Gene NRBP (Sea Urchin)
NRBP
Sequence
Protein domains of NRBP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | NRBP.AA | NRBP | 90-269 | 70 | 2.3e-103 | 349.73 | In-house | 1-176 (261) | Show / Hide |
Range on Protein: 90-269 Range on HMM: 1-176/261 Sequence Identity: 70% (126 aa) QRDVPGIDVAYLAMDMEEGREVVWNEVQFSARRDFKAQEDILHLLLHHLIHLQHLLIVKLHNHCHDTMLHIDQLHIRVIFITEYMSSGSLKQFLKKIKKD ||||||||.|||||| ||| |||||||||| |..|||||. .. . .|| |.|. |||.| . || . ..|||||||||||||.||||||.||. QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTK----EEKPRVIFITEYMSSGSMKQFLKKTKKN KRNIQEKSWRRWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNGLIKIGSVAPDAINNHVKTYTEEQRNMHYIAPEYG ..|..||.|.||||||||||||||||||||||||||.||.|||||||||||.|.||||..||.| ||.||||..||||| HKNMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYG |
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Kinase | NRBP.AA | WNK | 167-240 | 44 | 3.4e-18 | 55.29 | In-house | 77-148 (261) | Show / Hide |
Range on Protein: 167-240 Range on HMM: 77-148/261 Sequence Identity: 44% (34 aa) VIFITEYMSSGSLKQFLKKIKKDKRNIQEKSWRRWCTQILSALSYLHSCDP-PIIHGNLTTDTVFIQ-HNGLIKIG .. .|| | || || .|| || .. | |.|| |||. |..||.. | |||| | | .|| .| .||| IVLVTELMTSGTLKTYLKRFKK----MKPKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIG |
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Kinase | NRBP.AA | TKL | 169-240 | 22 | 1.9e-12 | 41.13 | In-house | 115-196 (364) | Show / Hide |
Range on Protein: 169-240 Range on HMM: 115-196/364 Sequence Identity: 22% (21 aa) FITEYMSSGS-LKQFLKKIKKDKRNIQEKSWRRWCTQILSALSYLHSCD------PPIIHGNLTTDTVFIQHNGL--------------IKIG ...||.. || | ... ||. .| ....||||.. ||||| .|... ... |. .||. IVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC |
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Kinase | NRBP.AA | Ciliate-E2-Unclassified | 157-239 | 25 | 1.7e-10 | 32.66 | In-house | 86-188 (352) | Show / Hide |
Range on Protein: 157-239 Range on HMM: 86-188/352 Sequence Identity: 25% (27 aa) MLHIDQLHIRVIFITEYMSSGSLKQFLKKIKK----------DKRN---IQEKSWR-----RWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNG--- |....| .....||. |.|.|..|| || .... ..|. . ... |||..|.|||. ||| ... . .... || MFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNY LIKI ||| YIKI |
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Kinase | NRBP.AA | TK | 146-240 | 12 | 3.6e-10 | 29.5 | In-house | 105-293 (486) | Show / Hide |
Range on Protein: 146-240 Range on HMM: 105-293/486 Sequence Identity: 12% (24 aa) IVKLHNHCHDTM------LHIDQLHIRVIFITEYMSSGS----LKQFLKKIKKDKRN------------------------------------------- ||.|. .|.. . . . .. ..|||. |. |...|.| ...... IVRLYGVCTQGEPKPCFEV-V-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDD ---------IQEKSWRR-------------------WCTQILSALSYLHSCDP----PIIHGNLTTDTVFIQHNGL-----------IKIG ...| . .| || ....||||. ..|..| . . . .|. .||. DLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA |
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Kinase | NRBP.AA | SgK071 | 172-224 | 37 | 7.2e-10 | 30.43 | In-house | 80-130 (283) | Show / Hide |
