Gene NEK9 (Sea Urchin)

NEK9

Species: Sea Urchin
Alias: Spk169, SPU_007456, NEK9
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK9

Sequence

Name Sequence Type Origin Length Description Download
NEK9.AA Protein None 963 None Fasta, JSON
NEK9.kin_dom Protein Kinase Domain None 271 None Fasta, JSON

Protein domain

Protein domains of NEK9.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK9.AA NEK8 30-300 57 6.2e-250 721.96 In-house 1-278 (278) Show / Hide 
Range on Protein: 30-300
Range on HMM: 1-278/278
Sequence Identity: 57% (159 aa)

YTPVRVLGKGAFGEAVLYRKTEDN--SLVVWKEVNLTRCSERVMYDAQNEIEILSMLNHANIISYFNHFLDDQSLFIEMEYANGGTLYEKIVHQDGTLFE
|...||.|.||||...|||..||.  .||.||..|..|.||.....|||||..||||.|.|||||..||..|..|.||||||.|||||..|.||...|||
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

EEKQLKQVNHCFNITFNLQLVLWYLFQTVSAVAYIHQIDVLHRDIKTLNIFMTKS-GLIKVGDFGISKVLGDD-KMAES--VVGTPLYMSPELVKGQQYN
||.|||||||||||.||.|..|||.||..|||...||...||||.||.|||||.. ...|.|||||||..... .|...  |||||.|||||...|..||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

AKSDVWAIGCVLYELLTLRRVFEASNQLKVVWGIVQ-KEHEDIDERYSKEMHSLVTQLLAKDPENRPSAAEIMANPLL
.|||.||.||||||...|.|.|||||....||.|.| ...|.|...||.||..||...|..|||.||||..|||.||.
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK9.AA NEK 30-300 37 7.1e-136 457.69 In-house 1-286 (286) Show / Hide 
Range on Protein: 30-300
Range on HMM: 1-286/286
Sequence Identity: 37% (113 aa)

YTPVRVLGKGAFGEAVLYRKTEDNSL-----VVWKEVNLTRCSERVMYDAQ-NEIEILSMLNHANIISYFNHFLDDQ--SLFIEMEYAN-GGTLYEK---
|. ....|.|.||.. ..|...|..      .|||..|....||.   .|| ||. ||..|.| ||..|...|...|  .|.|.|||.. ||.||.|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IVHQD--GTLFEEEKQLKQVNHCFNITFNLQLVLWYLFQTVSAVAYIHQI-----DVLHRDIKTLNIFMTKSGL----IKVGDFGISKVLGDD-KMAES-
| .|   |..||||                  ......| ..|. |.|.       .||||||. |||.||..     .|.|||||||||... .|| . 
IKKQKQKGKYFEEE-----------------QIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTT

VVGTPLYMSPELVKGQQYNAKSDVWAIGCVLYELLTL--RRVFEAS--NQLKVVWGIVQK-EHEDIDER--YSKEMHSLVTQLLAKDPENRPSAAEIMAN
.|||| |||||..... || |||.|..||||||. ||  .. |||.  |..  .. |..  . . | ..  ||.....|..|.| ||||.|||. .|...
QVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEM

PLL
|..
PFI
Kinase NEK9.AA NEK4 30-300 36 7.5e-73 248.34 In-house 1-257 (257) Show / Hide 
Range on Protein: 30-300
Range on HMM: 1-257/257
Sequence Identity: 36% (101 aa)

YTPVRVLGKGAFGEAVLYRKTEDNSLVVWKEVNLTRCSERVMYDAQNEIEILSMLNHANIISYFNHFLDDQS--LFIEMEYANGGTLYEKIVHQDGTLFE
|  ..| ||| .||  | |.. |    | | ..| . | |   .|  |...|| | | ||..|.. .  .    |.| | . .|| ||.|   | . . |
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EEKQLKQVNHCFNITFNLQLVLWYLFQTVSAVAYIHQIDVLHRDIKTLNIFMTKSGLIKVGDFGISKVLG-DDKMAESVVGTPLYMSPELVKGQQYNAKS
|.                | | |.  |   |  |.|.  .|||| || |||.||  .||.||||||.||     ||. ..||| |||||.   . |. ||
EY----------------QVVEWFV-QIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKS

DVWAIGCVLYELLTLRRVFEASNQLKVVWGIVQKEHEDIDERYSKEMHSLVTQLLAKDPENRPSAAEIMANPLL
|.|..|| .||. ||.  |.| .    .. |.|     .   ||...  || |.| | |..|||  .|.  | .
DIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK9.AA S_TKc 30-300 27 9.7e-70 238.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 30-300
Range on HMM: 1-231/231
Sequence Identity: 27% (78 aa)

YTPVRVLGKGAFGEAVLYRKTEDNSLVVWKEVNLTRCSERVMYDAQNEIEILSMLNHANIISYFNHFLDDQSLFIEMEYANG--GTLYEKIVHQDGTLFE
|. .|..||||||.  . |..... .|  |...          ....||.||.. .| ||. .. .| | ..|.. |||..|  |.|.. |... .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR----

EEKQLKQVNHCFNITFNLQLVLWYLFQTVSAVAYIHQIDVLHRDIKTLNIFMTKSGLIKVGDFGISKVLGDDKMAESVVGTPLYMSPELVKGQQYNA-KS
         |  .  |.   .  |. |...|..|.|.  ..|||.|  ||....   ||..|||....|       ...||| ||.||..   .|.  |.
---------HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKC

DVWAIGCVLYELLTLRRVFEASNQLKVVWGIVQKEHEDIDERYSKEMHSLVTQLLAKDPENRPSAAEIMA-------NPLL
|.|..||.|||.|. .  |.   |..... ..           |.|. ... ..| ||||.||.| |...        | .
DWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK9.AA Pkinase 30-300 25 4.8e-64 223.88 Pfam 1-293 (293) Show / Hide 
Range on Protein: 30-300
Range on HMM: 1-293/293
Sequence Identity: 25% (80 aa)

YTPVRVLGKGAFGEAVLYRKTEDNSLVVWKEVNLTRCSERVMYDAQN--EIEILSMLNHANIISYFNHFLDDQSLFIEMEYANGG----TLYEKIVHQDG
|. .|..|.|.||.  . ..  .. .|. |.... . .. . . . .  ||.|. .||| ||. ..  | |.... . |||..||     |.. |     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

TLFEEEKQLKQVNHCFNITFNLQLVLWYLFQTVSAVAYIHQIDVLHRDIKTLNIFMTKSGLI----KVGDFGISKV--LGDDKMAESVVGTPLYMSPELV
            .|.  . |  . .  |. |......|.|.  ..|||.|  ||.. . | |    |..|||..|.  .  .  . ...||| ||.||..
-----------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVI

K-GQQYNAKSDVWAIGCVLYELLTLRRVFEAS------NQLKVVWGIVQ-KEHEDIDERYS-------------------KEMHSLVTQLLAKDPENRPS
. || |  |.|.|..||.|||.|. |  |  .      .|....  | . . |.|... .|                   .|. .... .|.|||. ||.
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

AAEIMANPLL
|..|.  | .
AEQILQHPWF
Kinase NEK9.AA STE 30-300 19 1.1e-59 204.63 In-house 1-359 (359) Show / Hide 
Range on Protein: 30-300
Range on HMM: 1-359/359
Sequence Identity: 19% (73 aa)

YTPVRVLGKGAFGEAVLYRKT------EDNSL---------VVWKEVNLTRCS---------------ERVMYDAQNEIEILSMLN--HANIISYFNHFL
.. ....||||||. .. ..       . . .         .  |..|| .|.               .  | . ..||.|.. .|  | ||. |. ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DD-------QSLFIEMEYANGGTLYEKIVHQDGTLFEEEKQLKQVNHCFNITFNLQLVLWYLFQTVSA-VAYIHQIDVLHRDIKTLNIFMTKSGLIKVGD
..       ..|.| ||| .||.| . | |  |....  .. .    . . .|. ... ....|.. .  .|.|.  . |||||  ||..     .|  |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ----H-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCD

FGISKVLGD-----------------DKMAESVVGTPLYMSPELVKG------QQYNAKSDVWAIGCVLYELLTLRRVFEASNQLKVVWGIVQK------
||... | |                 ...  ..|||| .|.|| ...      ..|..|.|.| .||.. |..| .  .   . ... . | ..      
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ

---------EHEDIDE-------------------RYSKEMHSLVTQLLAKDPENRPSAAEIMA--NPLL
         ..  . .                   ..|.|..  . . | |||..||.| . .    | .
FEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK9.AA ULK 30-300 23 8.9e-57 194.94 In-house 1-329 (329) Show / Hide 
Range on Protein: 30-300
Range on HMM: 1-329/329
Sequence Identity: 23% (79 aa)

YTPVRVLGKGAFGEAVLYRKT-EDN-----SLVVWKEVNLT-RCSERVMYD-------AQNEIEILSMLN--------HANIISYFNHFLDDQS--LFIE
|   ..||||.||  . |. . ...      .|. | . .     .  ...        .|||.|. .|.        | ||. ..  | ....  ..| 
YCLNHCLGKGSFG--KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

MEYANGGTLYEKIVHQDGTLFEEEKQLKQVNHCFNITFNLQLVLWYLFQTVSAVAYIHQIDVLHRDIKTLNIFMTKS------------GLIKVGDFGIS
||| |||.| |.. .....| |..         .. ... | .. .. | ...  ..|.  . |||||  || ...             | .|..||| .
MEYCNGGDL-EQYIKKNKKLPEDT-E-------EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA

KVLGDD----KMAESVV------GTPLYMSPELVK----GQQYN-AKSDVWAIGCVLYELLTLRRVFEASNQLKVVWGIVQKEHED------------ID
|.. .|    .|. . |      ||||||.|....    ...|. .|.|.| .||..||.|. .  |.|.   . .. |.||. ..            ..
KHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQ

ER-------YSKEMHSLVTQLLAKDPENRPSAAEIMANPLL
 .        |.|...|  ..| .|.. | |  |. ..|..
FPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase NEK9.AA CAMK 35-300 17 7.2e-56 178.15 In-house 1-425 (425) Show / Hide 
Range on Protein: 35-300
Range on HMM: 1-425/425
Sequence Identity: 17% (76 aa)

VLGKGAFGEAVLYRKTEDN------------SLVVWKEVNLTRCS--------------------------ERVMYDAQNEIEILSM-------LNHANI
.||.|.||.  | . ....              |  | .. .. .                          .. .   ..||||...       |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ISYFNHFLD-------------------DQSLFIEM---EYANGG----TLYEKIVHQ-------DGTLFEEEKQLKQVNHCFN------ITFNLQLVLW
|. . .. |                   |. ... |   ||. ||     |...|| .       |                          |. . .  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFD-----------------QFDIVERGRFTEREARR

YLFQTVSAVAYIHQIDVLHRDIKTLNIFMTKS-----------------GLIKVGDFGISKVLGD------------------------DKMAESVVGTP
|  | .|||.|.|. .. |||.|  || ....                 . ||. ||| .... .                        ... . ..|||
YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTP

LYMS-PELVKGQQ--------------YNAKSDVWAIGCVLYELLTLRRVFEAS--------------------NQLKVVWGIVQKE------------H
 ||. ||...|..              |. |.|.|..|..|| .|. .  |...                    . .|  .    ..             
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWW

EDIDER----YSKEMHSLVTQLLAKDPENRPSAAEIMANPLL
 || .      |.|  .|. ..| .|||.|........ | .
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK9.AA Ciliate-E2 30-300 20 1.9e-55 188.8 In-house 1-365 (365) Show / Hide 
Range on Protein: 30-300
Range on HMM: 1-365/365
Sequence Identity: 20% (80 aa)

YTPVRVLGKGAFG---EAVLYRKTE--------------------DNSLVVWKEVNLTRCSERVM-YDAQNEIE----------ILSMLNHANIISYFNH
|  ....|.|.||   ..  ... .                    .....  | ..     .  .  .  .||.          ||. ||| ||| .. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FL--DDQSLFIEMEYANGGTLYEKIVHQDGTLFEE--EKQLKQVNHCFNITFNLQLVL-------WYLFQTVSAVAYIHQID-VLHRDIKTLNIFMTKSG
|   ||..... |||..||.|.. | ...   ..|  . . |. ..   ...  |..         |. . ..|. |.|.   ..|||||  ||..    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

LIKVGDFGISKVLGDD--------------------------------KMAESVVGTPLYMSPELVKGQQ---------YNAKSDVWAIGCVLYELLTLR
 ||. |||.|| . ||                                 |. ...||| ||.|| ..|..         |. |.|.|..|..|||.|. .
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

RVFEASNQLKVVWGIVQKEHED----------------------IDERYSKEMHSLVTQ----LLAKDPENRPS-AAEIMANPLL
. |             |.....                      . .  |.|.  |  .    .| ||||.|.. . .|. .| .
PPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK9.AA NEK1 154-300 41 1.3e-54 187.71 In-house 112-276 (276) Show / Hide 
Range on Protein: 154-300
Range on HMM: 112-276/276
Sequence Identity: 41% (68 aa)

QTVSAVAYIHQIDVLHRDIKTLNIFMT--KSG---------------LIKVGDFGISKVLGD-DKMAESVVGTPLYMSPELVKGQQYNAKSDVWAIGCVL
| . |. .||   .||||||. ||| |  |.|               |.|.|||||...| . .  |  ..||| | |||.   . || |||.|. ||||
QICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNKSDIWSLGCVL

YELLTLRRVFEASNQLKVVWGIVQKEHEDIDERYSKEMHSLVTQLLAKDPENRPSAAEIMANPLL
|||.|| . ||| |    |  |.|     |  .||.| .|||.|.. ..|..|||.  |   | .
YELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK9.AA NEK-Unclassified 154-300 36 4.7e-50 163.74 In-house 105-258 (258) Show / Hide 
Range on Protein: 154-300
Range on HMM: 105-258/258
Sequence Identity: 36% (56 aa)

QTVSAVAYIHQIDVLHRDIKTLNIFMTKSGLIKVGDFGISKVLGDDKM-AESVVGTPLYMSPELVKGQQYNAKSDVWAIGCVLYELLTLRRVFEASNQLK
| . ||.||||  ..||| |. |||.|.. ..  ||||||... . .  |   |||. .|||| .. | || .||||. ||..||. |    | . | . 
QMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGE

VVWGIVQKEH------EDIDERYSKEMHSLVTQLLAKDPENRPSAAEIMANPLL
|  .|.| .       | .   ||  .  ... .| .... |||| ||.  .  
VYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase NEK9.AA ULK 30-300 22 9.3e-50 171.62 In-house 1-324 (324) Show / Hide 
Range on Protein: 30-300
Range on HMM: 1-324/324
Sequence Identity: 22% (77 aa)

YTPVRVLGKGAFG-EAVLYRKTEDN-SLVVWKEVNLTRCSERVMYDA----------QNEIEILSMLN---HAN--IISYFNHFLDDQS--LFIEMEYAN
|   ..||||.||      |. ..| . .... .   ... .  .            .|||.|. .|.   | |  |. ..  | ....  ..| ||| |
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGTLYEKIVHQDGTLFEEEKQLKQVNHCFNITFNLQLVLWYLFQTVSAVAYIHQIDVLHRDIKTLNIFMTK------------SGLIKVGDFGISKVLGD
||.| |.. .....| | .         .. ... | .. .. | ...  ..|.  . |||||  || ...            .| .|..||| .|.. .
GGDL-EQYIKKNKKLPE-T-E-------EKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

D----KMAESVV------GTPLYMSPELVK----GQQYN-AKSDVWAIGCVLYELLTLRRVFEASNQLKVVWGIVQKEHED-------IDE---------
.     |  . |      ||||||.|....    ...|. .|.|.| .||..||.|. .  |...   . ... .||. .        |           
NNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPP

---RYSKEMHSLVTQLLAKDPENRPSAAEIMANPLL
     |.|...|  ..| .|.. | |  || ..|..
KDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase NEK9.AA NEK1 30-128 36 5.8e-26 87.13 In-house 1-103 (276) Show / Hide 
Range on Protein: 30-128
Range on HMM: 1-103/276
Sequence Identity: 36% (38 aa)

YTPVRVLGKGAFGEAVLYRKTEDNSLVVWKEVNLTRCSERVMYDAQNEIEILSMLNHANIISYFNHFLDDQS--LFIEMEYANGGTLYEKIVHQ--DGTL
|.  ...|.|.|| |.| ...||... | || |... .|    .. ||  ||... | ||..|.. |    .  |.| |||..|| |. ||  |   | |
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FEE
| |
FSE
Kinase NEK9.AA TyrKc 30-300 20 1.6e-15 28.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 30-300
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

YTPVRVLGKGAFGEAVLYRKTEDNSLVVWKEVNLTRCSERVMYDAQNEIEILSML--NHANIISYFNHFLDD-------QSLFIEMEYANGGTLYEKIVH
 |  ..|| ||||| .. . .     |  | ..        . |  .|..|...|  .| ||.  .   ...       . |.| |||. .| | . .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QDGTLFEEEKQLKQVNHCFNITFNLQLVLWYLFQTVSAVAYIHQIDVLHRDIKTLNIFMTKSGLIKVGDFGISKVLGDD----KMAESVV-----GTP--
  ..                  ....  | . .|  .  .|.|.  . |||. . |.  .. . .|..||| |. ..||       .  .     |.   
HRPK------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM

L---YMSPELVKGQQYNAKSDVWAIGCVLYELLTLRRVFEAS-----NQLKVVWGIVQKEHEDIDERY---------SKEMHSLVTQLLAKDPENRPSAA
|    |.||  .   .. |||||. | ...|..|.               . |   |.. .      .         ..||... .|  . |||.||. .
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

EIMANPLL
||    ..
EI--HECF
Kinase NEK9.AA Pkinase_Tyr 76-241 19 4.2e-11 38.23 Pfam 52-210 (270) Show / Hide 
Range on Protein: 76-241
Range on HMM: 52-210/270
Sequence Identity: 19% (35 aa)

NEIEILSML-NHANIISYFNHFL-DDQS--LFIEMEYANGGTLYEKIVHQDGTLFEEEKQLKQVNHCFNITFNLQLVLWYLFQTVSAVAYIHQIDVLHRD
.|..|.. | .| ||...    . ....  ..| |||. .| |..    .                  .  ....  | . .|  .. .| ...   |||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRD

IKTLNIFMTKSGLIKVGDFGISKVLGDDKMAES-VVGT-----PLYMSPELVKGQQYNAKSDVWAIGCVLYELLTL
. . |.  |... .|..||| .. .   .  .  ....        |.||  .   .. |||||. | ...|..|.
LAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase NEK9.AA NEK-Unclassified 75-118 40 7e-06 15.16 In-house 41-84 (258) Show / Hide 
Range on Protein: 75-118
Range on HMM: 41-84/258
Sequence Identity: 40% (18 aa)

QNEIEILSMLNHANIISYFNHFLDDQSLFIEMEYANGGTLYEKI
|| | ||| | |  |. |   | .   ||   .|  || | ..|
QNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRI
Kinase NEK9.AA Pkinase_Tyr 30-43 57 4.788051 0.78 Pfam 1-14 (270) Show / Hide 
Range on Protein: 30-43
Range on HMM: 1-14/270
Sequence Identity: 57% (8 aa)

YTPVRVLGKGAFGE
 |  ..||.|||||
ITFGKKLGEGAFGE
RCC1 NEK9.AA RCC1 349-377 26 0.071958 8.95 Pfam 24-52 (52) Show / Hide 
Range on Protein: 349-377
Range on HMM: 24-52/52
Sequence Identity: 26% (8 aa)

RLTPLK-LEAFKDGNRALQVAAGHSHFASV
...| . .| . . .|  |||.|..| . .
CHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK9.AA RCC1 407-467 31 2.9e-16 55.66 Pfam 1-52 (52) Show / Hide 
Range on Protein: 407-467
Range on HMM: 1-52/52
Sequence Identity: 31% (20 aa)

EGQVYTFGSDYYGCLGRGEDYEPEDDDDDDEEEVKSPIL-VSFFNE-RPVNKISCGDNHILAL
.|.|||.|.  ||.|||           .|. ..  | . |.|.   ..| ...||..| .||
DGRVYTWGCNDYGQLGR---------IHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK9.AA RCC1 470-519 31 2.2e-16 56.06 Pfam 1-52 (52) Show / Hide 
Range on Protein: 470-519
Range on HMM: 1-52/52
Sequence Identity: 31% (17 aa)

DEQVYSWGCGEFGRLG--LGNEDDYKLPQK-VTFQGK-KEIKTVSAGSEGSFFL
| .||.|||...|.||  .|.. .   ||. |.|  . .... |..|.. ...|
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK9.AA RCC1 522-591 20 2.5e-10 36.39 Pfam 1-52 (52) Show / Hide 
Range on Protein: 522-591
Range on HMM: 1-52/52
Sequence Identity: 20% (15 aa)

DGKVYACGSNEHNRLGFNTVTAGLKRENSEAIVANECYDIPYKDIPTL-VKPLNR-YNIKAVSAGHTHSATI
||.||..|.|.. .||                   .  |  .. .|.. |. | . . .. |..|..|.. .
DGRVYTWGCNDYGQLGR------------------IHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK9.AA RCC1 595-644 32 5.5e-07 25.57 Pfam 2-52 (52) Show / Hide 
Range on Protein: 595-644
Range on HMM: 2-52/52
Sequence Identity: 32% (17 aa)

GRLIMFGSNQYGQLG--VGDCKGRSGICE-VKGFLTGKHVVTASCGDGFTIIA
||.  .|.|.|||||   ||.  ..  .  |...   ..|| ..||. .|.. 
GRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK9.AA RCC1 647-703 21 0.002242 13.84 Pfam 1-52 (52) Show / Hide 
Range on Protein: 647-703
Range on HMM: 1-52/52
Sequence Identity: 21% (13 aa)

DNQIFSFGHVDSGRLGHGDDLTGSHKKKQSVSTPKP-VFGSLH--MVSGLSCRYWHTIII
| .....|  | |.||.       |. . ....|.. | .      |.  .| ..||...
DGRVYTWGCNDYGQLGR------IHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL