NRBP

Species: Sea Urchin
Alias: NRBP, Spk183, SPU_020168
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: NRBP

Sequence

Name Sequence Type Origin Length Description Download
NRBP.AA Protein None 503 None Fasta, JSON
NRBP.kin_dom Protein Kinase Domain None 84 None Fasta, JSON

Protein domain

Protein domains of NRBP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NRBP.AA NRBP 90-269 70 2.3e-103 349.73 In-house 1-176 (261) Show / Hide
Range on Protein: 90-269
Range on HMM: 1-176/261
Sequence Identity: 70% (126 aa)

QRDVPGIDVAYLAMDMEEGREVVWNEVQFSARRDFKAQEDILHLLLHHLIHLQHLLIVKLHNHCHDTMLHIDQLHIRVIFITEYMSSGSLKQFLKKIKKD
||||||||.|||||| ||| |||||||||| |..|||||. .. .  .|| |.|. |||.| .  ||     . ..|||||||||||||.||||||.||.
QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTK----EEKPRVIFITEYMSSGSMKQFLKKTKKN

KRNIQEKSWRRWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNGLIKIGSVAPDAINNHVKTYTEEQRNMHYIAPEYG
..|..||.|.||||||||||||||||||||||||||.||.|||||||||||.|.||||..||.|  ||.||||..|||||
HKNMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYG

Kinase NRBP.AA WNK 167-240 44 3.4e-18 55.29 In-house 77-148 (261) Show / Hide
Range on Protein: 167-240
Range on HMM: 77-148/261
Sequence Identity: 44% (34 aa)

VIFITEYMSSGSLKQFLKKIKKDKRNIQEKSWRRWCTQILSALSYLHSCDP-PIIHGNLTTDTVFIQ-HNGLIKIG
.. .|| | || || .||  ||    .. |  |.|| |||. |..||.. | ||||  |  | .||   .| .|||
IVLVTELMTSGTLKTYLKRFKK----MKPKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIG

Kinase NRBP.AA TKL 169-240 22 1.9e-12 41.13 In-house 115-196 (364) Show / Hide
Range on Protein: 169-240
Range on HMM: 115-196/364
Sequence Identity: 22% (21 aa)

FITEYMSSGS-LKQFLKKIKKDKRNIQEKSWRRWCTQILSALSYLHSCD------PPIIHGNLTTDTVFIQHNGL--------------IKIG
...||.. || | ...                ||. .| ....||||..      ||||| .|... ...  |.               .||.
IVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC

Kinase NRBP.AA Ciliate-E2-Unclassified 157-239 25 1.7e-10 32.66 In-house 86-188 (352) Show / Hide
Range on Protein: 157-239
Range on HMM: 86-188/352
Sequence Identity: 25% (27 aa)

MLHIDQLHIRVIFITEYMSSGSLKQFLKKIKK----------DKRN---IQEKSWR-----RWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNG---
|....|    .....||.  |.|.|..|| ||          ....   ..|.  .     ... |||..|.|||.    ||| ... . .... ||   
MFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNY

LIKI
 |||
YIKI

Kinase NRBP.AA TK 146-240 12 3.6e-10 29.5 In-house 105-293 (486) Show / Hide
Range on Protein: 146-240
Range on HMM: 105-293/486
Sequence Identity: 12% (24 aa)

IVKLHNHCHDTM------LHIDQLHIRVIFITEYMSSGS----LKQFLKKIKKDKRN-------------------------------------------
||.|. .|..        . .  .   .. ..|||. |.    |...|.| ......                                           
IVRLYGVCTQGEPKPCFEV-V-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDD

---------IQEKSWRR-------------------WCTQILSALSYLHSCDP----PIIHGNLTTDTVFIQHNGL-----------IKIG
         ...|   .                   .| || ....||||.       ..|..| .  . . .|.            .||.
DLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA

Kinase NRBP.AA SgK071 172-224 37 7.2e-10 30.43 In-house 80-130 (283) Show / Hide
Range on Protein: 172-224
Range on HMM: 80-130/283
Sequence Identity: 37% (20 aa)

EYMSSGSLKQFLKKIKKDKRNIQEKSWRRWCTQILSALSYLHSCDPPIIHGNL
.| . |.. .|.|. .| |  . |   .||| |.| |. |||  .  ||| .|
DYYKMGDFDRFMKEKRKKKKIMCEEWMQRWCGQMLHAIEYLHHRN--IIHRDL

Kinase NRBP.AA LRRK 168-227 32 1.2e-08 26.67 In-house 131-195 (351) Show / Hide
Range on Protein: 168-227
Range on HMM: 131-195/351
Sequence Identity: 32% (21 aa)

IFITEYMSSGSLKQFLKKIKKDKR-----NIQEKSWRRWCTQILSALSYLHSCDPPIIHGNLTTD
....||.. |.| .||.. |.|..     .|      .  .|| ... ||||..||||| .|...
CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSP

Kinase NRBP.AA S_TKc 98-299 19 1.6e-08 -51.87 SMART 14-231 (231) Show / Hide
Range on Protein: 98-299
Range on HMM: 14-231/231
Sequence Identity: 19% (50 aa)

VAYLAMDMEEGREVVWNEVQFSARRDFKAQEDILHLLLHHLIHLQHLLIVKLHNHCHDTMLHIDQLHIRVIFITEYMSS--GSLKQFLKKIKKDKRN--I
. |.. . . ||.|   ..        ...  |  |        .|  ||||. ...|          .. ...||..   |.|....|| .. ...  .
KVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QEKSWRRWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNGLIKIGS----------------VAPDAINNHVKTYTE---------------------
 |   |... ||..|| |.||    |||  |  . ... .   |||.                 .||  .      |.                      
PE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPP

---EQRNMHYIAPEYGGFKQMNFLKRCLD-DVQSRPTARDLLL-------HPVL
   .|. .. |          .|...||. | . |||| ..|        || .
FPQMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase NRBP.AA MLK 170-221 28 4.9e-08 24.1 In-house 88-150 (291) Show / Hide
Range on Protein: 170-221
Range on HMM: 88-150/291
Sequence Identity: 28% (18 aa)

ITEYMSSGSLKQFLKKIKK----------DKRNIQEKSWRRWCTQILSALSYLHSCDP-PIIH
..||.. |||  .|. ...            |..   .  .|..|. ....|||| .| ||||
VMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIH

Kinase NRBP.AA NRBP 273-300 48 1e-06 19.35 In-house 233-261 (261) Show / Hide
Range on Protein: 273-300
Range on HMM: 233-261/261
Sequence Identity: 48% (14 aa)

QMNFLKRCLD-DVQSRPTARDLLLHPVLF
| .|...||  | . ||.||.|| |..||
QRDFIRKCLQKDPARRPSARELLFHQILF

Kinase NRBP.AA PAKA 275-299 50 1e-06 19.59 In-house 235-260 (260) Show / Hide
Range on Protein: 275-299
Range on HMM: 235-260/260
Sequence Identity: 50% (13 aa)

NFLKRCLD-DVQSRPTARDLLLHPVL
.||..||. ||..|..|..|| || |
DFLDKCLCVDVDRRASAQELLHHPFL

Kinase NRBP.AA STE 170-214 30 3e-06 18.09 In-house 115-170 (359) Show / Hide
Range on Protein: 170-214
Range on HMM: 115-170/359
Sequence Identity: 30% (17 aa)

ITEYMSSGSLKQFLKKIKKDKRN----------IQEKSWRRWCTQILSA-LSYLHS
. |||. ||| ...|. .. ...          ..|.  .. | ||| . |.||||
CMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS

Kinase NRBP.AA Pkinase 140-221 23 3.1e-05 19.58 Pfam 56-131 (293) Show / Hide
Range on Protein: 140-221
Range on HMM: 56-131/293
Sequence Identity: 23% (21 aa)

HLQHLLIVKLHNHCHDTMLHIDQLHIRVIFITEYMSSG----SLKQFLKKIKKDKRNI--QEKSWRRWCTQILSALSYLHSCDPPIIH
.|.|  ||.|.  ..|        . .. ...||.  |    .|. ...   ......  .|.  .....|||..| |.||.   |||
RLNHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIH

Kinase NRBP.AA STE 275-299 42 0.000145 12.18 In-house 332-359 (359) Show / Hide
Range on Protein: 275-299
Range on HMM: 332-359/359
Sequence Identity: 42% (12 aa)

NFLKRCLD-DVQSRPTARDLLL--HPVL
.|...||. | . |||| .||   || .
DFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase NRBP.AA Pkinase_Tyr 166-240 29 0.00032 14.92 Pfam 81-153 (270) Show / Hide
Range on Protein: 166-240
Range on HMM: 81-153/270
Sequence Identity: 29% (22 aa)

RVIFITEYMSSGSLKQFLKKIKKDKRNIQEKSWRRWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNGLIKIG
... ..|||  |.|. .|.| . ||...  |    .|.|| ....||.|    .||  | .  . . .|. .||.
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKIC

Kinase NRBP.AA TyrKc 118-299 15 0.00048 -157.23 SMART 1-280 (280) Show / Hide
Range on Protein: 118-299
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

FSARRDF--------------------KAQEDILHLLLHH----LIHL--QHLLIVKLHNHCHDT---MLHIDQLHIRVIFITEYMSSGSLKQFLKKIKK
 .  .                      . .||  .  ...    . .|  .|  ||.|.  | .     . |..| |    ..|||. |.||..|.| ..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMI----VMEYMPHGDLKDYLRKHRP

DKRNIQEKSWRRWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNGLIKIGSVAPD---AINNHVK--------TYTEE---QRN--------------
.   .. |    .|.|| .  .||||   ..||  | .  . . .|. .||.    |   . . . .        .|.     ...              
K---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKIS----DFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

--------------------MHYIAPEYGG--------------FKQMNFLKRCLD-----------------------DVQSRPTARDLLLHPVL
                    . | .. | |               || . ...  .                       |  .||| ...  |  .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase NRBP.AA PAKA 172-239 26 0.002881 7.5 In-house 78-144 (260) Show / Hide
Range on Protein: 172-239
Range on HMM: 78-144/260
Sequence Identity: 26% (18 aa)

EYMSSGSLKQFLKKIKKDKRN-IQEKSWRRWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNGLIKI
|||. |.|   ...  . . | ..|.     | ..|..|...||    .||  .  | . .  .| .||
EYMEGGCLTDVITQCCNIQCNYMDEGQIAYVCRECLQGLEFIHSKH--RIHRDIKSDNILLGMDGSVKI

Kinase NRBP.AA Pkinase 276-299 48 0.023652 9.4 Pfam 269-293 (293) Show / Hide
Range on Protein: 276-299
Range on HMM: 269-293/293
Sequence Identity: 48% (12 aa)

FLKRCLD-DVQSRPTARDLLLHPVL
|.|.||. | ..||||...| || .
FIKWCLCKDPKKRPTAEQILQHPWF

Kinase NRBP.AA WNK 275-299 23 0.05125 2.2 In-house 236-261 (261) Show / Hide
Range on Protein: 275-299
Range on HMM: 236-261/261
Sequence Identity: 23% (6 aa)

NFLKRCLDDVQ-SRPTARDLLLHPVL
..  .|.   .  ||....|| |  .
EIIEKCIRHNKEERPSIQQLLNHDFF

Kinase NRBP.AA Ciliate-E2-Unclassified 271-299 20 0.310663 0.06 In-house 319-352 (352) Show / Hide
Range on Protein: 271-299
Range on HMM: 319-352/352
Sequence Identity: 20% (7 aa)

FKQMNFLK----RCLDDVQS-RPTARDLLLHPVL
... .|..    ..|.  .. |.|. ..| || .
PEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF