Gene MOS2 (Sea Urchin)
MOS2
Sequence
Protein domains of MOS2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | MOS2.AA | MOS | 55-319 | 38 | 3.2e-100 | 333.03 | In-house | 1-289 (299) | Show / Hide |
Range on Protein: 55-319
Range on HMM: 1-289/299
Sequence Identity: 38% (112 aa)
VKLKEMIGKGGFGEVWKGQWRGTPVAVKLLNREVKILKLSRRSLWGNVLYRRALHPNIVQLMAVGQRSPGDGSNLGTIIFEVGG*IVLRKTIKKLTRNPS
|.|..|||.||||.|||.|..|.|||||..|...|.||..|||.|..|.|.|..|.|||..|||.||||.|..||||||.|.|| ..|...|...||.|.
VCLCQMIGRGGFGSVWKAQYCGRPVAVKQVNKCTKNLKAMRRSFWAEVNYLRLRHDNIVRVMAVSQRSPEDFNNLGTIIMECGGNQTLHQVIYEPTRHPP
----IISCRMAILMNSC*RYSRDILSAVTFLHHCKILHLDIKPQNVIVPN-----------------QDVSKLPDFIDEQKERVSNVQKQCADDINKAYE
||.|||.|||..| .||.|...|....||..|||||.||.|.|| ||| || || |. .|| . ||
GDAGIIHCRMLILMHCC-KYSLDVVNALQYCHHQNILHLDVKPANIIVDEGTKSSITCNSSKIKVKRQDVCKLCDFGCSQQMFDSNGKEFCAWTNPHYLK
ESIR----EILIGEVKSPIGQIYHFTWMLWLHTTI*IPYTNELKHVQKLVIDYKIKPKDGGTIFSSTNQERSLSSCLVSSWSGRRLTRPS
. |.| |. | || | .| .| .|| | |.. . || . . . .. .. . | . . |||
GTCTYMAPELLCGDTPTPKADIYSFGITMWQMQTRETPYHGEDCHHVYAYQVYKHRMRPDNPVYENSCENDWYRQLIQKCWPKQPEQRPS
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| Kinase | MOS2.AA | TKL | 61-198 | 19 | 7.3e-23 | 79.17 | In-house | 1-173 (364) | Show / Hide |
Range on Protein: 61-198
Range on HMM: 1-173/364
Sequence Identity: 19% (39 aa)
IGKGGFGEVWKGQWRG----------TPVAVKLLNREV-------------------------KILKLSRRSLWGNVLYRRALHPNIVQLMAVGQRSPG-
||.||||||.||.||| ..|||| .... .. .. . .. .| ||||||.|.. ...|.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
--------------------DGSN-LGTIIFEVGG*IVLRKTIKKLTRNPSIISCRMAILMNSC*RYSRDILSAVTFLHHCK--------ILHLDIKPQN
.| . | ... .. | ..|| ... .|| .. |.| |.|..|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN
VIV
. |
ILV
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| Kinase | MOS2.AA | TKL-Sp1 | 171-198 | 67 | 2.7e-15 | 43.85 | In-house | 104-131 (263) | Show / Hide |
Range on Protein: 171-198 Range on HMM: 104-131/263 Sequence Identity: 67% (19 aa) SRDILSAVTFLHHCKILHLDIKPQNVIV |...|.||||.| |.|||||||| ||.| SCEVLQAVTFMHACNILHLDIKPANVMV |
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| Kinase | MOS2.AA | Type1 | 55-82 | 60 | 3.2e-15 | 37.3 | In-house | 1-28 (290) | Show / Hide |
Range on Protein: 55-82 Range on HMM: 1-28/290 Sequence Identity: 60% (17 aa) VKLKEMIGKGGFGEVWKGQWRGTPVAVK ... | |||| .||||.|.||| |||| IQMIECIGKGRYGEVWRGKWRGENVAVK |
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| Kinase | MOS2.AA | STKR | 55-82 | 59 | 2.2e-14 | 42.63 | In-house | 1-32 (312) | Show / Hide |
Range on Protein: 55-82 Range on HMM: 1-32/312 Sequence Identity: 59% (19 aa) VKLKEMIGKGGFGEVWKGQWRG----TPVAVK ..| |.|||| .||||||.||| |||| IQLIECIGKGRYGEVWKGKWRGNGEKETVAVK |
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| Kinase | MOS2.AA | Trio | 172-198 | 55 | 1.6e-13 | 30.39 | In-house | 102-128 (258) | Show / Hide |
Range on Protein: 172-198 Range on HMM: 102-128/258 Sequence Identity: 55% (15 aa) RDILSAVTFLHHCKILHLDIKPQNVIV ...|.|| || | |||||||| |... WQMLEAVHYLHNCHILHLDIKPENMMM |
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| Kinase | MOS2.AA | MLK | 55-82 | 48 | 5.6e-12 | 37.97 | In-house | 1-33 (291) | Show / Hide |
Range on Protein: 55-82 Range on HMM: 1-33/291 Sequence Identity: 48% (16 aa) VKLKEMIGKGGFGEVWKGQWRGTP-----VAVK ...| ||.|.||.||||.||.. |||| IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVK |
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| Kinase | MOS2.AA | Dicty4 | 55-92 | 44 | 1.1e-11 | 35.38 | In-house | 1-43 (277) | Show / Hide |
Range on Protein: 55-92 Range on HMM: 1-43/277 Sequence Identity: 44% (19 aa) VKLKEMIGKGGFGEVWKGQWRGTPVAVKLL--NREV---KILK . . ||||.|||| || |||. ||||.| . .. ..|. INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLN |
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| Kinase | MOS2.AA | TKL-Sp1 | 55-82 | 53 | 1.4e-10 | 28.89 | In-house | 1-28 (263) | Show / Hide |
Range on Protein: 55-82 Range on HMM: 1-28/263 Sequence Identity: 53% (15 aa) VKLKEMIGKGGFGEVWKGQWRGTPVAVK . . .||| ||.| . ||||||||| LDMGPVVGKGQFGVVHRASWRGTPVAVK |
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| Kinase | MOS2.AA | Pkinase | 55-118 | 29 | 6.6e-10 | 36.11 | Pfam | 1-68 (293) | Show / Hide |
Range on Protein: 55-118 Range on HMM: 1-68/293 Sequence Identity: 29% (20 aa) VKLKEMIGKGGFGEVWKGQWRGTP--VAVKLLNREVKILKLSRRSLW-GNVLYRRAL-HPNIVQLMAV .... ||.|.||.|.|....||. |||| .... . . .. .. . . . | |||||.| . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDW |
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| Kinase | MOS2.AA | Pkinase_Tyr | 55-85 | 40 | 1.3e-09 | 33.14 | Pfam | 1-37 (270) | Show / Hide |
Range on Protein: 55-85 Range on HMM: 1-37/270 Sequence Identity: 40% (15 aa) VKLKEMIGKGGFGEVWKGQWR------GTPVAVKLLN ... ...|.| ||||.|| |. ..||||| |. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK |
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| Kinase | MOS2.AA | CAMK | 60-118 | 16 | 2.7e-08 | 22.07 | In-house | 1-106 (425) | Show / Hide |
Range on Protein: 60-118 Range on HMM: 1-106/425 Sequence Identity: 16% (19 aa) MIGKGGFGEVWKGQWRGTP--------------VAVKL---------------------------------------LNREVKILKL---SRRSLWGNVL .|.|.||.| ... . |. ||.| . ||..|.|. .. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGN------- YRRALHPNIVQLMAV . ||||..| | --KLDHPNIIKLYEV |
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| Kinase | MOS2.AA | CAMK | 169-198 | 46 | 2.7e-08 | 22.08 | In-house | 183-212 (425) | Show / Hide |
Range on Protein: 169-198 Range on HMM: 183-212/425 Sequence Identity: 46% (14 aa) RYSRDILSAVTFLHHCKILHLDIKPQNVIV || | |.||| ..| ..| |.|.|| |. . RYFRQICSAVHYCHSHNIVHRDLKPENILL |
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| Kinase | MOS2.AA | CMGC | 170-209 | 20 | 3.8e-07 | 18.56 | In-house | 185-248 (513) | Show / Hide |
Range on Protein: 170-209 Range on HMM: 185-248/513 Sequence Identity: 20% (13 aa) YSRDILSAVT--FLHHCK--ILHLDIKPQNVIVPNQDVS--------------------KLPDF |.. || .. ..| . |.| |.||.|. . .. . |. || YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF |
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| Kinase | MOS2.AA | S_TKc | 55-257 | 18 | 3.9e-07 | -72.22 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 55-257
Range on HMM: 1-231/231
Sequence Identity: 18% (49 aa)
VKLKEMIGKGGFGEVWKGQWRG--TPVAVKLLN----REVKILKLSRRSLWGNVLYRRALHPNIVQLMAVGQRSPGDGSNLGTIIFEVGG*--IVLRKTI
.. . ||||.||.|.|..... ||.| .. ||..||| |||||.| | | . ...| . |.. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK--------------HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYI
KKLTRNPSIISCRMAILMNSC*RYSRDILSAVTFLHHCKILHLDIKPQNVIVPNQDVSKLPDF----------------------IDE------------
|| |.. | . . .| . |..|. ..| .|.| |.||.|. . . . |. || .
KKRGRHG----LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCIL
-----------QKERVSNVQKQCADDINKAYEESIREILIGEVK--SPIGQIYH-------FTWM
| ... .. . . . || .| . . . .. . |.
YEMLCGYPPFPQMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | MOS2.AA | TKL-Sp1 | 105-121 | 70 | 5.9e-07 | 17.33 | In-house | 48-64 (263) | Show / Hide |
Range on Protein: 105-121 Range on HMM: 48-64/263 Sequence Identity: 70% (12 aa) RRALHPNIVQLMAVGQR ||| ||||||.||.| . RRACHPNIVQMMALGYQ |
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| Kinase | MOS2.AA | CMGC | 55-92 | 21 | 6.9e-07 | 17.67 | In-house | 1-76 (513) | Show / Hide |
Range on Protein: 55-92 Range on HMM: 1-76/513 Sequence Identity: 21% (16 aa) VKLKEMIGKGGFGEVWKGQWRGTP----------------VAVKLLN----------------------REVKILK . . ||.| .|.|.|.. . | ||.| . ||.|||| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILK |
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| Kinase | MOS2.AA | Pkinase | 164-209 | 30 | 9.4e-07 | 24.96 | Pfam | 107-156 (293) | Show / Hide |
Range on Protein: 164-209 Range on HMM: 107-156/293 Sequence Identity: 30% (15 aa) MNSC*RYSRDILSAVTFLHHCKILHLDIKPQNVIVPNQDVS----KLPDF .. | .| . ||... ..| ..|.| |.||.|. . |... |. || EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF |
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| Kinase | MOS2.AA | TyrKc | 55-264 | 15 | 2.7e-05 | -137.1 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 55-264
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)
VKLKEMIGKGGFGEVWKGQWRGTPVAVKLLNREVKILKLSRRSLWGNVLYRRAL---HPNIVQLMAVGQRSPGDGS---NLGTIIFEVGG*IVLRKTIKK
..|....| | ||||.||.|. ..|||| |. . |. . . | |||||.| .| . . |..| |.. ..|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRK
LTRNPSIISCRMAILMNSC*RYSRDILSAVTFLHHCKILHLDIKPQNVIVPNQDVSKLPDF-----IDEQ----------------KER-----------
.. . | .. .| . .||. .. | |. |. | .. . | || |.. ..
HRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE
-------------------------------VS-----NVQKQCADDINKAYEESIREI--------LIGEVKSPIGQIYHF-----TWMLWLHTTI
.. .. . | . . |. . . | |. . .| .
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | MOS2.AA | Dicty4 | 178-198 | 34 | 0.01651 | 4.38 | In-house | 125-147 (277) | Show / Hide |
Range on Protein: 178-198 Range on HMM: 125-147/277 Sequence Identity: 34% (8 aa) VTFLHH--CKILHLDIKPQNVIV .. || . |.|.|.|. | | MNWLHCCNPVIIHRDLKSHNLLV |
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| Kinase | MOS2.AA | MLK | 171-209 | 20 | 0.017686 | 4.57 | In-house | 130-177 (291) | Show / Hide |
Range on Protein: 171-209 Range on HMM: 130-177/291 Sequence Identity: 20% (10 aa) SRDILSAVTFLHHCK---ILHLDIKPQNVIVPN------QDVSKLPDF . .. ... .|| . | | |.|..|. . . ... | || ALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDF |
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