PRPK

Species: Sea Urchin
Alias: PRPK, Spk354, SPU_001931
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: Bud32

Sequence

Name Sequence Type Origin Length Description Download
PRPK.AA Protein None 240 None Fasta, JSON
PRPK.kin_dom Protein Kinase Domain None 89 None Fasta, JSON

Protein domain

Protein domains of PRPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PRPK.AA Bud32 19-238 45 2.2e-134 432.5 In-house 1-269 (269) Show / Hide
Range on Protein: 19-238
Range on HMM: 1-269/269
Sequence Identity: 45% (123 aa)

SKLTLLK--------QGAEARIYL--------------STFMGR------SSIVKQRFKKSYRHPKLDAKLSQKRTGQEVRTIVKCRKAGITTPVVYFVD
. | |.|        ||||||...                | ||        |.| || |.|||| ||..|. .|| ||||   .|||||| .|.|||.|
MSLELYKDVDIAPISQGAEARVFYTCYLTVSKQKVYTTCNFQGRAKDSHQQCIIKERFPKAYRHPQLDQQLTKHRTKQEVRAMNRCRKAGICVPYVYFCD

NDTHSIHMEYIEDS------LTVREYIQQIQNSGES-NDDERLVSLASKVGTTLASMHNVDIIHGDLTTSNMLLRQPYEDS-----RLIMIDFGLSQISH
|..|.|.|||||.|      .||..||.|.|..... ..|..|.....|||.....||...|||||||||||.||.||.|.     ....|||||| || 
NYNHCIYMEYIEESPGGHGFYTVKNYIWQHQETQKEDQHDQCLREFCKKVGRQIGKMHWNHIIHGDLTTSNMMLRHPYADWTKLYGQMHLIDFGLSYISN

MS-EDKGVDLYVLERAFLSSHPNTEE-----LFKTVLDVYA---ENYKKSGEVLKKLEEVRQRGRKRVM
   |||||||||||||||| ||..|.     .| ... .|     . ||. .||||..||| ||||| |
SVPEDKGVDLYVLERAFLSTHPKCEQKYNAWIFEHFMENYRKQDTKCKKFKAVLKKFNEVRLRGRKRTM

Kinase PRPK.AA Dicty3 87-183 23 1e-06 18.02 In-house 69-194 (351) Show / Hide
Range on Protein: 87-183
Range on HMM: 69-194/351
Sequence Identity: 23% (30 aa)

YFVDNDT--HSIHMEYIEDSLTVRE----YIQQIQNSGESNDDERLVSLASKVGTTLASMHNVD-IIHGDLTTSNMLLRQPYE-----------------
| .||..  | | ||||| .  . .     .  ...  . |..|. .... .   ||.. |.   |||.|... | .| .  .                 
YCCDNNNDNHYIYMEYIEGEIPISFVKTNNMLKKHKNNRFNEHEI-SKIICDLVKTLNYIHKNCHIIHRDIKCDNIMLDNDEQHQCNNNNNKMSSTCRDI

------DSRLIMIDFGLS-QISHMSEDK
         .  |||||| .||  | ..
QCYYSNEINWKLIDFGLSKNISYYS-NN

Kinase PRPK.AA Ciliate-E8 141-174 44 1e-06 16.6 In-house 106-138 (138) Show / Hide
Range on Protein: 141-174
Range on HMM: 106-138/138
Sequence Identity: 44% (15 aa)

HNVDIIHGDLTTSNMLLRQPYEDSRLIMIDFGLS
||  ||| |.   | |. |.  |..  .|||| |
HNNNIIHCDFKLNNILV-QRNDDTKIKIIDFGFS

Kinase PRPK.AA RSK 136-183 22 2e-06 20.19 In-house 116-163 (278) Show / Hide
Range on Protein: 136-183
Range on HMM: 116-163/278
Sequence Identity: 22% (11 aa)

TLASMHNVDIIHGDLTTSNMLLRQPYED-SRLIMIDFGLSQISHMSEDK
..  .|  .||| ||  .|.|. .   .  ..  .|||.. ... .. .
AVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQ

Kinase PRPK.AA Ciliate-E2 137-178 32 4e-06 17.11 In-house 173-207 (365) Show / Hide
Range on Protein: 137-178
Range on HMM: 173-207/365
Sequence Identity: 32% (14 aa)

LASMHNVD-IIHGDLTTSNMLLRQPYEDSRLIMIDFGLSQISH
| ..|.   ||| |.  .| |.        .  ||||||.. .
LEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYD

Kinase PRPK.AA TKL 137-183 22 1.1e-05 16.5 In-house 145-210 (364) Show / Hide
Range on Protein: 137-183
Range on HMM: 145-210/364
Sequence Identity: 22% (15 aa)

LASMHNVD--------IIHGDLTTSNMLLRQPYE-----------DSRLIMIDFGLSQISHMSEDK
.. .|. .        ||| ||...| |. . ..           | ..   |||||.  ..|...
MNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNM

S_TKc PRPK.AA S_TKc 18-240 17 2.5e-05 -98.89 SMART 1-220 (231) Show / Hide
Range on Protein: 18-240
Range on HMM: 1-220/231
Sequence Identity: 17% (44 aa)

QSKLTLLKQGAEARIYLSTFMG--RSSIVKQRFKKSYRHPKLDAKLSQKRTGQEVRTIVKCRKAGITTPVVYFVDNDTHSIHMEYIE-DSLTVREYIQQI
  .| .. .|| .. |. .  .  |   .|.                 ... .|..   | .   | .   .|.| |   . |||.. |  ....||.. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

QNSG--ESNDDERLVSLASKVGTTLASMHNVDIIHGDLTTSNMLLRQPYEDSRLIMIDFGLSQISHMSE--------------DK-GVD----------L
.  |     .  .  ...  .   |. .|.  ||| ||  .| || .     ..  .||||. .  ..               .|  .|          .
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEM

YVLERAFLSSHPNTEELFKTVLDVYAENYKKSGEVL----KKLE-EVRQRGRKRVMLG
.. .  |     . ...|| ..         | |..    | |. . ..|      | 
LCGYPPFP----QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQ

Kinase PRPK.AA Ciliate-F2 137-176 40 3.4e-05 15.09 In-house 108-145 (200) Show / Hide
Range on Protein: 137-176
Range on HMM: 108-145/200
Sequence Identity: 40% (16 aa)

LASMHNVDIIHGDLTTSNMLLRQPYEDSRLIMIDFGLSQI
|| . |. .||||  ..||. . |    | .. ||.| ||
LAELENLGLIHGDIKIENMIYNRP--KQRFMFDDFQLIQI

Kinase PRPK.AA Ciliate-E1 109-212 18 4.6e-05 12.95 In-house 94-202 (202) Show / Hide
Range on Protein: 109-212
Range on HMM: 94-202/202
Sequence Identity: 18% (21 aa)

EYIQQIQNSGESNDDERLVSLASKVGTTLASMHNVDIIHGDLTTSNMLLRQPYEDSRLIMIDFGLSQ--ISHMSEDKGVDLYVLERAFLSSHP------N
||.||.|.   . ... .....      |. .|.  |||.|.  .| |  .  . ....  |||.|.  ...  ... .. |    .            |
EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINN--Q-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHN

TEELFKTVLDVY
 ..  .  .|.|
KNQKINYKSDIY

Kinase PRPK.AA NZAK 90-176 26 5e-05 12.26 In-house 73-154 (329) Show / Hide
Range on Protein: 90-176
Range on HMM: 73-154/329
Sequence Identity: 26% (23 aa)

DNDTHSIHMEYIE-DSLTVREYIQQIQNSGESNDDERLVSLASKVGTTLASMHNVDIIHGDLTTSNMLLRQPYEDSRLIMIDFGLSQI
|.  | | ||..| . ||  ... . .  .. .. .. ...   .  |.  .|   ||| |....|..|        | .|||| | |
DDNYHCIYMEWMEGGNLT--QFLMNDKKQLRFKEHRI-IKMIADIAETMSYLHKHHIIHRDIKSNNVILDF---NKNLKLIDFGSSII

Kinase PRPK.AA MSK 137-176 32 5e-05 12.92 In-house 114-153 (277) Show / Hide
Range on Protein: 137-176
Range on HMM: 114-153/277
Sequence Identity: 32% (13 aa)

LASMHNVDIIHGDLTTSNMLLRQPYEDSRLIMIDFGLSQI
. .|| . |||.||   | |.    .. .. .||||.. .
VDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARL