Gene Haspin (Sea Urchin)
Haspin
Sequence
Protein domains of Haspin.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Haspin.AA | Haspin | 484-741 | 36 | 3.3e-87 | 296.02 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 484-741 Range on HMM: 1-264/264 Sequence Identity: 36% (98 aa) KCVKIGEGVYGEVFRTFNNRKSSVALKIIPVEGDFP-----VNEENQKPFEEILPEIVISWELSMLRE-GEETMTTNFIGVNHVSCVKGSYPKKLLDEWD .| |||||.|||||.. .|. ..|..||||.... .. |.|. ..|.|.||.| ... |. . ||.| . |..|.|...|||. || NCKKIGEGCYGEVFSVTWNG-KEVVMKIIPIHWSCCKYYGEYCGEHQQTNDEALNEIIIMKKMGKLSHRNMCPNFPNFCGMCVVTQVPGKCCKKLNKMWD KYDRRKTSGSENDRPDIFPSDQLFIIFEFADGGKDLESF--EFENIHQAVSVIRQVTVALAVAERELEFEHRDLHWGNVLVG-ATDDDQVTFMLDGQVIS .| ..| .||||||| | .||.|......||..|..| .|... | .|.. | ......|..|..|.|.||||||||. |... . . .||..| HY--CYTHHSENDRPDFFKKNQLHIHWIMEYGGRPLDNFRWKFNTCNQCISIMCQLVMSMYIAKDEMQFWHNDLHWGNVLIKRKTKKKWLHYTMDGKTIK VESHGLHISIIDFTLSRLQKDDCTVFCDLAEDPTLFTGEGDKQFDVYRSMKEHNNNQWEGFQPKTNV . |||. . ||||..||..||......|. | |.|.. .| ||||||.|.. ... |. . .|... IKSHGVMVTIIDFCKSRCGKDNKKIYWDWKNDETMFEQFWDYQFDVYRDMRKNCQHFWFVHHAKNWK |
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| Kinase | Haspin.AA | DUF3635 | 707-751 | 37 | 4.2e-16 | 57.12 | Pfam | 1-56 (121) | Show / Hide |
Range on Protein: 707-751 Range on HMM: 1-56/121 Sequence Identity: 37% (21 aa) PTLFTGEG---------DKQFDVYRSMKEHNNN--QWEGFQPKTNVFWIEYLLDKI . .|.|.| | |||.||.|. ..| .| | |.||| | || .|. HDFFQGKGKSKINEYQYDYQFDIYRMMRKMLKNPICWSQFHPMTNVLWLHYLIHKL |
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| Kinase | Haspin.AA | S_TKc | 482-793 | 11 | 3e-06 | -85.95 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 482-793
Range on HMM: 1-231/231
Sequence Identity: 11% (42 aa)
MKKCVKIGEGVYGEVFRTFNNR-KSSVALKIIPVEGDFPVNEENQKPFEEILPEIVISWELSMLREGEETMTTNFIGVNHVSCVKGSYPKKLLDEWDKYD
.. |||.| .|.|.. ... . ||.|||. . | |...|.. . .. ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------EHIRREIQILKK----------HHPNIVKLYDVFQD----------
RRKTSGSENDRPDIFPSDQLFIIFEFADG-----GKDLESFEF------ENIHQAVSVIRQVTVALAVAERELEFEHRDLHWGNVLVGATDDDQVTFMLD
| |....|..|| . ... . .| ....|. ||. . . |||| |.|.
-----------------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-----------
GQVISVESHGLHISIIDFTLSR----------------LQKDDC---------TVFCDLAEDPTLFTGEGDKQFDVYRSMKEHNNNQWEGFQPKTNVFWI
|| |.|| |.| | . .. .. .. ..| .. ... ..
-----------HIKICDFGLARQLTTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-------------------
EYLLDKIIWEKKYPTDRSQRRVLGQLKTLVREIQQY-----LSAEDVFK------NSDLL
..| ..| . |. ..| .... . .
----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Haspin.AA | CDK | 483-515 | 38 | 3e-06 | 15.91 | In-house | 2-40 (284) | Show / Hide |
Range on Protein: 483-515 Range on HMM: 2-40/284 Sequence Identity: 38% (15 aa) KKCVKIGEGVYGEVFRTFNNR------KSSVALKIIPVE .|. ||||| ||.|.. . . . |||| | .| EKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRME |
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| Kinase | Haspin.AA | CDC2 | 483-517 | 41 | 1.6e-05 | 12.34 | In-house | 2-37 (301) | Show / Hide |
Range on Protein: 483-517 Range on HMM: 2-37/301 Sequence Identity: 41% (15 aa) KKCVKIGEGVYGEVFRTFNNR-KSSVALKIIPVEGD .| ||||| ||.|.. ... . |||| | .| . QKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQE |
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| Kinase | Haspin.AA | CAMK | 487-513 | 22 | 2.3e-05 | 12.49 | In-house | 1-40 (425) | Show / Hide |
Range on Protein: 487-513 Range on HMM: 1-40/425 Sequence Identity: 22% (9 aa) KIGEGVYGEVFRTFNNRKSS-------------VALKIIP ..|.| .|.|.. .. . || |||. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIID |
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| Kinase | Haspin.AA | CMGC | 482-512 | 28 | 3.3e-05 | 12.07 | In-house | 1-46 (513) | Show / Hide |
Range on Protein: 482-512 Range on HMM: 1-46/513 Sequence Identity: 28% (13 aa) MKKCVKIGEGVYGEVFRTFNNR---------------KSSVALKII .. ||||| ||.|.. ...| . ||.|.| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKI |
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| Kinase | Haspin.AA | STE | 482-537 | 20 | 4.8e-05 | 13.9 | In-house | 1-81 (359) | Show / Hide |
Range on Protein: 482-537 Range on HMM: 1-81/359 Sequence Identity: 20% (17 aa) MKKCVKIGEGVYGEVFRTFNNRKS----------------SVALKIIPVEGDFPVNEE----------NQKPFEEILPEIVI .. |||.| .|.|.. |. .. .| |....| . . . | |.. ...|| || | WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKI |
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| Kinase | Haspin.AA | CDK-DD1 | 487-531 | 32 | 7.5e-05 | 10.25 | In-house | 6-46 (379) | Show / Hide |
Range on Protein: 487-531 Range on HMM: 6-46/379 Sequence Identity: 32% (15 aa) KIGEGVYGEVFRTFNNR-KSSVALKIIPVEGDFPVNEENQKPFEEI |.|.| || || . .. ||||.. . .|.|. | .|. KCGQGIYGSVFKAIHKITHCMVALKNFKD-----WNQEDGEPKVEC |
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| Kinase | Haspin.AA | CDK5 | 483-517 | 38 | 0.000299 | 8.8 | In-house | 2-37 (287) | Show / Hide |
Range on Protein: 483-517 Range on HMM: 2-37/287 Sequence Identity: 38% (14 aa) KKCVKIGEGVYGEVFRTFN-NRKSSVALKIIPVEGD .| ||||| || |.. | . . |||| . . . EKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSE |
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| Kinase | Haspin.AA | MST | 483-518 | 32 | 0.00052 | 8.55 | In-house | 2-38 (254) | Show / Hide |
Range on Protein: 483-518 Range on HMM: 2-38/254 Sequence Identity: 32% (12 aa) KKCVKIGEGVYGEVFRTFN-NRKSSVALKIIPVEGDF . |.|.| || |.. . .. || |..||..|. DIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNEDL |
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| Kinase | Haspin.AA | Worm5 | 644-656 | 53 | 0.000828 | 7.43 | In-house | 127-139 (260) | Show / Hide |
Range on Protein: 644-656 Range on HMM: 127-139/260 Sequence Identity: 53% (7 aa) FEHRDLHWGNVLV | |||.||.|... FIHRDCHWQNIMF |
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