYMHRCK-IIHGDIKPDNFLINTDNDENFTCSQEPSS .|.|| . |.|.|.|. | | .. | ..| .... .||| .||.| . ||| ||||.| |. LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------------- LVKLIDFGRSID-------------MTLFPEGT-----------------VFTAKCKTSGFNCTEMQSDQP---------WTYQVDYYGIAGTVHCLMFG .|.|||| | . . .... .| | | |. . |. . .. ..|..|.. . . ....|| -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG KY |. KP |
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| Kinase | BUB1.AA | AGC | 1312-1405 | 24 | 2.2e-19 | 45.36 | In-house | 100-202 (395) | Show / Hide |
Range on Protein: 1312-1405
Range on HMM: 100-202/395
Sequence Identity: 24% (29 aa)
YQD--K--SCMVTEYKS---------KG-TLLDLINKVKAVNKKDLSEDWVLFFAIE-------ILQTVEYMHR-CKIIHGD-IKPDNFLINTDNDENFT
.|| . ..| || . | |. . ... ... ..|... |.| | |. .||.|. .||| | .||.| |.. |
FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRR--KEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED------
CSQEPSSLVKLIDFGRS
.|| ||| .
------GHIKLTDFGLC
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| Kinase | BUB1.AA | CAMK | 1311-1409 | 22 | 1.6e-17 | 52.33 | In-house | 125-247 (425) | Show / Hide |
Range on Protein: 1311-1409
Range on HMM: 125-247/425
Sequence Identity: 22% (29 aa)
IYQD---KSCMVT---EYKSKG----TLLDLINKVKA---------VNKKD--LSEDWVLFFAIEILQTVEYMHRCKIIHGDIKPDNFLINTDNDEN---
.. . . .||. || | | |.| | . . . .. ..|. . .. |.. |.|.| ..|.| |.||.| |....||..
VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPV
-----FTCSQEPSSLVKLIDFGRSIDMT
| . . .|.|||| .. ..
EHDEIF-D--WNNNNIKIIDFGFANKFD
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| Kinase | BUB1.AA | CAMKL | 1314-1421 | 26 | 5.5e-17 | 50.6 | In-house | 94-194 (297) | Show / Hide |
Range on Protein: 1314-1421 Range on HMM: 94-194/297 Sequence Identity: 26% (30 aa) DKSCMVTEYKSKGTLLDLINKVKAVNKKD--LSEDWVLFFAIEILQTVEYMHRCKIIHGDIKPDNFLINTDNDENFTCSQEPSSLVKLIDFGRSIDMT-L .| ..|.|| | | .|| ..... .. ..|. .. |. |.|.|...|.| ||||.| |. .... .|.|||| |. .. KKIYLVMEYCSGGE-MDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN----------NIKIIDFGFSNMYRPC -FPEGTVFTAKC |..| .. | IFGPGQKLKTFC |
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| Kinase | BUB1.AA | STE | 1308-1403 | 24 | 2.1e-15 | 50.96 | In-house | 97-192 (359) | Show / Hide |
Range on Protein: 1308-1403
Range on HMM: 97-192/359
Sequence Identity: 24% (28 aa)
CAHIYQ-------DKSCMVTEYKSKGTLLDLINKVKAVNKKD---------LSEDWVLFFAIEILQT-VEYMHRCKIIHGDIKPDNFLINTDNDENFTCS
..... |. ... || . |.| |.|.... ..| . ..|... ... .||. .| |. .||| ||||.| |.
GCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----------
QEPSSLVKLIDFG
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------VKLCDFG
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| Kinase | BUB1.AA | S_TKc | 1232-1508 | 18 | 1.1e-14 | 38.43 | SMART | 1-220 (231) | Show / Hide |
Range on Protein: 1232-1508 Range on HMM: 1-220/231 Sequence Identity: 18% (53 aa) YSVMEKVGEGAFATIYLAACLDALDMTDLDRDFRRVALKVQHPPCPWEMYVIKELHARLSRLPSQIDVRPSIMTAECAHIYQDKSCMVTEYKSK--GTLL | ...|.|.|||.. |.. . . |.||.|. . ...|. . | | . . |. .||.|| . |.|. YEILRKIGKGAFGKVYKCRHKK---------TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLF DLINKVKAVNKKD-LSEDWVLFFAIEILQTVEYMHRCKIIHGDIKPDNFLINTDNDENFTCSQEPSSLVKLIDFGRSIDMTLFPEGTVFTAKCKTSGFNC |.| | . .. ..| .. |.. .|.. .||.|. .||| |.||.| |... .|..||| . . | | | . DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------HIKICDFGLARQL---------TTFCGTPWYMA TEMQSDQPWTY-QVDYYGIAGTVHCLMFGKY-----MKVFREGGIWKMTSKVPRCAKVDWKGFFHTLLNVPSCDPSDLPHLGDLRR |. .... .| . . .. .. |. ...|. | . . . . . ||.. | .. . PEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQ |
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| Kinase | BUB1.AA | Pkinase | 1303-1403 | 30 | 3.7e-14 | 51.14 | Pfam | 62-157 (293) | Show / Hide |
Range on Protein: 1303-1403 Range on HMM: 62-157/293 Sequence Identity: 30% (33 aa) IMTAECAHIYQDKSCMVTEYKSKG----TLLDLINKVKAVNKKDL--SEDWVLFFAIEILQTVEYMHRCKIIHGDIKPDNFLINTDNDENFTCSQEPSSL | . .. . |. .||.|| .| | |.| ... . ||. . |.. .||. .||.|...||| |.||.|.||. .|... . IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA-------C VKLIDFG ||..||| VKICDFG |
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| Kinase | BUB1.AA | Ciliate-E2-Unclassified | 1317-1403 | 29 | 6.6e-14 | 44.65 | In-house | 97-192 (352) | Show / Hide |
Range on Protein: 1317-1403 Range on HMM: 97-192/352 Sequence Identity: 29% (31 aa) CMVTEYKSKGTLLDLINKVKA------------VNKKDLSEDWVL-----FFAIEILQTVEYMHRCK-IIHGDIKPDNFLINTDNDENFTCSQEPSSLVK ..|.|| |.|.. |.| | ..| ..| .. |.. .||| ||.|. . ||| ||||.| |.. .. .| YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---------NYYIK LIDFG .|||| IIDFG |
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| Kinase | BUB1.AA | CK1-Unclassified | 1355-1379 | 56 | 1.6e-11 | 30.32 | In-house | 113-137 (244) | Show / Hide |
Range on Protein: 1355-1379 Range on HMM: 113-137/244 Sequence Identity: 56% (14 aa) ILQTVEYMHRCKIIHGDIKPDNFLI ..| .||.|.. .|| ||||||||. MIQRIEYLHNKNFIHRDIKPDNFLM |
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| Kinase | BUB1.AA | CK1 | 1355-1403 | 38 | 2.1e-11 | 35.7 | In-house | 114-154 (271) | Show / Hide |
Range on Protein: 1355-1403 Range on HMM: 114-154/271 Sequence Identity: 38% (19 aa) ILQTVEYMHRCKIIHGDIKPDNFLINTDNDENFTCSQEPSSLVKLIDFG ..| .||.| . .|| ||||||||. . .. . | .|||| MIQRIEYVHNKNFIHRDIKPDNFLMGR--------YGKHCHQVYIIDFG |
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| Kinase | BUB1.AA | CK1-Unclassified | 1232-1271 | 30 | 6e-06 | 13.52 | In-house | 1-31 (244) | Show / Hide |
Range on Protein: 1232-1271 Range on HMM: 1-31/244 Sequence Identity: 30% (12 aa) YSVMEKVGEGAFATIYLAACLDALDMTDLDRDFRRVALKV | | ||.| |.| ||.. ...... . ||.|. YRVIEKIGQGSFGEIYKC--------INMQTN-EEVAIKL |
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| Kinase | BUB1.AA | TyrKc | 1232-1486 | 16 | 8e-06 | -128.32 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1232-1486
Range on HMM: 1-280/280
Sequence Identity: 16% (53 aa)
YSVMEKVGEGAFATIYLAACLDALDMTDLDRDFRRVALKVQHPPCPWEMYVIKELHARLSRLPSQIDVRP--SIMTAE-------------CAH-----I
. .| ||||| ..|.. . || |. .. . . | . .||. | . .
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDA-------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFM
YQDKSCMVTEYKSKGTLLDLINKVKAVNKKDLSEDWVLFFAIEILQTVEYMHRCKIIHGDIKPDNFLINTDNDENFTCSQEPSSLVKLIDFGRSIDMTLF
| . ..|.|| ..| |.| . | . |. . | |.. | . || |. ..|| |. | |.. .. || ||| | | .
YIEPLMIVMEYMPHGDLKDYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------TVKISDFGLSRDIYDD
----PEGTVFTA----KCK-----------TSGFNCTEMQSDQPWTY-----------QVDYYG-----IAGT--VHCLMFGKYMKVFRE----------
.. . .. .| . ... .|| | . | |.| . . ..... |..|. .
DQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV-WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP
-------GGIWKMTSKVPRCAKVDWKGFF
|. . |. . . .|
DEMYQIMKQCWHEDPED-RPTFSEIHECF
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| Kinase | BUB1.AA | CK1 | 1232-1249 | 50 | 0.001636 | 8.19 | In-house | 1-18 (271) | Show / Hide |
Range on Protein: 1232-1249 Range on HMM: 1-18/271 Sequence Identity: 50% (9 aa) YSVMEKVGEGAFATIYLA | | .|.|.|.| |||. YRVGRKIGQGSFGDIYLG |
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| Kinase | BUB1.AA | STE | 1232-1253 | 40 | 0.003164 | 7.39 | In-house | 1-22 (359) | Show / Hide |
Range on Protein: 1232-1253 Range on HMM: 1-22/359 Sequence Identity: 40% (9 aa) YSVMEKVGEGAFATIYLAACLD . .||.|.||| | |.|.. . WEGIEKIGKGAFGTVYKAMNHK |
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| Kinase | BUB1.AA | Ciliate-E2 | 1232-1249 | 33 | 0.004691 | 6.31 | In-house | 1-18 (365) | Show / Hide |
Range on Protein: 1232-1249 Range on HMM: 1-18/365 Sequence Identity: 33% (6 aa) YSVMEKVGEGAFATIYLA | . .| |.|.|...|.. YKFIKKIGQGNFGSVYKC |
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| Kinase | BUB1.AA | Ciliate-E2-Unclassified | 1232-1249 | 27 | 0.008113 | 5.63 | In-house | 1-18 (352) | Show / Hide |
Range on Protein: 1232-1249 Range on HMM: 1-18/352 Sequence Identity: 27% (5 aa) YSVMEKVGEGAFATIYLA | . .. |.|.|...|.. YKIIKQIGQGGFGKVYKC |
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| Kinase | BUB1.AA | Pkinase | 1232-1249 | 33 | 0.015091 | 10.09 | Pfam | 1-18 (293) | Show / Hide |
Range on Protein: 1232-1249 Range on HMM: 1-18/293 Sequence Identity: 33% (6 aa) YSVMEKVGEGAFATIYLA | . .|.|.|.|.. |.. YHIGRKIGSGSFGCVYKC |
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| Kinase | BUB1.AA | CAMK | 1237-1249 | 30 | 0.028852 | 2.3 | In-house | 1-13 (425) | Show / Hide |
Range on Protein: 1237-1249 Range on HMM: 1-13/425 Sequence Identity: 30% (4 aa) KVGEGAFATIYLA . |.|.|.. .|. TLGRGSFGKVKLC |
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| Kinase | BUB1.AA | CAMKL | 1232-1245 | 28 | 0.101103 | 1.1 | In-house | 1-14 (297) | Show / Hide |
Range on Protein: 1232-1245 Range on HMM: 1-14/297 Sequence Identity: 28% (4 aa) YSVMEKVGEGAFAT | . . |.|.|.. YRIGKTLGKGSFGK |
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