Range on Protein: 172-224 Range on HMM: 80-130/283 Sequence Identity: 37% (20 aa) EYMSSGSLKQFLKKIKKDKRNIQEKSWRRWCTQILSALSYLHSCDPPIIHGNL .| . |.. .|.|. .| | . | .||| |.| |. ||| . ||| .| DYYKMGDFDRFMKEKRKKKKIMCEEWMQRWCGQMLHAIEYLHHRN--IIHRDL |
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Kinase | NRBP.AA | LRRK | 168-227 | 32 | 1.2e-08 | 26.67 | In-house | 131-195 (351) | Show / Hide |
Range on Protein: 168-227 Range on HMM: 131-195/351 Sequence Identity: 32% (21 aa) IFITEYMSSGSLKQFLKKIKKDKR-----NIQEKSWRRWCTQILSALSYLHSCDPPIIHGNLTTD ....||.. |.| .||.. |.|.. .| . .|| ... ||||..||||| .|... CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSP |
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Kinase | NRBP.AA | S_TKc | 98-299 | 19 | 1.6e-08 | -51.87 | SMART | 14-231 (231) | Show / Hide |
Range on Protein: 98-299 Range on HMM: 14-231/231 Sequence Identity: 19% (50 aa) VAYLAMDMEEGREVVWNEVQFSARRDFKAQEDILHLLLHHLIHLQHLLIVKLHNHCHDTMLHIDQLHIRVIFITEYMSS--GSLKQFLKKIKKDKRN--I . |.. . . ||.| .. ... | | .| ||||. ...| .. ...||.. |.|....|| .. ... . KVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF QEKSWRRWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNGLIKIGS----------------VAPDAINNHVKTYTE--------------------- | |... ||..|| |.|| ||| | . ... . |||. .|| . |. PE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPP ---EQRNMHYIAPEYGGFKQMNFLKRCLD-DVQSRPTARDLLL-------HPVL .|. .. | .|...||. | . |||| ..| || . FPQMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | NRBP.AA | MLK | 170-221 | 28 | 4.9e-08 | 24.1 | In-house | 88-150 (291) | Show / Hide |
Range on Protein: 170-221 Range on HMM: 88-150/291 Sequence Identity: 28% (18 aa) ITEYMSSGSLKQFLKKIKK----------DKRNIQEKSWRRWCTQILSALSYLHSCDP-PIIH ..||.. ||| .|. ... |.. . .|..|. ....|||| .| |||| VMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIH |
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Kinase | NRBP.AA | NRBP | 273-300 | 48 | 1e-06 | 19.35 | In-house | 233-261 (261) | Show / Hide |
Range on Protein: 273-300 Range on HMM: 233-261/261 Sequence Identity: 48% (14 aa) QMNFLKRCLD-DVQSRPTARDLLLHPVLF | .|...|| | . ||.||.|| |..|| QRDFIRKCLQKDPARRPSARELLFHQILF |
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Kinase | NRBP.AA | PAKA | 275-299 | 50 | 1e-06 | 19.59 | In-house | 235-260 (260) | Show / Hide |
Range on Protein: 275-299 Range on HMM: 235-260/260 Sequence Identity: 50% (13 aa) NFLKRCLD-DVQSRPTARDLLLHPVL .||..||. ||..|..|..|| || | DFLDKCLCVDVDRRASAQELLHHPFL |
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Kinase | NRBP.AA | STE | 170-214 | 30 | 3e-06 | 18.09 | In-house | 115-170 (359) | Show / Hide |
Range on Protein: 170-214 Range on HMM: 115-170/359 Sequence Identity: 30% (17 aa) ITEYMSSGSLKQFLKKIKKDKRN----------IQEKSWRRWCTQILSA-LSYLHS . |||. ||| ...|. .. ... ..|. .. | ||| . |.|||| CMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS |
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Kinase | NRBP.AA | Pkinase | 140-221 | 23 | 3.1e-05 | 19.58 | Pfam | 56-131 (293) | Show / Hide |
Range on Protein: 140-221 Range on HMM: 56-131/293 Sequence Identity: 23% (21 aa) HLQHLLIVKLHNHCHDTMLHIDQLHIRVIFITEYMSSG----SLKQFLKKIKKDKRNI--QEKSWRRWCTQILSALSYLHSCDPPIIH .|.| ||.|. ..| . .. ...||. | .|. ... ...... .|. .....|||..| |.||. ||| RLNHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIH |
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Kinase | NRBP.AA | STE | 275-299 | 42 | 0.000145 | 12.18 | In-house | 332-359 (359) | Show / Hide |
Range on Protein: 275-299 Range on HMM: 332-359/359 Sequence Identity: 42% (12 aa) NFLKRCLD-DVQSRPTARDLLL--HPVL .|...||. | . |||| .|| || . DFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | NRBP.AA | Pkinase_Tyr | 166-240 | 29 | 0.00032 | 14.92 | Pfam | 81-153 (270) | Show / Hide |
Range on Protein: 166-240 Range on HMM: 81-153/270 Sequence Identity: 29% (22 aa) RVIFITEYMSSGSLKQFLKKIKKDKRNIQEKSWRRWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNGLIKIG ... ..||| |.|. .|.| . ||... | .|.|| ....||.| .|| | . . . .|. .||. QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKIC |
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Kinase | NRBP.AA | TyrKc | 118-299 | 15 | 0.00048 | -157.23 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 118-299 Range on HMM: 1-280/280 Sequence Identity: 15% (45 aa) FSARRDF--------------------KAQEDILHLLLHH----LIHL--QHLLIVKLHNHCHDT---MLHIDQLHIRVIFITEYMSSGSLKQFLKKIKK . . . .|| . ... . .| .| ||.|. | . . |..| | ..|||. |.||..|.| .. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMI----VMEYMPHGDLKDYLRKHRP DKRNIQEKSWRRWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNGLIKIGSVAPD---AINNHVK--------TYTEE---QRN-------------- . .. | .|.|| . .|||| ..|| | . . . .|. .||. | . . . . .|. ... K---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKIS----DFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN --------------------MHYIAPEYGG--------------FKQMNFLKRCLD-----------------------DVQSRPTARDLLLHPVL . | .. | | || . ... . | .||| ... | . YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | NRBP.AA | PAKA | 172-239 | 26 | 0.002881 | 7.5 | In-house | 78-144 (260) | Show / Hide |
Range on Protein: 172-239 Range on HMM: 78-144/260 Sequence Identity: 26% (18 aa) EYMSSGSLKQFLKKIKKDKRN-IQEKSWRRWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNGLIKI |||. |.| ... . . | ..|. | ..|..|...|| .|| . | . . .| .|| EYMEGGCLTDVITQCCNIQCNYMDEGQIAYVCRECLQGLEFIHSKH--RIHRDIKSDNILLGMDGSVKI |
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Kinase | NRBP.AA | Pkinase | 276-299 | 48 | 0.023652 | 9.4 | Pfam | 269-293 (293) | Show / Hide |
Range on Protein: 276-299 Range on HMM: 269-293/293 Sequence Identity: 48% (12 aa) FLKRCLD-DVQSRPTARDLLLHPVL |.|.||. | ..||||...| || . FIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | NRBP.AA | WNK | 275-299 | 23 | 0.05125 | 2.2 | In-house | 236-261 (261) | Show / Hide |
Range on Protein: 275-299 Range on HMM: 236-261/261 Sequence Identity: 23% (6 aa) NFLKRCLDDVQ-SRPTARDLLLHPVL .. .|. . ||....|| | . EIIEKCIRHNKEERPSIQQLLNHDFF |
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Kinase | NRBP.AA | Ciliate-E2-Unclassified | 271-299 | 20 | 0.310663 | 0.06 | In-house | 319-352 (352) | Show / Hide |
Range on Protein: 271-299 Range on HMM: 319-352/352 Sequence Identity: 20% (7 aa) FKQMNFLK----RCLDDVQS-RPTARDLLLHPVL ... .|.. ..|. .. |.|. ..| || . PEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |